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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-jie zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Optimized Bi-level Control for Day-ahead and Real-time Active Power Balancing of an Off-grid Wind Power-to-hydrogen System With ESS Considering Wind Power Uncertainty

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Dianwang Jishu/Power System Technology 2025年第1期49卷 52-62页

作者： Qiu, Yiwei Sun, Qingjie Wu, Chenxu zhu, jie Zeng, Yangjun Chen, Shi Zhou, Buxiang College of Electrical Engineering Sichuan University Sichuan Province Chengdu 610065 China State Grid Ningbo Power Supply Company Zhejiang Province Ningbo 315012 China

Since off-grid wind power-to-hydrogen (Wp2H) systems are not connected to the utility grid, the hydrogen production load and the energy storage system (ESS) must be coordinated to absorb wind power fluctuations and maintain system stability. Such coordination must consider the flexibility constraints of hydrogen production units, the overall hydrogen yield, and the degradation of batteries in the ESS to meet the economic goals of green hydrogen production. Therefore, an optimized bi-level control method for the active power balance is proposed. Firstly, using the Itô process to characterize wind power fluctuations and considering the real-time flexibility reserve of multiple electrolyzers, the upper level is formulated as an intra-day scheduling problem with a 15-minute resolution. Secondly, the lower level optimizes the real-time power of the electrolyzers and the ESS based on their on-off states and baseline power commanded by the upper level, considering the degradation cost of the ESS. This helps to absorb second-level wind power fluctuations. Finally, based on a project plan in Inner Mongolia, China, a case study verifies the effectiveness of the proposed method. © 2025 Power System Technology Press. All rights reserved.

关键词： Hydrogen storage

Multifunctional Fire-Resistant Paper Based on Ultralong Hydroxyapatite Nanowires

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Chinese Journal of Chemistry 2021年第8期39卷 2296-2314页

作者： Ying-jie zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of Sciences1295 Ding-Xi RoadShanghai 200050China

Paper was one of the greatest inventions in ancient China,and it greatly promoted the rapid development of human *** in today's electronic information age,paper and paper-derived products are still indispensable to people's daily work and ***;the traditional paper based on cellulose fibers from plants has some *** instance:(1)papermaking consumes a large amount of precious natural resources such as trees;(2)the papermaking industry causes environmental pollution;(3)the traditional paper consisting of organic cellulose fibers is highly flammable and easy to burn;(4)the traditional paper based on cellulose fibers turns to yellow color with time;(5)the lifetime of the traditional paper is relatively short because of the degradation of cellulose *** efforts are needed to investigate and solve these problems facing the traditional *** recent years,a new kind of multifunctional fire-resistant paper based on ultralong hydroxyapatite nanowires has been developed and investigated for various applications,and many research findings have been documented in the *** review article provides a comprehensive summary and discussion on recent research advances for this new kind of multifunctional fire-resistant paper based on ultralong hydroxyapatite nanowires,including the synthesis,properties,applications,and future perspectives.

关键词： Nano wires Hydroxyapatite Fire-resistant paper Nanostructures Green chemistry

Implementation procedure for the generalized moving Preisach model based on a first order reversal curve diagram

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Rare Metals 2009年第4期28卷 355-360页

作者： HAN Yong zhu jie State Key laboratory for Advanced Metals and Materials University of Science and Technology Beijing Beijing 100083 China

First order reversal curves （FORC） of nanocomposite Nd2Fe14B/Fe3B magnetic materials were measured to attain a FORC diagram, which characterizes reversible magnetization, irreversible magnetization, and magnetic interactions in a hysteresis system. Then, generalized mov- ing Preisach model （GMPM） was implemented based on the FORC diagram. Reversible and irreversible magnetizations shown in FORCs and a FORC diagram were used as an input of GMPM. Coupling interaction between reversible and irreversible magnetizations was added when calculating reversible magnetization. Meanwhile, irreversible magnetic moments＇ interaction was approximately represented by mean field interaction. The result shows that the simulated main curves mostly coincide with the experimental curves.

关键词： FORC diagram Preisach model reversible magnetization irreversible magnetization magnetic interactions

Multipurpose audio watermarking algorithm

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第4期9卷 517-523页

作者： Ning CHEN jie zhu Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

To make audio watermarking accomplish both copyright protection and content authentication with localization, a novel multipurpose audio watermarking scheme is proposed in this paper. The zero-watermarking idea is introduced into the design of robust watermarking algorithm to ensure the transparency and to avoid the interference between the robust watermark and the semi-fragile watermark. The property of natural audio that the VQ indices of DWT-DCT coefficients among neighboring frames tend to be very similar is utilized to extract essential feature from the host audio, which is then used for watermark ex-traction. And, the chaotic mapping based semi-fragile watermark is embedded in the detail wavelet coefficients based on the instantaneous mixing model of the independent component analysis (ICA) system. Both the robust and semi-fragile watermarks can be extracted blindly and the semi-fragile watermarking algorithm can localize the tampering accurately. Simulation results demonstrate the effectiveness of our algorithm in terms of transparency, security, robustness and tampering localization ability.

