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Human neural stem cell-derived extracellular vesicles protect against ischemic stroke by activating the PI3K/AKT/mTOR pathway

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Neural Regeneration Research 2025年第11期20卷 3245-3258页

作者： jiayi wang Mengke Zhao Dong Fu Meina wang Chao Han Zhongyue Lv Liang wang Jing Liu Stem Cell Clinical Research Center The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cell and Precision Medicine DalianLiaoning ProvinceChina Institute(College)of Integrative Medicine Dalian Medical UniversityDalianLiaoning ProvinceChina

Human neural stem cell-derived extracellular vesicles exhibit analogous functions to their parental cells,and can thus be used as substitutes for stem cells in stem cell therapy,thereby mitigating the risks of stem cell therapy and advancing the frontiers of stem cell-derived *** lays a foundation for the development of potentially potent new treatment modalities for ischemic ***,the precise mechanisms underlying the efficacy and safety of human neural stem cell-derived extracellular vesicles remain unclear,presenting challenges for clinical *** promote the translation of therapy based on human neural stem cell-derived extracellular vesicles from the bench to the bedside,we conducted a comprehensive preclinical study to evaluate the efficacy and safety of human neural stem cell-derived extracellular vesicles in the treatment of ischemic *** found that administration of human neural stem cell-derived extracellular vesicles to an ischemic stroke rat model reduced the volume of cerebral infarction and promoted functional recovery by alleviating neuronal *** human neural stem cell-derived extracellular vesicles reduced neuronal apoptosis by enhancing phosphorylation of phosphoinositide 3-kinase,mammalian target of rapamycin,and protein kinase B,and these effects were reversed by treatment with a phosphoinositide 3-kinase *** findings suggest that human neural stem cell-derived extracellular vesicles play a neuroprotective role in ischemic stroke through activation of phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin signaling ***,we showed that human neural stem cell-derived extracellular vesicles have a good in vivo safety ***,human neural stem cell-derived extracellular vesicles are a promising potential agent for the treatment of ischemic stroke.

关键词： behavior exosome extracellular vesicles ischemic stroke mammalian target of rapamycin(mTOR) middle cerebral artery occlusion neural stem cells neuronal apoptosis phosphoinositide 3-kinase(PI3K) protein kinase B(AKT)

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A Feed-Forward Wavelet Neural Network Adaptive Observer-Based Fault Detection Technique for Spacecraft Attitude Control Systems

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Chinese Journal of Electronics 2018年第1期27卷 102-108页

作者： WEN Xin wang jiayi LI Xin College of Astronautics Nanjing University of Aeronautics and Astronautics Shanghai Aerospace Control Technology Institute College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

This paper presents a novel neural network-based fault detection technique applicable to a class of nonlinear systems. The adaptive observer was designed for fault detection based on a single hidden layer feed-forward wavelet neural network. In order to guarantee network convergence, the network weights are updated according to a modified back-propagation algorithm, and the Lyapunov function is introduced to ensure *** proposed fault detection scheme was tested on the actuators of a typical spacecraft attitude control system, and the results demonstrated the effectiveness and feasibility of the proposed observer in detecting nonlinear system failure.

关键词： Single hidden layer feed-forward wavelet neural network Fault detection Nonlinear system Adaptive observer

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Global Governance in Cyberspace: Process,Conflict and China’s Proposals

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学术界 2020年第6期 226-234页

作者： wang jiayi School of Cyber Security and Information Law Chongqing University of Posts and Telecommunications Chongqing 400065

In recent years,problems such as cyber warfares,cyber espionages and cyber crimes have become global public nuisances and always challenge the authority of the sovereign states. Therefore,the governance of the derivative problems concerning the global cyberspace has become an issue of importance in the international law. To overcome these challenges,sovereign states begin to get involved in cyberspace and seek international cooperation,so as to promote the evolution of the international rule of law in cyberspace. Currently,the cyberspace is filled with contradictions and conflicts. The cyber hegemonic states monopolize basic resources for cyberspaces,and their liberalism of double standards is the best tool to maintain their centralized and dominant situations. Moreover,the differences on governance problems between different camps leads to the significant institutional supply shortage. Accordingly,as a responsible power,China should advocate the Chinese solution and wisdom so as to create the reform of global cyberspace governance system. Possible specific measures include clarifying the governance structure of sovereign state-orientation,adhering to the model of shared governance with multilateral approach and multi-party participation.

