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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1387-1398页

作者： Zirui Chen Liyuan Wang jiayu zhao Guanhua Cui Zhuo Gao Zhiyuan Fan Xiaohui Shi Junwei Qiao College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

A refractory high entropy alloy Ti_(62)Nb_(12)Mo_(12)Ta_(12)W_(2)was prepared by mechanical alloying and spark plasma *** microstructure and mechanical properties of the Ti_(62)Nb_(12)Mo_(12)Ta_(12)W_(2)alloy were *** experimental results show that the microstructure of the alloy is composed of two BCC phases,an FCC precipitated phase,and the precipitated phase which is a mixture of TiC,TiN and *** alloy exhibits good room temperature compressive *** plasticity of the sample sintered at 1550℃can reach 10.8%,and for the sample sintered at 1600℃,the yield strength can be up to 2032 MPa,in the meantime the plasticity is 9.4%.The alloy also shows high strength at elevated *** yield strength of the alloy exceeds 420 MPa at 900℃,and value of which is still above 200 MPa when the test temperature reaches 1000℃.Finally,the compressive yield strength model at room temperature is *** prediction error of the model ranges from−7.9%to−12.4%,expressing fair performance.

关键词： Refractory high-entropy alloy(RHEA) Mechanical alloying Mechanical properties Model Spark plasma sintering

Boosting rate performance of layered lithium-rich cathode materials by oxygen vacancy induced surface multicomponent integration

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Journal of Energy Chemistry 2024年第5期92卷 250-262页

作者： Youyou Fang Yuefeng Su Jinyang Dong jiayu zhao Haoyu Wang Yun Lu Bin Zhang Hua Yan Feng Wu Lai Chen Beijing Key Laboratory of Environmental Science and Engineering School of Material Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Chongqing Innovation Center Beijing Institute of TechnologyChongqing 401120China Yibin Libode New Materials Co. Ltd.Yibin 64400SichuanChina School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina

The rapid development of electric vehicles and portable energy storage systems demands improvements in the energy density and cost-effectiveness of lithium-ion batteries,a domain in which Lithium-rich layered cathode(LLO)materials inherently ***,these materials face practical challenges,such as low initial Coulombic efficiency,inferior cycle/rate performance,and voltage decline during cycling,which limit practical *** study introduces a surface multi-component integration strategy that incorporates oxygen vacancies into the pristine LLO material Li1.2Mn_(0.6)Ni_(0.2)O_(2).This process involves a brief citric acid treatment followed by calcination,aiming to explore rate-dependent degradation *** induced surface oxygen vacancies can reduce surface oxygen partial pressure and diminish the generation of O_(2)and other highly reactive oxygen species on the surface,thereby facilitating the activation of Li ions trapped in tetrahedral sites while overcoming transport ***,the formation of a spinel-like phase with 3D Li+diffusion channels significantly improves Li^(+)diffusion kinetics and stabilizes the surface *** optimally modified sample boasts a discharge capacity of 299.5 mA h g^(-1)at a 0.1 C and 251.6 mA h g^(-1)at a 1 C during the initial activation cycle,with an impressive capacity of 222.1 mA h g^(-1)at a 5 *** notably,it retained nearly 70%of its capacity after 300 cycles at this elevated *** straightforward,effective,and highly viable modification strategy provides a crucial resolution for overcoming challenges associated with LLO materials,making them more suitable for practical application.

