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Current Medical Science 2024年第1期44卷 232-240页

作者： Zhi-bin ZHU Meng-jie LIU Jing WANG Zhou SHU jie cao Department of Stomatology Chengdu Seventh People's HospitalChengdu 610044China Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective Secoemestrin C(SC),an epitetrathiodioxopiperazine isolated from Aspergillus nidulans,has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis.However,the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain unclear.This study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in vivo.Methods In vitro,HaCaT cells were induced with tumor necrosis factor-alpha(TNF-α,10 ng/mL)to establish an inflammatory injury model,and the expression of nuclear transcription factor-κB(NF-κB)pathway components was measured using qRT-PCR and Western blotting.An in vivo mouse model of imiquimod(IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating psoriasis.Results SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT cells.In addition,systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse model.SC reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin lesions.Conclusion The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis.

关键词： secoemestrin C(SC) psoriasis tumor necrosis factor-alpha(TNF-α) nuclear transcription factor-kB(NF-kB) inflammation

A near-zero quiescent power breeze wake-up anemometer based on a rolling-bearing triboelectric nanogenerator

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Microsystems & Nanoengineering 2024年第2期10卷 241-249页

作者： Xianpeng Fu Zhichao Jiang jie cao Zefang Dong Guoxu Liu Meiling Zhu Chi Zhang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing100049China Center on Nanoenergy Research Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science&TechnologyGuangxi UniversityNanning530004China Institute of Intelligent Flexible Mechatronics Jiangsu UniversityZhenjiang212013China College of Engineering Mathematics and Physical ScienceUniversity of ExeterExeterEX44QFUK

Wind sensors have always played an irreplaceable role in environmental information monitoring and are expected to operate with lower power consumption to extend service lifetime.Here,we propose a breeze wake-up anemometer(B-WA)based on a rolling-bearing triboelectric nanogenerator(RB-TENG)with extremely low static power.The B-WA consists of two RB-TENGs,a self-waking-up module(SWM),a signal processing module(SPM),and a wireless transmission unit.The two RB-TENGs are employed for system activation and wind-speed sensing.Once the ambient wind-speed exceeds 2 m/s,the wake TENG(W-TENG)and the SWM can wake up the system within 0.96 s.At the same time,the SPM starts to calculate the signal frequency from the measured TENG(M-TENG)to monitor the wind speed with a sensitivity of 9.45 Hz/(m/s).After the wind stops,the SWM can switch off the B-WA within 0.52 s to decrease the system energy loss.In quiescent on-duty mode,the operating power of the B-WA is less than 30 nW,which can greatly extend the service lifetime of the B-WA.By integrating triboelectric devices and rolling bearings,this work has realized an ultralow quiescent power and self-waked-up wireless wind-speed monitoring system,which has foreseeable applications in remote weather monitoring,IoT nodes,and so on.

关键词： generator power service

Effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated transport

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Aquaculture and Fisheries 2024年第2期9卷 265-272页

作者： Bo Wu Zhenkun Xu jie cao Qi Wang Jun Mei Jing Xie College of Food Science and Technology Shanghai Ocean UniversityShanghai201306China National Experimental Teaching Demonstration Center for Food Science and Engineering Shanghai Ocean UniversityShanghai201306China Shanghai Engineering Research Center of Aquatic Product Processing and Preservation Shanghai201306China Shanghai Professional Technology Service Platform on Cold Chain Equipment Performance and Energy Saving Evaluation Shanghai201306China

