检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2021年第9期11卷 2609-2644页

作者： Liming Lin jiaying chi Yilang Yan Rui Luo Xiaoqian Feng Yuwei Zheng Dongyi Xian Xin Li Guilan Quan Daojun Liu Chuanbin Wu Chao Lu Xin Pan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China College of Pharmacy Jinan UniversityGuangzhou 511443China Shantou University Medical College Shantou 515041China The Third Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510630China

Membrane-disruptive peptides/peptidomimetics(MDPs)are antimicrobials or anticarcinogens that present a general killing mechanism through the physical disruption of cell membranes,in contrast to conventional chemotherapeutic drugs,which act on precise targets such as DNA or specific enzymes.Owing to their rapid action,broad-spectrum activity,and mechanisms of action that potentially hinder the development of resistance,MDPs have been increasingly considered as future therapeutics in the drug-resistant era.Recently,growing experimental evidence has demonstrated that MDPs can also be utilized as adjuvants to enhance the therapeutic effects of other agents.In this review,we evaluate the literature around the broad-spectrum antimicrobial properties and anticancer activity of MDPs,and summarize the current development and mechanisms of MDPs alone or in combination with other agents.Notably,this review highlights recent advances in the design of various MDP-based drug delivery systems that can improve the therapeutic effect of MDPs,minimize side effects,and promote the codelivery of multiple chemotherapeutics,for more efficient antimicrobial and anticancer therapy.

关键词： Membrane-disruptive peptides/peptidomimetics Drug-resistance Drug delivery systems Combination therapy

Virus-inspired surface-nanoengineered antimicrobial liposome:A potential system to simultaneously achieve high activity and selectivity

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2021年第10期6卷 3207-3217页

作者： Yin Shi Xiaoqian Feng Liming Lin Jing Wang jiaying chi Biyuan Wu Guilin Zhou Feiyuan Yu Qian Xu Daojun Liu Guilan Quan Chao Lu Xin Pan Jianfeng Cai Chuanbin Wu College of Pharmacy Jinan UniversityGuangzhouGuangdong511443China Department of Pharmaceutics School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhouGuangdong510006China Medical College Shantou UniversityShantouGuangdong15041China Department of Chemistry University of South FloridaTampaFL33620United States

Enveloped viruses such as SARS-CoV-2 frequently have a highly infectious nature and are considered effective natural delivery systems exhibiting high efficiency and specificity.Since simultaneously enhancing the activity and selectivity of lipopeptides is a seemingly unsolvable problem for conventional chemistry and pharmaceutical approaches,we present a biomimetic strategy to construct lipopeptide-based mimics of viral architectures and infections to enhance their antimicrobial efficacy while avoiding side effects.Herein,a surface-nanoengineered antimicrobial liposome(SNAL)is developed with the morphological features of enveloped viruses,including a moderate size range,lipid-based membrane structure,and highly lipopeptide-enriched bilayer surface.The SNAL possesses virus-like infection to bacterial cells,which can mediate high-efficiency and high-selectivity bacteria binding,rapidly attack and invade bacteria via plasma membrane fusion pathway,and induce a local“burst”release of lipopeptide to produce irreversible damage of cell membrane.Remarkably,viral mimics are effective against multiple pathogens with low minimum inhibitory concentrations(1.6-6.3μg mL􀀀1),high bactericidal efficiency of>99%within 2 h,>10-fold enhanced selectivity over free lipopeptide,99.8%reduction in skin MRSA load after a single treatment,and negligible toxicity.This bioinspired design has significant potential to enhance the therapeutic efficacy of lipopeptides and may create new opportunities for designing next-generation antimicrobials.

关键词： Virus-inspired mimics Antimicrobial lipopeptides Liposomes Virus-like infections Activity and selectivity

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

习近平关于建设优良家风重要论述的深刻意蕴

中州学刊 2024年第7期 23-28页

作者：刘晓哲邓嘉颖山西大学马克思主义学院山西太原030006

优良家风是中华民族生生不息、中华文明薪火相传的重要精神支撑。注重家风建设是中国共产党一以贯之的光荣传统。党的十八大以来,习近平从治国理政的高度谋划部署家庭家教家风建设工作,对建设优良家风做出一系列重要论述,内涵丰富深刻,... 详细信息

优良家风是中华民族生生不息、中华文明薪火相传的重要精神支撑。注重家风建设是中国共产党一以贯之的光荣传统。党的十八大以来,习近平从治国理政的高度谋划部署家庭家教家风建设工作,对建设优良家风做出一系列重要论述,内涵丰富深刻,为新时代进一步建设优良家风提供了理论指导和实践指南,是习近平新时代中国特色社会主义思想的重要组成部分。习近平关于建设优良家风的重要论述是对马克思主义家庭观与中华优秀传统家风思想的继承发展,是对中国共产党注重家风传统的历史赓续,是对新时代建设优良家风现实需要的积极回应,为新时代新征程建设优良家风提供了科学的理论指导和实践指南。

