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基于体验记忆模型的服务触点优化策略研究

包装工程 2024年第12期45卷 129-136页

作者：贺雪梅田安洁宋宁曾佳屿陕西科技大学西安710021

目的将体验记忆模型应用于服务触点的优化研究,结合体验与记忆两个因素筛选需优化服务触点(即威胁触点),建立基于体验记忆模型的服务触点优化策略。方法首先,基于特定服务系统梳理并确定用户群,建立用户画像。基于行为追踪获取服务触点... 详细信息

目的将体验记忆模型应用于服务触点的优化研究,结合体验与记忆两个因素筛选需优化服务触点(即威胁触点),建立基于体验记忆模型的服务触点优化策略。方法首先,基于特定服务系统梳理并确定用户群,建立用户画像。基于行为追踪获取服务触点,并采取量表法对服务触点进行体验评价。其次,根据艾宾浩斯遗忘曲线确定记忆评分的3个时间点,选取定量用户并分别对服务触点进行记忆评分,结合服务触点体验评价构建体验记忆分区图,明确服务系统中的威胁触点。最后,结合用户需求,提出威胁触点的优化建议,并最终完成服务触点原型输出。结果以公园骑行服务触点优化为例证,验证了该策略的可靠性。结论体验记忆模型可有效筛选服务触点,提高设计效率,降低服务优化成本。

关键词：服务触点体验记忆模型优化策略记忆评分

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数据资产化的理论逻辑与现实挑战

中国卫生信息管理杂志 2024年第3期21卷 331-335,360页

作者：赵治纲曾家瑜中国财政科学研究院北京市100142

数字时代,数据是新型生产要素,数据要素是发展新质生产力的关键基础。数据资源是企事业单位的战略性资源,数据资产是未来企事业单位的核心资产,数据资产化则是企事业单位释放数据要素价值的重要推动力。本文首先对数据资产化所涉核心概... 详细信息

数字时代,数据是新型生产要素,数据要素是发展新质生产力的关键基础。数据资源是企事业单位的战略性资源,数据资产是未来企事业单位的核心资产,数据资产化则是企事业单位释放数据要素价值的重要推动力。本文首先对数据资产化所涉核心概念进行了有效厘清;其次,对数据资产化的理论和政策逻辑进行了系统阐释,从而为企事业单位的数据资产化工作奠定基础;最后指出企事业单位开展数据资产化工作仍然面临三大现实挑战,并提出了有序开展数据资产化工作的实施步骤和建议。

关键词：数据资产化数据要素理论逻辑数据资产管理

Intelligent bio-assembly imaging-guided platform for real-time bacteria sterilizing and infectious therapy

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Nano Research 2022年第5期15卷 4164-4174页

作者： jiayu zeng zengchao Guo Yihan Wang Zhaojian Qin Yi Ma Hui Jiang Yossi Weizmann Xuemei Wang State Key Laboratory of Bioelectronics(Chien-Shiung Wu Lab) School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Chemistry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel Department of Engineering China Pharmaceutical UniversityNanjing 211198China

Bacterial infection is rising as a threatening health *** of the present delay in early diagnosis of bacterial diseases as well as the abuse of antibiotics,it has become a vital issue in the development of in-time detection and therapy of bacterial ***,we designed a multifunctional nanotheranostics platform based on the unique micro-environment of bacterial infections to achieve specific bioimaging and simultaneous inactivation of the target *** showed that in bacterial infections,the metal precursors(i.e.,HAuCl_(4),FeCl_(2),and herring sperm DNA)could be readily bio-self-assembled to multifunctional nanoclusters(NCs)that exhibit luminescence,in which AuCl_(4)-was biosynthesized via reductive biomolecules such as NADPH to the fluorescent *** DNA may assist as an encapsulation and delivery vector,and Fe^(2+)served as a fluorescence intensifier and reduced reactive oxygen species(ROS)to produce the iron *** the bacteria were being visualized,the microenvironment-responsive NCs were enabled to sterilize bacteria efficiently due to electrostatic effect,cell membrane destruction,inhibition of biofilm formation,and ROS ***,the bio-responsive self-assembled NCs complexes contributed to accelerating bacteria-infected wound healing and showed negligible side effects in long-term toxicity tests in ***,intracellular molecules involved in microenvironmental response were *** work may become an effective strategy for the detection and real-time sterilization of intractable bacterial infections.