关键词： Multipurpose audio watermarking Copyright protection Content authentication

Predicting the fault-proneness of class hierarchy in object-oriented software using a layered kernel

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1390-1397页

作者： Peng HUANG jie zhu Department of Electronic Engineering Shanghai Jiao Tong University Shanghai 200240 China

A novel kernel learning method for object-oriented （00） software fault prediction is proposed in this paper. With this method, each set of classes that has inheritance relation named class hierarchy, is treated as an elemental software model. A layered kernel is introduced to handle the tree data structure corresponding to the class hierarchy models. This method was vali- dated using both an artificial dataset and a case of industrial software from the optical communication field. Preliminary experi- ments showed that our approach is very effective in learning structured data and outperforms the traditional support vector learning methods in accurately and correctly predicting the fault-prone class hierarchy model in real-life OO software.

关键词： Object-oriented software Fault-proneness Support vector machine Structured kernel

Nanowires:Synthesis and Energy/Environmental Applications

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Energy & Environmental Materials 2021年第4期4卷 544-561页

作者： Heng Li Ying-jie zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

As the main inorganic component of human bones and teeth,hydroxyapatite(HAP)materials have been widely investigated for various applications especially in the biomedical ***,HAP nanowires(HAP NWs)have attracted research interest in the energy and environment-related fields owing to their advantages such as excellent biocompatibility and bioactivity,high-thermal stability,surface modification and functionalization,and selfassembly to form nanoscale porous networked *** this review,we first briefly discuss the synthesis of HAP *** we focus on summarizing the foremost advances in energy and environment-related applications of HAP NWs,including the battery,solar energy-assisted water evaporation,light-driven self-propelled device,thermal insulation,fireresistant inorganic paper,water purification,air purification,molecular detection,superhydrophobic surface,and high-strength nanocomposite *** addition,the future research directions on HAP NWs and their energy and environmental applications are *** review aims to provide inspiration and stimulate extensive future studies in the energy and environmental applications of HAP NWs and other inorganic NWs.

关键词： hydroxyapatite nanowire application energy environment

Nanostructured Materials of Calcium Phosphates and Calcium Silicates： Synthesis, Properties and Applications

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Chinese Journal of Chemistry 2017年第6期35卷 769-790页

作者： Ying-jie zhu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 China

Calcium phosphates are a family of compounds with different chemical compositions, structures and properties containing calcium ions and functional groups of orthophosphate （ pO34- ）, metaphosphate （ PO3- ） or pyrophosphate （ P2O4-7 ） and sometimes hydrogen or hydroxide ions. Calcium phosphates can be widely found in nature as well as in hard tissues （bone and tooth） of the vertebrate. Owing to similar chemical composition and structure to the main inorganic constituents of bone and tooth, calcium phosphate-based materials are promising biomaterials with high biocompatibility, and have been investigated for applications in various biomedical areas. Calcium silicate-based materials have attracted much attention on their potential applications in various biomedical fields such as bone de- fect repair and drug delivery. In recent years, this research group has been focusing on the research in this exciting and rapidly evolving research field, and has published many papers. This article will provide a brief review on our main research work on the synthesis, characterization, properties and applications of nanostructured materials of calcium phosphates and calcium silicates. Finally, future perspectives and challenges for the research and applica- tions of nanostructured materials of calcium phosphates and calcium silicates are discussed.

关键词： calcium phosphate calcium silicate nanostructured materials biomaterials biomedical applications

Performance Analysis and Improvement of Flat Torque Converters Using DOE Method

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Chinese Journal of Mechanical Engineering 2018年第4期31卷 101-109页

作者： Guang-Qiang Wu jie Chen Wen-jie zhu School of Automotive Studies Tongji University Institute of Industrial Science The University of Tokyo

Automotive torque converters have recently been designed with an increasingly narrower profile for the purpose of achieving a smaller axial size and reducing weight. Design of experiment(DOE) and computational fluid dynamics(CFD) techniques are applied to improve the performance of a flat torque converter. Four torque converters with different flatness ratios(0.204, 0.186, 0.172, and 0.158) are designed and simulated first to investigate the effects of flatness ratio on their overall performance, including efficiency, torque ratio, and impeller torque factor. The simulation results show that the overall performance tends to deteriorate as the flatness ratio decreases. Then a parametric study covering six geometric parameters, namely, inlet and outlet angles of impeller, turbine, and stator is carried out. The results demonstrate that the inlet and outlet angles play an important role in determining the performance characteristics of a torque converter. Furthermore, the relative importance of the six design parameters is investigated using DOE method for each response(stall torque ratio and peak efficiency). The turbine outlet angle is found to exert the greatest influence on both responses. After DOE analysis, an optimized design for the flat torque converter geometry is obtained. Compared to the conventional product, the width of the optimized flat torque converter torus is reduced by about 20% while the values of stall torque ratio and peak efficiency are only decreased by 0.4% and 1.7%, *** proposed new optimization strategy based on DOE method together with desirability function approach can be used for performance enhancement in the design process of flat torque converters.

关键词： Torque converter Flatness ratio Computational fluid dynamics(CFD) Parametric study Design of experiment(DOE)