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Deformation-induced interfacial-twin-boundary ω-phase in an Fe_(48)Mn_(37)Al_(15) body-centered cubic metastable alloy

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Journal of Materials Science & Technology 2023年第15期146卷 252-258页

作者： Huabei Peng Xiao yang Lixin Sun Liqiu Yong jiazhen Yan Jinyong Zhang Bingnan Qian Yuhua Wen School of Mechanical Engineering Sichuan UniversityChengdu 610065China School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China School of Materials and Physics China University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Innovation Center NPU ChongqingChongqing 401135China Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China

Omega(ω)phase has a trigonal or hexagonal crystal structure and was first discovered inβ-type Ti-Cr alloys[1].Since then,theω-phase has been widely reported in numerous group IV transition metal(Ti,Ta,Hf,and Zr)based alloys[2–9].The morphologies ofω-phase could be particle-like(athermalω-phase)[10],ellipsoidal or cuboidal after aging(isothermalω-phase)[11],and plate-like after deformation(stress-relatedω-phase)[12].Amongst,the stressrelatedω-phase is usually located at the twinning boundary,thus also called interfacial-twin-boundary-ω(ITB-ω)*** formation of the ITB-ωphase is considered to be related to the formation of{112}bccmechanical twin(i.e.,{112}bcc twin)in bodycentered cubic(BCC)metals and alloys[13].

关键词： alloys alloy deformation

RNA nanostructure transformation into DNA ones

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Nano Research 2022年第10期15卷 9199-9203页

作者： jiazhen Lyu Shiyu Ma Chong Zhang Zhen Huang Key Laboratory of Bio-resource and Eco-environment of Ministry of Education College of Life SciencesSichuan UniversityChengdu 610065China The State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610041China SeNA Research Institute Chengdu 610000China

RNAs and their assemblies can form diverse nano-structures and nano-shapes,offering various biological ***,by simply mimicking RNA sequences,DNAs cannot normally form the corresponding nanostructures,which makes the natureinspired transformations and designs *** understand the possible designs and connections between related RNA and DNA nano-shapes,herein we have reported several DNA squares transformed and derived from an RNA assembled square,by gradually replacing RNA with DNA *** have found that there were key RNA nucleotides:Their presences maintained the square,while their absences disrupted ***,we have revealed that as long as the conditions of higher ionic strengths or longer duplexes were included,the square RNA assembly could be completely replaced with DNA nucleotides,still offering the stable DNA *** experimental results have demonstrated that similar RNA nanostructure can be easily transformed into DNA ones via designing and increasing ionic strengths or duplex lengths.

关键词： RNA nanostructure DNA square assembly molecular transformation ionic strength duplex length

猪繁殖与呼吸综合征病毒MS2装甲病毒样颗粒质控品的制备及应用

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中国兽医学报 2024年第11期44卷 2316-2323页

作者：何嘉敏庞旋飞罗律杨佳臻张宝真伍建敏刘文娜李中圣白挨泉佛山科学技术学院生命工程与工程学院广东海大畜牧兽医研究院有限公司

为研制一种可以应用猪繁殖与呼吸综合征病毒(PRRSV)实时荧光定量PCR(RT-qPCR)核酸检测的阳性质控品，本研究使用MS2噬菌体装甲RNA(Armored RNA)技术制备PRRSV-1和PRRSV-2 M基因的阳性质控品。将扩增的PRRSV-1和PRRSV-2 M基因进行纯化回... 详细信息

为研制一种可以应用猪繁殖与呼吸综合征病毒(PRRSV)实时荧光定量PCR(RT-qPCR)核酸检测的阳性质控品，本研究使用MS2噬菌体装甲RNA(Armored RNA)技术制备PRRSV-1和PRRSV-2 M基因的阳性质控品。将扩增的PRRSV-1和PRRSV-2 M基因进行纯化回收，连接到内含MS2成熟酶蛋白基因与衣壳蛋白的pET28b载体，通过转化至BL21(DE3)后，经IPTG诱导表达，利用PEG6000沉淀法纯化，制备出内含PRRSV M基因装甲RNA病毒样颗粒(AR-PRRSV)。后续进行性能评估，作为PRRSV-1和PRRSV-2 M基因的阳性质控品，AR-PRRSV1M和AR-PRRSV2M使用YY/T 1652-2019标准进行计算，数据表明均匀性良好，-20、4、25℃能稳定保存60 d, 37℃能稳定保存30 d。使用RT-qPCR进行初步定量后，利用数字定量PCR(ddPCR)对制备的装甲病毒样颗粒AR-PRRSV1M和AR-PRRSV2M进行定值，结果10～4拷贝/μL的AR-PRRSV1M和AR-PRRSV2M ddPCR定值均为(1.33±0.50)×10～4拷贝/μL。本研究结果表明，应用定值后的AR-PRRSVM,能够实现对检测全过程(核酸提取、反转录和RT-qPCR)的质量控制。

