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Discovery of the anti-angiogenesis effect of eltrombopag in breast cancer through targeting of HuR protein

Acta Pharmaceutica Sinica B 2020年第8期10卷 1414-1425页

作者： Yuying Zhu Liuqing yang jiazhen Xu Xiyan yang Pengwei Luan Qianfei Cui Pei Zhang Feiyun Wang Ruixiang Li Xinyue Ding Lixian Jiang Guoqiang Lin Jiange Zhang The Research Center of Chiral Drugs Innovation Research Institute of Traditional Chinese Medicine(IRI)Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Drug Discovery and Development School of Pharmaceutical SciencesZhengzhou UniversityZhengzhou 450001China

HuR(human antigen R), an mRNA-binding protein responsible for poor prognosis in nearly all kinds of malignancies, is a potential anti-tumor target for drug development. While screening HuR inhibitors with a fluorescence polarization(FP) based high-throughput screening(HTS) system, the clinically used drug eltrombopag was identified. Activity of eltrombopag on molecular level was verified with FP, electrophoretic mobility shift assay(EMSA), simulation docking and surface plasmon resonance(SPR). Further, we showed that eltrombopag inhibited in vitro cell proliferation of multiple cancer cell lines and macrophages, and the in vivo anti-tumor activity was also demonstrated in a 4T1 tumor-bearing mouse model. The in vivo data showed that eltrombopag was efficient in reducing microvessels in tumor tissues. We then confirmed the HuR-dependent anti-angiogenesis effect of eltrombopag in 4T1 cells and RAW264.7 macrophages with qRT-PCR, HuR-overexpression and HuR-silencing assays, RNA stability assays, RNA immunoprecipitation and luciferase assays. Finally, we analyzed the in vitro anti-angiogenesis effect of eltrombopag on human umbilical vein endothelial cells(HUVECs) mediated by macrophages with cell scratch assay and in vitro Matrigel angiogenesis assay. With these data, we revealed the HuR-dependent anti-angiogenesis effect of eltrombopag in breast tumor, suggesting that the existing drug eltrombopag may be used as an anti-cancer drug.

关键词： RAW264.7 eltrombopag angiogenesis

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AN X-RAY STUDY OF THERMODIFFUSION PROCESSES ON TYRE WIRE COATING

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Transactions of Nonferrous Metals Society of China 1996年第1期6卷 110-113页

作者： Wang Yandong Zhang Fang Liu Yandong Xu jiazhen Department of Materials Science and Engineering Northeastern UniversityShenyang 110006

The thermodiffusion behaviors of brass coating on tyre wire obtained by electro-deposition of copper and zinc with controlled thickness,followed by continuous annealing in industry and isothermal annealing at laboratory,respectively,were studied by means of X-ray diffraction *** the information of X-ray diffraction,the fraction of phase during different thermodiffusion processes was given and the phase homogeneity of a phase in the films was discussed.

关键词： tyre wire electro-deposition diffusion X-ray diffraction

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Projecting Wintertime Newly Formed Arctic Sea Ice through Weighting CMIP6 Model Performance and Independence

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Advances in Atmospheric Sciences 2024年第8期41卷 1465-1482页

作者： jiazhen ZHAO Shengping HE Ke FAN Huijun WANG Fei LI Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway School of Atmospheric Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate Research Bergen 5007Norway Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

Precipitous Arctic sea-ice decline and the corresponding increase in Arctic open-water areas in summer months give more space for sea-ice growth in the subsequent cold seasons. Compared to the decline of the entire Arctic multiyear sea ice,changes in newly formed sea ice indicate more thermodynamic and dynamic information on Arctic atmosphere–ocean–ice interaction and northern mid–high latitude atmospheric teleconnections. Here, we use a large multimodel ensemble from phase 6 of the Coupled Model Intercomparison Project(CMIP6) to investigate future changes in wintertime newly formed Arctic sea ice. The commonly used model-democracy approach that gives equal weight to each model essentially assumes that all models are independent and equally plausible, which contradicts with the fact that there are large interdependencies in the ensemble and discrepancies in models' performances in reproducing observations. Therefore, instead of using the arithmetic mean of well-performing models or all available models for projections like in previous studies, we employ a newly developed model weighting scheme that weights all models in the ensemble with consideration of their performance and independence to provide more reliable projections. Model democracy leads to evident bias and large intermodel spread in CMIP6 projections of newly formed Arctic sea ice. However, we show that both the bias and the intermodel spread can be effectively reduced by the weighting scheme. Projections from the weighted models indicate that wintertime newly formed Arctic sea ice is likely to increase dramatically until the middle of this century regardless of the emissions ***, it may decrease(or remain stable) if the Arctic warming crosses a threshold(or is extensively constrained).

