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Arginine methylation of ALKBH5 by PRMT6 promotes breast tumorigenesis via LDHA-mediated glycolysis

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Frontiers of Medicine 2024年第2期18卷 344-356页

作者： Xue Han Chune Ren Aifang Jiang Yonghong Sun jiayi lu Xi Ling Chao lu Zhenhai Yu Department of Reproductive Medicine Affiliated Hospital of Weifang Medical UniversityWeifang261053China Department of Pathology Affiliated Hospital of Weifang Medical UniversityWeifang261053China

ALKBH5 is a master regulator of N6-methyladenosine(m6A)modification,which plays a crucial role in many biological ***,we show that ALKBH5 is required for breast tumor ***,PRMT6 directly methylates ALKBH5 at R283,which subsequently promotes breast tumor ***,arginine methylation of ALKBH5 by PRMT6 increases LDHA RNA stability via m6A demethylation,leading to increased aerobic ***,PRMT6-mediated ALKBH5 arginine methylation is confirmed in PRMT6-knockout ***,these findings identify a PRMT6-ALKBH5-LDHA signaling axis as a novel target for the treatment of breast cancer.

关键词： PRMT6 ALKBH5 N6-methyladenosine glycolysis tumor growth

Surface air temperature change in the Wuyi Mountains,southeast China

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Journal of Mountain Science 2024年第6期21卷 1992-2004页

作者： QIN Yihui WEI Yuxing lu jiayi MAO Jiahui CHEN Xingwei GAO lu CHEN Ying LIU Meibing DENG Haijun Institute of Geography Fujian Normal UniversityFuzhou 350117China National Demonstration Center for Experimental Geography Education Fujian Normal UniversityFuzhou 350117China School of Geographical Science Fujian Normal UniversityFuzhou 350117China Fujian Provincial Engineering Research Center for Monitoring and Assessing Terrestrial Disasters Fujian Normal UniversityFuzhou 350117China Laboratory for Humid Subtropical Eco-geographical Processes of the Ministry of Education Fujian Normal UniversityFuzhou 350117China

Detecting changes in surface air temperature in mid-and low-altitude mountainous regions is essential for a comprehensive understanding of warming trend with *** use daily surface air temperature data from 64 meteorological stations in Wuyi Mountains and its adjacent regions to analyze the spatio-temporal patterns of temperature *** results show that Wuyi Mountains have experienced significant warming from 1961 to *** warming trend of the mean temperature is 0.20℃/decade,the maximum temperature is 0.17℃/decade,and the minimum temperature is 0.26℃/*** 1961-1990,more than 63%of the stations showed a decreasing trend in annual mean temperature,mainly because the maximum temperature decreased during this ***,in 1971-2000,1981-2010 and 1991-2018,the maximum,minimum and mean temperatures *** fastest increasing trend of mean temperature occurred in the southeastern coastal plains,the quickest increasing trend of maximum temperature occurred in the northwestern mountainous region,and the increase of minimum temperature occurred faster in the southeastern coastal and northwestern mountainous regions than that in the central ***,this study suggests that elevation does not affect warming in the Wuyi *** results are beneficial for understanding climate change in humid subtropical middle and low mountains.

关键词： Climate change Surface air temperature Temporal and spatial changes Mann-Kendall nonparametric test Wuyi Mountains

Charting epimutation dynamics in human hematopoietic differentiation Xiaohuan Qina

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Blood Science 2024年第3期6卷 1-10页

作者： jiayi lu Peng Wu Chunyong Zhang Lei Shi Ping Zhu State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemDepartment of Stem Cell and Regenerative MedicineInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeTianjinChina The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesTianjin Medical UniversityTianjinChina

DNA methylation plays a critical role in hematopoietic *** is a stochastic variation in DNA methylation that induces epigenetic ***,the effects of epimutations on normal hematopoiesis and hematopoietic diseases remain *** this study,we developed a Julia package called EpiMut that enabled rapid and accurate quantification of *** was used to evaluate and provide an epimutation landscape in steady-state hematopoietic differentiation involving 13 types of blood cells ranging from hematopoietic stem/progenitor cells to mature *** showed that substantial genomic regions exhibited epigenetic variations rather than significant differences in DNA methylation levels between the myeloid and lymphoid *** dynamics of epimutations were observed during the differentiation of each ***,we found that epimutation significantly enriched signals associated with lineage ***,epimutations in hematopoietic stem cells(HSCs)derived from various sources and acute myeloid leukemia were related to the function of HSCs and malignant cell *** together,our study comprehensively documented an epimutation map and uncovered its important roles in human hematopoiesis,thereby offering insights into hematopoietic regulation.