Transport in water is the most common method for transporting live fish in China,however,transport is a strong stressor.Transport stress could lead to a reduced immune and antioxidant system function of tiger grouper,resulting in sickness and death.Besides,tiger grouper were continuously stressed during transport,which resulted in quality deterioration.It is necessary that find a way to relieve the stress of transportation of tiger grouper.Ascorbic acid is not only a good anti-stress agent,but it is also an effective immunostimulant.β-1,3-glucan is a feed additive that can enhance the immune response of fish.Therefore,this study evaluated the effects ofβ-1,3-glucan and ascorbic acid on the nutritional-immune response and antioxidant signaling pathways of live tiger grouper during simulated transport.Results indicated that addingβ-1,3-glucan and ascorbic acid in transport-water muted the increase of alanine aminotransferase(ALT)and aspartate aminotransferase(AST)activity.In addition,β-1,3-glucan and ascorbic acid activated Nrf2 and mediated TOR expression and then up-regulate related mRNA expression of antioxidant and immune enzymes.We concluded that the application ofβ-1,3-glucan and ascorbic acid inhibit the increase of metabolism enzymes and inflammatory factors and activate immune and antioxidant signaling pathways to relieve oxidant stress,immune response,and apoptosis.Reducing the loss of amino acids provided nutrients to relieve oxidative stress and immune response,which demonstrated immune-nutritional response in live tiger grouper during simulated transport.These results may provide a new solution for alleviating the decline of immune and antioxidant function of tiger grouper caused by transportation stress.

关键词： Tiger grouper β-1,3-Glucan Ascorbic acid Immune response Antioxidant signaling pathway

Reform and Development of English Teaching in Colleges and Universities with the Integration of ChatGPT Technology

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Journal of Contemporary Educational Research 2024年第6期8卷 71-76页

作者： jie cao Jing cao Yuan Tao College of Foreign Studies Hubei Normal UniversityHuangshi435002Hubei ProvinceChina Boda College of Jilin Normal University Siping 136000Jilin ProvinceChina School of Mathematics and Computer Science Jilin Normal UniversitySiping 136000Jilin ProvinceChina

As an artificial intelligence-powered language generation model based on natural language processing,ChatGPT,like other artificial intelligence technologies,possesses super real-time dialogue capabilities and is considered an innovative and intelligent auxiliary teaching tool in the field of language learning.This article first analyzes the current state of development of artificial intelligence technologies such as ChatGPT.Secondly,it examines the challenges encountered in the reform and development of English teaching in colleges and universities in China.Lastly,it summarizes the applications and recommendations for using ChatGPT technology in college-level English teaching.

关键词： ChatGPT Artificial intelligence technologies College English Reform and development

Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease:A dietary salt-intervention trial

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Science China Life Sciences 2024年第8期 1666-1675页

作者： Zhennan Lin Jianxin Li Fangchao Liu jie cao Shufeng Chen Jichun Chen Keyong Huang Yaqin Wang Hongfan Li Yan Wang Jianfeng Huang Dongfeng Gu Xiangfeng Lu Key Laboratory of Cardiovascular Epidemiology Department of EpidemiologyFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical College/National Center for Cardiovascular Diseases Medical School Southern University of Science and Technology

Individuals with a high degree of salt sensitivity(SS) have a greater risk of cardiovascular disease(CVD),but whether SS fosters CVD by influencing metabolomics homeostasis remains unclear.This study aimed to reveal the role of the SS-related metabolomics signature in the development of CVDs,based on the Meta Salt study,which was a dietary salt-intervention trial conducted at four centers in China in 2019.A total of 528 participants were recruited and underwent 3 days of baseline observations,a 10-day low-salt intervention,and a 10-day highsalt intervention.Plasma untargeted metabolomics,lipidomics,and BP measurements were scheduled at each stage.Participants were grouped into extreme SS,moderate SS,and salt-resistant(SR) individuals according to their BP responses to salt.Linear mixed models were used to identify SS-related metabolites and determine the relationship between the SS-related metabolomics signature and arterial stiffness.Mendelian randomization(MR) analyses were applied to establish the causal pathways among the SS-related metabolites,BP,and CVDs.Among the 713 metabolites,467 were significantly changed after the high-salt intervention.Among them,the changes in 30 metabolites from the low-salt to the high-salt intervention differed among the SS groups.Of the remaining nonsalt-related metabolites,the baseline levels of 11 metabolites were related to SS.These 41 metabolites explained 23% of the variance in SS.Moreover,SS and its metabolomics signature were positively correlated with arterial stiffness.MR analyses demonstrated that the SS-related metabolites may affect CVD risk by altering BP,indicating that the increase in BP was the consequence of the changes in SS-related metabolites rather than the cause.Our study revealed that the metabolomics signature of SS individuals differs from that of SR individuals and that the changes in SS-related metabolites may increase arterial stiffness and foster CVDs.This study provides insight into understanding the biology and targets of SS and its role in CVDs.

