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Journal of Interventional Medicine 2023年第2期6卷 99-102页

作者： Pengxu ding Wen Zhou jiayin ding Shaofeng Shui Luo Xu Edward Wolfgang Lee Department of Intervention The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Department of Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Division of Interventional Radiology Department of RadiologyUCLA Medical CenterDavid Geffen School of Medicine at UCLALos AngelesCAUSA Division of Liver and Pancreas Transplant Surgery Department of SurgeryUCLA Medical CenterDavid Geffen School of Medicine at UCLALos AngelesCAUSA

Budd-Chiari syndrome(BCS)is a rare condition characterized by hepatic venous outflow *** angioplasty,with or without stenting,is the recommended first-line treatment modality in Asian *** a supplement to balloon angioplasty,expandable metallic Z-stent deployment can effectively improve long-term inferior vena cava(IVC)*** stent placement is a standard and frequently performed treatment,very few IVC stent-related complications,such as stent fractures,have been *** we present a case series and a comprehensive review of IVC stent fractures in patients with *** most common characteristic of IVC stent fractures is a protrusion of the proximal segment of the IVC stent into the right atrium and its systolic and diastolic movements along with heart *** stent deployment,large-diameter balloon dilation,patient breath-holding training,preferential selection of a triple stent,and the use of an internal jugular vein approach to stent deployment may ensure precise stent localization and avoid postoperative complications.

关键词： Budd-Chiari syndrome Inferior vena cava Angioplasty Stenting Fracture

增值税留抵退税对审计质量的影响研究——基于沪深A股上市公司的经验证据

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科技创业月刊 2024年第11期37卷 143-150页

作者：苏亚民丁佳音中南民族大学管理学院湖北武汉430074

高质量审计是推动国家治理体系和治理能力现代化的重要力量,增值税留抵退税改变了审计工作的内容和环境,对于审计工作质量有着重要影响。基于《关于2018年退还部分行业增值税留抵税额有关税收政策的通知》(财税[2018]70号)文件设立准自... 详细信息

高质量审计是推动国家治理体系和治理能力现代化的重要力量,增值税留抵退税改变了审计工作的内容和环境,对于审计工作质量有着重要影响。基于《关于2018年退还部分行业增值税留抵税额有关税收政策的通知》(财税[2018]70号)文件设立准自然实验,以2015-2021年沪深A股上市公司为研究样本,使用双重差分模型检验了增值税留抵退税对审计质量的影响。研究发现,增值税留抵退税能够通过提高信息透明度和优化公司治理水平来提高审计质量。进一步研究发现,政策实施对审计质量的正向影响在大规模事务所、民营企业以及内部控制较好的企业中发挥更明显的作用。研究结果拓展了增值税留抵退税带来的审计后果,为注册会计师合理应对留抵退税带来的工作变化提供了经验证据,对于寻求审计工作高质量发展有着积极作用。

关键词：增值税留抵退税审计质量信息透明度公司治理水平

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基于腐蚀环境服役结果的氯化釜结构改进

化纤与纺织技术 2020年第11期49卷 11-13,39页

作者：赵清雅王承益丁家兴南京宝色股份公司江苏南京211161

应用于橡塑行业的氯化釜操作温度高,内部介质(CPE、HCl、H_(2)O、Cl)腐蚀能力强、腐蚀最严重的部件是轴,其次是贴条的T型接头处。氯化釜所采用的搅拌系统中轴的稳定性及抗腐蚀特性尤为重要。根据现役氯化釜使用后的结果显示,单纯改变搅... 详细信息

应用于橡塑行业的氯化釜操作温度高,内部介质(CPE、HCl、H_(2)O、Cl)腐蚀能力强、腐蚀最严重的部件是轴,其次是贴条的T型接头处。氯化釜所采用的搅拌系统中轴的稳定性及抗腐蚀特性尤为重要。根据现役氯化釜使用后的结果显示,单纯改变搅拌轴的材料已无法满足使用及寿命要求,必须改进搅拌轴的相关结构,改进的着力点集中于三个部位:联轴器及紧固件的保护套、上下半轴的包覆、轴尾的防串动结构。结构改进后,搅拌轴的抗腐蚀性能及机械性能得到了大幅度的改善。

关键词：腐蚀环境氯化釜结构

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping ding Liyun Wu Songfeng E Qian He Nanyang Wang Hui Zuo Zhengyang Zhou Feng ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia Sheng Quanju ding Yujun Wang Jiwei Zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

长江源区北麓河流域退化高寒草甸植物群落特征和土壤特性

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生态环境学报 2024年第7期33卷 1063-1071页

作者：李成阳梁志辉李臻明蔡敏许瑞瑶陈秀宇丁佳音许秋云彭飞岭南师范学院地理科学学院广东湛江524048 中国科学院西北生态环境资源研究院/中国科学院沙漠与沙漠化重点实验室甘肃兰州730000

生态系统退化严重威胁着全球生态和环境安全,充分认识退化过程和机理是开展和实现退化生态系统修复的关键。以往大部分高寒草甸退化相关研究缺乏长期的观测资料,难以合理分析退化的形成过程和机理。以具有长期观测资料的长江源多年冻土... 详细信息

