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中国麻风皮肤病杂志 2024年第10期40卷 749-753页

作者：彭嘉怡王洪生中国医学科学院、北京协和医学院皮肤病医院皮肤病研究所江苏南京210042

皮肤类器官是由多能干细胞分化形成的与皮肤成分和功能相似的结构。研究表明皮肤类器官可应用于研究皮肤疾病发病机制、药物筛选及皮肤损伤修复。本文就近年来皮肤类器官的构建方法及其在皮肤疾病研究及再生医学中的应用进行综述。

关键词：皮肤类器官三维多能干细胞再生医学

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慢性阻塞性肺疾病患者延续性护理研究进展

结核与肺部疾病杂志 2024年第3期5卷 254-259页

作者：屈春瑾彭佳怡刘鈊逸肖冠琛顾芬李楠楠上海交通大学护理学院上海200025 复旦大学附属华东医院护理部上海200040

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD;简称“慢阻肺”)是一种以持续存在的呼吸系统症状和气流受限为特征的呼吸系统疾病。随着人口老龄化和环境污染问题加剧,慢阻肺的患病率和死亡率不断上升。延续性护理作为... 详细信息

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD;简称“慢阻肺”)是一种以持续存在的呼吸系统症状和气流受限为特征的呼吸系统疾病。随着人口老龄化和环境污染问题加剧,慢阻肺的患病率和死亡率不断上升。延续性护理作为一种慢病管理的有效模式,通过定期随访、个性化教育和自我管理支持,实现由医院到社区、家庭护理的过渡。因此,研究慢阻肺的延续性护理对于改善患者的生活质量和预后具有重要意义。笔者对国内外慢阻肺患者延续性护理的发展现状、实施模式、干预研究等内容进行综述,旨在为发展适合中国国情的慢阻肺患者延续性护理提供参考。

关键词：肺疾病,慢性阻塞性护理综述文献(主题)

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Effect of Baroclinicity on Vortex Axisymmetrization. Part Ⅱ:Baroclinic Basic Vortex

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Advances in Atmospheric Sciences 2014年第6期31卷 1267-1278页

作者： jiayi peng Melinda S.peng Tim LI Eric HENDRICKS IMSG at Environmental Modeling Center NCEP/NOAA College Park Maryland USA Naval Research Laboratory Monterey California USA Department of Meteorology and IPRC University of Hawaii at Manoa Honolulu Hawaii USA

The effect of baroclinicity on vortex axisymmetrization is examined within a two-layer dynamical *** basic state vortices are constructed with varying degrees of baroclinicity：（i） barotropic,（ii） weak baroclinic,and （iii） strong *** linear and nonlinear evolution of wavenumber-2 baroclinic disturbances are examined in each of the three basic state *** results show that the radial propagating speed of the vortex Rossby wave at the lower level is larger with the stronger baroclinicity,resulting in a faster linear axisymmetrization process in the stronger baroclinic *** is found that the nonlinear axisymmetrization process takes the longest time in the strongest baroclinic vortex among the three different basic vortices due to the weaker kinetic energy transfer from asymmetric to symmetric circulations at the lower level.A major finding in this study is that the same initial asymmetric perturbation can have different effects on symmetric vortices depending on the initial vortex *** numerical weather prediction models,this implies that there exists a sensitivity of the subsequent structural and intensity change solely due to the specification of the initial vertical shear of the tropical cyclone vortex.

关键词： vortex axisymmetrization asymmetry baroclinicity

Effect of Baroclinicity on Vortex Axisymmetrization. Part Ⅰ:Barotropic Basic Vortex

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Advances in Atmospheric Sciences 2014年第6期31卷 1256-1266页

作者： Melinda S.peng jiayi peng Tim LI Eric HENDRICKS Naval Research Laboratory Monterey California USA IMSG at Environmental Modeling Center NCEP/NOAA College Park Maryland USA Department of Meteorology and IPRC University of Hawaii at Manoa Honolulu Hawaii USA

The barotropic and baroclinic disturbances axisymmetrized by the barotropic basic vortex are examined in an idealized modeling framework consisting of two *** a Wentzel-Kramers-Brillouin approach,the radial propagation of a baroclinic disturbance is shown to be slower than a barotropic disturbance,resulting in a slower linear axisymmetrization for baroclinic *** slower-propagating baroclinic waves also cause more baroclinic asymmetric kinetic energy to be transferred directly to the barotropic symmetric vortex than from barotropic disturbances,resulting in a faster axisymmetrization process in the nonlinear baroclinic wave case than in the nonlinear barotropic wave case.

