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医院卓越服务研究进展与展望

中国护理管理 2024年第3期24卷 442-446页

作者：李金花祝益民朱丽辉李旭英湖南省肿瘤医院护理部长沙市410013 湖南省卫生健康委员会

我国已进入服务经济时代,全过程就医感受需要不断改善,患者体验需要持续提升,传统的医疗服务难以全面满足人民群众的需求,医疗服务高质量发展成为“十四五”时期医药卫生体制改革的焦点。卓越服务是满足患者需求的重要途径,是医院高质... 详细信息

我国已进入服务经济时代,全过程就医感受需要不断改善,患者体验需要持续提升,传统的医疗服务难以全面满足人民群众的需求,医疗服务高质量发展成为“十四五”时期医药卫生体制改革的焦点。卓越服务是满足患者需求的重要途径,是医院高质量发展的前提。文章通过阐述卓越服务概念与内涵、卓越服务国内外现状、我国医院服务面临的问题等,提出开展医院卓越服务的建议,为推动医院高质量发展提供参考依据。

关键词：医院卓越服务研究进展

Tildrakizumab for moderate-to-severe plaque psoriasis in Chinese patients:A 12.week randomized placebo-controlled phase III trial with long-term extension

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Chinese Medical Journal 2024年第10期137卷 1190-1198页

作者： Chen Yu Songmei Geng Bin Yang Yunhua Deng Fuqiu li Xiaojing Kang Mingye Bi Furen Zhang Yi Zhao Weili Pan Zhongwei Tian {2. Xu Zhenghua Zhang Nan Yu Xinsuo Duan Shuping Guo Qing Sun Weiquan li Juan Tao Zhijun liu Yuanyuan Yin Gang Wang department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710032China department of Dermatology The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China department of Dermatology Dermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China department of Dermatology Tongji HospitalHuazhong University of Science and TechnologyWuhanHubei 430030China department of Dermatology The Second Hospital of Jilin UniversityChangchunJilin 130041China department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China department of Dermatology Wuxi People’s Hospital of Wuxi CityWuxiJiangsu 214023China department of Dermatology Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and VenereologyShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250022China department of Dermatology Beijing Tsinghua Changgung HospitalBeijing 102218China department of Dermatology Zhejiang Provincial People’s HospitalHangzhouZhejiang 310014China department of Dermatology The First Affiliated Hospital of Xinxiang Medical CollegeXinxiangHenan 453100China department of Dermatology Huashan Hospital Affiliated to Fudan UniversityShanghai 200040China department of Dermatology General Hospital of Ningxia Medical UniversityYinchuanNingxia 750000China department of Dermatology Affiliated Hospital of Chengde Medical UniversityChengdeHebei 067000China department of Dermatology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China department of Dermatology Qilu Hospital of Shandong UniversityJinanShandong 250012China department of Dermatology Yuebei People’s HospitalShaoguanGuangdong 512026China department of Dermatology Union Hospital Tongji Medical Collage Huazhong University of Science and TechnologyWuhanHubei 430022China department of Dermatology and Venereal Diseases The First Affiliated Hospit

Background:There is a need for effective and safe therapies for psoriasis that provide sustained *** aim of this study was to assess the efficacy and safety of tildrakizumab,an anti-interleukin-2.p19 monoclonal antibody,for treating moderate-to-severe plaque psoriasis in Chinese ***:In this multi-center,double-blind,phase III trial,patients with moderate-to-severe plaque psoriasis were enrolled and randomly assigned(1:1)to receive subcutaneous tildrakizumab 100 mg or placebo at weeks 0 and *** initially assigned to placebo were switched to receive tildrakizumab at weeks 12.16,and every 12.weeks *** in the tildrakizumab group continued with tildrakizumab at week 16,and every 12.weeks until week *** primary endpoint was the Psoriasis Area and Severity Index(PASI 75)response rate at week ***:At week 12.tildrakizumab demonstrated significantly higher PASI 75 response rates(66.4%[73/110]vs.12.7%[14/110];difference,51.4%[95%confidence interval(CI),40.72.62.13];P2.;P2. weeks(86.8%[92.106]vs.82.4%[89/108])and maintained up to 52.weeks(91.3%[95/104]vs.87.4%[90/103]).Most treatment-emergent adverse events were mild and not related to ***:Tildrakizumab demonstrated durable efficacy through week 52.and was well tolerated in Chinese patients with moderate-to-severe plaque *** registration:***,NCT05108766.

