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掺杂复合凝胶对棉织物的导电整理与性能表征

上海纺织科技 2022年第7期50卷 56-58页

作者：郭琦路佳仪东北师范大学美术学院吉林长春130117

探讨了利用对甲苯磺酸钠掺杂微晶纤维素与吡咯复合凝胶对棉织物进行整理,改善棉织物的导电性能。测试结果表明,棉织物表面出现结块现象,说明复合凝胶在一定程度上起到了增塑作用,使织物断裂强力增加,断裂伸长率、折皱回复角下降。选择0.... 详细信息

探讨了利用对甲苯磺酸钠掺杂微晶纤维素与吡咯复合凝胶对棉织物进行整理,改善棉织物的导电性能。测试结果表明,棉织物表面出现结块现象,说明复合凝胶在一定程度上起到了增塑作用,使织物断裂强力增加,断裂伸长率、折皱回复角下降。选择0.8 mol/L的对甲苯磺酸钠整理棉织物,其导电性能改善效果较好,且在空气中导电性稳定,但应合理控制使用环境温度。

关键词：棉织物整理掺杂导电性能微观形貌环境稳定性服用性能

数字化堆积导板中截骨导板引导后截骨量的即刻精度研究

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华西口腔医学杂志 2021年第6期39卷 732-738页

作者：卢嘉仪余嘉怡解晨阳高静于海洋口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔修复科成都610041

目的初步评价数字化堆积导板中截骨导板引导后截骨量的即刻精度。方法选择2018年11月-2020年1月于四川大学华西口腔医院修复科就诊的4例无牙颌患者,所有患者符合即刻种植即刻修复的设计条件,由于患者的骨平面上的目标修复体空间不足,种... 详细信息

目的初步评价数字化堆积导板中截骨导板引导后截骨量的即刻精度。方法选择2018年11月-2020年1月于四川大学华西口腔医院修复科就诊的4例无牙颌患者,所有患者符合即刻种植即刻修复的设计条件,由于患者的骨平面上的目标修复体空间不足,种植方案设计包含术中截骨,根据患者术前锥形束CT(CBCT)数据,结合患者数字微笑设计(DSD)分析、虚拟蜡型设计等,进行目标骨平面的预先虚拟设计,制作并三维打印集截骨导板、种植导板及临时修复体于一体的数字化堆积导板,以期指导术中精确截骨、正确位点种植和上部即刻修复。术中在数字化堆积导板中截骨导板的引导下,进行截骨操作。对比所有患者的术前、术后CBCT,计算实际截骨与预设截骨的体积偏差、位移偏差和角度偏差。结果4例患者术后截骨与预设截骨的体积偏差量平均值为492.94 mm³,占预设截骨体积的21.21%;位移偏差值平均值为0.0248 mm,位移偏差量的散点集中趋势显著;角度偏差平均为6.03°。结论数字化堆积导板中截骨导板引导下进行种植固定修复过程中的截骨操作,实际截骨骨量、骨平面角度与预先设计一致性程度较好,是一种值得推广的精准可量化的临床技术。

关键词：数字化堆积导板种植固定修复骨面目标修复空间高度

基于Pareto最优的江苏省土地利用最佳集约度研究

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中国农业资源与区划 2019年第3期40卷 136-145页

作者：鲁嘉颐方斌李欣南京师范大学地理科学学院南京师范大学新型城镇化与土地问题研究中心江苏省地理信息资源开发与利用协同创新中心江苏省物质循环与污染控制重点实验室

[目的]为避免土地粗放利用或过度利用,实现最佳土地利用效率提供科学依据。[方法]基于"Pareto最优"思想,以江苏省55个县域单元为研究区,建立土地集约利用水平与经济、社会、生态效益关系的曲线估计模型,利用LINGO软件求解多目标规划模型... 详细信息

[目的]为避免土地粗放利用或过度利用,实现最佳土地利用效率提供科学依据。[方法]基于"Pareto最优"思想,以江苏省55个县域单元为研究区,建立土地集约利用水平与经济、社会、生态效益关系的曲线估计模型,利用LINGO软件求解多目标规划模型的"理想点",得到土地利用的最佳集约度,并划分不同程度土地利用集约区。[结果](1)在2015年末的社会经济技术条件下,苏南、苏中、苏北土地利用最佳集约度分别为6 287. 96 (万元/km2)、4 944. 00 (万元/km2)、2 954. 70 (万元/km2)。(2)总体上,研究区的地区经济水平与土地集约利用水平、土地利用最佳集约度呈正相关。(3)存在低度、中度集约区的经济、社会产出效益超过理想值,高度集约区的社会产出效益低于理想值的综合效益失衡现象。[结论]研究运用多目标规划模型的"理想点"法求解土地集约利用产出效益问题的Pareto最优解,较好地处理了最佳集约度难以定量求解的问题,对我国县域城市土地集约利用具有指导意义。