关键词： vortex axisymmetrization asymmetry baroclinicity

Transcriptomic and cellular decoding of scaffolds-induced suture mesenchyme regeneration

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International Journal of Oral Science 2024年第2期16卷 306-321页

作者： jiayi Wu Feifei Li peng Yu Changhao Yu Chuyi Han Yitian Wang Fanyuan Yu Ling Ye State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Department of Pediatric Dentistry West China Hospital of StomatologySichuan UniversityChengduChina

Precise orchestration of cell fate determination underlies the success of scaffold-based skeletal *** extensive studies on mineralized parenchymal tissue rebuilding,regenerating and maintaining undifferentiated mesenchyme within calvarial bone remain very challenging with limited advances *** knowledge has evidenced the indispensability of rebuilding suture mesenchymal stem cell niches to avoid severe brain or even systematic *** to date,the absence of promising therapeutic biomaterials/scaffolds *** reason lies in the shortage of fundamental knowledge and methodological evidence to understand the cellular fate regulations of *** address these issues,in this study,we systematically investigated the cellular fate determinations and transcriptomic mechanisms by distinct types of commonly used calvarial *** data elucidated the natural processes without scaffold transplantation and demonstrated how different scaffolds altered in vivo cellular responses.A feasible scaffold,polylactic acid electrospinning membrane(PLA),was next identified to precisely control mesenchymal ingrowth and self-renewal to rebuild non-osteogenic suture-like tissue at the defect center,meanwhile supporting proper osteointegration with defect bony ***,transcriptome analysis and cellular mechanisms underlying the well-orchestrated cell fate determination of PLA were *** study for the first time cellularly decoded the fate regulations of scaffolds in suture-bony composite defect healing,offering clinicians potential choices for regenerating such complicated injuries.

关键词： injuries healing suture

Improving Multi-Model Ensemble Forecasts of Tropical Cyclone Intensity Using Bayesian Model Averaging

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Journal of Meteorological Research 2018年第5期32卷 794-803页

作者： Xiaojiang SONG Yuejian ZHU jiayi peng Hong GUAN Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting Center Environmental Modeling Center NOAA/NWS/NCEP I.M.Systems Group Inc. and NOAA/NWS/NCEP/EMC System Research Group Inc. Colorado Springs CO 80901 and NOAA/NWS/NCEP/EMC

This paper proposes a method for multi-model ensemble forecasting based on Bayesian model averaging （BMA）, aiming to improve the accuracy of tropical cyclone （TC） intensity forecasts, especially forecasts of minimum surface pressure at the cyclone center （Pmin）＇ The multi-model ensemble comprises three operational forecast models： the Global Forecast System （GFS） of NCEP, the Hurricane Weather Research and Forecasting （HWRF） models of NCEP, and the Integrated Forecasting System （IFS） of ECMWF. The mean of a predictive distribution is taken as the BMA forecast. In this investigation, bias correction of the minimum surface pressure was applied at each forecast lead time, and the distribution （or probability density function, PDF） of emin was used and transformed. Based on summer season forecasts for three years, we found that the intensity errors in TC forecast from the three models var-ied significantly. The HWRF had a much smaller intensity error for short lead-time forecasts. To demonstrate the proposed methodology, cross validation was implemented to ensure more efficient use of the sample data and more reliable testing. Comparative analysis shows that BMA for this three-model ensemble, after bias correction and distri-bution transformation, provided more accurate forecasts than did the best of the ensemble members （HWRF）, with a 5%-7% decrease in root-mean-square error on average. BMA also outperformed the multi-model ensemble, and it produced ＂predictive variance＂ that represented the forecast uncertainty of the member models. In a word, the BMA method used in the multi-model ensemble forecasting was successful in TC intensity forecasts, and it has the poten-tial to be applied to routine operational forecasting.