关键词： Tildrakizumab Interleukin 2. Plaque psoriasis Chinese Randomized controlled trial

Propagation of liquid surface waves over finite graphene structured arrays of cylinders

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Theoretical & Applied Mechanics Letters 2011年第5期1卷 73-76页

作者： Xuemei liu,1,2.Yong Wei,1 Sheng li,1 Yousheng Xu,1,Detang Lu,3 and Boming Yu 4 1) {2. of Physics,zhejiang Normal university,jinhua 32.004,zhejiang,China 2. Hangzhou No.14 Middle School,Hangzhou 310006,China 3) {2. of Modern Mechanics,university of Science and Technology of China,Hefei 2.002.,China 4) School of Physics,Huazhong university of Science and Technology,Wuahn 430074,China School of Physics Huazhong University of Science and Technology Wuahn 430074 China

Based on the multiple scattering method,this paper investigates a benchmark problem of the propagation of liquid surface waves over finite graphene (or honeycomb) structured arrays of *** the graphene structured array with the square structured and with triangle structured arrays,it finds that the finite graphene structure can produce more complete band gaps than the other finite structures,and the finite graphene structure has less localized ability than the other finite structures.

关键词： propagation liquid surface wave graphene structured array multiple scattering method

儿童弥漫性中线胶质瘤伴H3K2.变异型102.临床病理特征

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临床与实验病理学杂志 2024年第7期40卷 696-700页

作者：李金华王立峰王佳上海交通大学医学院附属新华医院病理科上海200092

目的探讨儿童弥漫性中线胶质瘤(diffuse midline gliomas, DMG)伴H3K2.变异型的临床病理特点和分子学特征。方法收集102.DMG伴H3K2.变异型患者临床资料,采用HE、免疫组化EnVision两步法染色,应用Sanger测序法行分子检测,分析其临床... 详细信息

目的探讨儿童弥漫性中线胶质瘤(diffuse midline gliomas, DMG)伴H3K2.变异型的临床病理特点和分子学特征。方法收集102.DMG伴H3K2.变异型患者临床资料,采用HE、免疫组化EnVision两步法染色,应用Sanger测序法行分子检测,分析其临床病理特征并复习相关文献。结果患者发病年龄1~14岁,中位年龄7岁。发病部位:脑干83例(81.4%),非脑干如丘脑、基底节和松果体等19例(18.6%)。临床表现主要为头晕、头痛和步态不稳等。MRI示T1低信号或等信号,T2.信号。组织学示高级别64例(62.7%),低级别38例(37.3%)。免疫表型:H3K2.me3表达降低或缺失(100%,81/81),表达H3K2.M(98%,100/102.、EZHIP(2.,2.102.、BRAF V600E(2.2.,2.89);p53突变型占53.6%(52.97);ATRX失表达(19.1%,18/94);IDH1不表达(100%,89/89)。分子检测示BRAF突变占1.7%(1/59);EGFR突变占9.1%(1/11)。结论儿童DMG伴H3K2.变异型好发于脑干,组织学以高级别为主,H3K2.me3染色呈不同程度表达缺失,分子变异包括H3K2.M突变、EZHIP过表达和EGFR突变。

关键词：弥漫性中线胶质瘤伴H3K2.变异型儿童临床病理免疫组织化学

The ALMA-QUARKS Survey.Ⅰ.Survey Description and Data Reduction

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Research in Astronomy and Astrophysics 2024年第2期24卷 104-124页

