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Journal of Contemporary Educational Research 2024年第7期8卷 192-196页

作者： Ying Zhang Chunlin Zhu jiayu he Chen Jiang hematology Department F irst T eaching H ospital of T ianjin U niversity of T raditional C hinese M edicineN ational Clinical Research Center for Chinese Medicine Acupuncture and MoxibustionTianjin 300110China

Patients with advanced-stage tumors may experience various psychological problems that can have a significant impact on the effectiveness of cancer treatment and the quality of their ***,it is crucial for oncologists to prioritize addressing the psychological issues that patients encounter throughout the diagnosis and treatment *** future frontline healthcare professionals,oncology medical students should receive education on end-of-life care early on in their *** will enable them to develop a profound appreciation for the value of life,deliver improved medical services,and contribute to the humanization of ***,they will be able to provide terminal patients and their families with effective professional guidance,assisting patients in finding peaceful endings with minimal pain and helping families come to terms with the inevitable realities they ***,this education can effectively enhance their sense of responsibility toward life and cultivate a positive and optimistic attitude toward their own lives.

关键词： Death education Oncology Medical students Necessity

RpL 38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis

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Science China Life Sciences 2024年

作者： Yang Fang Fengchao Zhang Fangzhen Zhao Jiajia Wang Xinkai Cheng Fei Ye jiayu he Long Zhao Ying Su Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China College of Marine Life Sciences Ocean University of China Fisheries College Ocean University of China

Switching from mitotic spermatogonia to meiotic spermatocytes is critical to producing haploid sperms during male germ cell differentiation. However, the underlying mechanisms of this switch remain largely unexplored. In Drosophila melanogaster, the gene RpL38encodes the ribosomal protein L38, one component of the 60S subunit of ribosomes. We found that its depletion in spermatogonia severely diminished the production of mature sperms and thus led to the infertility of male flies. By examining the germ cell differentiation in testes,we found that RpL38-knockdown blocked the transition from spermatogonia to spermatocytes and accumulated spermatogonia in the testis. To understand the intrinsic reason for this blockage, we conducted proteomic analysis for these spermatogonia populations. Differing from the control spermatogonia, the accumulated spermatogonia in RpL38-knockdown testes already expressed many spermatocyte markers but lacked many meiosis-related proteins, suggesting that spermatogonia need to prepare some important proteins for meiosis to complete their switch into spermatocytes. Mechanistically, we found that the expression of bag of marbles (bam), a crucial determinant in the transition from spermatogonia to spermatocytes, was inhibited at both the mRNA and protein levels upon RpL38 depletion. We also confirmed that the bam loss phenocopied RpL38 RNAi in the testis phenotype and transcriptomic profiling. Strikingly, overexpressing bam was able to fully rescue the testis abnormality and infertility of RpL38-knockdown flies, indicating that bam is the key effector downstream of RpL38 to regulate spermatogonia differentiation. Overall, our data suggested that germ cells start to prepare meiosis-related proteins as early as the spermatogonial stage, and RpL38 in spermatogonia is required to regulate their transition toward spermatocytes in a bamdependent manner, providing new knowledge for our understanding of the transition process from spermatogonia to spe

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基于河南地方志的药王庙研究

中华医史杂志 2024年第1期54卷 58-61页

作者：何佳禹何静张思思中国中医科学院中国医史文献研究所北京100700 中国中医药出版社有限公司期刊编辑部北京100027

梳理中国数字方志库、中国方志库地方志资料, 发现河南共有450种地方志, 其中45种载有药王庙。据45种地方志可知, 河南25个县(市)共修建了35处药王庙, 多分布在河南的西部、北部、南部, 尤以西部最多。其中8处药王庙记载了修建时间, 修... 详细信息