关键词： DNA methylation Epimutation Hematopoietic differentiation Hematopoietic stem cell

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注意缺陷多动障碍的父母培训临床实践进展

中华儿科杂志 2024年第5期62卷 478-481页

作者：陆佳怡马骏上海交通大学医学院附属上海儿童医学中心发育行为儿科上海200127

注意缺陷多动障碍(ADHD)的临床干预方法主要为药物治疗与行为治疗。父母培训包含了心理教育、行为治疗等内容,通常作为ADHD患儿进入治疗的第一步,并且贯穿全治疗过程。父母培训在不同的治疗阶段起到相应辅助作用,对于药物干预的具体实... 详细信息

注意缺陷多动障碍(ADHD)的临床干预方法主要为药物治疗与行为治疗。父母培训包含了心理教育、行为治疗等内容,通常作为ADHD患儿进入治疗的第一步,并且贯穿全治疗过程。父母培训在不同的治疗阶段起到相应辅助作用,对于药物干预的具体实施也有着一定的积极意义。本文将对父母培训的目的、具体内容及实证性研究进行综述,并总结相关培训计划的实践进展。

关键词：注意缺陷多动障碍父母培训临床干预临床实践 ADHD 药物干预实证性研究药物治疗

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重塑记忆:“黄河”舞蹈话语的书写与诠释

艺术传播研究 2024年第3期 132-144页

作者：陆佳漪上海体育大学艺术学院

“黄河”舞蹈话语是中华民族共同体的“动觉符号系统”的重要组成部分。乡土与革命是“黄河”舞蹈话语反复书写的两大主题,前者促成了“黄河派”舞蹈艺术创作,后者推动了“黄河主题”舞蹈艺术创作。“黄河”舞蹈话语受到中华民族社会框... 详细信息

“黄河”舞蹈话语是中华民族共同体的“动觉符号系统”的重要组成部分。乡土与革命是“黄河”舞蹈话语反复书写的两大主题,前者促成了“黄河派”舞蹈艺术创作,后者推动了“黄河主题”舞蹈艺术创作。“黄河”舞蹈话语受到中华民族社会框架、同质性认知及表征符号系统的制约,它基于时空关联、群体关联和可重构性三个维度,立足当下,重塑集体记忆,从政治与文化两个方面助力构建中华民族的国族认同。按照“黄河”舞蹈话语铸牢中华民族共同体意识的实践逻辑来看,它在时代语境中以动觉符号具象化了集体记忆,在艺术创作中以行动实践诠释了社会意义,进而可以为中国故事的表征赋能,为铸牢中华民族共同体意识的进程提质增效。

关键词： “黄河”舞蹈话语集体记忆国族认同记忆重塑动觉符号

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福建省前后汛期极端降水危险性的空间差异

中国水土保持科学 2024年第2期22卷 34-43页

作者：卢嘉怡陈艺倩陈兴伟邓海军福建师范大学地理科学学院福州350007 地理学国家级实验教学示范中心(福建师范大学) 福州350007 福建师范大学数学与统计学院福州350007 福建省陆地灾害监测评估工程技术研究中心福州350007

受台风与季风降水的不同影响,我国东南沿海地区前后汛期极端降水差异显著。为揭示该区域前后汛期极端降水危险性的差异,以福建省为典型区,应用熵权-CRITIC组合权重模型赋权的TOPSIS方法,选取最大1 d降水量、最大连续5d降水量、降水强度... 详细信息

受台风与季风降水的不同影响,我国东南沿海地区前后汛期极端降水差异显著。为揭示该区域前后汛期极端降水危险性的差异,以福建省为典型区,应用熵权-CRITIC组合权重模型赋权的TOPSIS方法,选取最大1 d降水量、最大连续5d降水量、降水强度、暴雨时间和强降水量等5项代表性指标,分别对25个气象站点1960—2020年的前后汛期极端降水危险性进行评价。结果表明:1)福建省前汛期极端降水危险性指数总体较高,呈现自东部沿海向西北山区递增的趋势;后汛期极端降水危险性总体较低,呈现自东部沿海向西北山区递减的趋势;2)福建省前后汛期极端降水危险性指数差异大,可分为前汛期显著型站点14个、前后汛期相当型站点6个和后汛期显著型站点5个。因此,区分前后汛期并分别进行极端降水危险性评价,能够更合理地揭示区域极端降水危险性及其空间变化的规律,为区域防汛抗涝、水土保持等工作提供科技支撑。