作者：刘训川 Tie liu Lei Zhu Guido Garay Hong-li liu Paul Goldsmith Neal Evans Kee-Tae Kim Sheng-Yuan liu Fengwei Xu Xing Lu Anandmayee Tej Xiaofeng Mai Leonardo Bronfman Shanghuo li Diego Mardones Amelia Stutz Ken'ichi Tatematsu Ke Wang Qizhou Zhang Sheng-li Qin Jianwen Zhou Qiuyi Luo Siju Zhang Yu Cheng jinhua He Qilao Gu Ziyang li Zhenying Zhang Suinan Zhang Anindya Saha Lokesh Dewangan Patricio Sanhueza Zhiqiang Shen Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile School of Physics and Astronomy Yunnan UniversityKunming 650091China Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA department of Astronomy The University of Texas at AustinTX 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia Max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Departamento de Astronomía Universidad de ConcepciónCasilla 160-CConcepciónChile Nobeyama Radio Observatory National Astronomical Observatory of JapanNational Institutes of Natural Sciences462-2 NobeyamaMinamimakiMinamisakuNagano 384-1305Japan Center for Astrophysics∣Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA Max-Planck-Institut für Radioastronomie Auf dem Hügel 69D-53125 BonnGermany School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China National Astronomical Observatory of Japan 2-21-1 OsawaMitakaTokyo181-8588Japan Yunnan Observatories Chinese Academy of SciencesKunming 650216China Physical Research Laboratory NavrangpuraAhmedabad-380009India Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan university of Science and Technology Korea(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic o

This paper presents an overview of the QUARKS survey,which stands for Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures."The QUARKS survey is observing139 massive clumps covered by 156 pointings at Atacama Large Millimeter/submillimeter Array(ALMA)Band 6(λ~1.3 mm).In conjunction with data obtained from the ALMA-ATOMS survey at Band 3(λ~3 mm),QUARKS aims to carry out an unbiased statistical investigation of massive star formation process within protoclusters down to a scale of 1000 *** overview paper describes the observations and data reduction of the QUARKS survey,and gives a first look at an exemplar source,the mini-starburst Sgr B2.M).The wide-b and width(7.5 GHz)and high-angular-resolution(~0."3)observations of the QUARKS survey allow for the resolution of much more compact cores than those could be done by the ATOMS survey,and to detect previously unrevealed fainter filamentary *** spectral windows cover transitions of species including CO,SO,N_(2.D^(+),SiO,H_(30)α,H_(2.CO,CH_(3)CN,and many other complex organic molecules,tracing gas components with different temperatures and spatial *** aims to deepen our understanding of several scientific topics of massive star formation,such as the mass transport within protoclusters by(hub-)filamentary structures,the existence of massive starless cores,the physical and chemical properties of dense cores within protoclusters,and the feedback from already formed high-mass young protostars.

关键词： stars formation-stars kinematics and dynamics-ISM clouds-ISM molecules

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岩石磁学方法在海洋样品研究中的多解性讨论

地球物理学报 2024年第5期67卷 1891-1912页

作者：张强刘双迟刘建兴刘传周李金华刘青松中国科学院地质与地球物理研究所岩石圈演化国家重点实验室北京100029 自然资源部第一海洋研究所海洋地质与成矿作用重点实验室青岛266061 中国科学院地质与地球物理研究所地球与行星物理院重点实验室北京100029 南方科技大学海洋科学与工程系深圳518055

岩石磁学是研究自然以及人工合成磁性矿物性质变化的应用型学科.海底岩石和海洋沉积物等海洋样品中含有不同成因及来源的磁性矿物.这些磁性矿物蕴含了全球气候变化、微生物矿化、地球动力学演化等关键地质信息.岩石磁学可以快速解析这... 详细信息