关键词：家庭家教家风建设

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于Leslie模型的人口语言分布预测

现代信息科技 2019年第10期3卷 1-4,8页

作者：蔡银辉李淑锦池嘉莹杭州电子科技大学经济学院浙江杭州310018 杭州电子科技大学卓越学院浙江杭州310018

本文基于人口发展模型以及Leslie模型分析人口年龄分布和语言发展的关系,提出了语言年龄比例函数,使用阻滞增长模型预测语言传播率,得到了计算语言使用者总量和年龄分布的语言发展模型。选取杭州市统计局统计年鉴数据,使用C++进行编程,... 详细信息

本文基于人口发展模型以及Leslie模型分析人口年龄分布和语言发展的关系,提出了语言年龄比例函数,使用阻滞增长模型预测语言传播率,得到了计算语言使用者总量和年龄分布的语言发展模型。选取杭州市统计局统计年鉴数据,使用C++进行编程,预测2020年至2035年的人口语言分布。预测结果表示二孩开放的政策使未来杭州的15-64岁年龄段普通话使用者占比明显提高,并且劳动人口抚养压力减缓,对于杭州的城市发展是有利的。另外,我们发现未来1-15岁人口数量与未开放二孩时相比会出现上升的情况,而杭州未来希望推广国际化教育,这提醒杭州政府要对未来的教育人才储备做出计划。

关键词：人口发展模型阻滞增长 Leslie模型全面二孩政策

E-CHAID决策模型下骨髓增生异常综合征DRGs分组实际运行效果分析

在线全文

学校读者我要写书评

暂无评论

中国医院统计 2024年第2期31卷 124-128,133页

作者：华恃彬任晋文朱佳英浙江省人民医院医保物价办公室浙江杭州310000

目的分析E-CHAID决策模型下骨髓增生异常综合征DRGs分组对住院费用的实际影响。方法回顾性搜集2021年2月至2023年2月浙江省某三甲医院HIS系统中病案首页出院诊断首项为骨髓增生异常综合征的患者资料。对病案首页全部指标进行组间多元... 详细信息

目的分析E-CHAID决策模型下骨髓增生异常综合征DRGs分组对住院费用的实际影响。方法回顾性搜集2021年2月至2023年2月浙江省某三甲医院HIS系统中病案首页出院诊断首项为骨髓增生异常综合征的患者资料。对病案首页全部指标进行组间多元线性回归检验、Mann-Whitney U检验及Kruskal-Wallis H检验,以VIF(方差膨胀因子)<10、单因素筛选中P<0.05的指标为自变量,以住院费用为因变量,采用E-CHAID穷举算法建立DRGs分组决策树模型。以各DRGs病例组合“住院费用中位数+1.5倍标准差”为费用上限,计算各DRGs分组上限费用与所有病例上限费用之比,分析住院费用分布特征。结果共纳入2 223例骨髓异常综合征患者。是否使用单克隆抗体、是否ICU入住、输血次数3个变量为E-CHAID决策树模型的分层分类变量节点,建立了12个节点,共生成7个终端节点,变异系数CV分别为0.40、0.15、0.23、0.21、0.25、0.51、0.46,各DRGs分组间Kruskal-Wallis H检验具备统计学意义(H=2 816.568,P<0.001)。2 223例患者中超出费用上限76例(3.42%),超上限费用患者的住院总花费为662 241.71万元,占DRGs总住院费用的1.40%;DRGs 1~7组相对权重分别为1.49、2.42、2.14、1.33、1.10、0.47、0.24。结论 E-CHAID决策模型下骨髓增生异常综合征DRGs分组异质性较强,组间分布合理,可为浙江省后续开展骨髓增生异常综合征等恶性血液疾病的地方性DRGs医疗付费改革提供一定依据。

关键词：疾病诊断相关分组骨髓增生异常综合征穷举卡方自动交互检测医疗保险住院费用

甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)对原发性肝癌发病的影响

在线全文

学校读者我要写书评

暂无评论

临床肝胆病杂志 2024年第4期40卷 753-759页

作者：贾建国马向明田菲张亚丽戴佳盈罗赛芳曹立瀛华北理工大学研究生院河北唐山063000 华北理工大学附属开滦总医院肝胆外科河北唐山063000 华北理工大学附属医院肿瘤放化疗科河北唐山063000

