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The Family of Global Attractors for Kirchhoff-Type Coupled Equations

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Journal of Applied Mathematics and Physics 2022年第6期10卷 2040-2060页

作者： Guoguang lin jiaying Zhou Department of Mathematics Yunnan University Kunming China

This paper mainly studies the initial value problems of Kirchhoff-type coupled equations. Firstly, by giving the hypothesis of Kirchhoff stress term , the Galerkin’s method obtains the existence uniqueness of the overall solution of the above problem by using a priori estimates in the spaces of E0 and Ek, and secondly, it proves that there is a family of global attractors for the above problem, and finally estimates the Hausdorff dimension and the Fractal dimension of the family of global attractors.

关键词： Kirchhoff Equation the Existence and Uniqueness of Global Solution the Family of Global Attractors Hausdorff Dimension and Fractal Dimension of Global Attractor

宿主免疫反应标志物对脓毒症的预测及预后判断价值

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温州医科大学学报 2023年第10期53卷 775-781页

作者：翁杰宋佳泽许哲田伟华何董源林佳颖杨静雯王志翊温州医科大学附属第二医院全科医学科浙江温州325027 温州医科大学第二临床医学院浙江温州325035 温州医科大学附属第二医院急诊医学科浙江温州325027 温州医科大学附属台州妇女儿童医院全科医学科浙江台州317700

目的:探讨宿主免疫反应标志物在预测感染患者进展为脓毒症的风险及预后判断中的价值,为防治脓毒症提供参考依据。方法:收集温州医科大学附属第二医院2019年1月至2021年12月因感染性疾病在急诊留观并住院治疗的成人患者。收集感染患者人... 详细信息

目的:探讨宿主免疫反应标志物在预测感染患者进展为脓毒症的风险及预后判断中的价值,为防治脓毒症提供参考依据。方法:收集温州医科大学附属第二医院2019年1月至2021年12月因感染性疾病在急诊留观并住院治疗的成人患者。收集感染患者人口学资料、基础合并症、英国国家早期预警(NEWS)评分、宿主免疫反应标志物等资料。根据感染患者是否进展为脓毒症分为脓毒症组和感染组。采用单因素及多因素Logistic回归分析筛选具有独立预测感染进展为脓毒症的宿主免疫反应标志物,并采用ROC曲线下面积(AUC)、灵敏度、特异度、阳性预测值和阴性预测值对标志物预测性能进行评估。结果:最终纳入294例感染患者,其中138例(46.9%)进展为脓毒症,院内死亡32例(10.9%)。CD3、CD4、C3、CD19、IL-6、IL-10和IgE是感染进展脓毒症的预测因素(OR=0.971、0.965、0.973、1.068、1.028、1.569,均P<0.05)。其中,IL-10预测感染进展为脓毒症的能力最佳,AUC为0.803(0.753~0.854),联合NEWS评分后,AUC达0.844(0.797~0.890);IL-6预测院内死亡的能力最佳,AUC为0.799(0.714~0.884)。结论:宿主免疫反应标志物在感染早期即发生失调,其中IL-6和IL-10预测感染进展为脓毒症和预后的能力最佳,IL-10联合NEWS评分能进一步提升早期脓毒症风险识别能力。

关键词：感染脓毒症宿主免疫反应标志物预测

珠江口盆地深层低渗储层成岩相及可压裂性分析——以惠州-陆丰地区文昌组为例

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中国海上油气 2025年第1期37卷 26-38页

作者：丁琳傅筱涵李晓艳李小平靳子濠王宇辰吴琼玲杨佳颖远光辉中海石油(中国)有限公司深圳分公司广东深圳518067 深层油气全国重点实验室中国石油大学(华东) 山东青岛266580 海洋国家实验室海洋矿产资源评价与探测技术功能实验室山东青岛266071

珠江口盆地深层文昌组储层不同成岩相物性差异大,各类储层是否具备可压裂性及可压裂性的效果明显制约了油气勘探开发的进程。以珠江口盆地惠州-陆丰地区文昌组低渗碎屑岩储层为对象,运用地质、工程“双甜点”识别方法以寻找可动用的高... 详细信息

珠江口盆地深层文昌组储层不同成岩相物性差异大,各类储层是否具备可压裂性及可压裂性的效果明显制约了油气勘探开发的进程。以珠江口盆地惠州-陆丰地区文昌组低渗碎屑岩储层为对象,运用地质、工程“双甜点”识别方法以寻找可动用的高产储层,通过划分主要成岩相类型、开展地层温压条件约束的岩石脆性验证实验等手段,明确了不同成岩相储层可压裂性,预估出压裂后储层增产效果,并提出各类储层下一步开发指导建议。结果表明:(1)惠州-陆丰地区文昌组储层可划分为中弱压实-弱胶结-弱溶解成岩相(Ⅰ类)、中等压实-弱胶结-中等溶解成岩相(Ⅱ类)、中强压实-弱胶结-强溶解(Ⅲ类)、中等压实-凝灰质高岭石(磷灰石)化-中等溶解成岩相(Ⅳ类)、强压实/强胶结-弱溶解致密成岩相(Ⅴ类)5类成岩相。(2)Ⅰ类成岩相储层孔隙结构较好,自然产能高,无需压裂;Ⅱ类、Ⅲ类成岩相储层中—大孔多,压裂后能够被裂缝有效沟通,压裂增产效果明显,下一步可优先压裂;Ⅳ类成岩相储层压裂造缝仅可以连通其周围的少部分微孔隙,大部分微孔隙并未有效沟通,压裂增产效果一般,可作为试点区域;Ⅴ类成岩相储层质量差,压裂意义不大,不建议动用。通过成岩相与岩石可压裂性之间的对应关系,筛选出增产效果明显的储层类型,对低渗油气层有效开发具有重要的参考意义和指导作用。