梳理中国数字方志库、中国方志库地方志资料, 发现河南共有450种地方志, 其中45种载有药王庙。据45种地方志可知, 河南25个县(市)共修建了35处药王庙, 多分布在河南的西部、北部、南部, 尤以西部最多。其中8处药王庙记载了修建时间, 修建时间上至明朝下至民国, 但大多修建于清朝时期。8处记述了建造人员, 多为政府地方官员。3处记述了供奉的人物, 分别为岐伯、华佗、扁鹊、孙思邈、韦慈藏, 其中2处皆供奉孙思邈。各县市的药王庙建筑格局差异较大, 从三进院落到天然石洞不等。地方志中载有药王的各式传说故事, 是药王信仰在民间流传的具体体现, 药王信仰不仅体现着世人对健康的渴求, 也有祈求风调雨顺之意。

关键词：医药卫生文物医药卫生遗迹遗址中医药祠庙药王药王庙

《八戒之天蓬下界》:中国式英雄的塑造与传统改编的破局

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当代动画 2024年第2期 26-29页

作者：何佳雨北京化工大学艺术与设计系

2024年春节档上映的电影《八戒之天蓬下界》是国产首部以猪八戒为主角的动画电影,与其档期排片和票房不符的是,本片的质量可圈可点。影片以3D动画的形式展现了天蓬从傲慢的秩序守护者到成为自食其力的劳动者,并为此失去重新成为神仙的机... 详细信息

2024年春节档上映的电影《八戒之天蓬下界》是国产首部以猪八戒为主角的动画电影,与其档期排片和票房不符的是,本片的质量可圈可点。影片以3D动画的形式展现了天蓬从傲慢的秩序守护者到成为自食其力的劳动者,并为此失去重新成为神仙的机会,完成了从神性到人性的转变。对待中国经典文化并且根据时代精神与技术进步进行改编,从传统文化中提炼具有关键性的文化元素作为当代动画创作的素材都面临着挑战,无论是对于中国家喻户晓的神话英雄人格觉醒的刻画还是传统文化题材改编《八戒之天蓬下界》都是一次有意义的尝试。

关键词：《八戒之天蓬下界》中国式英雄传统改编系列IP

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“我在经历炼丹术士的一生”——舒飞廉论

上海文化 2024年第3期 44-59页

作者：贺嘉钰不详

半个多世纪前,一只田鼠在意大利托斯卡纳山区一座营建于17世纪的农庄里,无所事事。当同伴们都在为即将到来的冬天采集粮食辛勤劳作时,这只叫作阿佛的田鼠,就总是落在忙碌队伍的最后,有时发呆,有时坐在大石头上,几乎快睡着了。伙伴们问起... 详细信息

半个多世纪前,一只田鼠在意大利托斯卡纳山区一座营建于17世纪的农庄里,无所事事。当同伴们都在为即将到来的冬天采集粮食辛勤劳作时,这只叫作阿佛的田鼠,就总是落在忙碌队伍的最后,有时发呆,有时坐在大石头上,几乎快睡着了。伙伴们问起来,阿佛便说,他也在干活,只不过他做的,是采集阳光,采集颜色和采集词语的事。因为,冬天将寒冷又漫长,而他们会早早把话都说完的。

关键词：炼丹术田鼠 17世纪冬天

特发性肺纤维化无进展生存结局指标应用现状及思考

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世界中医药 2024年第10期19卷 1476-1485页

作者：何佳宇杨曙光于宁霞余学庆河南中医药大学郑州450046 河南中医药大学第一附属医院郑州450000

目的:系统总结分析特发性肺纤维化(IPF)无进展生存(PFS)结局指标的应用现状,为临床合理应用提供参考。方法:计算机系统检索PubMed、EMbase、The Cochrane Library、国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学... 详细信息

目的:系统总结分析特发性肺纤维化(IPF)无进展生存(PFS)结局指标的应用现状,为临床合理应用提供参考。方法:计算机系统检索PubMed、EMbase、The Cochrane Library、国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)及中文科技期刊数据库(CCD)中有关IPF无进展生存结局指标的文献,检索时限为各数据库建库至2022年12月31日。筛选文献,提取资料,整理IPF防治研究中的PFS结局指标,对其应用频次,涵盖各项单一结局指标的差异进行分析。结果:纳入51篇文献,PFS存结局指标是临床常用的复合结局指标,主要涵盖肺功能、肺移植、6MWD(6分钟步行距离)、死亡、AE-IPF(特发性肺纤维化急性加重)等结局指标中的一项或多项。结论:目前IPF防治研究中PFS结局指标应用标准不统一,有待于进一步完善及规范、统一。