岩石磁学是研究自然以及人工合成磁性矿物性质变化的应用型学科.海底岩石和海洋沉积物等海洋样品中含有不同成因及来源的磁性矿物.这些磁性矿物蕴含了全球气候变化、微生物矿化、地球动力学演化等关键地质信息.岩石磁学可以快速解析这些海洋样品中磁性矿物种类、含量、磁畴等特征的变化,为提取相关地质演化信息提供丰富的指标记录.然而,由于磁性矿物循环和海洋内部过程的固有复杂性,岩石磁学参数解译在海洋样品研究中存在多解性,在一定程度上制约了相关地质信息的深入解读.解决这一问题的关键在于对样品中载磁矿物的准确识别和量化.为此,本文首先简述了海洋样品中主要的磁性矿物类型,随后系统论述了应用岩石磁学方法评估海洋样品磁性矿物种类、含量以及磁畴状态等方面的多解性和注意事项.本文同时对岩石磁学的局限性、新兴技术和未来研究思路进行了展望.

关键词：岩石磁学磁性矿物海洋地质海洋科学参数多解性

可视化环锯成形治疗单节段腰椎间盘突出症的1年随访

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中国组织工程研究 2024年第21期28卷 3344-3348页

作者：陈风李东亚潘彬袁海波吴继彬徐州医科大学江苏省徐州市221000 徐州医科大学附属医院骨科江苏省徐州市221000

背景:随着脊柱微创手术的进步,脊柱内镜下腰椎减压已广泛应用于腰椎间盘突出症患者的治疗,不同内窥镜手术入路的适应证不同,具体手术方案的决策需要结合实际情况和临床手术医师的选择。目的:探讨经皮内镜下可视化环锯成形治疗单节段腰... 详细信息

背景:随着脊柱微创手术的进步,脊柱内镜下腰椎减压已广泛应用于腰椎间盘突出症患者的治疗,不同内窥镜手术入路的适应证不同,具体手术方案的决策需要结合实际情况和临床手术医师的选择。目的:探讨经皮内镜下可视化环锯成形治疗单节段腰椎间盘突出症的近期疗效。方法:纳入2.19年1月至2.2.年12.徐州医科大学附属医院收治的符合纳入标准的单节段腰椎间盘突出症患者90例,根据经皮内镜下可视化环锯成形的不同入路分为经椎间孔入路组(对照组,n=48)和经椎板间入路组(试验组,n=42.,记录两组患者一般情况,包括性别、年龄、病程、体质量指数、切口长度、手术耗时、术中透视次数、住院天数、出血量,评估不同随访阶段的疼痛目测类比评分、日本骨科协会评分,采用改良MacNab标准评估末次随访时的临床效果,并统计术后并发症及复发率情况。结果与结论:①试验组手术耗时及术中透视次数较对照组少,差异有显著性意义(P0.05);②两组术前目测类比评分及日本骨科协会评分的差异无显著性意义(P>0.05),术后1周及3,6,12.月的目测类比评分及日本骨科协会评分与术前相比均显著改善(P<0.05);③末次随访的改良MacNab标准优良率,对照组为94%,试验组为95%;④对照组有1例患者术后仍感腰腿痛,行开放性手术,术后恢复良好,无明显后遗症状;而试验组术后未出现并发症及复发病例;⑤提示经皮椎间孔入路及椎板间入路内镜下可视化环锯成形治疗单节段腰椎间盘突出症都具有良好的短期临床疗效和较高的患者满意度,但经椎板间入路手术耗时更短、术中透视次数更少。

关键词：腰椎间盘突出症环锯成形术经皮椎间孔内镜经皮椎间孔入路经皮椎板间入路

Strain‑Induced Surface Interface Dual Polarization Constructs PML‑Cu/Bi_(12.O_(17)Br_(2. High‑Density Active Sites for CO_(2. Photoreduction

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Nano-Micro Letters 2024年第5期16卷 169-183页

