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国家中医药综合改革示范区“十四五”中医药发展规划政策文本分析

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中国医疗管理科学 2024年第1期14卷 13-19,20页

作者：谭浩王军永张嘉颖杨荣王力江西中医药大学经济与管理学院南昌330004 江西中医药大学大健康发展研究院南昌330004

目的剖析我国7个国家中医药综合改革示范区的“十四五”中医药发展规划政策的特征及政策工具使用情况,探讨政策缺陷,并提出优化策略,为推进国家中医药综合改革示范区建设提供参考。方法基于7省份“十四五”中医药发展规划,构建“政策工... 详细信息

目的剖析我国7个国家中医药综合改革示范区的“十四五”中医药发展规划政策的特征及政策工具使用情况,探讨政策缺陷,并提出优化策略,为推进国家中医药综合改革示范区建设提供参考。方法基于7省份“十四五”中医药发展规划,构建“政策工具—政策要素—政策清晰度”三维分析框架,进行多维度量化分析。结果7份中医药政策共提取564条编码,政策工具中命令规制型、激励型、能力建设型、系统变革型、象征劝诫型工具分别占比13.3%、7.1%、53.0%、22.9%、3.7%,政策要素中服务体系提及频率最高,占比33.9%,政策清晰度等级为“清晰”的编码条目占比9.4%。结论中医药政策激励机制不够完善,宣传力度不足,政策要素内部缺乏联动,政策工具与政策要素契合度不高,政策清晰度有待提升。建议丰富激励型与象征劝诫型政策工具的使用,建立中医药发展要素联动机制,优化政策工具内部结构,提升政策发展目标清晰度。

关键词：中医药政策工具政策要素政策清晰度文本分析

The anti-HIV-1 activity of polyphenols from Phyllanthus urinaria and the pharmacokinetics and tissue distribution of its marker compound, gallic acid

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Journal of Traditional Chinese Medical Sciences 2017年第2期4卷 158-166页

作者： Xiaoxue zhang Qing Xia Guanghui Yang Dan Zhu Yanyan Shao jiaying zhang Yaping Cui Rufeng Wang Lanzhen zhang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100102China

Objective:To investigate the in vitro anti-HIV-1 activities and its associated mechanism of action of an extract isolated from Phyllanthus urinaria (P.urinaria) and to develop an HPLC test method for detecting gallic acid (GA) in plasma and tissues to study its pharmacokinetics and tissue distribution in rats.Methods:An extract of P.urinaria was isolated and purified by phytochemistry and chromatography techniques.The anti-HIV-1 activities and toxicities of the extract and its component GA were determined in human T lymph cells (MT-4) by theMTTr method.The mechanism of its anti-HIV-1 action was studied to examine the in vitro binding of its components with HIV-1 target proteins by Biacore technique.The pharmacokinetics and tissue distribution of GA were investigated after oral administration of polyphenol extract (PE) and pure GA in rats.The concentrations of GA in plasma and tissues were determined by HPLC.Results:The PE and GA isolated from P.urinaria had anti-HIV-1 activities with IC50s of 0.61 μg/mL and 0.76 μg/mL,respectively.The Biacore study indicated that PE and GA interacted with HIV-1 RT,gp120,and P24.The pharmacokinetic parameters Tmax,Cm ax,AUC0-t,and T1/2 for GA were (60.0 ± 3.0) minutes,(2.87 ± 0.50) μg·mL-1,(343.5 ± 11.2) mg·min·L-1,and (113.3 ± 9.3) minutes while the parameters for GA in the PE were (10.0 ± 1.3) minutes,(3.89 ± 0.90) μg·mL-1,(394.7 ± 14.0) mg· min· L-1,and (81.7 ± 4.1) minutes,respectively.GA was detected in rat lungs,liver,kidneys,heart and spleen.Conclusion:APE isolated from P.urinaria containing GA has anti-HIV-1 activities.GA is quickly absorbed and slowly eliminated in rats after oral administration.The pharmacokinetics of GA administered as a PE is desirable,and it is widely distributed in the main tissues of lung and liver.Both its properties and anti-HIV-1 activities make it of interest for further studies.