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Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue cao Ru Wu Yan‑Yan Gao Yang Zhou Jun‑jie Zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore microenvironments.Since the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy storage.Among them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive interest.In this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and aptasensors.Notably,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary applications.Additionally,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors

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Impact pressure of waves generated by landslides on bank slopes

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Journal of Mountain Science 2024年第3期21卷 918-931页

作者： cao Ting WANG Pingyi QIU Zhenfeng LIU jie Key Laboratory of Hydraulic and Waterway Engineering of Ministry of Education Chongqing Jiaotong UniversityChongqing 400074China Engineering Research Center of Diagnosis Technology and Instruments of Hydro-Construction Chongqing Jiaotong UniversityChongqing 400074China

Impulse waves that are generated by landslides in narrow reservoir areas threaten the stability of buildings and bank slopes.To discuss the action process and evolution law of the wave pressure on bank slopes,a three-dimensional physical model test that considers impulse waves generated by landslides was performed,and factors including landslide width,thickness,slope angles of the sliding surface,and bank slope angle were considered.Based on wave forms on the bank slopes,wave pressure curve characteristics,and peak value,the action process of wave pressure could be divided into the following stages:maximum pulsating pressure stage,wave impact stage(when waves break),and stationary pulsation stage.It was found that wave breaking is dependent on the value of the surf similarity parameterξ.The distribution pattern of impact pressure decays linearly on both sides of the maximum impact pressure point,and the attenuation degree decreases when it attains 40%of the maximum value.Thus,it is proposed that the prediction formula for the maximum effective impact pressure of the bank slope be related to the reciprocal of wave steepness,relative water depth,and slope rate.The prediction formula provides strong theoretical support for early safety warning and for predicting the bank slope under impulse waves generated by landslides.

关键词： Model test Impact pressure Action stage Breaking discrimination Distribution model

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Materials and structural design for preferable Zn deposition behavior toward stable Zn anodes

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SmartMat 2024年第1期5卷 1-37页

作者： Qinghe cao Yong Gao jie Pu Abdelnaby M.Elshahawy cao Guan Key Laboratory of Flexible Electronics of Zhejiang Province Ningbo Institute of Northwestern Polytechnical UniversityNingboChina Institute of Flexible Electronics Northwestern Polytechnical UniversityXi'anChina Department of Physics Faculty of ScienceAssiut UniversityAssiutEgypt

Benefiting from the high capacity of Zn metal anodes and intrinsic safety of aqueous electrolytes,rechargeable Zn ion batteries(ZIBs)show promising application in the post‐lithium‐ion period,exhibiting good safety,low cost,and high energy density.However,its commercialization still faces problems with low Coulombic efficiency and unsatisfied cycling performance due to the poor Zn/Zn2+reversibility that occurred on the Zn anode.To improve the stability of the Zn anode,optimizing the Zn deposition behavior is an efficient way,which can enhance the subsequent striping efficiency and limit the dendrite growth.The Zn deposition is a controlled kinetics‐diffusion joint process that is affected by various factors,such as the interaction between Zn2+ions and Zn anodes,ion concentration gradient,and current distribution.In this review,from an electrochemical perspective,we first overview the factors affecting the Zn deposition behavior and summarize the modification principles.Subsequently,strategies proposed for interfacial modification and 3D structural design as well as the corresponding mechanisms are summarized.Finally,the existing challenges,perspectives on further development direction,and outlook for practical applications of ZIBs are proposed.