目的探究甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)对原发性肝癌发病的影响。方法采用前瞻性队列研究的方式,收集2006年7月—2007年12月参加开滦集团健康体检的99750例在职及离退休职工的体检资料,并对其原发性肝癌的发病情况进行随... 详细信息

目的探究甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)对原发性肝癌发病的影响。方法采用前瞻性队列研究的方式,收集2006年7月—2007年12月参加开滦集团健康体检的99750例在职及离退休职工的体检资料,并对其原发性肝癌的发病情况进行随访,随访截止时间为2021年12月31日。根据TG/HDL-C三分位水平将受试者分成3组,分别为Q1组(TC/HDL-C<0.66,n=33229)、Q2组(0.66≤TC/HDL-C<1.14,n=33302)、Q3组(TC/HDL-C≥1.14,n=33219)。计算各组原发性肝癌的发病密度。符合正态分布的计量资料多组间比较采用单因素方差分析;符合偏态分布的计量资料多组间比较采用Kruskal-Wallis H检验。计数资料组间比较采用χ2检验。采用Kaplan⁃Meier法计算各组原发性肝癌的累积发病率,以Logrank检验比较各组间累积发病率的差异。采用Cox比例风险模型分析不同TG/HDL-C水平分组对原发性肝癌发病的影响。结果3组受试者年龄、男性比例、腰围、BMI、空腹血糖、收缩压、舒张压、TG、TC、HDL-C、LDL-C、ALT、超敏C-反应蛋白、慢性肝病、高血压病、糖尿病、恶性肿瘤家族史、饮酒、吸烟、体育锻炼、受教育程度组间对比差异均有统计学意义(P值均<0.05)。在平均(14.06±2.71)年的随访过程中,新发肝癌共计484例,其中男446例,女38例。Q1组、Q2组、Q3组原发性肝癌的发病密度分别是0.39/千人年、0.35/千人年、0.30/千人年。3组受试者的原发性肝癌累积发病率分别是6.03‰、5.28‰和4.49‰,经Log-rank检验,差异有统计学意义(χ^(2)=6.06,P=0.048)。校正了考虑到的混杂因素后,Cox比例风险模型结果显示,以Q3组为对照,Q1、Q2组的风险比及95%可信区间分别为2.04(1.61~2.58)、1.53(1.21~1.92)(P for trend<0.05)。结论TG/HDL-C水平降低与原发性肝癌发病风险升高有关,特别是在慢性肝病的人群中这种关联更加明显。

关键词：肝肿瘤甘油三酯类胆固醇,HDL 队列研究

Analysis on the Independent Extracurricular Practice of Students in the Specialized Dance Sport--Shenyang Sport University is Taken for Example

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

国际技术管理 2013年第5期 1-3页

作者： chi BEN jiaying YU Shenyang Sport University Shenyang Liaoning 110102

Implementing a “free” tuberculosis (TB) care policy under the integrated model in Jiangsu, china: practices and costs in the real world

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2016年第1期5卷 1-8页

作者： Xinxin Jia jiaying Chen Siyuan Zhang Bing Dai Qian Long Shenglan Tang Center for Health Policy Studies Nanjing Medical UniversityHanzhong Road 140210029 NanjingChina The Second Affiliated Hospital of Soochow University SuzhouJiangsu ProvinceChina Zhenjiang Center for Disease Control and Prevention ZhenjiangJiangsu ProvinceChina Duke Global Health Institute Duke UniversityDurhamNCUSA Global Health Research Center Duke Kunshan UniversityKunshanChina

Background:In the 1990s,china introduced a“free”tuberculosis(TB)care policy under the national TB control program.Recently,as a part of a new TB diagnosis and treatment model,it has been recommended that the integrated model scale up.This paper examines whether or not TB designated hospitals in the selected project sites have provided TB care according to the national and local guidelines,and analyzes the actual practices and expenditures involved in completing TB treatment.It also explores the reasons why“free”TB care in china cannot be effectively implemented under the integrated model.Methods:This study was conducted in three counties of Zhenjiang city,Jiangsu province.Mixed methods were used,which comprised reviewing the national and local TB control guidelines,conducting TB patient surveys,collecting TB inpatient and outpatient hospital records,and conducting qualitative interviews with stakeholders.Descriptive statistics were used for quantitative data analysis across counties and in order to compare patients who received only outpatient care and those who received both outpatient and inpatient care.The chi-square test and analysis of variance were performed where necessary.Qualitative data were analyzed using the framework approach.Results:Although the national TB care guidelines recommend outpatient care as a basis for TB treatment in china,we found high hospital admission rates for TB patients ranging from 39%in Yangzhong county to 83%in Dantu county.Almost all outpatient TB patients paid for lab tests and over 80%paid for liver protection drugs and around 70%paid for image examinations.These three components accounted for three-quarters of the total outpatient expenditure.For patients who received only outpatient care,the total expenditure upon completion of TB treatment was on average 1,135 chinese yuan.For patients who received outpatient and inpatient care,the total expenditure upon completion of TB treatment was 11,117 chinese yuan.Conclusion:The“free”TB care policy under the integrated model has no