关键词： wintertime newly formed Arctic sea ice model democracy model weighting scheme model performance model independence

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骶管注射加穴位埋线法治疗腰椎间盘突出症的临床疗效观察

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中国医药导报 2010年第23期7卷 54-56页

作者：覃一珏覃光地杨嘉珍陈希李云燕张大国唐阿方广西壮族自治区人民医院中医科广西南宁530021

目的:观察骶管注射加穴位埋线法与常规治疗腰椎间盘突出症的疗效差异。方法:将160例患者随机分为治疗组和对照组,各80例。治疗组采用骶管注射加羊肠线穴位埋线,骶管注射为每周1次,1次为1个疗程,一般注射2次,必要时1周后再注射1次;穴位... 详细信息

目的:观察骶管注射加穴位埋线法与常规治疗腰椎间盘突出症的疗效差异。方法:将160例患者随机分为治疗组和对照组,各80例。治疗组采用骶管注射加羊肠线穴位埋线,骶管注射为每周1次,1次为1个疗程,一般注射2次,必要时1周后再注射1次;穴位埋线为每周1次,3次为1个疗程。对照组采用牵引推拿配合中药内服,每天1次,1周为1个疗程,共3个疗程。结果:治疗3个疗程后,治疗组JOA评分及总有效率均优于对照组(均P<0.05)。结论:骶管注射加穴位埋线法治疗腰椎间盘突出症疗效较好,值得临床应用。

关键词：腰椎间盘突出症骶管注射埋线

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Effect of temperature on corrosion behavior of alloy 690 in high temperature hydrogenated water

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Journal of Materials Science & Technology 2018年第8期34卷 1419-1427页

作者： jiazhen Wang Jianqiu Wang Hongliang Ming Zhiming Zhang En-Hou Han Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Reactor Engineering Research Sub-lnstitute Nuclear Power Institute of ChinaChengdu 610213China

The influence of temperature on the corrosion behavior of Alloy 690 is evaluated using potentiodynamic polarization curves, electrochemical impedance spectra （EIS）, scanning electron microscopy （SEM）, X- ray photoelectron spectroscopy （XPS） and transmission electron microscopy （TEM）. The corrosion rate of Alloy 690 reaches a local maximum at 250℃. The kinetic control step of the growth of oxide film changes from the diffusion process of aqueous-phase ions to the growth of Cr-rich barrier layer in the temperature range of 200-300 ℃. A modified double-layer model is proposed to describe the effect of temperature on the structure and composition of the oxide film.

关键词： Alloy Polarization EIS SEMTEM High temperature corrosion

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Crystallite Orientation Analysis for a Multidirectionally Cold Rolled α-Ti Alloy (TA7) Thin Sheet

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Rare Metals 1989年第2期9卷 31-36页

作者： Zuo, Liang Liang, Zhide Xu, jiazhen Zhao, Xiang Northeast Univ of Technology China

A microcomputer software determining the crystallite orientation distribution functions (ODFs) and inverse pole figures of hexagonal materials with or without orthorhombic physical symmetry has been worked out the first time. The texture measurements and the ODF calculations were performed for a multidirectionally cold rolled α-Ti alloy (TA7) sheet by the application of this software. It is shown that the rolling planes of most grains in the sheet tend to be parallel to (0001) with a deviation to the extent of 40° and is shown a predominance of the orientation zone containing (1016), while the rolling directions are, as a whole, uniformly distributed along all the directions over the rolling planes. Of all the texture components, (2¯117) [01¯10] is slightly stronger than the other.

关键词： Computer Programming Flowcharting Crystals Orientation Mathematical Techniques Least Squares Approximations Metallography Textures Titanium Metallography Computer Simulation

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Improvement and application of Y2O3 directional solidification crucible

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Chinese Journal of Aeronautics 2016年第2期29卷 554-559页

作者： Ma Limin Zhang jiazhen Yue Guangquan Zhang Huarui Zhou Li Zhang Hu Beijing Aeronautical Science & Technology Research Institute of COMAC Bering 102211 Chinab School of Materials Science and Engineering Beihang University Beijing 100191 China

In order to satisfy the drastic temperature change and high chemical activity in direc- tional solidification of Nb Si based alloys, Y2O3 crucible is demanded to possess high thermal shock resistance and erosion resistance. This paper improved the sintering degree and density of Y2O3 crucible by optimizing the sintering temperature and time, and its practical application per- formance was investigated. Y2O3 grains gathered with the increase of sintering temperature and time, and the contact area enlarged, resulting in the open pores being changed into closed pores. The higher density caused the improvement of erosion resistance of Y2O3 crucibles. However, exces- sive density weakened the thermal shock resistance. Considering high-temperature strength, erosion resistance, thermal shock resistance and costs, optimum sintering temperature and time of Y2O3 directional solidification crucible were 1800 ℃ and 120min, respectively, and the porosity was 20%. Improved Y2O3 crucible has been successfully applied to directional solidification of Nb Si based alloys, and significantly reduced the oxygen contamination. Slight interaction occurred between Hf and Y2O3, but no obvious dissolution, penetration or erosion was found, showing good erosion resistance and thermal shock resistance.