关键词： Phyllanthus urinaria Anti-HIV-1 activity Pharmacokinetic Polyphenol extract Gallic acid

基于三维政策工具分析框架的省级中医药传承创新发展政策文本量化分析

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亚太传统医药 2024年第3期20卷 7-12页

作者：梅杰万兆伟张嘉颖李欣咪王军永江西中医药大学中医药与大健康发展研究院江西南昌330004

目的:分析各省(自治区、直辖市)中医药传承创新发展政策中政策工具的侧重点与不足,为提高中医药传承创新发展政策执行的有效性提供建议。方法:基于政策工具理论,构建政策工具-中医药传承创新体系-政府干预强度三维分析框架,使用内容分... 详细信息

目的:分析各省(自治区、直辖市)中医药传承创新发展政策中政策工具的侧重点与不足,为提高中医药传承创新发展政策执行的有效性提供建议。方法:基于政策工具理论,构建政策工具-中医药传承创新体系-政府干预强度三维分析框架,使用内容分析法对中医药传承创新发展政策进行编码和统计分析。结果:政策工具的运用以环境型(占49.06%)为主,供给型政策工具(占38.40%)运用适中,需求型政策工具(占12.53%)运用最少;从中医药传承创新体系维度看,服务体系占主导(占30.03%),其次是中医药产业(占20.78%)和管理机制(占17.49%),科技创新(12.60%)和教育人才(12.53%)占比较为接近,中医药文化占比严重不足(占6.57%);从政府干预强度维度看,混合型政策工具使用频率最高,强制型政策工具次之,自愿型政策工具使用频率最低;各维度内部构成均有待优化。结论:建议要加强政策工具使用的协调性、提高不同政策工具内部的均衡性,推进中医药传承创新体系各维度协同发展,政府干预强度应合理、适度。

关键词：中医药传承创新政策工具三维分析框架

抑郁障碍青少年对情绪信息的注意偏向的眼动特征及其与反刍思维相关性

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健康研究 2024年第1期44卷 15-19页

作者：林子江章新月黄圣云张嘉瑛虞瑞豪陈莉杨闯温州医科大学附属第一医院精神卫生科浙江温州325015 中南大学湘雅二医院医学心理中心湖南长沙410011 温州医科大学应用心理学系温州医科大学临床医学系浙江温州325035

目的分析抑郁障碍青少年对情绪信息的注意偏向的眼动行为特点,及其与反刍思维的相关性。方法采用注意偏向的眼动测验、反刍思维问卷分别对35例抑郁障碍青少年和45名正常大学生进行测定。结果抑郁障碍青少年和正常大学生间,注意偏向... 详细信息

目的分析抑郁障碍青少年对情绪信息的注意偏向的眼动行为特点,及其与反刍思维的相关性。方法采用注意偏向的眼动测验、反刍思维问卷分别对35例抑郁障碍青少年和45名正常大学生进行测定。结果抑郁障碍青少年和正常大学生间,注意偏向潜伏期、刺激类别效应、交叉效应分数的差异均有统计学意义(F=8.31、9.39、13.64,均P0.05)。正性首视点潜伏期分和享受快乐分、积极应对呈显著负相关(r=-0.392、-0.166,均P<0.05),负性首视点潜伏期分和享受快乐分呈显著正相关(r=0.289,P<0.05)。正性首视点注视时间分和享受快乐、积极应对(r=0.309、0.268)呈正相关(均P<0.05),负性首视点注视时间分和消极归因呈正相关(r=0.194,P<0.05)。结论抑郁障碍青少年缺乏对积极情绪信息的初始注意,反刍思维和抑郁青少年对情绪信息的注意定向加速、注意维持时间有关。

