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康德究竟如何看待几何学的可能性?

哲学研究 2020年第6期 95-104,128页

作者：钱捷中山大学哲学系(珠海)

康德“超绝演绎”的主旨直接关涉到可能经验的构成。而对于并非经验性的几何学知识,康德却欲言又止,定位不清,这就给诠释者们带来了极大的困难。其第二版B161上的注释便是极端的一例。为此我们须先跳出相关争论,从整体视野上探明康德心... 详细信息

康德“超绝演绎”的主旨直接关涉到可能经验的构成。而对于并非经验性的几何学知识,康德却欲言又止,定位不清,这就给诠释者们带来了极大的困难。其第二版B161上的注释便是极端的一例。为此我们须先跳出相关争论,从整体视野上探明康德心目中几何学的意指与其对象之所是,并在明确知性的综合与综合统一运作的结构之前提下澄清几何学概念构造的机理,特别是揭示空间直观形式的连续性本质。在完成这一主要的、可说是“正本清源的”工作之后,前述注释之谜也就迎刃而解了。

关键词：康德几何学空间直观形式超绝统觉连续性

NT-PGC-1a promotes mitochondrial biogenesis in brown adipose tissue

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NT-PGC-1a promotes mitochondrial biogenesis in brown adipose...

Multifaceted role of microRNAs in gastric cancer stem cells: Mechanisms and potential biomarkers

中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议

作者： jie qian Jing Wu Yubin Zhang China Pharmaceutical University

Obesity has reached epidemic proportions,and complications related to obesity contribute substantially to health care costs and *** accumulation of fat is the net result of a prolonged state of imbalance between energy intake and energy *** adipose tissue represents a natural target for the modulation of energy expenditure. This tissue is far from being a fat *** activated,it requires the uptake of substrate from the circulation,mostly free fatty acids,but also *** brown adipose tissue,

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 300-313页

作者： qian-Hui Sun Zi-Yu Kuang Guang-Hui Zhu Bao-Yi Ni jie Li Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Graduate College Beijing University of Traditional Chinese MedicineBeijing 100029China Department of Oncology Heilongjiang University of Chinese MedicineHarbin 150040Heilongjiang ProvinceChina

MicroRNAs(miRNAs)have received much attention in the past decade as potential key epigenomic regulators of tumors and cancer stem cells(CSCs).The abnormal expression of miRNAs is responsible for different phenotypes of gastric cancer stem cells(GCSCs).Some specific miRNAs could be used as promising biomarkers and therapeutic targets for the identification of *** review summarizes the coding process and biological functions of miRNAs and demon-strates their role and efficacy in gastric cancer(GC)metastasis,drug resistance,and apoptosis,especially in the regulatory mechanism of *** shows that the overexpression of onco-miRNAs and silencing of tumor-suppressor miRNAs can play a role in promoting or inhibiting tumor metastasis,apart from the initial formation of *** also discusses the epigenetic regulation and potential clinical applications of miRNAs as well as the role of CSCs in the pathogenesis of *** believe that this review may help in designing novel therapeutic approaches for GC.

关键词： Gastric cancer,Cancer stem cells MicroRNAs Epigenetics Therapeutic target

Combined subfascial endoscopic perforator surgery and endovenous laser treatment without impact on the great saphenous vein for management of lower-extremity varicose veins

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Chinese Medical Journal 2013年第3期126卷 405-408页

作者： GAN Shu-jie qian Shui-xian ZHANG Ci MAO jie-qi LI Ke TANG Jing-dong Department of Vascular Surgery Shanghai First People's Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200080 China

Background Conventional high ligation and stripping of the great saphenous vein （GSV） has a good curative effect but is highly traumatic with a considerable relapse rate. Subfascial endoscopic perforator surgery （SEPS） plus endovenous laser treatment （EVLT） could be applied as individual therapy. This study aimed to evaluate the feasibility of performing combined SEPS and EVLT without impacting GSV in the management of valvular insufficiency of the lower-limb venous perforators. Methods Placement of lower-limb venous perforator insufficiency was marked by ascending phlebography in 83 affected limbs from September 2010 to June 2011. After randomization, SEPS was performed on 41 limbs to address the insufficiency of the venous perforators under the deep fascia, in combination with EVLT to close the superficial varicose veins without impacting the GSV. The remaining 42 limbs were treated using traditional GSV phlebectomy as controls. Results Postoperatively, all varicose veins were resolved, with lightening of the pigmentation and healing of the ulcer. Within a follow-up period of 5-11 months, no symptoms had recurred. Compared with the control group, the operation time, the number of incisions sutured, and the in-hospital time decreased on average by 1.5 hours, 4.7, and 6.8 days, respectively （P 〈0.01 in all cases）. Conclusion Combined SEPS and EVLT for treatment of valvular insufficiency of the lower-limb venous perforators offer the advantages of microtrauma and rapid cure.