关键词： Lithium-ion battery Layered lithium rich cathode Surface multicomponent integration Rate-dependent degradation and Li^(+) diffusion kinetics

Modularized viromimetic polymer nanoparticle vaccines(VPNVaxs) to elicit durable and effective humoral immune responses

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National Science Review 2024年第3期11卷 200-214页

作者： Zichao Huang Xinyu Zhuang Liping Liu jiayu zhao Sheng Ma Xinghui Si Zhenyi Zhu Fan Wu Ningyi Jin Mingyao Tian Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China Changchun Veterinary Research Institute Chinese Academy of Agricultural Sciences Jilin Biomedical Polymers Engineering Laboratory State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

Virus-like particle(VLP) vaccines had shown great potential during the COVID-19 pandemic, and was thought to be the next generation of antiviral vaccine technology due to viromimetic structures. However,the time-consuming and complicated processes in establishing a current recombinant-protein–based VLP vaccine has limited its quick launch to the out-bursting pandemic. To simplify and optimize VLP vaccine design, we herein report a kind of viromimetic polymer nanoparticle vaccine(VPNVax), with subunit receptor-binding domain(RBD) proteins conjugated to the surface of polyethylene glycol-b-polylactic acid(PEG-b-PLA) nanoparticles for vaccination against SARS-CoV-2. The preparation of VPNVax based on synthetic polymer particle and chemical post-conjugation makes it possible to rapidly replace the antigens and construct matched vaccines at the emergence of different viruses. Using this modular preparation system, we identified that VPNVax with surface protein coverage of 20%–25% had the best immunostimulatory activity, which could keep high levels of specific antibody titers over 5 months and induce virus neutralizing activity when combined with an aluminum adjuvant. Moreover, the polymer nano-vectors could be armed with more immune-adjuvant functions by loading immunostimulant agents or chemical chirality design. This VPNVax platform provides a novel kind of rapidly producing and efficient vaccine against different variants of SARS-CoV-2 as well as other viral pandemics.

关键词： vaccine polymer nanomaterials SARS-CoV-2

Heterocyclic Molecules Tethered Branched Polymers with Innate Immune Stimulating Activity

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CCS Chemistry 2024年第5期6卷 1278-1288页

作者： jiayu zhao Liping Liu Yibo Wang Zichao Huang Yu Zhang Ruirui Qiao Thomas P.Davis zhaohui Tang Wantong Song Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026 Laboratory of Chemical Biology Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022 Jilin Biomedical Polymers Engineering Laboratory Changchun 130022 Australian Institute of Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072

We report herein an interesting finding that heterocyclic molecules tethered branched polymers exhibit innate immune stimulating *** we conjugated a series of five-,six-,or seven-membered heterocyclic molecules to branched polyethylenimine(bPEI),over 70%of them could induce the secretion of interferon-β(IFN-β)from murine dendritic and human leukemia monocytic(DC2.4 and THP-1)cells through activating the stimulator of interferon genes(STING)*** further proved that this kind of innate stimulating activity was dependent on the macromolecular architecture as heterocyclic molecules tethered linear PEI(lPEI)or dendritic polyamidoamine(PAMAM)induced no or much less IFN-β***,we prepared a series of poly-L-lysine(PLL)-derivatives with different branches to tether with heterocyclic molecules and proved that this kind of bPEI-like structure was important in en hancing the binding affinity with STING proteins and for exhibiting innate stimulating activity.

关键词： bioactive materials polymers heterocycles branched structure immunity

Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

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Research 2024年第1期2023卷 763-778页

作者： Qing Liu Qiaoyun Long jiayu zhao Wenjie Wu Zexin Lin Wei Sun Ping Gu Tuo Deng Kerry Martin Loomes Donghai Wu Alice P.S.Kong Jingying Zhou Alfred S.Cheng Hannah Xiaoyan Hui School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina China-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina Department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina School of Biological Sciences and Maurice Wilkins Centre University of AucklandAucklandNew Zealand Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipose browning has demonstrated therapeutic potentials in several ***,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold *** major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown *** findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to *** adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is ***,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)*** adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to *** data reveal fundamental changes during cold-evoked adipose browning.