关键词：抑郁障碍情绪信息注意偏向反刍思维

基于政策扩散理论的我国家庭医生签约服务政策推广路径与动因分析

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卫生软科学 2024年第3期38卷 58-62页

作者：梅杰刘霞万兆伟张嘉颖李欣咪王军永江西中医药大学中医药与大健康发展研究院江西南昌330004 江西中医药大学中医学院江西南昌330004

基于政策扩散理论,利用政策文本分析法对我国31个省份首次出台的家庭医生签约服务政策扩散的时间、空间特征,扩散能力及其影响因素进行比较分析。发现省级家庭医生签约政策扩散在时间上具有明显的集聚效应,在空间上具有明显的近邻效应... 详细信息

基于政策扩散理论,利用政策文本分析法对我国31个省份首次出台的家庭医生签约服务政策扩散的时间、空间特征,扩散能力及其影响因素进行比较分析。发现省级家庭医生签约政策扩散在时间上具有明显的集聚效应,在空间上具有明显的近邻效应、自上而下的层级效应和由东向西的演进特点;家庭医生签约服务政策扩散受多重因素的综合作用,经济因素、治理因素、技术因素以及横向纵向压力是该政策扩散的主要动因。为加快政策扩散,应加强区域协调发展,增强政府的信息化水平;辩证看待上级压力对于政策扩散的驱动效应,合理使用强制机制,优化同级政府间学习和竞争机制。

关键词：家庭医生签约服务政策扩散特征动因

Genetic Insights into Glycine’s Protective Role Against CAD—European and East Asia,2015 and 2020

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China CDC weekly 2024年第9期6卷 168-172,I0003-I0008页

作者： jiaying Yu Zhuolin Zhu Ting Wang Yuanhao Wei Lianjie Huang Qianru zhang Yuting zhang Yiran Wang Guiyou Liu Xiang Shu Rennan Feng Department of Nutrition and Food Hygiene School of Public HealthHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina Key Laboratory of Precision Nutrition and Health of Ministry of Education School of Public HealthHarbin Medical UniversityHarbin CityHeilongjiang ProvinceChina Songyang County Center for Disease Prevention and Control Songyang CityZhejiang Province China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer CenterNew York CityNYUSA

Introduction:The purpose of this study is to examine the potential causal relationship between levels of circulating glycine and coronary artery disease(CAD)using a two-step Mendelian randomization(MR)analysis.Methods:We analyzed data from genome-wide association studies(GWAS)conducted on European and East Asian populations.To assess the causal effects of circulating glycine levels on the risk of CAD.We used the inverse-variance weighting(IVW),weighted median(WM),MR-Egger,and Mendelian Randomization Pleiotropy RESidual Sum and Outlier(MR-PRESSO)methods.Furthermore,we conducted mediation analysis to investigate the contribution of blood pressure and other cardiovascular disease-related traits.Results:The two-step Mendelian randomization analysis revealed that higher levels of glycine in the blood were associated with a reduced risk of CAD in Europeans[odds ratio(OR)=0.84,95%confidence interval(CI):0.72,−0.98;P=0.029]and East Asians:(OR=0.76,95%CI:0.66,−0.89;P=3.57×10−4).Sensitivity analysis confirmed the robustness of these findings.Additionally,our results suggest that about 6.06%of the observed causal effect is mediated through genetically predicted systolic blood pressure(SBP)in the European population.Discussion:Our results contribute to the current knowledge regarding the involvement of glycine in the progression of CAD,and provide valuable methodological insights for the prevention and treatment of this condition.

关键词： CAD prevention involvement

A Retrieval Algorithm of Sheet Metal Parts Based on Relationships of Features

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Chinese Journal of Aeronautics 2012年第3期25卷 453-472页

作者： WANG Dawei YAN Guangrong LEI Yi zhang jiaying School of Mechanical Engineering and Automation Beihang University Beijing 100191. China Modern Education Center. Shandong University of Science and Technology. Ta ian 271019. China

