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Phytic acid-modified CeO_(2) as Ca^(2+) inhibitor for a security reversal of tumor drug resistance

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Nano Research 2022年第5期15卷 4334-4343页

作者： Zhimin Tian Junlong Zhao Shoujie Zhao Huicheng li Zhixiong Guo Zechen liang jiayuan li Yongquan Qu Dongfeng Chen Lei liu Department Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Cancer Biology Department of Medical Genetics and Developmental BiologyFourth Military Medical UniversityXi’an 710032China Department of General Surgery Tangdu HospitalFourth Military Medical UniversityXi’an 710038China The State Key Laboratory of Cancer Biology Department of Biochemistry and Molecular BiologySchool of Basic MedicineFourth Military Medical UniversityXi’an 710032China Department of Gastroenterology Daping HospitalArmy Medical UniversityChongqing 400042China

Ca^(2+)plays critical roles in the development of diseases,whereas existing various Ca regulation methods have been greatly restricted in their clinical applications due to their high toxicity and *** solve this issue,with the help of Ca overexpressed tumor drug resistance model,the phytic acid(PA)-modified CeO_(2) nano-inhibitors have been rationally designed as an unprecedentedly safe and efficient Ca2+inhibitor to successfully reverse tumor drug resistance through Ca^(2+)negative regulation *** doxorubicin(Dox)as a model chemotherapeutic drug,the Ca^(2+)nano-inhibitors efficiently deprived intracellular excessive free Ca2+,suppressed P-glycoprotein(P-gp)expression and significantly enhanced intracellular drug accumulation in Dox-resistant tumor *** Ca^(2+)negative regulation strategy improved the intratumoral Dox concentration by a factor of 12.4 and nearly eradicated tumors without obvious adverse ***,nanocerias as pH-regulated nanozyme greatly alleviated the adverse effects of chemotherapeutic drug on normal cells/organs and substantially improved survivals of *** anticipate that this safe and effective Ca^(2+)negative regulation strategy has potentials to conquer the pitfalls of traditional Ca inhibitors,improve therapeutic efficacy of common chemotherapeutic drugs and serves as a facile and effective treatment platform of other Ca^(2+) associated diseases.

关键词： Ca^(2+)nano-inhibitor nanoceria tumor drug resistance phytic acid nanozyme

Biochemical responses of the freshwater microalga Dictyosphaerium sp. upon exposure to three sulfonamides

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Journal of Environmental Sciences 2020年第11期32卷 141-148页

作者： Shan Chen jiayuan li Wenbo Feng Mingzhe Yuan Wei Zhang Houtao Xu Xiaoyan Zheng liqing Wang Centre for Research on Environmental Ecology and Fish Nutrient of the Ministry of Agriculture Key Laboratory of Exploration and Utilization of Aquatic Genetic ResourcesMinistry of EducationShanghai Ocean UniversityShanghai 201306China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Aquatic Environmental Engineering Co. LtdShanghai 200090China

Sulfonamides(SAs)are common antimicrobial drugs,which are frequently detected in surface water systems,and are difficult to degrade,posing a potential threat to the aquatic ***,little is known about the potential adverse effects of SAs on nontarget organisms(e.g.,microalgae)in the aquatic *** this study,the effect of SAs(sulfadiazine(SD),sulfamerazine(SM1),and sulfamethazine(SM2)at 1,5,20,and 50 mg/L concentrations,respectively)on the freshwater microalga Dictyosphaerium *** investigated,with respect to changes of biomass and chlorophyll a content and induction of extracellular polymer substances(EPS),including protein and polysaccharide *** the same time,the residue of SAs was *** results showed that Dictyosphaerium *** tolerant to the three SAs,and the chlorophyll a content in Dictyosphaerium *** decreased on day 7,followed by a"compensation phenomena".The increase in protein and polysaccharide contents played a defensive role in Dictyosphaerium *** antibiotic stress,and there was a strong positive correlation between polysaccharide contents and antibiotic *** *** 35%–45%,30%–42%,and 26%–51%removal of SD,SM1,and SM2,*** study is helpful to understand the changes of EPS in the defense process of microalgae under the action of antibiotics,and provides a new insight for the ecological removal of antibiotic pollution in natural surface water system.