关键词：珠江口盆地低渗储层成岩相地层温压可压裂性模拟实验

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Pharmacological effects of denervated muscle atrophy due to metabolic imbalance in different periods

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BIOCELL 2023年第11期47卷 2351-2359页

作者： jiaying QIU YAN CHANG WENPENG LIANG MENGSI lin HUI XU WANQING XU QINGWEN ZHU HAIBO ZHANG ZHENYU ZHANG Department of Prenatal Screening and Diagnosis Center Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Nantong Institute of Genetics and Reproductive Medicine Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Department of Emergency Medicine Affiliated Maternity and Child Health Care Hospital of Nantong UniversityNantong226001China Medical School of Nantong University Nantong UniversityNantong226001China School of Life Sciences Nantong UniversityNantong226001China

Denervation-induced skeletal muscle atrophy can potentially cause the decline in the quality of life of patients and an increased risk of *** pathophysiological mechanisms with dynamic alterations have been documented in skeletal muscle atrophy resulting from innervation ***,an in-depth comprehension of the key mechanisms and molecules governing skeletal muscle atrophy at varying stages,along with targeted treatment and protection,becomes essential for effective atrophy *** preliminary research categorizes the skeletal muscle atrophy process into four stages using microarray *** review extensively discusses the pathways and molecules potentially implicated in regulating the four stages of denervation and muscle ***,drugs targeting the reactivare oxygen species stage and the inflammation stage assume critical *** intervention during the initial atrophy stages can expedite protection against skeletal muscle ***,pharmaceutical intervention in the ubiquitin-proteasome pathway associated with atrophy and autophagy lysosomes can effectively slow down skeletal muscle *** molecules within this stage encompass MuRF1,MAFbx,LC3II,p62/SQSTM1,*** review also compiles a profile of drugs with protective effects against skeletal muscle atrophy at distinct postdenervation stages,thereby augmenting the evidence base for denervation-induced skeletal muscle atrophy treatment.

关键词： Pharmacological effects Denervated muscle atrophy Metabolic imbalance

Functions of Nitrogen,Phosphorus and Potassium in Energy Status and Their Influences on Rice Growth and Development

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Rice science 2022年第2期29卷 166-178页

作者： MA jiaying CHEN Tingting lin Jie FU Weimeng FENG Baohua LI Guangyan LI Hubo LI Juncai WU Zhihai TAO Longxing FU Guanfu National Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Agronomy College Jilin Agricultural UniversityChangchun 130118China

Nitrogen(N),phosphorus(P)and potassium(K)are important essential nutrients for plant growth and development,but their functions in energy status remains ***,we grew Nipponbare rice seedlings in a growth chamber for 20 d at 30℃/24℃day/night)under natural sunlight conditions with different nutrient *** results showed that N had the strongest influence on the plant growth and development,followed by P and *** highest nonstructural carbohydrate content,dry matter weight,net photosynthetic rate(Pn),ATP content,as well as NADH dehydrogenase,cytochrome oxidase and ATPase activities were found in the plants that received sufficient N,P and *** lowest values of these parameters were detected in the N-deficient *** dry matter accumulation was observed in the K-deficient than in the P-deficient treatments,but there was no significant difference in the ratio of respiration rate to Pn between these two treatments,suggesting that differences in energy production efficiency may have accounted for this *** hypothesis was confirmed by higher ATP contents and activities of NADH dehydrogenase,cytochrome oxidase and ATPase in the K-deficient plants than in the P-deficient *** therefore inferred different abilities in energy production efficiency among N,P and K in rice seedlings,which determined rice plant growth and development.

关键词： rice nutrient element photosynthesis respiration plant growth and development energy production efficiency

Scaffolds with anisotropic structure for neural tissue engineering

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Engineered Regeneration 2022年第2期3卷 154-162页

作者： Yangnan Hu Hui Zhang Hao Wei Hong Cheng jiaying Cai Xiaoyan Chen lin Xia Huan Wang Renjie Chai State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyAdvanced In stitute for Life and HealthJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096China Department of Otolaryngology Head and Neck Surgery Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100086China Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

Nervous system injuries remain a great challenge due to limited natural tissue regeneration *** tissue engineering has been regarded as a promising approach for repairing nerve defects,which utilizes external biomaterial scaffolds to allow cells to migrate to the injury site and repair the ***,scaffolds with anisotropic structures biomimicking the native extracellular matrix(ECM)can effectively guide neural orientation and ***,the advancements of scaffolds with anisotropic structures in the field of neural tissue engineering are *** fabrication strategies of scaffolds with anisotropic structures and their effects in vitro and in vivo are *** also discuss the challenges and provide a perspective of this field.