生态系统退化严重威胁着全球生态和环境安全,充分认识退化过程和机理是开展和实现退化生态系统修复的关键。以往大部分高寒草甸退化相关研究缺乏长期的观测资料,难以合理分析退化的形成过程和机理。以具有长期观测资料的长江源多年冻土区北麓河流域未退化和退化高寒草甸为对象,根据研究区实际,探讨了草地退化下植物群落结构特征和土壤理化特性的变化及其相互关系,为查明多年冻土区高寒草甸退化机理和退化草地修复提供理论依据。结果表明:1)退化使地上和地下生物量显著降低,植物群落优势物种由浅根系的莎草科植物向深根系的杂草类植物转变;2)Shannon-Wiener多样性指数和物种丰富度指数呈单峰变化趋势,即在中度退化阶段显著增加,但在严重退化阶段显著降低;3)退化后,土壤容重、pH和总磷显著增加,但硝态氮、铵态氮、速效氮、总氮和有机碳呈降低趋势;4)冗余分析结果显示,群落生物量与土壤有机碳、总氮、硝态氮、铵态氮、速效氮和速效磷呈正相关,Shannon-Wiener多样性指数和物种丰富度指数与粉粒、水分和pH负相关,速效氮、速效磷、土壤水分对植被生物量和物种多样性的解释率分别为57.8%、27.3%和9.9%。因此,长江源多年冻土区退化高寒草甸植物生长可能主要受速效养分限制,在对其的修复过程中,应首先考虑土壤养分的恢复。

关键词：高寒草甸草地退化青藏高原理化特征群落结构多年冻土区

Optimization Strategies of Na_(3)V_(2)(PO_(4))_(3) Cathode Materials for Sodium‑Ion Batteries

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Nano-Micro Letters 2025年第2期17卷 204-251页

作者： Jiawen Hu Xinwei Li Qianqian Liang Li Xu Changsheng ding Yu Liu Yanfeng Gao School of Materials Science and Engineering Shanghai UniversityShanghai 200444People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China

Na_(3)V_(2)(PO_(4))_(3)(NVP)has garnered great attentions as a prospective cathode material for sodium-ion batteries(SIBs)by virtue of its decent theoretical capacity,superior ion conductivity and high structural ***,the inherently poor electronic conductivity and sluggish sodium-ion diffusion kinetics of NVP material give rise to inferior rate performance and unsatisfactory energy density,which strictly confine its further application in ***,it is of significance to boost the sodium storage performance of NVP cathode *** to now,many methods have been developed to optimize the electrochemical performance of NVP cathode *** this review,the latest advances in optimization strategies for improving the electrochemical performance of NVP cathode material are well summarized and discussed,including carbon coating or modification,foreign-ion doping or substitution and nanostructure and morphology *** foreign-ion doping or substitution is highlighted,involving Na,V,and PO_(4)^(3−)sites,which include single-site doping,multiple-site doping,single-ion doping,multiple-ion doping and so ***,the challenges and prospects of high-performance NVP cathode material are also put *** is believed that this review can provide a useful reference for designing and developing high-performance NVP cathode material toward the large-scale application in SIBs.

关键词： Sodium-ion batteries Na_(3)V_(2)(PO_(4))_(3) Cathode materials Electrochemical performance Optimization strategies

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-Yuan Hu ding ding Yu Song Ya-Feng Deng Cheng-Ming Zhang Tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu Yi ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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外周T细胞淋巴瘤的治疗和生存预后分析

肿瘤基础与临床 2024年第1期37卷 27-32页

作者：丁佳音夏亚勤毛菁华丁师琦南飞飞孙振昌付晓瑞郑州大学第一附属医院肿瘤科河南郑州450052 河南省淋巴瘤诊疗中心河南郑州450052

目的分析外周T细胞淋巴瘤(PTCL)的临床特征、生存和预后影响因素。方法回顾性分析253例PTCL患者的临床特征、生存和预后影响因素等资料。采用Kaplan-Meier法进行生存分析,log-rank检验进行组间比较,Cox比例风险回归模型进行单因素及多... 详细信息

目的分析外周T细胞淋巴瘤(PTCL)的临床特征、生存和预后影响因素。方法回顾性分析253例PTCL患者的临床特征、生存和预后影响因素等资料。采用Kaplan-Meier法进行生存分析,log-rank检验进行组间比较,Cox比例风险回归模型进行单因素及多因素分析。结果253例患者中位年龄为60岁,3、5、10 a的疾病无进展生存(PFS)率分别为43.70%、36.60%和20.60%,3、5和、10 a的总生存(OS)率分别为56.60%、49.20%和30.00%。多因素Cox分析结果回示,Ann Arbor分期(HR=3.600,95%CI=1.277~10.145,P=0.015)是PFS独立的不良预后因素,Ann Arbor分期(HR=4.812,95%CI=1.389~16.679,P=0.013)和国际预后指数评分(HR=0.308,95%CI=0.109~0.870,P=0.026)是OS独立的不良预后因素。GDPT方案组患者的总反应率、PFS率和OS率明显高于CHOP方案组(P=0.033、0.011、0.042)。结论Ann Arbor分期和IPI评分是影响PFS和OS的预后因素,GDPT是一种具有前景的新方案,有望成为PTCL的一线疗法。

关键词：外周T细胞淋巴瘤预后因素 IPI评分