关键词： bacterial microenvironment response self-assembled Fe@Au-DNA complexes bacterial fluorescence bioimaging bacteria inactivation wound healing

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文化符号在灯具设计中的语义重构研究

艺术科技 2024年第4期37卷 56-59页

作者：贺雪梅田安洁曾佳屿欧阳嘉豪陕西科技大学设计与艺术学院陕西科技大学阿尔斯特学院陕西西安710016

目的:为了响应国家号召,大力推动文化事业和文化产业繁荣发展,打造良好的文化环境,丰富人们的精神世界,文章从文化和产品两端切入,构建文化符号在产品设计中的语义重构模型,以丰富产品文化内涵。方法:首先,通过激活扩散模型反复搜索相... 详细信息

目的:为了响应国家号召,大力推动文化事业和文化产业繁荣发展,打造良好的文化环境,丰富人们的精神世界,文章从文化和产品两端切入,构建文化符号在产品设计中的语义重构模型,以丰富产品文化内涵。方法:首先,通过激活扩散模型反复搜索相关文化资料,构建较为完善的文化语义库,在产品端进行前期调研,洞察用户痛点,了解目标用户对产品的需求;其次,通过专家打分法计算词语关联度评分,筛选文化语义核心词,同时根据感知映射理论分析产品构造,以用户感知为导向输出产品设计要素;最后,根据前期研究结果综合考量设计要素,产出具体设计方案,通过灯具设计验证该流程的可行性。结果:运用该设计流程对古代四大美人进行语义重构,在文化端,收集大量文化语义,通过筛选、整理及编码形成四大美人文化语义库,之后邀请5名专家对文化语义进行评分,获得12个核心语义;在产品端,通过开展市场调研、大数据分析,构建产品语用图,了解用户特征及需求,然后以用户感知为基础,将核心语义转化为灯具设计中的颜色、造型、材质及交互四个设计要素,最终经过建模及渲染产出四个具有文化内涵的灯具。结论:实例证明,该研究流程可有效实现文化符号在产品设计中的语义转换及重构,对灯具设计具有一定指导意义。

关键词：文化符号灯具设计语义重构

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Genes & Diseases 2024年第1期11卷 367-381页

作者： Yunchao Zhang jiayu Tang Cheng Wang Qinxiu Zhang Anqi zeng Linjiang Song School of Medical and Life Sciences Chengdu University of Traditional Chinese MedicineChengduSichuan 611137China Institute of Translational Pharmacology and Clinical Application Sichuan Academy of Chinese Medical ScienceChengduSichuan 610041China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengduSichuan 611137China

The incidence and mortality rates of cancer are increasing every year worldwide but the survival rate of cancer patients is still ***,it is necessary to further elucidate the molecular mechanisms involved in tumor development and drug resis-tance to improve cancer cure or survival *** recent years,autophagy has become a hot topic in the field of oncology research,which plays a double-edged role in tumorigenesis,pro-gression,and drug ***,long non-coding RNA(lncRNA)has also been shown to regulate autophagy,and the two-sided nature of autophagy determines the dual regulatory role of autophagy-related IncRNAs(ARlncRNAs).Therefore,ARlncRNAs can be effective ther-apeutic targets for various ***,the high abundance and stability of ARlncR-NAs in tumor tissues make them promising *** this review,we summarized the roles and mechanisms of ARlncRNAs in tumor cell proliferation,apoptosis,migration,invasion,drug resistance,angiogenesis,radiation resistance,and immune *** addition,we described the clinical significance of these ARlncRNAs,including as biomarkers/therapeutic targets and their association with clinical drugs.