关键词： varicose veins perforator, subfascial endoscopic perforator surgery, endoscopic perforator surgery, endovenous laser treatment, endovenous laser treatment

Recent progress in co-detection of single-cell transcripts and proteins

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Nano Research 2024年第1期17卷 132-150页

作者： Shanqing Huang qian Fan Yidi Wang Zhi Huang Weixiong Shi Yanli Gong Ting Yang jie Wang Lingling Wu Chaoyong Yang Discipline of Intelligent Instrument and Equipment College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Molecular Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of General Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen 361101China Research Center for Analytical Sciences Department of ChemistryCollege of SciencesNortheastern UniversityShenyang 110819China

Cellular heterogeneity is a universal property of living systems,and the interrogation of single cells facilitates in-depth understanding of distinct cellular states and functions in various biological ***-analysis of transcripts and proteins from the same single cells opens the way to decipher complex RNA regulatory frameworks and phenotypes,facilitating the understanding of cellular fate and function regulations,discovery of novel cell types,and construction of a high-resolution cell ***,we review the state-of-art advances in the development of methodologies for co-analysis of single-cell transcripts and ***,imaging-based methods are summarized with particular emphasis on optical and mass spectrometry ***,sequencing-based approaches for high-throughput and sensitive co-analysis of single-cell transcripts and proteins are described,including droplet-,microwell-,and split-pool-based ***,combined methods with more flexibility and universality are *** methods commonly employ different strategies or reactions to convert transcripts and proteins of single cells into distinct signals simultaneously,which can be detected by different instruments or ***,some perspectives on the future challenges and development trends in this field are presented.

关键词： single cell optical imaging mass spectrometry imaging single-cell RNA sequencing(scRNA-seq) co-detection

Inkjet-Printing Controlled Phase Evolution Boosts the Efficiency of Hole Transport Material Free and Carbon-Based CsPbBr_(3) Perovskite Solar Cells Exceeding 9%

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Energy & Environmental Materials 2024年第2期7卷 209-220页

作者： Lihua Zhang Shi Chen jie Zeng Zhengyan Jiang qian Ai Xianfu Zhang Bihua Hu Xingzhu Wang Shihe Yang Baomin Xu Department of Materials Science and Engineering and Shenzhen Engineering Research and Development Center for Flexible Solar Cells Southern University of Science and TechnologyShenzhen 518055China Department of Chemistry The Hong Kong University of Science and TechnologyClear Water BayHong KongChina Henan Key Laboratory of Photovoltaic Materials Henan UniversityKaifeng 475004China Guangdong Key Lab of Nano-Micro Material Research School of Chemical Biology and BiotechnologyShenzhen Graduate SchoolPeking UniversityShenzhen 518055China Key University Laboratory of Highly Efficient Utilization of Solar Energy and Sustainable Development of Guangdong Southern University of Science and TechnologyShenzhen 518055China Guangdong-Hong Kong-Macao Joint Laboratory for Photonic-Thermal-Electrical Energy Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

Hole transport material free carbon-based all-inorganic CsPbBr_(3)perovskite solar cells(PSCs)are promising for commercialization due to its low-cost,high open-circuit voltage(V_(oc))and superior *** to the different solubility of PbBr_(2)and CsBr in conventional solvents,CsPbBr_(3)films are mainly obtained by multi-step spin-coating through the phase evolution from PbBr_(2)to CsPb_(2)Br_(5)and then to CsPbBr_(3).The scalable fabrication of high-quality CsPbBr_(3)films has been rarely ***,an inkjet-printing method is developed to prepare high-quality CsPbBr_(3)*** formation of long-range crystalline CsPb_(2)Br_(5)phase can effectively improve phase purity and promote regular crystal stacking of CsPbBr_(3).Consequently,the inkjet-printed CsPbBr_(3)C-PSCs realized PCEs up to 9.09%,8.59%and 7.81%with active areas of 0.09,0.25,and 1 cm^(2),respectively,demonstrating the upscaling potential of our fabrication method and *** high performance is mainly ascribed to the high purity,strong crystal orientation,reduced surface roughness and lower trap states density of the as-printed CsPbBr_(3)*** work provides insights into the relationship between the phase evolution mechanisms and crystal growth dynamics of cesium lead bromide halide films.