关键词： evoked programming generating

小型化光学超声传感器及其在光声成像中的应用进展(特邀)

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激光与光电子学进展 2024年第2期61卷 453-465页

作者：邱显坤赵佳玉沈乐成中山大学电子与信息工程学院广东广州510006 华东师范大学精密光谱科学与技术国家重点实验室上海200241

目前光声成像中用于探测超声波的主流器件是基于压电材料的超声换能器,考虑到这类换能器的探测性能随器件尺寸的减小而大幅下降,科研者们近年来开始逐渐关注于小型化光学超声传感器的研究与开发。相较于传统的压电超声换能器,这些小型... 详细信息

目前光声成像中用于探测超声波的主流器件是基于压电材料的超声换能器,考虑到这类换能器的探测性能随器件尺寸的减小而大幅下降,科研者们近年来开始逐渐关注于小型化光学超声传感器的研究与开发。相较于传统的压电超声换能器,这些小型化的光学超声传感器通常具备较宽的探测带宽和与尺寸几乎无关的高灵敏度,在推动更深和更高分辨率的光声成像方面展现出了巨大的潜力。本文首先对光学超声传感器的发展历程进行了简要回顾,然后比较了3种重要的小型化光学超声传感器以及并行寻址的方法,其次介绍了这些传感器在光声活体成像方面的应用进展,最后展望了光学超声传感器的未来前景。

关键词：光声成像光学超声传感器片上器件法布里-珀罗干涉仪光纤布拉格光栅微环谐振器

基于深度自编码器的城市固废焚烧过程燃烧状态识别

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控制工程 2024年第10期31卷 1729-1737页

作者：王印松赵佳玉华北电力大学自动化系河北保定071003

国内城市固废(municipal solid waste,MSW)的组分复杂且多变,其焚烧过程的燃烧状态识别主要依靠人工判断,难以维持稳定的运行工况。针对上述问题,提出了一种基于深度自编码器的分区域燃烧状态识别方法。首先,依据炉排结构对燃烧段和燃... 详细信息

国内城市固废(municipal solid waste,MSW)的组分复杂且多变,其焚烧过程的燃烧状态识别主要依靠人工判断,难以维持稳定的运行工况。针对上述问题,提出了一种基于深度自编码器的分区域燃烧状态识别方法。首先,依据炉排结构对燃烧段和燃烬段的分界线进行标定;然后,利用具有深层结构的卷积稀疏自编码器(convolutional sparse autoencoder,CSAE)提取两部分火焰图像的特征;最后,将特征分别输入到相应的最小二乘支持向量机进行状态识别。基于处理规模为750 t/d的焚烧炉的不同燃烧状态图像进行实验,实验结果表明,在有限的标记样本数量下,所提方法的平均识别准确率为98.04%,该方法能够实现MSW燃烧状态的实时监测。

关键词：炉排炉燃烧状态识别深度自编码器最小二乘支持向量机

基于中西医临床病证特点的老年衰弱综合征动物模型分析

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中药药理与临床 2024年第4期40卷 110-114页

作者：赵佳峪郑珺杨琳王振裕北京中医药大学北京100029 首都医科大学附属北京中医医院北京100010

随着全球老龄化程度加深,衰弱成为近年老年医学研究的重点之一,建立契合临床的衰弱模型相当重要。本文基于老年衰弱的中西医临床诊断和病证特点,总结当前衰弱模型的制作方法,评价其优势与局限并进行吻合度分析。结果显示脂多糖诱导衰弱... 详细信息

随着全球老龄化程度加深,衰弱成为近年老年医学研究的重点之一,建立契合临床的衰弱模型相当重要。本文基于老年衰弱的中西医临床诊断和病证特点,总结当前衰弱模型的制作方法,评价其优势与局限并进行吻合度分析。结果显示脂多糖诱导衰弱法西医吻合度最高,自然衰弱法中医吻合度最高,此外应用衰弱指数为评估工具的动物模型更贴合临床病证特点,诱导衰弱法能带来更丰富的中医证候要素。这为未来建立更贴合临床的衰弱模型,建立统一的衰弱评估标准提供了思路,能更好地推动老年衰弱综合征的深入研究。