作者： Yi Zhang Fangyu Guo Jun Di Keke Wang Molly Meng‑Jung li Jiayu Dai Yuanbin She Jiexiang Xia Huaming li School of Chemistry and Chemical Engineering Institute for Energy ResearchSchool of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013People’s Republic of China State Key Laboratory Breeding Base of Green Chemistry‑Synthesis Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014People’s Republic of China College of Science and Hunan Key Laboratory of Extreme Matter and ApplicationsNational University of Defense TechnologyChangsha 410073People’s Republic of China department of Applied Physics The Hong Kong Polytechnic UniversityHung HomHong KongPeople’s Republic of China School of Chemistry and Chemical Engineering National Special Superfine Powder Engineering Research CenterNanjing University of Science and TechnologyNanjing 210094People’s Republic of China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials Zhejiang Normal UniversityJinhua 321004People’s Republic of China

The insufficient active sites and slow interfacial charge trans-fer of photocatalysts restrict the efficiency of CO_(2. *** synchronized modulation of the above key issues is demanding and ***,strain-induced strategy is developed to construct the Bi–O-bonded interface in Cu porphyrin-based monoatomic layer(PML-Cu)and Bi_(12.O_(17)Br_(2.(BOB),which triggers the surface interface dual polarization of PML-Cu/BOB(PBOB).In this multi-step polarization,the built-in electric field formed between the interfaces induces the electron transfer from con-duction band(CB)of BOB to CB of PML-Cu and suppresses its reverse ***,the surface polarization of PML-Cu further promotes the electron converge in Cu *** introduction of PML-Cu endows a high density of dispersed Cu active sites on the surface of PBOB,significantly promoting the adsorption and activation of CO_(2. and CO *** conversion rate of CO_(2. photoreduction to CO for PBOB can reach 584.3μmol g-1,which is 7.83 times higher than BOB and 2..01 times than *** work offers valuable insights into multi-step polarization regulation and active site design for catalysts.

关键词： Bi_(12.O_(17)Br_(2. Porphyrin CO_(2.photoreduction Polarization Active sites

年龄联合术后2.h乳酸负荷对心脏瓣膜术后急性肾损伤的预测价值

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中国现代医生 2024年第6期62卷 58-62页

作者：莫基斌李水珠福建医科大学省立临床医学院福建省立医院重症医学四科福建福州350001 福建医科大学附属第一医院心血管内科福建福州350004

目的探讨年龄、术后2.h乳酸负荷与成人体外循环心脏瓣膜术后急性肾损伤发生的关系。方法回顾性收集2.19年6月至2.2.年8月于福建省立医院心血管外科行心脏瓣膜手术的180例住院患者的临床资料,根据术后是否出现急性肾损伤(acute kidney in... 详细信息

目的探讨年龄、术后2.h乳酸负荷与成人体外循环心脏瓣膜术后急性肾损伤发生的关系。方法回顾性收集2.19年6月至2.2.年8月于福建省立医院心血管外科行心脏瓣膜手术的180例住院患者的临床资料,根据术后是否出现急性肾损伤(acute kidney injury,AKI)分为AKI组(n=91)和非AKI组(n=89)。对心脏瓣膜术后AKI发生的危险因素进行单因素及多因素Logistic分析,采用受试者操作特征曲线(receiver operating characteristic curve,ROC曲线)分析各危险因素对心脏瓣膜术后AKI的预测价值。结果单因素分析结果显示AKI组患者的年龄、体外循环时间、停机乳酸、术后2.h液体正平衡量、术后2.h乳酸负荷均高于非AKI组,差异均有统计学意义(P2.h乳酸负荷是心脏瓣膜术后AKI的独立危险因素(OR值分别为1.064、1.014,P2.h乳酸负荷对心脏瓣膜术后AKI有预测价值,年龄和术后2.h乳酸负荷联合指标对心脏瓣膜术后AKI的预测价值优于单一指标。结论年龄联合术后2.h乳酸负荷对心脏瓣膜术后急性肾损伤有较好的临床预测价值。

关键词：心脏瓣膜体外循环急性肾损伤乳酸负荷

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