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The spatial transcriptomic landscape of human gingiva in health and periodontitis

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Science China(Life Sciences) 2024年第4期67卷 720-732页

作者： Zongshan Shen Ran Zhang Yunjia Huang Jiayao Chen Mengjun Yu Chunhua Li Yong Zhang Lingling Chen Xin Huang jichen yang Zhengmei Lin Songlin Wang Bin Cheng Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologyGuanghua School of StomatologySun Yat-sen UniversityGuangzhou 510055China Beijing Laboratory of Oral Health Capital Medical UniversityBeijing 100050China Department of Oral Pathology Peking University School and Hospital of Stomatology&National Center of Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100050China Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions Chinese Academy of Medical SciencesBeijing 100050China BGI-Qingdao BGI-ShenzhenQingdao 266555China

The gingiva is a key oral barrier that protects oral tissues from various stimuli.A loss of gingival tissue homeostasis causes periodontitis,one of the most prevalent inflammatory diseases in *** human gingiva exists as a complex cell network comprising specialized *** understand the tissue-specific pathophysiology of the gingiva,we applied a recently developed spatial enhanced resolution omics-sequencing(Stereo-seq)technique to obtain a spatial transcriptome(ST)atlas of the gingiva in healthy individuals and periodontitis *** utilizing Stereo-seq,we identified the major cell types present in the gingiva,which included epithelial cells,fibroblasts,endothelial cells,and immune cells,as well as subgroups of epithelial cells and immune *** further observed that inflammation-related signalling pathways,such as the JAK-STAT and NF-κB signalling pathways,were significantly upregulated in the endothelial cells of the gingiva of periodontitis patients compared with those of healthy ***,we characterized the spatial distribution of periodontitis risk genes in the gingiva and found that the expression of IFI16 was significantly increased in endothelial cells of inflamed *** conclusion,our Stereo-seq findings may facilitate the development of innovative therapeutic strategies for periodontitis by mapping periodontitis-relevant genes and pathways and effector cells.

关键词： spatial transcriptomics gingiva periodontal disease periodontitis risk genes

Flocking shape analysis of multi-agent systems

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Science China(Technological Sciences) 2010年第3期53卷 741-747页

作者： yang jichen,LU QiShao &LANG XiuFeng Department of Dynamics and Control,Beihang University,Beijing 100191,China Department of Dynamics and Control Beihang University Beijing China

In this paper,we consider the shape control in flocking behavior of a multi-agent system with a virtual *** the traditional flocking control terms,which include a gradient-based term,a velocity consensus term and a navigational feed-back in general,a new piecewise smooth neighbor-based local controller is added to regulate the configuration to the desired flocking *** agent velocities approach the desired velocity asymptotically,while collisions among agents can be ***,based on the proved stability,we obtain three kinds of flocking shapes,such as those in a single line,vee shape or corner *** numerical simulation results are provided to demonstrate theoretical issues.

关键词： flocking non-smooth control multi-agent system

Synthesis and Modulation of Low-Dimensional Transition Metal Chalcogenide Materials via Atomic Substitution

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Nano-Micro Letters 2024年第9期16卷 49-94页

作者： Xuan Wang Akang Chen XinLei Wu Jiatao Zhang jichen Dong Leining Zhang Key Laboratory of Cluster Science Ministry of Education of ChinaBeijing Key Laboratory of Photoelectronic and Electrophonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of Chemistry Chinese Academy of SciencesBeijing 100190People’s Republic of China

In recent years,low-dimensional transition metal chalcogenide(TMC)materials have garnered growing research attention due to their superior electronic,optical,and catalytic properties compared to their bulk *** controllable synthesis and manipulation of these materials are crucial for tailoring their properties and unlocking their full potential in various *** this context,the atomic substitution method has emerged as a favorable *** involves the replacement of specific atoms within TMC structures with other elements and possesses the capability to regulate the compositions finely,crystal structures,and inherent properties of the resulting *** this review,we present a comprehensive overview on various strategies of atomic substitution employed in the synthesis of zero-dimensional,one-dimensional and two-dimensional TMC *** effects of substituting elements,substitution ratios,and substitution positions on the structures and morphologies of resulting material are *** enhanced electrocatalytic performance and photovoltaic properties of the obtained materials are also provided,emphasizing the role of atomic substitution in achieving these ***,challenges and future prospects in the field of atomic substitution for fabricating low-dimensional TMC materials are summarized.