关键词：猪繁殖与呼吸综合征病毒装甲RNA 核酸检测质控品

A novel dense descriptor based on structure tensor voting for multi-modal image matching

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Chinese Journal of Aeronautics 2020年第9期33卷 2408-2419页

作者： jiazhen LU Maoqing HU Jing DONG Songlai HAN Ang SU School of Aeronautics and Astronautics Central South UniversityChangsha 410083China Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Automatic and robust matching of multi-modal images can be challenging owing to the nonlinear intensity differences caused by radiometric variations among these *** address this problem,a novel dense feature descriptor and improved similarity measure are proposed for enhancing the matching *** proposed descriptor is built on a voting scheme of structure tensor that can effectively capture the geometric structural properties of *** is not only illumination and contrast invariant but also robust against the degradation caused by significant ***,the similarity measure is improved to adapt to the reversal of orientation caused by the intensity inversion between multi-modal *** proposed dense feature descriptor and improved similarity measure enable the development of a robust and practical templatematching algorithm for multi-modal *** verify the proposed algorithm with a broad range of multi-modal images including optical,infrared,Synthetic Aperture Radar(SAR),digital surface model,and map *** experimental results confirm its superiority to the state-of-the-art methods.

关键词： Dense feature descriptor Remote sensing images Similarity measurement Structure tensor Template matching

Real-time mosaicking for infrared videos from an oblique sweeping camera

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Chinese Journal of Aeronautics 2021年第1期34卷 309-319页

作者： jiazhen LU Fangde SUN Jing DONG Songlai HAN Ang SU School of Aeronautics and Astronautics Central South UniversityChangsha 410083China Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China

Image mosaicking is widely used in Geographic Information Systems(GISs)for largescale ground surface ***,most existing mosaicking methods can only be used in offline processing due to the enormous amounts of *** this paper,we propose a novel and practical algorithm for real-time infrared video *** achieve this,a novel fast template matching algorithm based on Sum of Cosine Differences(SCD)is proposed to coarsely match the sequential *** high speed of the proposed template matching algorithm is obtained by computing correlation with Fast Fourier Transform(FFT).We also propose a novel fast Least Squares Matching(LSM)algorithm for inter-frame fine registration,which can significantly reduce the computation without degrading the matching *** addition,the proposed fast LSM can effectively adapt for noise degradation and geometric *** on the proposed fast template matching algorithm and fine registration algorithm,we develop a practical real-time mosaicking approach which can produce seamless mosaic image highly *** on synthetic and real-world datasets demonstrate that the proposed algorithm is not just computationally efficient but also robust against various noise distortions.

关键词： Fast Fourier transform Least squares matching Map fusion Mosaic Real-time Template matching

All-at-once arrangement of both oxygen atoms of dioxygen into aliphatic C(sp^(3))–C(sp^(3))bonds for hydroxyketone difunctionalization

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Science China Chemistry 2021年第5期64卷 770-777页

作者： Xiaofeng Qiao Yuhan Lin jiazhen Li Wanhong Ma Jincai Zhao Key Laboratory of Photochemistry CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Bothβ-andγ-hydroxyketone structures are important units in biologically active molecules,synthetic drugs and fine *** there are some routes available for their manufacture from pre-functionalized groups on one or two matrix molecule(s),the approaches to simply and simultaneously deposit two oxygen atoms from dioxygen into two specific C(sp^(3))positions of pure saturated hydrocarbons have rarely succeeded because they are involved in the targeted activation of three inert C–Hσbonds all at ***,we show that a TiO_(2)-CH_(3)CN photocatalytic suspension system enables the insertion of dioxygen into one C(sp^(3))–C(sp^(3))bond of strained cycloparaffin derivatives,by which difunctionalized hydroxyketone products are obtained in a one-pot *** the cleavage event to release strain as the directional driving force,as-designed photocatalytic reaction systems show 21 examples ofβ-hydroxyketone products with 31%–76%isolated yields for three-membered ring derivatives and 5 examples ofγ-hydroxyketone products with 30%–63%isolated yields for four-membered ring substrates.^(18)O isotopic labeling experiments using^(18)O2,Ti^(18)O_(2) and intentionally added H218O,respectively,indicated that both oxygen atoms of hydroxyketone products were exclusively from dioxygen,suggesting a previously unknown H^(+)/TiO_(2)-e−catalyzed arrangement pathway of the hydroperoxide intermediate to convert dioxygen into hydroxyketone units.