关键词：老年衰弱综合征动物模型病证结合中西医衰弱指数 Fried表型

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基于手机信令数据的城市通勤碳排放分析

武汉理工大学学报（交通科学与工程版） 2024年第2期48卷 205-210页

作者：于谦刘海海邱树荣赵嘉雨长安大学运输工程学院西安710064 东南大学交通学院南京211189 中国民航大学空中交通管理学院天津300300

文中提出了一种在缺少用户个人社会经济属性数据的情况下,基于低频手机信令数据、POI数据、互联网位置数据,以及先验知识的面向宏观碳排放核算的出行方式判别方法,并通过基于实际通勤距离的自下而上碳排放计算方法实现不同通勤出行方式... 详细信息

文中提出了一种在缺少用户个人社会经济属性数据的情况下,基于低频手机信令数据、POI数据、互联网位置数据,以及先验知识的面向宏观碳排放核算的出行方式判别方法,并通过基于实际通勤距离的自下而上碳排放计算方法实现不同通勤出行方式碳排放量化.基于提出的核算方法对上海市31 938人次的通勤碳排放进行了核算分析.结果表明:不同交通方式通勤碳排放量差异显著;存在高碳排放通勤群体,其样本量仅占总样本的11%,但其产生的碳排放占总量的55%.高碳排放通勤是长距离通勤和高碳排放出行方式共同影响的结果.

关键词：通勤碳排放手机信令数据互联网位置数据方式划分生命周期碳排放

淡水养殖池塘CO_(2)通量多时间尺度变化特征及其影响要素

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农业环境科学学报 2024年第1期43卷 190-201页

作者：葛培赵佳玉张弥肖薇邱吉丽贾磊包恒鑫石婕赵若男南京信息工程大学大气环境中心南京210044 南京信息工程大学应用气象学院南京210044 广东海洋大学海洋与气象学院广东湛江524088 贵州省黔南州平塘县气象局贵州黔南558000 河北省气象与生态环境重点实验室石家庄050021

为探讨淡水养殖CO_(2)通量的多时间尺度变化特征及其影响因子,本研究以我国长江三角洲区域典型淡水养殖池塘为研究对象,基于涡度相关法(Eddy covariance,EC)测定的2016—2021年高频连续CO_(2)通量数据,对CO_(2)通量的多时间尺度变化特... 详细信息

为探讨淡水养殖CO_(2)通量的多时间尺度变化特征及其影响因子,本研究以我国长江三角洲区域典型淡水养殖池塘为研究对象,基于涡度相关法(Eddy covariance,EC)测定的2016—2021年高频连续CO_(2)通量数据,对CO_(2)通量的多时间尺度变化特征及其环境、人为影响要素进行分析。结果表明:养殖池塘CO_(2)通量(以C计)存在明显的日变化、季节变化和年际变化特征,其年尺度交换量的变化范围为-671~1005 kg·hm^(-2)·a^(-1),年均值为(-74±688)kg·hm^(-2)·a^(-1),表现为CO_(2)的弱汇。CO_(2)通量在不同时间尺度的主控因子存在明显差异,其中在0.5 h尺度上,太阳辐射和气温分别是白天和夜晚CO_(2)通量的主要影响因子;日尺度和月尺度的CO_(2)通量则分别受太阳辐射和归一化植被指数(NDVI)调控,且CO_(2)通量与上述要素均呈显著负相关;年际尺度上,养殖池塘CO_(2)通量受饲料投入量与NDVI的共同作用,二者建立的回归方程可以解释64%的CO_(2)年总通量变化,其中CO_(2)排放量随饲料投入量的增加呈线性增加(R2=0.55,P<0.05)。根据本研究结果,建议在未来可将提高饲料利用率作为控制养殖水体温室气体排放、改善水体生态环境、实现水产养殖业可持续发展的重要途径。

关键词：淡水养殖池塘涡度相关法 CO_(2)通量多时间尺度影响因子