关键词： Directional solidification Erosion resistance Microstructure Nb-Si based alloy Thermal shock resistanceY2O3 crucible

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Manufacturers’strategy for introducing remanufactured products under a government subsidy:Introduce or not?

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Journal of Management Science and Engineering 2023年第1期8卷 128-148页

作者： Zhen Wang jiazhen Huo Yongrui Duan School of Economics and Management Tongji UniversityShanghai200092China Bosch-Tongji University Chair of Global Supply Chain Management Shanghai200092China

With strong government advocacy and encouragement,many manufacturers hope to enter the remanufacturing *** who have entered the remanufacturing market hope to increase their profits through effective *** game-theoretic models,this study investigates manufacturers’conditions for introducing remanufactured products and the production decisions after the introduction by constructing a consumer utility *** study demonstrates that manufacturers’decision-making method directly affects their decision to introduce remanufactured *** a manufacturer plans to introduce remanufactured products,they should adopt a centralized decision-making method for the two *** this decision-making method,when the ratio of the government subsidy to the cost of new products is not too large or too small,the manufacturer can introduce remanufactured ***,the range of the ratio of the government subsidy to the cost of new products is related to the difference between the ratio of the cost of remanufactured products to that of new products and the substitutability of the remanufactured ***,when formulating a subsidy,the government should control it within a reasonable range and formulate differentiated subsidy strategies based on different enterprises’specific conditions to give full play to the benefits of the government ***,after the manufacturer has introduced remanufactured products,the consumer surplus and manufacturer’s profit increase with the government ***,social welfare increases only when the government subsidy is within a reasonable ***,compared with subsidizing consumers,it is found that subsidizing the manufacturer does not affect their profit,the consumer surplus,and social welfare;however,the range within which the manufacturer can introduce remanufactured products narrows.

关键词： Remanufacturing Government subsidy Consumer utility Decision-making method Game model

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Gel-state polybenzimidazole proton exchange membranes with flexible alkyl sulfonic acid side chains for a wider operating temperature range(25–240 ℃)

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Journal of Energy Chemistry 2023年第10期85卷 91-101,I0005页

作者： Taizhong Zhu Danyi Zhu jiazhen Liang Liang Zhang Fei Huang Lixin Xue Center for Membrane Separation and Water Science&Technology College of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014ZhejiangChina College of Chemistry and Materials Engineering Wenzhou UniversityWenzhou 325035ZhejiangChina Received 18 April 2023Revised 30 May 2023Accepted 31

High-temperature proton exchange membrane fuel cells(HT-PEMFC) possess distinct technical advantages of high output power, simplified water/heat management, increased tolerance to fuel impurities and diverse fuel sources, within the temperature range of 120–200 ℃. However, for practical automobile applications, it was crucial to broaden their low-temperature operating window and enable cold start-up capability. Herein, gel-state phosphoric acid(PA) doped sulfonated polybenzimidazole(PBI) proton exchange membranes(PEMs) were designed and synthesized via PPA sol-gel process and in-situ sultone ring-opening reactions with various proton transport pathways based on absorbed PA, flexible alkyl chain connected sulfonic acid groups and imidazole sites. The effects of flexible alkyl sulfonic acid side chain length and content on PA doping level, proton conductivity, and membrane stability under different temperature and relative humidity(RH) were thoroughly investigated. The prepared gel-state membranes contained a self-assembled lamellar and porous structure that facilitated the absorption of a large amount of PA with rapid proton transporting mechanisms. At room temperature, the optimized membrane exhibited a proton conductivity of 0.069 S cm^(-1), which was further increased to 0.162 and 0.358 S cm^(-1)at 80 and 200 ℃, respectively, without additional humidification. The most significant contribution of this work was demonstrating the feasibility of gel-state sulfonated PBI membranes in expanding HT-PEMFC application opportunities over a wider operating range of 25 to 240 ℃.

关键词： Wide temperature range Proton exchange membrane Fuel cell Gel-state Polybenzimidazole

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Extraction of Tungsten and Molybdenum by Various Organic Compounds as Extractants

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Rare Metals 1989年第3期9卷 15-19页

作者： Yuan, Qun Cheng, Xin Luo, jiazhen Yuan, Chengye Shanghai Inst of Organic Chemistry China

Seventy organic compounds including various organophosphorus esters, amines and oxygen-based ligands were investigated as extractants. The experiment results show that amines are excellent extractants for W and Mo. Their sequence of extraction ability for W is as follows: quarternary amine > tertiary amine > secondary amine > primary amine. Acidic organophosphorus extractants do not extract W, but can extract Mo with high extraction ability from the acidic solution. These extractants could provide a potential process for separating W from Mo.

关键词： Alcohols Applications Amines Applications Molybdenum Ore Treatment Solvent Extraction Phosphorus Compounds Organic Solvents Organic

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