关键词：土地集约利用最佳集约度 Pareto最优多目标规划江苏省

The efficacy of a novel tomato extracts formulation on skin aging and pigmentation:A randomized,double-blind,parallel-controlled trial

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Journal of dermatologic science and cosmetic technology

Journal of dermatologic science and cosmetic technology 2024年第1期1卷 13-20页

作者： Silu Zhang Shan lu Yun Wang jiayi Ni Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering Co.Ltd.Shenzhen 518116China Department of Dermatology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Sprim(China)Consulting Co.Ltd. Shanghai 201201China

Background:Oxidative stress is a significant factor in skin aging and pigmentation,which can be precipitated by various *** and tyrosinase inhibitors,such as carotenoids,yeast extract(glutathione),sodium hyaluronate,astaxanthin,and niacin,can individually protect the skin against aging through distinct *** mechanisms potentially enhance the skin barrier and improve signs of aging and ***,the synergistic effects of these compounds,as found in a golden tomato extract formulation,have been scarcely ***:To evaluate the effects of an orally administered formulation on the skin aging and *** and Methods:In this study,a randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLAB?Tomato Niacinamide *** of all participants,62 volunteers completed the experiment and were included in the statistical ***:The results indicated that after eight weeks of consuming the research product,there were no significant changes in the skin indicators within the placebo *** contrast,the treatment group receiving the sample formulation exhibited a 35.63%increase in stratum corneum hydration and a 29.39%reduction in transepidermal water loss(TEWL),suggesting enhanced skin *** assessments revealed improvements in skin color and gloss index by 15.03%and 11.41%,respectively,in the treatment ***,the skin gloss and individual typology angle(ITA)value increased by 18.59%and 6.36%,respectively,leading to a lighter skin *** enhancements were also observed in skin pigmentation,color uniformity,and *** eight weeks of intervention with the sample,blood levels of superoxide dismutase(SOD)and glutathione peroxidase(GPx)increased,while malondialdehyde(MDA)levels ***:These findings confirm that continuous intake of the tomato extract formulation over eight weeks effectively improved the volunteers'skin w

关键词： Skin whitening Skin aging Antioxidant Gold tomato extracts Combination effect

Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 136-152页

作者： Xiaoju Guo Xiaoxiao Chen jiayi Ding Feng Zhang Shunyang Chen Xin Hu Shiji Fang Lin Shen Chenying lu Zhongwei Zhao Jianfei Tu Gaofeng Shu Minjiang Chen Jiansong Ji Lishui Central Hospital Shaoxing UniversityShaoxing 312000China Zhejiang Key Laboratory of Imaging and Interventional Medicine Imaging Diagnosis and Interventional Minimally Invasive InstituteThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000China Clinical College of The Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000China Key Laboratory of Precision Medicine of Lishui Lishui 323000China

Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strongly restricted by the acidic and hypoxic tumor environment. Herein, we have successfully formulated PLGA-based nanoparticles concurrently loaded with doxorubicin (DOX), hemoglobin (Hb) and CaCO3 by a CaCO3-assisted emulsion method, aiming at the effective treatment of TNBC. We found that the obtained nanomedicine (DHCaNPs) exhibited effective drug encapsulation and pH-responsive drug release behavior. Moreover, DHCaNPs demonstrated robust capabilities in neutralizing protons and oxygen transport. Consequently, DHCaNPs could not only serve as oxygen nanoshuttles to attenuate tumor hypoxia but also neutralize the acidic tumor microenvironment (TME) by depleting lactic acid, thereby effectively overcoming the resistance to chemotherapy. Furthermore, DHCaNPs demonstrated a notable ability to enhance antitumor immune responses by increasing the frequency of tumor-infiltrating effector lymphocytes and reducing the frequency of various immune-suppressive cells, therefore exhibiting a superior efficacy in suppressing tumor growth and metastasis when combined with anti-PD-L1 (αPD-L1) immunotherapy. In summary, this study highlights that DHCaNPs could effectively attenuate the acidic and hypoxic TME, offering a promising strategy to figure out an enhanced chemo-immunotherapy to benefit TNBC patients.