关键词： Transition metal chalcogenides Atomic substitution Ion exchange Low-dimensional materials Controllable synthesis

Caffeic acid 3,4-dihydroxyphenethyl ester prevents colorectal cancer through inhibition of multiple cancer-promoting signal pathways in 1,2-Dimethylhydrazine/dextran sodium sulphate mouse model

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Journal of Traditional Chinese Medicine 2024年第1期44卷 70-77页

作者： JIN Tao ZHOU Qian SHEN jichen ZHANG Zhizhong LIAN Xiaoyuan College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Ocean College Zhoushan Campus of Zhejiang UniversityZhoushan 316021China

OBJECTIVE:To elucidate the potential feature and mechanism of the caffeic acid 3,4-dihydroxyphenethyl ester(CADPE)molecule,which can prevent colorectal cancer(CRC)in the 1,2-Dimethylhydrazine(DMH)/dextran sodium sulphate(DSS)-induced mouse ***:Institute of cancer research(ICR)male mice were injected with 20 mg/kg DMH for a *** that,2%DSS was administered in the drinking water for another 7 *** CADPE treatment was given to the DMH/DSS induced male mice at three different periods until their *** examination was used for observing the CRC development at colonic ***(IHC),blood cells smearing and crypt damage scoring methods were used for investigating the anti-inflammation feature of CADPE related to *** reversing targets searching method was applied with artificial intelligence(AI),computeraided drug designing(CADD)and Ingenuity Pathway Analysis(IPA)techniques for predicting the potential targets and mechanism of CADPE highly related to ***:The data indicated that CADPE inhibited CRC tumor development in the colitis-associated DMH/DSS induced mouse model after giving the early *** also impeded the acute inflammation by decreasing the infiltration of neutrophils significantly during the initial stage of CRC ***,our data showed that CADPE prevented CRC by blocking active sites of three pivotal protein targets including epidermal growth factor receptor(EGFR),extracellular signal-regulated kinase(ERK)and mammalian target of rapamycin(m TOR)in two major cancer development ***:CADPE effectively prevented CRC at early stage of tumor germination in the DMH/DSS mouse model highly likely due to its anti-acute inflammation characteristic and the ability of blocking EGFR,ERK and m TOR activities in two highly related CRC developing pathways.

关键词： caffeic acids colorectal neoplasms inflammation chemoprevention Sarcandra glabra

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基于感知子空间分解模型的音频特征提取方法

华中科技大学学报（自然科学版） 2015年第3期43卷 83-88页

作者：贺前华张雪源杨继臣林沛华南理工大学电子与信息学院广东广州510640

提出了一种基于谐波-瞬时-残差感知子空间分解模型的音频特征提取方法.首先,根据心理声学的研究成果,提出了基于感知的谐波分子、瞬时原子和残差分布字典,可分别用于提取音频中的长时谐波成分、瞬时频率成分和残差谱分布特性;随后,利用... 详细信息

提出了一种基于谐波-瞬时-残差感知子空间分解模型的音频特征提取方法.首先,根据心理声学的研究成果,提出了基于感知的谐波分子、瞬时原子和残差分布字典,可分别用于提取音频中的长时谐波成分、瞬时频率成分和残差谱分布特性;随后,利用该字典和匹配追踪算法,将音频信号分解到谐波子空间、瞬时子空间和残差子空间这三个感知子空间;最后,通过融合各子空间的特征参数生成音频特征.实验表明:在15类音效分类任务中,所提出的特征比传统梅尔频率倒谱特征准确性提升9.1%,比基于传统匹配追踪的特征提升8.3%.

关键词：音频信号处理特征提取音效分类心理声学感知子空间匹配追踪

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基于深层说话人矢量的说话人检索

华中科技大学学报（自然科学版） 2015年第7期43卷 62-65页

作者：李威杨继臣贺前华李艳雄华南理工大学电子与信息学院广东广州510640

为了解决浅层特征不能有效刻画说话人特征,导致说话人检索率不高的问题,提出了一种基于深层说话人矢量的说话人检索方法.使用受限波尔兹曼机逐层构建一个多层的深层特征提取器用以提取说话人深层特征.为说话人构建基于深层特征的深层说... 详细信息

为了解决浅层特征不能有效刻画说话人特征,导致说话人检索率不高的问题,提出了一种基于深层说话人矢量的说话人检索方法.使用受限波尔兹曼机逐层构建一个多层的深层特征提取器用以提取说话人深层特征.为说话人构建基于深层特征的深层说话人矢量.通过计算要检索的说话人的深层说话人矢量和检索库中的说话人深层特征之间的最小距离,对目标说话人进行检索.实验结果表明:在深层特征下,使用深层说话人矢量可以检索到绝大部分的目标说话人;随着深度层数的增加,检索率先增后减,检索率最高对应的深度层数是7;随着深度层数的增加,检索时间非线性增加.