关键词： Sulfonamides Dictyosphaerium Tolerance Polysaccharide Removal

Construction of the hierarchical porous biochar with an ultrahigh specific surface area for application in high-performance lithium-ion capacitor cathode

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Biochar 2023年第1期5卷 803-814页

作者： Haotian Zhu jiayuan li Dichao Wu Gaoyue Zhang YunJuan Sun Ao Wang Kang Sun Institute of Chemical Industry of Forest Products Chinese Academy of ForestryNanjing 210042China Key Laboratory of Biomass Energy and Material Nanjing 210042JiangsuChina National Engineering Laboratory for Biomass Chemical Utilization Nanjing 210042China Key and Open Laboratory on Forest Chemical Engineering SFANanjing 210042China Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China School of Energy and Environment Southeast UniversityNanjing 210096China

Biochar with a highly accessible specific surface area can display a higher performance when it is used as the cathode of lithium-ion *** the complex composition and diversity of biomass precursors,there is a lack of a universally applicable method to construct hierarchical porous biochar *** this work,a multi-stage activation strategy combining the feature of different activation methods is proposed for this *** confirm the porous characteristic in prepared samples,N2 adsorption-desorption and transmission electron microscope were *** the optimal sample,BC-P3K4S had the highest specific surface area of 3583.3 m^(2) g^(−1).Evaluated as the electrode for a lithium-ion capacitor,BC-P3K4S displayed a capacity of 139.1 mAh g^(−1) at 0.1 A g^(−1).After coupling it with pre-lithiated hard carbon,the full device exhibited a high energy density of 129.3 W h kg^(−1) at 153 W kg^(−1).The work outlined herein offers some insights into the preparation of hierarchical porous biochar from complex biomass by multistep activation method.

关键词： Ultrahigh specific surface area Hierarchical porous biochar Multistage activation lithium-ion capacitor Cathode materials

Systematic screening and structural characterization of dipeptides using offline 2D LC-LTQ-Orbitrap MS:A case study of Cordyceps sinensis

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Journal of Pharmaceutical Analysis 2022年第2期12卷 263-269页

作者： Xiaodie li Changliang Yao Yun li Zhengming Qian c Wenlong Wei Jianqing Zhang jiayuan li Qirui Bi Wenjia li Yajun Cui De-an Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for Traditional Chinese Medicine Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China Shanghai University of Traditional Chinese Medicine Shanghai201203China Key Laboratory of State Administration of Traditional Chinese Medicine Sunshine Lake Pharma Co.LtdDongguanGuangdong523850China

Cordyceps sinensis(***)is a widely used and highly valuable traditional Chinese *** dipeptides have been detected in ***,but current scientific knowledge of its chemical makeup remains *** this study,an improved approach that integrates offline two-dimensional liquid chromatography(2D LC)separation,precursor ion list,library screening,and diagnostic ion filtering was established to systematically screen and characterize dipeptides in *** 2D LC integrating hydrophilic interaction LC and reverse phase separations was established to eliminate interference and identify the target dipeptides.A library containing the potential 400 dipeptides was created,and a precursor ion list with all theoretical precursor ions was adopted to trigger the MS/MS scan with high *** identify dipeptides,the type and connection sequence of amino acids were determined according to the product *** and Leu residues were differentiated for the first time according to the characteristic ion at m/z ***,170 dipeptides were identified or tentatively characterized from ***,and most are reported for the first time in this species *** addition,the identified dipeptides were also applied for discrimination among the three Cordyceps species,and 11 markers were *** obtained results provide a deeper understanding of the chemical basis of ***.