关键词： Neural tissue engineering Anisotropic structure Neural scaffolds Biofabrication Nerve regeneration

单羟基咔咯的合成、晶体的生长和光动力抗菌活性研究

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人工晶体学报 2023年第3期52卷 510-519页

作者：吴淑琼何裕良郑嘉琪黄婉瑜陈培妮莫晓琳叶嘉欣欧晓倩林佳颖郭惠琳黄慧琳许逸戈史蕾佘婷婷钟永辉广东第二师范学院化学与材料科学学院广州510800 广东第二师范学院生物与食品工程学院广州510303 佛山市第四人民医院结核科佛山528041

光动力抗菌疗法(PDAT)是一种新型的治疗微生物感染的手段,咔咯在光动力抗肿瘤方面具有显著优势,但在光动力抗菌方面却鲜有报道。本文合成了单羟基咔咯即10-(4-羟基苯基)-5,15-二(2,3,4,5,6-五氟苯基)咔咯(P-OH),并进一步研究其晶体结构... 详细信息

光动力抗菌疗法(PDAT)是一种新型的治疗微生物感染的手段,咔咯在光动力抗肿瘤方面具有显著优势,但在光动力抗菌方面却鲜有报道。本文合成了单羟基咔咯即10-(4-羟基苯基)-5,15-二(2,3,4,5,6-五氟苯基)咔咯(P-OH),并进一步研究其晶体结构和光动力抗菌活性。结果表明,单羟基咔咯属于正交晶系,具有良好的光动力抗菌活性,药物浓度大于2MIC时其显示出杀菌作用,药物浓度小于2MIC时其显示出抑菌作用,其最低杀菌浓度和最低抑菌浓度皆比卟啉低,是一种良好的光动力抗菌光敏剂。

关键词：咔咯单羟基咔咯合成晶体结构光动力抗菌疗法

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基于数据挖掘探讨肝胃郁热型吞酸病用药规律

世界中医药 2019年第11期14卷 2925-2929页

作者：黄佳钦曹云符欣常炳龙何莹林稼樱张忠绵张婧李志红北京中医药大学东直门医院

目的:基于数据挖掘技术探讨中药复方治疗肝胃郁热型吞酸的用药规律。方法:以中国方剂数据库为检索库,检索治疗"吞酸"的中药方剂,再根据方剂主治及功效筛选治疗肝胃郁热型吞酸的方剂,并采用Excel、SPSS 20.0软件进行频数及频率分析、因... 详细信息

目的:基于数据挖掘技术探讨中药复方治疗肝胃郁热型吞酸的用药规律。方法:以中国方剂数据库为检索库,检索治疗"吞酸"的中药方剂,再根据方剂主治及功效筛选治疗肝胃郁热型吞酸的方剂,并采用Excel、SPSS 20.0软件进行频数及频率分析、因子分析。结果:中药复方治疗吞酸涉及复方291首,治疗肝胃郁热型吞酸涉及69首,中药107种,高频中药25味,陈皮、甘草、木香、砂仁、青皮和厚朴较为常用;在功效方面,理气药、化湿药、活血化瘀药、消食药及清热药选用次数均较多。五味以辛、苦为主;归经以脾经、胃经、肝经选用次数较多。因子分析最后提取了7组影响肝胃郁热型吞酸的药物组合因子;通过聚类分析,提取了8个常用的药对或药组。结论:该研究结果与田德禄教授应用"清降"法治疗吞酸的学术思想有许多相似之处。

关键词：中药复方肝胃郁热吞酸用药规律数据挖掘聚类分析因子分析田德禄教授 “清降”理论

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田德禄教授对肝气证治的认识

现代中医临床 2022年第3期29卷 19-22,33页

作者：张忠绵李志红曹云黄佳钦符欣林稼樱张轶斐郭志玲田德禄(指导) 北京中医药大学东直门医院北京100700 北京中医药大学不详

肝为刚脏,主疏泄、藏血,以条达畅通为顺,体阴而用阳。田德禄教授从肝论治消化系统病证有独特的学术观点,主要体现在以下方面:①疏肝气,通肝络,柔肝体。包括:隐曲不伸疏肝气、肝郁络病通瘀滞、体用失调宜柔肝;②木土同病调肝脾。包括:培... 详细信息

肝为刚脏,主疏泄、藏血,以条达畅通为顺,体阴而用阳。田德禄教授从肝论治消化系统病证有独特的学术观点,主要体现在以下方面:①疏肝气,通肝络,柔肝体。包括:隐曲不伸疏肝气、肝郁络病通瘀滞、体用失调宜柔肝;②木土同病调肝脾。包括:培土缓肝、培土泄木、培土散肝、泄肝和胃、泄降肝气;③木叩金鸣抑肝气。

关键词：肝气证治名医经验田德禄

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