关键词： cyberspace global governance sovereign state international rule of law

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Tracking lithiation with transmission electron microscopy

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Science China Chemistry 2024年第1期67卷 291-311页

作者： Xincheng Lei Jianxiong Zhao jiayi wang Dong Su Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China South China Academy of Advanced Optoelectronics&International Academy of Optoelectronics at Zhaoqing South China Normal UniversityGuangzhou 510006China

Li-ion batteries(LIBs)have dominated energy-storage techniques for portable electronic devices and electric cars,and are expanding their territory into the large-scale energy *** energy storage of LIBs is realized by the reversible shuttle of lithium ions between *** is essential to track the lithium diffusion and obtain a profound insight into the lithiation mechanism during the work cycle of *** electron microscopy(TEM)is a powerful tool for the structural characterization,which can provide the information about the lithiation at the atomic *** this review,we summarize the research frontiers of TEM applications on *** introduce the techniques for the direct observation of Li species in LIB-related ***,the application of cryo-TEM is ***,in-situ TEM technique is further discussed since it shows great advantages in studying the dynamical structure changes of *** perspectives and strategies in this review offer feasible guidance for researchers to further improve the performance of LIBs.

关键词： lithium-ion battery electrode materials transmission electron microscopy cryo-TEM in-situ TEM

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Mechanical-Hydraulic Co-Simulation of Full Hydraulic Articulated Steering System

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Computer Systems Science & Engineering 2021年第6期37卷 381-398页

作者： jiayi wang Xinhui Liu Jinshi Chen Tongjian wang Xin wang School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130022China

With the development and improvement of the hydraulic steering system,the articulated steering system became the research focus of numerous domestic and foreign *** full hydraulic steering system with a compact structure and ease of operation,is widely used in articulated steering ***,its performance can directly impact the steering sensitivity and *** paper studies the working principle and actual structure of the priority valve and the steering control valve,which are very *** setting up a mathematic model,the system’s load-sensing characteristics and the impact of steering control valve bypass throttle damping on steering stability can be *** Hydraulic Components Design(HCD)model was established for the hydraulic part of this *** is proved that the model can reflect the system’s actual properties by comparing simulation and experimental *** dynamic model is based on its actual prototype parameters by taking the tire and ground forces into *** steering process’s dynamic characteristics are co-simulated in the 1D+3D system model by combining AMESim and *** *** simulation results show that the system’s load-sensing characteristics ensure the sensitivity of the steering operation,and the bypass throttle damping has significantly improved the operation stability and lowered down the cylinder pressure *** can improve the system performance by appropriate optimization.

关键词： Articulated vehicle full hydraulic steering system load-sensing steering

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Emerging roles of exosomes in oral diseases progression

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International Journal of Oral Science 2024年第1期16卷 36-51页

作者： jiayi wang Junjun Jing Chenchen Zhou Yi Fan State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Oral diseases, such as periodontitis, salivary gland diseases, and oral cancers, significantly challenge health conditions due to their detrimental effects on patient's digestive functions, pronunciation, and esthetic demands. Delayed diagnosis and non-targeted treatment profoundly influence patients' prognosis and quality of life. The exploration of innovative approaches for early detection and precise treatment represents a promising frontier in oral medicine.