关键词： Apoptosis Autophagy Biomarker Cancer Drug resistance LncRNA

Bio-assembled smart nanocapsules for targeted delivery of KRAS shRNA and cancer cell bioimage

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Chinese Chemical Letters 2023年第1期34卷 270-273页

作者： Maonan Wang zengchao Guo jiayu zeng Liu Liu Yihan Wang Jinpeng Wang Hongbing Lu Haijun Zhang Hui Jiang Xuemei Wang State Key Laboratory of Bioelectronics(Chien-Shiung Wu Lab) School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Department of Biomedical Engineering/Computer Application Fourth Military Medical UniversityXi’an 710032China Department of Oncology Zhongda HospitalMedical School of Southeast UniversityNanjing 210009China

The five-year survival rate for pancreatic cancer is less than 5%. However, the current clinical multimodal therapy combined with first-line chemotherapy drugs only increases the patient’s median survival from 5.0 months to 7.2 months. Consequently, a new strategy of cancer treatments is urgently needed to overcome this high-fatality disease. Through a series of biometric analyses, we found that KRAS is highly expressed in the tumor of pancreatic cancer patients, and this high expression is closely related to the poor prognosis of patients. It shows that inhibiting the expression of KRAS has great potential in gene therapy for pancreatic cancer. Given those above, we have exploited the possibility of targeted delivery of KRAS shRNA with the intelligent and bio-responsive nanomedicine to detect the special oxidative stress microenvironment of cancer cells and realize efficient cancer theranostics. Our observations demonstrate that by designing the smart self-assembled nanocapsules of melanin with fluorescent nanoclusters we can readily achieve the bio-recognition and bioimaging of cancer cells in biological solution or *** self-assembled nanocapsules can make a significant bio-response to the oxidative stress microenvironment of cancer cells and generate fluorescent zinc oxide Nanoclusters in situ for targeted cell bioimaging. Moreover, it can also readily facilitate cancer cell suppression through the targeted delivery of KRAS shRNA and low-temperature hyperthermia. This raises the possibility to provide a promising theranostics platform and self-assembled nanomedicine for targeted cancer diagnostics and treatments through special oxidative stress-responsive effects of cancer cells.

关键词： Smart bio-responsive nanocapsules Intelligent nanomedicine shRNA KRAS Fluorescent bioimaging Oxidative stress response

Enhanced photocatalytic nitrogen fixation performance via in situ constructing BiO_(2-x)/NaNbO_(3) heterojunction

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Chinese Journal of Chemical Engineering 2024年第5期69卷 92-100页

作者： jiayu Zhang Zhihao zeng Lin Yue Chunran Zhao Xin Hu Leihong Zhao Xiuwen Wang Yiming He Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China Heilongjiang Provincial Key Laboratory of Surface Active Agent and Auxiliary School of Chemistry and Chemistry EngineeringQiqihar UniversityQiqihar 161006China Department of Materials Science and Engineering Zhejiang Normal UniversityJinhua 321004China

The fabrication of heterojunction catalysts is an effective strategy to enhance charge separation efficiency,thereby boosting the performance of *** this study,BiO_(2-x)nanosheets were synthesized through a hydrothermal process and loaded onto NaNbO_(3) microcube to construct a series of BiO_(2-x)/NaNbO_(3) heterojunctions for photocatalytic N_(2) *** indicated that 2.5%BiO_(2-x)/NaNbO_(3) had the highest photocatalytic *** NH_(3) production rate under simulated solar light reached 406.4μmol·L^(-1)·g^(-1)·h^(-1),which reaches 2.6 and 3.8 times that of NaNbO_(3) and BiO_(2-x),***_(2-x)nanosheets primarily act as electron trappers to enhance the separation efficiency of charge *** strong interaction between BiO_(2-x)and NaNbO_(3) facilitates the electron migration between ***,the abundant oxygen vacancies in BiO_(2-x)nanosheets may facilitate the adsorption and activation of N_(2),which may be another possible reason of the high photocatalytic activity of the BiO_(2-x)/NaNbO_(3).This study may offer new insights for the development of semiconductor materials in photocatalytic nitrogen fixation.