关键词：极端降水危险性前后汛期空间变化 TOPSIS 福建省

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A New Paradigm for Simulating and Forecasting China's Economic Growth in the Medium and Long Term

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Chinese Geographical Science 2022年第1期32卷 64-78页

作者： SUN Dongqi lu jiayi Key Laboratoty of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Taking the system philosophy of human-earth relationship as the theoretical axis,and under the three-dimensional goals of economic growth,social development,and protection of the ecological environment,this paper constructs the supporting system of China’s economic *** this basis,guided by the basic principles of system theory and system dynamics,and combined with the theories of other related disciplines,we constructed an economic geography-system dynamics(EG-SD)integrated forecasting model to simulate and quantitatively forecast China’s economic growth in the medium and long ***’s economic growth will be affected by quantifiable and unquantifiable *** the main unquantifiable factors are not taken into account in the simulation and prediction of China’s economic growth in the medium and long term,the accuracy and objectivity of the prediction results will be ***,based on situation analysis(Strengths,Weaknesses,Opportunities,and Threats,SWOT),we combined scenario analysis with the Delphi method,and established a qualitative prediction simulation model(referred to as the S-D compound prediction model)to make up for the shortcomings associated with quantitative simulation ***-SD and S-D are organically combined to construct a simulation and prediction paradigm of China’s economic growth in the medium and long *** paradigm not only realizes the integration of various forecasting methods and the combination of qualitative and quantitative measures,but also realizes the organic combination of unquantifiable and quantifiable elements by innovatively introducing fuzzy simulation of system dynamics,which renders the simulation and prediction results more objective and accurate.

关键词： economic growth simulation and prediction prediction model fuzzy simulation paradigm

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PPP养老项目审计方法与应用研究

湖南人文科技学院学报 2024年第3期41卷 50-56页

作者：严长远卢嘉怡陕西国防工业职业技术学院经济管理学院陕西西安710300

随着人口老龄化加剧,仅仅利用财政资金已不能满足养老服务多样化的需求,为此,亟需将PPP模式引入养老项目。基于PPP养老项目特征,必须对其进行严格审计才能确保养老事业可持续发展。但是,传统PPP养老项目审计存在科学性不足、自我完善体... 详细信息

随着人口老龄化加剧,仅仅利用财政资金已不能满足养老服务多样化的需求,为此,亟需将PPP模式引入养老项目。基于PPP养老项目特征,必须对其进行严格审计才能确保养老事业可持续发展。但是,传统PPP养老项目审计存在科学性不足、自我完善体系缺失、监管不够、风险意识薄弱等问题,审计效果有待提升。基于此,设计依托区块链视角、全生命周期、全过程跟踪的大数据审计方案,实现对PPP养老项目深度审计,进而促进PPP养老项目规范运行,最终实现养老产业健康发展。

关键词：养老服务业 PPP养老项目审计方法

含DOPO/吲哚的磺胺类化合物的合成及阻燃环氧树脂

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高分子材料科学与工程 2024年第3期40卷 56-65页

作者：许文迪陆嘉怡蔡博禹王璐泽罗钟琳王标兵常州大学材料科学与工程学院江苏常州213164

以吲哚-3-甲醛、磺胺胍和9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物(DOPO)为原料,合成了一种含DOPO/吲哚的磺胺类化合物(SIAD),并制备了环氧树脂(EP)/SIAD复合材料。加入6%SIAD后,EP/SIAD-6复合材料通过UL-94 V-0等级测试,LOI值提升至32%,... 详细信息

以吲哚-3-甲醛、磺胺胍和9,10-二氢-9-氧杂-10-磷杂菲-10-氧化物(DOPO)为原料,合成了一种含DOPO/吲哚的磺胺类化合物(SIAD),并制备了环氧树脂(EP)/SIAD复合材料。加入6%SIAD后,EP/SIAD-6复合材料通过UL-94 V-0等级测试,LOI值提升至32%,其峰值放热率(535 kW/m^(2))、总热释放(64.2 MJ/m^(2))和平均有效燃烧热(18.1 MJ/kg)值较纯EP分别下降了37.3%,33.6%和22.5%,呈现出良好的火灾安全性。SIAD通过释放出含磷自由基和不可燃性气体等起到气相阻燃作用,同时通过促进形成致密的连续炭层在凝聚相中起到阻燃作用。

关键词：环氧树脂阻燃机理磺胺类化合物