关键词： 3D structuraldesign interfacialmodification long‐term stability Znanode Zndeposition behavior

Efficient construction of calcium fluoride nanoaggregates for enhanced water vapor adsorption

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Particuology 2024年第6期89卷 191-197页

作者： Dan-Lei Yang Jing cao Rong-Kun Liu jie-Xin Wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing100029China Petrochemical Research Institute PetroChinaBeijing102206China

Calcium fluoride(CaF_(2))is an ideal adsorbent for the dehydration of gaseous hydrogen fluoride(HF)containing water vapor.In this work,a novel CaF_(2)absorbent,spherical CaF_(2)nanoaggregates(NAs)with a closely packed structure,was proposed and efficiently fabricated by spray drying technology.As the building blocks of CaF_(2)NAs,the CaF_(2)nanoparticles(NPs)were prepared by the addition of excess calcium ions(Ca^(2+))or fluorine ions(F−)in the synthesis.The results indicated that the CaF_(2)NPs synthesized by excess Ca^(2+)and the corresponding NAs exhibited much better water vapor adsorption properties than their counterparts by excess F−,owing to higher zeta potentials.More importantly,whether excess Ca^(2+)or F^(−),CaF_(2)NAs had further enhanced water vapor adsorption capacity compared to primary CaF_(2)NPs,possibly owing to their unique nano-micro secondary structures and higher surface areas.This work has great potential in the development of high-performance absorbents for separating moisture from corrosive gas HF.

关键词： CaF_(2)nanoaggregates Water vapor adsorption Spray drying

Association of daily sitting time and leisure-time physical activity with body fat among U.S.adults

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Journal of Sport and Health Science 2024年第2期13卷 195-203页

作者： Jingwen Liao Min Hu Kellie Imm Clifton J.Holmes jie Zhu Chao cao Lin Yang Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion Guangzhou Sport UniversityGuangzhou 510500China Scientific Research Center Guangzhou Sport UniversityGuangzhou 510500China Division of Epidemiology&Genetics Department of Population and Public Health SciencesKeck School of Medicine of the University of Southern CaliforniaLos AngelesCA 90033USA Program in Physical Therapy Washington University School of MedicineSt.LouisMO 63110USA Center for Human Nutrition Washington University School of MedicineSt.LouisMO 63110USA Department of Plastic and Reconstructive Surgery Shanghai East HospitalTongji UniversityShanghai 200070China Department of Cancer Epidemiology and Prevention Research Alberta Health ServicesCalgary T2S 3C3Canada Department of Oncology and Community Health Sciences University of CalgaryCalgary T2N 1N4Canada

Background:Prolonged sitting and reduced physical activity lead to low energy expenditures.However,little is known about the joint impact of daily sitting time and physical activity on body fat distribution.We investigated the independent and joint associations of daily sitting time and physical activity with body fat among adults.Methods:This was a cross-sectional analysis of U.S.nationally representative data from the National Health and Nutrition Examination Survey2011-2018 among adults aged 20 years or older.Daily sitting time and leisure-time physical activity(LTPA)were self-reported using the Global Physical Activity Questionnaire.Body fat(total and trunk fat percentage)was determined via dual X-ray absorptiometry.Results:Among 10,808 adults,about 54.6%spent 6 h/day or more sitting;more than one-half reported no LTPA(inactive)or less than 150 min/week LTPA(insufficiently active)with only 43.3%reported 150 min/week or more LTPA(active)in the past week.After fully adjusting for sociodemographic data,lifestyle behaviors,and chronic conditions,prolonged sitting time and low levels of LTPA were associated with higher total and trunk fat percentages in both sexes.When stratifying by LTPA,the association between daily sitting time and body fat appeared to be stronger in those who were inactive/insuufficiently active.In the joint analyses,inactive/insuufficiently active adults who reported sitting more than 8 h/day had the highest total(female:3.99%(95%confidence interval(95%CI):3.09%-4.88%);male:3.79%(95%CI:2.75%-4.82%))and trunk body fat percentages(female:4.21%(95%CI:3.09%-5.32%);male:4.07%(95%CI:2.95%-5.19%))when compared with those who were active and sitting less than 4 h/day.Conclusion:Prolonged daily sitting time was associated with increased body fat among U.S.adults.The higher body fat associated with 6 h/day sitting may not be offset by achieving recommended levels of physical activity.

关键词： Adults Body fat distribution Physical activity Sitting time

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