关键词： Tuberculosis Anti-TB treatment practice guidelines Free Expenditure Jiangsu province china

Factors that determine catastrophic expenditure for tuberculosis care: a patient survey in china

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases of Poverty 2016年第1期5卷 44-53页

作者： Chengchao Zhou Qian Long jiaying Chen Li Xiang Qiang Li Shenglan Tang Fei Huang Qiang Sun Henry Lucas Department of Health Service Management and Maternal and child Health School of Public HealthShandong UniversityJinanChina Duke Global Health Institute Duke UniversityDurhamNCUSA Global Health Research Center Duke Kunshan UniversityKunshanChina School of Health Policy and Management Nanjing Medical UniversityNanjingChina School of Medicine and Health Management Huazhong University of Science and TechnologyWuhanChina School of Public Health Xi’an Jiaotong UniversityXi’anChina National Center for TB Control and Prevention China CDCBeijingChina Center for Health Management and Policy Shandong UniversityWen-hua-xi Road No.44Jinan City 250012China Key Lab of Health Economic and Policy Studies of Ministry of Health JinanChina Institute of Development Studies Sussex UniversityBrightonUK

Background:Tuberculosis(TB)often causes catastrophic economic effects on both the individual suffering the disease and their households.A number of studies have analyzed patient and household expenditure on TB care,but there does not appear to be any that have assessed the incidence,intensity and determinants of catastrophic health expenditure(CHE)relating to TB care in china.That will be the objective of this paper.Methods:The data used for this study were derived from the baseline survey of the china Government–Gates Foundation TB Phase Ⅱ program.Our analysis included 747 TB cases.Catastrophic health expenditure for TB care was estimated using two approaches,with households defined as experiencing CHE if their annual expenditure on TB care:(a)exceeded 10%of total household income;and(b)exceeded 40%of their non-food expenditure(capacity to pay).chi-square tests were used to identify associated factors and logistic regression analysis to identify the determinants of CHE.Results:The incidence of CHE was 66.8%using the household income measure and 54.7%using non-food expenditure(capacity to pay).An inverse association was observed between CHE rates and household income level.Significant determinants of CHE were:age,household size,employment status,health insurance status,patient income as a percentage of total household income,hospitalization and status as a minimum living security household.Factors including gender,marital status and type of TB case had no significant associations with CHE.Conclusions:Catastrophic health expenditure incidence from TB care is high in china.An integrated policy expanding the free treatment package and ensuring universal coverage,especially the height of UHC for TB patients,is needed.Financial and social protection interventions are essential for identified at-risk groups.

关键词： Catastrophic health expenditure Tuberculosis Determinants china

一种新型高能量密度和低成本两相双凸极永磁电机(英文)

在线全文

学校读者我要写书评

暂无评论

电工技术学报 2013年第9期28卷 310-320页

作者：周智庆迟永滨何嘉颖华南理工大学机械与汽车工程学院广州510641 江西省荷谱科技有限公司永新343400

提出了一种新型绕组结构两相双凸极永磁电机(TDSPM)。该新型电机的结构与现存的三相双凸极永磁电机(DSPM)相同,与后者不同的是,其绕组结构临近线匝跨越三个定子极,并且只形成两相。分析了该新型电机的工作原理,以一台1.8kW的TDSPM电机为... 详细信息

提出了一种新型绕组结构两相双凸极永磁电机(TDSPM)。该新型电机的结构与现存的三相双凸极永磁电机(DSPM)相同,与后者不同的是,其绕组结构临近线匝跨越三个定子极,并且只形成两相。分析了该新型电机的工作原理,以一台1.8kW的TDSPM电机为例,建立了其动态物理模型。基于有限元法,调查了该新型电机的特点,包括气隙磁通密度分布以及两相绕组磁链。进一步结合实验验证,结果显示。与现存的DSPM电机相比,TDSPM的非工作定子凸极上有更少的漏磁。并且其相磁链具有非对称和双极性的特性,以及更大的变化率,从而,可以获得更高的反电动势,这使得该新型电机具有更高的功率密度以及绕组和空间利用率。进一步基于建立的动态物理模型,动态分析被执行,验证了提出的两相TDSPM电机不存在零扭矩区域,在任何位置可以起动。然而,由于双凸极的结构特征,仍然存在输出扭矩波动的缺陷。

关键词：双凸极永磁电机两相电机新绕组结构永磁电机开关磁阻电机