关键词： CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy

Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia

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Food Science and Human Wellness 2024年

作者： Jiaojiao Han jiayi Xiong Zhixiang Bai Yang Qin Chenyang lu Jun Zhou Ye Li Tinghong Ming Zhen Zhang Xiurong Su State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products， Ningbo University School of Marine Science， Ningbo University

Iron deficiency anemia (IDA) is a nutritional deficiency disease with a high incidence rate worldwide. Bioactive peptides are safe and effective， have multiple functions and can serve as potential candidates for alleviating IDA. In this study， the anti-anemia effects of tuna dark muscle peptides were explored in a diet-induced IDA mouse model. The results showed that tuna dark muscle peptides alleviated the IDA phenotype， oxidative stress and iron metabolism. In addition， tuna dark muscle peptides reversed gut microbiota dysbiosis in IDA mice. Furthermore， the transplanted fecal microbiota from tuna dark muscle peptide-treated mice also alleviated IDA symptoms and regulated iron metabolism and the gut microbiota， indicating that the anti-anemic effects were at least partially mediated by the gut microbiota. Thus， we identified a new and safe prebiotic material to alleviate IDA and provided ideas for the development of peptides. At the same time， these data also provided a theoretical basis for fecal microbiota transplantation (FMT) to alleviate IDA.

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安第斯国家矿业法律特点及对中国企业矿业投资的影响

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地质通报 2017年第12期36卷 2332-2343页

作者：卢佳义赵宏军朱小三国浩律师(北京)事务所北京100026 中国地质调查局发展研究中心北京100037 中国地质科学院地质研究所北京100037

针对中国企业在安第斯地区矿业投资日益增多的现状,在分析研究安第斯国家矿业法律特点的基础上,评述了各国的矿业投资环境,并结合中国企业在该地区矿业投资存在的问题与经验教训,从防范法律风险的角度,提出了中资企业在安第斯地区矿业... 详细信息

针对中国企业在安第斯地区矿业投资日益增多的现状,在分析研究安第斯国家矿业法律特点的基础上,评述了各国的矿业投资环境,并结合中国企业在该地区矿业投资存在的问题与经验教训,从防范法律风险的角度,提出了中资企业在安第斯地区矿业投资中应注意的五点问题:一是重视项目前期尽职调查;二是妥善处理社区问题,实现互利共赢发展;三是正确处理好劳资关系;四是要防范法律变动风险;五是发挥好中国律师在矿业投资中的作用。为降低中国企业在该地区的矿业投资风险提供了相关信息和指导意见。

关键词：安第斯国家矿业法律中国企业矿业投资

Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women

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Journal of dermatologic science and cosmetic technology

Journal of dermatologic science and cosmetic technology 2024年第2期1卷 26-37页

作者： Shan lu Silu Zhang Yun Wang jiayi Ni Tiantian Zhao Guoxun Xiao Wonderlab Innovation Centre for Healthcare Shenzhen Porshealth Bioengineering CoLtd.Shenzhen 518116China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural affairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhouGuangdong 510610China Department of Dermatology Shanghai Ninth People‘s HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Sprim(China)Consulting Co.Ltd. Shanghai 201201China e Department of Food Science Rutgers UniversityNew BrunswickNJ 08901United States

Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging *** positive results in animal models,the combination effects of CP and EP and the bioavailability of CP in human studies,particularly in young and middle-aged women,remain ***:To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged *** and Methods:A single-center,randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLABR fish collagen tripeptide *** consumed the drink over an 8-week ***:Compared to the placebo group,the collagen drink group showed significant improvements in skin hydration(39.19%increase),transepidermal water loss(33.45%decrease),skin elasticity(25.37%increase),dermal collagen content(21.64%increase),pore size(7.94%decrease),wrinkle length(18.09%decrease),skin smoothness(2.85%improvement),and skin roughness(15.32%decrease).Overall pore volume decreased by 60%,and visual assessments indicated a decrease in skin luminosity by 15.20%and smoothness index by 22.55%.Mass spectrometry demonstrated a significant increase in collagen efficacy components,including blood pH and GPH levels(Plusion:The study confirmed the combination nourishing and anti-skin aging effects of EP and CP on the skin of young and middle-aged women,demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides.

关键词： Collagen tripeptides Elastin peptides Anti-aging Skin protection Peptide absorption

基于七融合的《基础会计》活页式教材设计与开发

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北京工业职业技术学院学报 2023年第3期22卷 94-99页

作者：卢嘉怡陕西国防工业职业技术学院西安710300

为加快职教改革步伐、完善高水平教育教学体系,对《基础会计》活页式教材的设计与开发进行了研究。基于对传统《基础会计》教材使用现状的分析,提出基于德技融合、产教融合、理实融合、学评融合、赛教融合、课证融合、纸数融合的活页式... 详细信息

为加快职教改革步伐、完善高水平教育教学体系,对《基础会计》活页式教材的设计与开发进行了研究。基于对传统《基础会计》教材使用现状的分析,提出基于德技融合、产教融合、理实融合、学评融合、赛教融合、课证融合、纸数融合的活页式教材设计思路。进而,从构建活页式教材开发路径、按照岗位职责重构教学内容、依据工作流程编排教材结构、建设配套立体化数字资源、进行活页式装订等方面进行基于七融合的《基础会计》活页式教材开发实践。

关键词：七融合开发理念基础会计活页式教材开发实践