关键词： Dipeptides Cordyceps sinensis Two-dimensional liquid chromatography Identification Isoleucine

Architecture of PtFe/C catalyst with high activity and durability for oxygen reduction reaction

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Nano Research 2014年第10期7卷 1519-1527页

作者： jiayuan li Guoxiong Wang Jing Wang Shu Miao Mingming Wei Fan Yang liang Yu Xinhe Bao State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China UniversityofChineseAcademyofSciences Beijing 100039 China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

A PtFe/C catalyst has been synthesized by impregnation and high-temperature reduction followed by acid-leaching. X-ray diffraction, X-ray photoelectron spectroscopy and X-ray atomic near edge spectroscopy characterization reveal that PtgFe alloy formation occurs during high-temperature reduction and that unstable Fe species are dissolved into acid solution. The difference in Fe concentration from the core region to the surface and strong O-Fe bonding may drive the outward diffusion of Fe to the highly corrugated Pt-skeleton, and the resulting highly dispersed surface FeOx is stable in acidic medium, leading to the construction of a PtBFe@Pt-FeOx architecture. The as prepared PtFe/C catalyst demonstrates a higher activity and comparable durability for the oxygen reduction reaction compared with a Pt/C catalyst, which might be due to the synergetic effect of surface and subsurface Fe species in the PtFe/C catalyst.

关键词： Pt3Fe@Pt-FeOx architecture activity durability oxygen reduction reaction proton exchangemembrane fuel cell

基于国家基本公共卫生服务体检的中老年人2型糖尿病风险预测模型构建

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四川大学学报（医学版） 2024年第3期55卷 662-670页

作者：杨会芳袁璐吴结凤李星月龙璐滕屹霖冯琬婷吕良许彬马天佩肖金雨周丁子李佳圆四川大学华西公共卫生学院/四川大学华西第四医院成都610041 郫都区红光街道社区卫生服务中心成都611730 四川省卫生健康信息中心成都610041

目的利用基本公共卫生服务体检数据,通过Meta分析构建普适于中老年人群的2型糖尿病(diabetes mellitus type 2, T2DM) logistic函数风险预测模型。方法模型构建:计算机检索中英文数据库关于T2DM危险因素的队列研究,Meta合并危险因素... 详细信息

目的利用基本公共卫生服务体检数据,通过Meta分析构建普适于中老年人群的2型糖尿病(diabetes mellitus type 2, T2DM) logistic函数风险预测模型。方法模型构建:计算机检索中英文数据库关于T2DM危险因素的队列研究,Meta合并危险因素效应值(odds ratio, OR),转换为logistic函数的偏回归系数β;常数项α通过合并各队列研究的发病率进行估计。模型验证:使用受试者操作特征(receiver operator characteristic, ROC)曲线,以成都市某社区卫生服务中心2017年–2022年7 602名初次体检未患T2DM者的基公卫体检随访数据验证模型预测效果。结果危险因素Meta分析具有统计学意义的基公卫体检条目有10个,来自40项队列研究,分别为年龄、中心性肥胖、吸烟、缺乏运动、空腹血糖受损、低高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)、高血压、体质量指数(body mass index, BMI)、甘油三酯-葡萄糖(triglyceride glucose, TYG)指数和糖尿病家族史,OR(95%置信区间)为1.04(1.03,1.05)、1.55(1.29,1.88)、1.36(1.11,1.66)、1.26(1.07,1.49)、3.93(2.94,5.24)、1.14(1.06,1.23)、1.47(1.34,1.61)、1.11(1.05,1.18)、2.15(1.75,2.62)、1.66(1.55,1.78);37项研究报告了发病率,合并发病率(95%置信区间)为0.08(0.07,0.09),常数α为-2.442。将构建的T2DM风险预测模型在7 602例基公卫体检数据中进行外部验证,曲线下面积(95%置信区间)为0.794(0.771,0.816)。结论利用基公卫健康体检数据构建的T2DM风险预测模型具有较好的预测性能,可作为中老年人群T2DM风险预测的实用工具。

关键词： 2型糖尿病风险预测基本公共卫生服务中老年人群

Pseudo-particle simulation of multi-scale heterogeneity in fluidization

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Chinese Science Bulletin 2003年第7期48卷 634-636页