关键词：特发性肺纤维化无进展生存结局指标中西医结合中医药

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快速响应的垂直结构二维钙钛矿光电探测器

激光与光电子学进展 2024年第5期61卷 133-140页

作者：张海博冀婷何嘉玉石林林李国辉崔艳霞太原理工大学光电工程学院山西太原030024

制备基于二维钙钛矿(PEA)_(2)(MA)_(4)Pb_(5)I_(16)[PEA为C_(6)H_(5)(CH_(2))NH_(3),MA为CH3NH3]的垂直结构光电探测器,当二维钙钛矿薄膜厚度为280 nm时,器件的亮电流最大,500 nm处外量子效率达到90%,响应率达到0.37 A/W,探测率达到3.4×10^(12)Jones(1 Jones=1 cm·Hz^(1/2)/W)。当二维钙钛矿薄膜厚度减小时,器件的响应时间没有持续减小,而在其厚度为80 nm时器件的响应时间最短,这是受载流子渡越时间和钙钛矿薄膜质量双重影响下的结果。在二维钙钛矿薄膜厚度为80 nm的基础上,通过减小器件的有效面积,其最终实现了113 ns的响应时间。本工作对推动低成本快速响应光电探测器的发展有着重要意义。

关键词：光电探测器二维钙钛矿快速响应垂直结构

Epidemiological characteristics of pulmonary tuberculosis in patients with pneumoconiosis based on its social determinants and risk factors in China:a cross-sectional study from 27 provinces

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Chinese Medical Journal 2022年第24期135卷 2984-2997页

作者： Huanqiang Wang Huaping Dai jiayu he Xiangpei Lyu Xinran Zhang Tao Li Department of Occupational Respiratory Disease National Institute for Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijing 100050China National Center for Respiratory Medicine National Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100029China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Department of Clinical Research and Data Management Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

Background:Patients with pneumoconiosis have an elevated risk of contracting pulmonary tuberculosis(PTB)and need particular ***,extensive population-based studies on the prevalence of PTB in patients with pneumoconiosis have not been reported in China since *** study aimed to investigate the epidemiological characteristics of PTB in patients with pneumoconiosis based on its social determinants and risk factors in ***:Based on the Commission on Social Determinants of health(CSDH)framework,data were obtained from a questionnaire survey of patients with pneumoconiosis from China’s 27 provinces(autonomous regions,municipalities)from December 2017 to June *** chi-square and multivariate logistic regression analyses,the epidemiological characteristics of PTB in the patients were identified based on its prevalence and odds ratio(OR)and associated social determinants and risk *** population attributable fractions(PAFs)of significant risk factors were also ***:The prevalence of PTB in patients with pneumoconiosis(n=10,137)was 7.5%(95%confidence interval[CI]:7.0-8.0%).Multivariate logistic regression analysis showed that risk factors included in-hospital exposure to patients with PTB(OR=3.30,95%CI:2.77-3.93),clinically diagnosed cases(OR=3.25,95%CI:2.42-4.34),and northeastern regions(OR=2.41,95%CI:1.76-3.31).In addition,lack of work-related injury insurance(WRII),being born in a rural area,being unemployed,living in western regions,household exposure to patients with PTB,smoking,being underweight,complications of pulmonary bullae or pneumothorax,hospitalization history,and former drinkers among the rural patients were also statistically significant risk *** born in a rural area,lack of WRII and in-hospital exposure to patients with PTB had higher PAFs,which were 13.2%(95%CI:7.9-18.5%),12.5%(95%CI:8.3-16.7%),and 11.6%(95%CI:8.8-14.3%),***:The prevalence of PTB in pneumoconiosis remains high