关键词：深层特征深层说话人矢量最小距离说话人检索检索率

Spatiotemporal variation and evaluation of agriculture green development: a case study of Hainan Province, China

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Frontiers of Agricultural Science and Engineering 2024年第1期11卷 83-99页

作者： Tianxiang YU jichen ZHOU Lin MA Fusuo ZHANG Zed RENGEL William JDAVIES Jianbo SHEN Department of Plant Nutrition College of Resources and Environmental SciencesCenter for ResourcesEnvironment and Food SecurityKey Laboratory of Plant-Soil interactionsMOENational Academy of Agriculture Green DevelopmentChina Agricultural UniversityBeijing 100193China Sanya Institute of China Agricultural University Sanya 572025China Soil Physics and Land Management Group Wageningen UniversityP.O.Box 476700 AA Wageningenthe Netherlands Key Laboratory of Agricultural Water Resources Center for Agricultural Resources ResearchInstitute of Genetic and Developmental BiologyChinese Academy of SciencesShijiazhuang 050021China Soil Science and Plant Nutrition UWA School of Agriculture and EnvironmentThe University of Western AustraliaPerth WA 6009Australia Institute for Adriatic Crops and Karst Reclamation 21000 SplitCroatia Lancaster Environment Centre University of LancasterLancaster LA14YQUK

The realization of green and sustainable development of agriculture is the common pursuit all over the world. Agriculture green development(AGD)program has been proposed as a sustainable development strategy in China,but insufficient is known about the quantitative evaluation of spatiotemporal variation in AGD at the regional scale. This study aimed to assess spatiotemporal patterns in AGD at the county/city-based regional level. For this purpose, a systematic index evaluation system was developed to assess the performance of socioeconomic, food production and environmental components in a key economic region(Hainan Province) of China. Hainan improved its AGD index(representing the overall performance toward achieving AGD) from 38.8 in 1988 to 40.9 in 2019. The socioeconomic development and agricultural productivity have improved with time;environmental quality declined due to overuse of chemicals from 1988 to 2013, but steadily improved after 2013, indicating positive effects of reducing chemical input. There was a higher AGD index in the coastal vs. central regions and the southern vs. northern regions. Scenarios featuring improved nutrient management or optimized diet structure and reduced waste improved economic benefits and social productivity while concurrently reducing environmental degradation. These results provide new insights for the future development of green and sustainable agriculture and formulation of agricultural policies in Hainan Province of China and even other developing countries that are facing or will soon face similar challenges.

关键词： Agriculture environmental impact green and sustainable development Hainan Province index evaluation system

基于子带双特征的自适应保留似然比鲁棒语音检测算法

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电子与信息学报 2016年第11期38卷 2879-2886页

作者：何伟俊贺前华吴俊峰杨继臣华南理工大学电子与信息学院广州510641

为了进一步提高低信噪比下语音激活检测（VAD）的准确率,该文提出一种基于子带双特征的自适应保留似然比鲁棒语音激活检测算法。算法采用子带归一化最大自相关函数与子带归一化平均过零率双重特征设置频率分量似然比的保留权值,同时利... 详细信息

为了进一步提高低信噪比下语音激活检测（VAD）的准确率,该文提出一种基于子带双特征的自适应保留似然比鲁棒语音激活检测算法。算法采用子带归一化最大自相关函数与子带归一化平均过零率双重特征设置频率分量似然比的保留权值,同时利用已过去固定时长的VAD判决结果及对应的子带特征参数自适应地估计似然比的保留阈值。实验结果表明,此算法的VAD检测准确率相比原保留似然比算法在10 d B,0 d B和-10 d B平稳白噪声下分别提高了1.2%,7.2%和8.1%,在10 d B和0 d B非平稳Babble噪声下分别提高了1.6%和3.4%。当其被用于2.4 kbps低速率声码器系统时,合成语音的感知语音质量评价（PESQ）比原声码器系统在白噪声下提高了0.098~0.153,在Babble噪声下提高了0.157~0.186。

关键词：语音激活检测似然比低信噪比子带过零率

Flocking shape analysis of multi-agent systems

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中国科学:技术科学 2010年第2期 221-221页

作者： yang jichen, LU QiShao & LANG XiuFeng Department of Dynamics and Control, Beihang University, Beijing 100191, China

In this paper, we consider the shape control in flocking behavior of a multi-agent system with a virtual leader. Besides the traditional flocking control terms, which include a gradient-based term, a velocity consensus term and a navigational feed-back in general, a new piecewise smooth neighbor-based local controller is added to regulate the configuration to the desired flocking shape. All agent velocities approach the desired velocity asymptotically, while collisions among agents can be avoided. Furthermore, based on the proved stability, we obtain three kinds of flocking shapes, such as those in a single line, vee shape or corner shape. Some numerical simulation results are provided to demonstrate theoretical issues.

关键词： flocking non-smooth control multi-agent system