作者： GE Wei, ZHANG jiayuan, li Tinghua & li Jinghai Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China Chinese Academy of Sciences

Fluidization is a process of wide application, but its dynamic behavior is not well understood because of its multi-scale heterogeneity and regime multiplicity which are difficult to simulate in traditional numerical methods. By discretizing the fluid phase into a large number of interactive simple particles, which can incorporate many-body moving boundaries easily, pseudo-particle modeling (PPM) has re-produced reasonable radial and axial heterogeneity on macro-scale as well as solids clustering and fluid flows on meso- and micro-scales. The simulation suggests a consistent evolution of the complexity across different scales with itself serving as an ideal exploring tool.

关键词：流化作用杂质拟粒子模型化粒子法拟粒子仿真

Characterization of natural peptides in Pheretima by integrating proteogenomics and label-free peptidomics

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Journal of Pharmaceutical Analysis 2023年第9期13卷 1070-1079页

作者： Xiaoxiao Luo Qirui Bi Dongdong Huang Yun li Changliang Yao Jianqing Zhang Wenlong Wei jiayuan li Zhenwei li Jingxian Zhang Shen Ji Yurong Wang De-an Guo School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing211198China Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China

Pheretima,also called“earthworms”,is a well-known animal-derived traditional Chinese medicine that is extensively used in over 50 Chinese patent medicines(CPMs)in Chinese Pharmacopoeia(2020 edition).However,its zoological origin is unclear,both in the herbal market and *** this study,a strategy for integrating in-house annotated protein databases constructed from close evolutionary relationship-sourced RNA sequencing data from public archival resources and various sequencing algorithms(restricted search,open search,and de novo)was developed to characterize the phenotype of natural peptides of three major commercial species of Pheretima,including Pheretima aspergillum(PA),Pheretima vulgaris(PV),and Metaphire magna(MM).We identified 10,477 natural peptides in the PA,7,451 in PV,and 5,896 in MM *** specific signature peptides were screened and then validated using synthetic peptides;these demonstrated robust specificity for the authentication of PA,PV,and ***,all marker peptides were successfully applied to identify the zoological origins of Brain Heart capsules and Xiaohuoluo pills,revealing the inconsistent Pheretima species used in these *** conclusion,our integrated strategy could be used for the in-depth characterization of natural peptides of other animal-derived traditional Chinese medicines,especially non-model species with poorly annotated protein databases.

关键词： Pheretima Natural peptides Label-free peptidomics Proteogenomics Animal derived medicine

SO_(2)-Insertion induced enantioselective oxysulfonylation to access β-chiral sulfones with quaternary carbon stereocenters

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Science China Chemistry 2024年第3期67卷 908-913页

作者： Jun Zhang Xuefeng Wang Peiqi Wang jiayuan Fang Shaoyu li Jie Wu School of Pharmaceutical and Chemical Engineering&Institute for Advanced Studies Taizhou UniversityShanghai 200438China Department of Chemistry Fudan UniversityShanghai 200438China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

β-Chiral sulfones are structural motifs widely found in natural products and bioactive molecules, while also serving as important intermediates for the synthesis of valuable chiral scaffolds. In contrast to the rapid growth of sulfur dioxide insertion chemistry over the last decade, enantioselective catalytic variants for accessing β-chiral sulfones, especially those bearing a quaternary carbon stereocenter, remain rare. Herein, we report an enantioselective copper/bisoxazoline catalyzed oxysulfonylation of alkenes to yield isoxazolinyl-containing β-chiral sulfones bearing quaternary carbon stereocenters with moderate to excellent yields and up to 96:4 er. The advantage and irreplaceability of this sulfur dioxide insertion catalytic system have been demonstrated by achieving transformations clearly unavailable with the previously reported sulfonyl chloride system. Additionally,the recoverability of the new-developed bisoxazoline ligand L9 and its reusability without any erosion of the catalytic activity and enantioselectivity further demonstrate the usefulness of the protocol.

关键词： β-chiral sulfones sulfur dioxide insertion oxysulfonylation copper catalysis enantioselectivity