关键词： Pulmonary tuberculosis Pneumoconiosis Social determinants Risk factors

RCEP成员国数字经济发展水平对中国文化产品出口的影响研究

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对外经贸 2024年第4期 29-32,39页

作者：张希颖石逍彤何佳渝河北经贸大学商学院河北石家庄050061

通过构建拓展的引力模型,从多个视角研究2010—2020年RCEP成员国的数字经济发展水平对中国核心文化产品出口的影响。研究发现,RCEP成员国数字经济发展水平能够显著地促进中国核心文化商品出口。提出中国应加大对RCEP成员国数字经济发展... 详细信息

通过构建拓展的引力模型,从多个视角研究2010—2020年RCEP成员国的数字经济发展水平对中国核心文化产品出口的影响。研究发现,RCEP成员国数字经济发展水平能够显著地促进中国核心文化商品出口。提出中国应加大对RCEP成员国数字经济发展水平的建设,搭建文化贸易数字化平台,同时要优化出口文化产品类目。

关键词： RCEP 文化产品数字经济引力模型

单宁酸对玉米赤霉烯酮致小鼠肝脏和肾脏氧化损伤的修复作用

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黑龙江畜牧兽医 2024年第11期 1-7页

作者：杨文江黄优黄春霖何家宇杨茗淇易金娥孔丽湖南农业大学动物医学院畜禽保健湖南省工程研究中心长沙410128

为了探究单宁酸(TA)对玉米赤霉烯酮(ZEA)中毒小鼠肝脏和肾脏损伤的修复作用,试验将75只健康雌性昆明小鼠随机分为5组,即对照组、ZEA(10 mg/kg)组和TA低、中、高剂量(50,100,200 mg/kg)组,每组15只。对照组灌服10%乙醇溶液,其余组均灌服Z... 详细信息

为了探究单宁酸(TA)对玉米赤霉烯酮(ZEA)中毒小鼠肝脏和肾脏损伤的修复作用,试验将75只健康雌性昆明小鼠随机分为5组,即对照组、ZEA(10 mg/kg)组和TA低、中、高剂量(50,100,200 mg/kg)组,每组15只。对照组灌服10%乙醇溶液,其余组均灌服ZEA(溶于10%乙醇),每天1次,连续7 d;之后除对照组和ZEA组灌服双蒸水外,TA组分别灌服不同剂量的TA,连续7 d。采集肝脏和肾脏,计算脏器指数,经苏木精-伊红染色后观察肝脏和肾脏的病理变化,检测肝脏和肾脏组织中活性氧(ROS)、丙二醛(MDA)、还原型谷胱甘肽(GSH)含量及超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)活性。结果表明:与对照组相比,ZEA组肝脏和肾脏指数无显著变化(P>0.05);肝细胞脂肪变性,伴有炎症细胞浸润,且部分肝细胞出现核固缩,同时中央静脉内红细胞和血浆沉积;肾脏皮质和髓质出现大量红细胞,肾小球和肾小管上皮细胞出现肿胀;肝脏中ROS和GSH含量显著或极显著增加(P<0.05或P<0.01),SOD活性极显著升高(P<0.01)。与ZEA组相比,TA各剂量组肝脏和肾脏形态结构损伤减轻。在肝脏,TA各剂量组ROS含量显著或极显著降低(P<0.01或P<0.05),TA低剂量组SOD和GSH-Px活性显著或极显著升高(P<0.05或P<0.01),TA各剂量量组GSH含量显著或极显著增加(P<0.05或P<0.01);在肾脏,TA低剂量组GSH含量显著增加(P<0.05),TA中、高剂量GSH-Px活性极显著降低(P<0.01)。说明TA通过恢复肝脏和肾脏形态结构维持氧化还原系统平衡,缓解ZEA造成的肝脏和肾脏氧化损伤,从而发挥保护作用。

关键词：单宁酸玉米赤霉烯酮氧化损伤肝脏肾脏

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