关键词： all-inorganic perovskite solar cells CsPbBr_(3) inkjet-printing phase evolution

Mechanical performance of 22SiMn2TiB steel welded with lowtransformation- temperature filler wire and stainless steel filler wire

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Journal of Iron and Steel Research International 2024年第4期31卷 967-981页

作者： Zi-dong Lin Kai-jie Song Zhen Sun Zi-qian Zhu Xue-feng Zhao Constantinos Goulas Wei Ya Xing-hua Yu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China Department of Design Production and Management Faculty of Engineering Technology.University of TwenteEnschede 7500 AETheNetherlands Rotterdam Additive Manufacture Fieldlab(RAMLAB) Rotterdam 3089 JWTheNetherlands

TX-80 low-transformation-temperature(LTT)welding wire was used to replace the traditional ER 307Si welding wire to realize the connection of 22SiMn2TiB armor steel in manual overlay *** previously existing issues,such as welding cracks,large welding deformation,and severe welding residual stress,were solved to ensure good strength and ductility *** particular,with the same welding conditions,TX-80 LTT wire eliminates welding *** reduces the welding deformation no matter the base pretreatment of pre-setting angle or no pre-setting *** comparison,it was found that the microstructure at the TX-80 weld is mainly composed of martensite and a small amount of retained *** contrast,the microstructure of the ER 307Si weld consists of a large amount of austenite and a small amount of skeleton-like *** variation trend of residual stress and microhardness from the weld to the base were investigated and compared with the mechanical properties of base *** TX-80 and the ER 307Si tensile samples elongation is 6.76%and 6.01%,while the ultimate tensile strengths are 877 and 667 MPa,*** average impact toughness at room temperature of the ER 307Si weld is 143.9 J/cm^(2),much higher than that of the TX-80 weld,which is only 36.7 J/cm^(2).The relationship between impact and tensile properties with microstructure species and distribution was *** addition,the fracture surface of the tensile and the impact samples was observed and *** dimples,fewer pores,larger radiation zone,and shear lips of TX-80 samples indicate better tensile ductility and worse impact toughness than those of ER 307Si weld.

关键词： Low-transformation-temperature material 22SiMn2TiB steel Welding deformation Residual stress Martensitic transformation Mechanical property

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采用群体统计学习的量子进化算法

西安交通大学学报 2012年第2期46卷 51-58页

作者：钱洁郑建国东华大学旭日工商管理学院上海200051 湖北汽车工业学院经济管理学院湖北十堰442002

针对传统量子进化算法采用精英个体作为吸引子,存在种群学习范围窄、优秀基因易丢失的缺陷,提出了一种采用群体统计学习的量子进化算法.该算法抛弃了传统量子进化算法中的精英保留策略,通过截断、比例、竞赛选择等方式对进化过程中优秀... 详细信息

针对传统量子进化算法采用精英个体作为吸引子,存在种群学习范围窄、优秀基因易丢失的缺陷,提出了一种采用群体统计学习的量子进化算法.该算法抛弃了传统量子进化算法中的精英保留策略,通过截断、比例、竞赛选择等方式对进化过程中优秀群体统计分析后构建整个种群的吸引子,避免了以单一个体为单位的学习方式,能较为全面地从整个优秀种群学习知识,并保留群体的优秀基因信息.同时,吸引子每代更新,避免了采用精英保留策略易陷入局部极值的问题.通过测试实验表明,提出的算法搜索精度和效率提高,收敛速度更快,算法综合性能提高.

关键词：量子进化统计学习基因信息背包问题组合优化

基于核心素养的教师教育评价话语价值反思和意义重构

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中国教育学刊 2023年第7期 45-49,102页

作者：钱洁南京晓庄学院江苏南京211171 南京师范大学家庭教育研究院

从话语理论挖掘教育评价话语建构核心素养的交互主体、整合核心素养的互动空间、凝练核心素养的德性内核等意义向度。文化失语消解核心素养承载主体、话语贫困窄化核心素养培育空间、对象性思维导致核心素养内涵萎缩仍是教师教育评价话... 详细信息

从话语理论挖掘教育评价话语建构核心素养的交互主体、整合核心素养的互动空间、凝练核心素养的德性内核等意义向度。文化失语消解核心素养承载主体、话语贫困窄化核心素养培育空间、对象性思维导致核心素养内涵萎缩仍是教师教育评价话语面临的实践困境。拓展时空并置的教育评价话语空间、生成素养本位的教育评价话语文化、探索尊重内在体验的教育评价话语逻辑是新时代教师教育评价话语意义重构的路径。

关键词：核心素养教师教育教育评价话语内在体验