关键词： Catalyst Solar energy Hydrothermal BiO_(2-x)/NaNbO_(3) Photocatalytic N_(2)-fixation

Trunk‑Inspired SWCNT‑Based Wrinkled Films for Highly‑Stretchable Electromagnetic Interference Shielding and Wearable Thermotherapy

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Nano-Micro Letters 2024年第11期16卷 429-444页

作者： Xiaofeng Gong Tianjiao Hu You Zhang Yanan zeng Ye Zhang Zhenhua Jiang Yinlong Tan Yanhong Zou Jing Wang jiayu Dai zengyong Chu College of Science National University of Defense TechnologyChangsha 410073People’s Republic of China Beijing Interdisciplinary Research Center National University of Defense TechnologyChangsha 410073People’s Republic of China School of Physics and Electronics Hunan UniversityChangsha 410082People’s Republic of China

Nowadays,the increasing electromagnetic waves generated by wearable devices are becoming an emerging issue for human health,so stretchable electromagnetic interference(EMI)shielding materials are highly *** trunks are capable of grabbing fragile vegetation and tearing trees thanks not only to their muscles but also to their folded *** by the wrinkled skin of the elephant trunks,herein,we propose a winkled conductive film based on single-walled carbon nanotubes(SWCNTs)for multifunctional EMI *** conductive film has a sandwich structure,which was prepared by coating SWCNTs on both sides of the stretched elastic latex cylindrical *** shrinking-induced winkled conductive network could withstand up to 200%tensile ***,when the stretching direction is parallel to the polarization direction of the electric field,the total EMI shielding effectiveness could surprisingly increase from 38.4 to 52.7 dB at 200%tensile *** is mainly contributed by the increased connection of the *** addition,the film also has good Joule heating performance at several voltages,capable of releasing pains in injured *** unique property makes it possible for strain-adjustable multifunctional EMI shielding and wearable thermotherapy applications.

关键词： Electromagnetic interference shielding Single-walled carbon nanotubes Wrinkles Stretchable Thermotherapy

核酸适配体在肿瘤血清标志物筛选中的应用研究

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生物医学工程学杂志 2018年第2期35卷 320-323页

作者：马淑玲曾家豫西北师范大学生命科学学院兰州730070

肿瘤血清标志物的核酸适配体是利用指数富集的系统进化技术(SELEX),从体外筛选获得的一种能与肿瘤血清标志物高特异性、高亲和性结合的寡核苷酸分子。利用核酸适配体的优势,探寻对肿瘤更具诊断价值的新的肿瘤标志物。目前在肝癌、胃癌... 详细信息

肿瘤血清标志物的核酸适配体是利用指数富集的系统进化技术(SELEX),从体外筛选获得的一种能与肿瘤血清标志物高特异性、高亲和性结合的寡核苷酸分子。利用核酸适配体的优势,探寻对肿瘤更具诊断价值的新的肿瘤标志物。目前在肝癌、胃癌等肿瘤的研究中已经取得了一定成果。本文综述了当前核酸适配体及其在肿瘤血清标志物筛选中的相关研究,讨论了肿瘤血清标志物的核酸适配体在肿瘤诊断中的价值以及目前的研究所存在的问题。期望通过本文的综合描述,有助于人们更好地了解肿瘤血清标志物核酸适配体的筛选,并为新的肿瘤血清标志物的发现提供帮助。

关键词：核酸适配体肿瘤血清标志物肿瘤诊断