关键词： TiO2 photocatalysis β-orγ-hydroxyketones strained cycloalkanes dioxygen activation

玉米皮膳食纤维脂肪替代物曲奇饼干配方优化研究

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农业科技与装备 2021年第5期 36-39页

作者：孙静阳肖志刚张一凡杨佳臻李圣贤袁媛沈阳师范大学粮食学院沈阳110034

将玉米皮膳食纤维改性制备成脂肪替代物添加到曲奇饼干中,替换其中部分黄油。通过单因素试验和Box-Behnken响应面法优化玉米皮膳食纤维脂肪替代物曲奇饼干配方。结果表明:最佳配方为黄油添加量55.74%,脂肪替代物添加量24.37%,白糖添加量... 详细信息

将玉米皮膳食纤维改性制备成脂肪替代物添加到曲奇饼干中,替换其中部分黄油。通过单因素试验和Box-Behnken响应面法优化玉米皮膳食纤维脂肪替代物曲奇饼干配方。结果表明:最佳配方为黄油添加量55.74%,脂肪替代物添加量24.37%,白糖添加量26.06%,鸡蛋添加量36.14%。按照此配方制作的曲奇饼干感官品质良好且低脂肪低热量。

关键词：玉米皮膳食纤维脂肪替代物曲奇饼干

Allosterically activating SHP2 by oleanolic acid inhibits STAT3-Th17 axis for ameliorating colitis

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2598-2612页

作者： Jinbo Hu Wen Liu Yi Zou Chenyang Jiao jiazhen Zhu Qiang Xu Jianjun Zou yang Sun Wenjie Guo State Key Laboratory of Pharmaceutical Biotechnology Nanjing Drum Tower HospitalSchool of Life SciencesNanjing UniversityNanjing 210093China Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China

Src homology 2 domain-containing tyrosine phosphatase 2(SHP2)is an essential tyrosine phosphatase that is pivotal in regulating various cellular signaling pathways such as cell growth,differentiation,and *** activation of SHP2 has been shown to have a therapeutic effect in colitis and Parkinson's ***,the identification of SHP2 activators and a complete understanding of their mechanism is *** used a two-step screening assay to determine a novel allosteric activator of SHP2 that stabilizes it in an open *** acid was identified as a suitable *** binding to R362,K364,and K366 in the active center of the PTP domain,oleanolic acid maintained the active open state of SHP2,which facilitated the binding between SHP2 and its *** oleanolic acid-activated SHP2 hindered Th17 differentiation by disturbing the interaction between STAT3 and IL-6Rαand inhibiting the activation of ***,via the activation of SHP2 and subsequent attenuation of the STAT3-Th17 axis,oleanolic acid effectively mitigated colitis in *** protective effect was abrogated by SHP2 knockout or administration of the SHP2 inhibitor *** findings underscore the potential of oleanolic acid as a promising therapeutic agent for treating inflammatory bowel diseases.

关键词： Oleanolic acid SHP2 STAT3 Th17 Colitis Allosteric activator

Paleoproterozoic Multistage Metamorphic Ages Registered in the Precambrian Basement Rocks at the Southeastern Margin of the North China Craton and Their Geological Implications

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Acta Geologica Sinica(English Edition) 2016年第6期90卷 2265-2266页

作者： LIU Yican ZHANG Pingang WANG Chengcheng NIE jiazhen CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space Sciences University of Science and Technology of China Hefei 230026 Anhui China Exploration Institute of Anhui Coalfield Geology Bureau Hefei 230088 Anhui China

The Precambrian basement rocks in the Bengbu and neighboring areas, located at the southeastern margin of the North China Craton, occur as granulite terrains and xenoliths in the Mesozoic dioritic porphyry.

关键词： Pb Paleoproterozoic Multistage Metamorphic Ages Registered in the Precambrian Basement Rocks at the Southeastern Margin of the North China Craton and Their Geological Implications