With the rapid increase in the number of three-dimensional （3D） models each year, to quickly and easily find the part desired has become a big challenge of enterprises. Meanwhile, many methods and algorithms have been proposed for part retrieval. However, most of the existing methods are designed lbr mechanical parts, and can not be well worked for sheet metal part re- trieval. An approach to feature-based retrieval of sheet metal parts is presented. Firstly, the features frequently used in sheet metal part design are chosen as the ＂＇key words＂ in retrieval. Based on those features, a relative position model is built to express the different relationships of the features in 3D space. Secondly, a description method of the model is studied. With the descrip- tion method the relative position of features in sheet metal parts can be expressed by four location description matrices. Thirdly, based on the relative position model and location description matrices, the equivalent definition of relationships of two feature groups is given which is the basis to calculate the similarity of two sheet metal parts. Next, the tbrmula of retrieval algorithm for sheet metal parts is given. Finally, a prototype system is developed to test and verify the effectiveness of the retrieval method suggested. Experiments verify that the new method is able to meet the requirements of searching sheet metal parts and possesses potentials in practical application.

关键词： CAD sheet metal retrieval algorithm features search 3D model

Effects of pH and soil texture on the adsorption and transport of Cd in soils

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Science China(Technological Sciences) 2009年第11期52卷 3293-3299页

作者： HUANG Shuang zhang RenDuo zhang jiaying PAN Rong State Key Laboratory of Water Resources and Hydropower Engineering Science School of Water Resources and Hydroelectric EngineeringWuhan UniversityWuhan 430072China School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

To better understand the adsorption and transport of Cd2+ in soils, column experiments were conducted with various soils and inflow solutions with different pH values. Breakthrough curves (BTCs) of the column tests were fitted using both the equilibrium and non-equilibrium models installed in the program of CXTFIT. Results showed that the equilibrium model fitted most of BTCs reasonably well. Values of the retardation factor (R) and the distribution coefficient (kd) for Cd2+ adsorption and transport increased with increasing pH values of the inflow solution and of the soil. However, the clay content was not a key factor to affect R and kd for Cd2+ adsorption and transport. The average dispersivity values and the variance values of dispersivity increased with increasing clay content of the soils.

关键词： cadmium pH soil texture adsorption and transport

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40例儿童布鲁氏菌病临床特征分析

传染病信息 2024年第1期37卷 41-44页

作者：吉杉牟丹蕾李侗曾张佳莹张龙玉孙蕊云高丽娟梁连春首都医科大学附属北京佑安医院感染综合科 100069

目的探讨儿童布鲁氏菌病的临床特征,以提高临床医师对该病的诊疗水平。方法将2012—2023年首都医科大学附属北京佑安医院感染科收治的40例年龄≤14岁的布鲁氏菌病患者纳入研究,收集患者的一般及临床资料并进行分析。结果40例患者中女性... 详细信息

目的探讨儿童布鲁氏菌病的临床特征,以提高临床医师对该病的诊疗水平。方法将2012—2023年首都医科大学附属北京佑安医院感染科收治的40例年龄≤14岁的布鲁氏菌病患者纳入研究,收集患者的一般及临床资料并进行分析。结果40例患者中女性(22例,55%)多于男性(18例,45%),年龄最小5月龄,最大14岁,中位年龄是4岁2个月。主要表现为发热(36例,90%)、多汗(25例,62.5%)、腿疼(19例,47.5%)及乏力(18例,45%)。实验室检查数据显示,40例患者中32例(80%)血常规白细胞计数为(4~10)×10^(9)/L;36例(90%)淋巴细胞计数升高;脏器损伤以肝功能异常为主。所有患者均应用至少2种抗菌药物进行治疗,包括利福平、复方磺胺甲噁唑、多西环素(≥8岁以上患者可使用),发生并发症的患者在基础治疗上联合复方磺胺甲噁唑或第三代头孢菌素。结论儿童布鲁氏菌病临床特征多不典型,流行病学史及发热是主要线索,且随着旅游行业、养殖业的发展,此病非流行区的发病率也逐渐上升;临床医生一定要仔细询问病情及是否接触过羊羔、奶制品、牧区,同时还要注意经食源性途径感染所致的发病情况。

关键词：布鲁氏菌病流行病学临床特征