关键词： diseases diagnosis salivary

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Tail Distortion Risk Measure for Portfolio with Multivariate Regularly Variation

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Communications in Mathematics and Statistics 2022年第2期10卷 263-285页

作者： Yu Chen jiayi wang Weiping Zhang Department of Statistics and Finance University of Science and Technology of ChinaHefei 230026China

For the multiplicative background risk model,a distortion-type risk measure is used to measure the tail risk of the portfolio under a scenario probability measure with multivariate regular *** this paper,we investigate the tail asymptotics of the portfolio loss ∑_(i=1)^(d)R_(i)S,where the stand-alone risk vector R=(R_(1),...,R_(d))follows a multivariate regular variation and is independent of the background risk factor *** explicit asymptotic formula is established for the tail distortion risk measure,and an example is given to illustrate our obtained results.

关键词： Background risk model Tail distortion risk measure Multivariate regular variation

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The Mechanisms and Applications of Quorum Sensing(QS) and Quorum Quenching(QQ)

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Journal of Ocean University of China 2019年第6期18卷 1427-1442页

作者： ZHANG Jingjing FENG Tao wang jiayi wang Yan ZHANG Xiao-Hua College of Marine Life Sciences Ocean University of ChinaQingdao 266003China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China

Quorum sensing(QS)is a regulatory system that regulates the behavior of microbial populations by sensing the concentration of signal molecules that are spontaneously produced and released by *** strategy of blocking the QS system and inhibiting the production of virulence factors is termed as quorum quenching(QQ).This strategy attenuates virulence without killing the pathogens,thereby weakening the selective pressure on pathogens and postponing the evolution of QQ-mediated drug *** recent years,there have been significant theoretical and practical developments in the field of QS and *** particular,with the development and utilization of marine resources,more and more marine microbial species have been found to be regulated by these two mechanisms,further promoting the research progress of QS and *** this review,we described the diversity of QS signals and QS-related regulatory systems,and then introduced mechanisms related to QS interference,with particular emphasis on the description of natural QQ enzymes and chemicals acting as QS ***,the exploitation of quorum sensing quenchers and the practical application of QQ were introduced,while some QQ strategies were proposed as promising tools in different fields such as medicine,aquaculture,agriculture and biological pollution prevention areas.

关键词： quorum sensing quorum quenching marine microorganisms antibiotic resistance

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Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

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Chinese Chemical Letters 2018年第6期29卷 977-980页

作者： Haiyang Sun Hui Li jiayi wang Gonghua Song Shanghai Key Laboratory of Chemical Biology School of Pharmacy East China University of Science and Technology

Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita（M. incognita）. While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 mmol/L.

关键词： 5-HT Barettin Nature product Nematicidal activity Piperazinedione derivatives

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Dynamic changes in urban land spatial inequality under the core-periphery structure in urban agglomerations

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Journal of Geographical Sciences 2023年第4期33卷 760-778页

作者： FANG Xiaoqian SU Dan WU Qing wang jiayi ZHANG Yangjian LI Guoyu CAO Yu Department of Land Management School of Public AffairsZhejiang UniversityHangzhou 310058China Institute of Geographic Sciences and Natural Resources Research CASBeijing 100101China Department of Forestry and Natural Resources Purdue UniversityWest LafayetteIN 47907USA

Relatively coordinated development among cities can typically promote the integration of the whole urban agglomeration,while urbanization of land has been found important to economic development in developing *** studies have measured the urban land expansion in urban ***,urban land spatial inequality under a specific spatial structure remains poorly ***,we combined theβ-convergence model and the core-periphery structure to explore the dynamic changes in urban land spatial inequality in urban *** Yangtze River Delta Urban Agglomeration(YRDUA)in China was selected as the study *** of urban land have been applied in conjunction with a modified conditionalβ-convergence model,while the existence of the core-periphery structure was tested by analyzing coefficients of the control *** results show that although the spatial inequality of urban land area had decreased during 2000–2020,the whole YRDUA had still shown an obvious core-periphery *** with urban land area,the spatial inequality of urban land economic density and population density had decreased more rapidly,and the core-periphery structure was less *** findings can help to improve our current understanding of urban agglomeration and serve as a scientific reference for the coordinated development of urban agglomerations.

关键词： urban agglomeration urban expansion core-periphery structure convergence analysis spatial ine-quality

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