关键词： tropical cyclone Bayesian model average intensity bias correction forecast uncertainty ensemble forecast

CSST Dense Star Field Preparation: A Framework for Astrometry and Photometry for Dense Star Field Images Obtained by the China Space Station Telescope(CSST)

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Research in Astronomy and Astrophysics 2024年第7期24卷 161-172页

作者： Yining Wang Rui Sun Tianyuan Deng Chenghui Zhao Peixuan Zhao jiayi Yang peng Jia Huigen Liu Jilin Zhou College of Electronic Information and Optical Engineering Taiyuan University of Technology School of Astronomy&Space Science Nanjing University peng Cheng Lab

The China Space Station Telescope(CSST) is a telescope with 2 m diameter, obtaining images with high quality through wide-field observations. In its first observation cycle, to capture time-domain observation data, the CSST is proposed to observe the Galactic halo across different epochs. These data have significant potential for the study of properties of stars and exoplanets. However, the density of stars in the Galactic center is high, and it is a well-known challenge to perform astrometry and photometry in such a dense star field. This paper presents a deep learning-based framework designed to process dense star field images obtained by the CSST, which includes photometry, astrometry, and classifications of targets according to their light curve periods. With simulated CSST observation data, we demonstrate that this deep learning framework achieves photometry accuracy of 2% and astrometry accuracy of 0.03 pixel for stars with moderate brightness mag = 24(i band), surpassing results obtained by traditional methods. Additionally, the deep learning based light curve classification algorithm could pick up celestial targets whose magnitude variations are 1.7 times larger than magnitude variations brought by Poisson photon noise. We anticipate that our framework could be effectively used to process dense star field images obtained by the CSST.

关键词： astrometry methods: data analysis techniques: photometric

HPLC combined with chemometrics for quality control of Huamoyan Granules or Capsules

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Chinese Herbal Medicines 2024年第3期16卷 449-456页

作者： Minhang Dou jiayi Huang Mimi Yu Huahua Li Yang Song Ziwei peng Shouying Du Jie Bai School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China Beijing Institute for Drug Control NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine(Traditional Chinese Patent Medicine)Beijing Key Laboratory of Analysis and Evaluation on Chinese MedicineBeijing 102206China

Objective:Huamaoyan Granules(HMYG)and Huamaoyan Capsules(HMYC)are Chinese patent medicines with different dosage forms of the same *** to the different preparation process,the chemical composition of these Chinese patent medicines varies greatly among different forms,but there were few studies on the difference comparison and quality control of *** order to improve the effectiveness and safety in its clinical application,an idea combining high performance liquid chromatography(HPLC)and chemometrics was put forward to study the quality control of Chinese patent medicines in different dosage forms of the same ***:The differential markers of HMYG and HMYC were explored based on HPLC fingerprint and chemometrics including orthogonal projections to latent structures-discriminant analysis(OPLS-DA),principal component analysis(PCA),and hierarchical cluster analysis(HCA).Finally,the quantitative analysis method of related components was established by ***:A quality control method for HMYG and HMYC was ***,the chemical components of HMYG and HMYC were systematically analyzed by HPLC *** exploration showed that there were 20 characteristic peaks and 57 common ***,the potential differential markers between HMYG and HMYC were explored by chemometrics,and the differential markers were screened after intersection with the 20 characteristic ***,HPLC quantitative analysis methods for nine components were established,including seven differential markers(neochlorogenic acid,protocatechualdehyde,chlorogenic acid,cryptochlorogenic acid,caffeic acid,rosmarinic acid and salvianolic acid A).The results of HPLC quantitative analysis showed that the contents of eight components in HMYG and HMYC samples were significantly *** to the above results,the differential markers between HMYG and HMYC screened based on HPLC fingerprint and chemometrics can effectively characterize the differ

关键词： chemometrics Chinese patent medicine high performance liquid chromatography fingerprint Huamoyan Granules/Capsules quality control synovitis

Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4

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Genes & Diseases 2024年第4期11卷 411-425页

作者： Mengmeng Guo Pan Hu jiayi Xie Kefu Tang Shixiu Hu Jialiang Sun Yundong He Jing Li Weiqiang Lu Huirong Liu Mingyao Liu Zhengfang Yi Shihong peng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Prenatal Diagnosis Center Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 201203China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201400China Shanghai Yuyao Biotech Co. Ltd.Shanghai 200241China

Gastric cancer is highly prevalent among digestive tract *** to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric ***,there is promising potential for immunotherapy targeting the prostaglandin E2 receptor subtype 4(EP4)in gastric *** our previous study,we identified a novel small molecule EP4 receptor antagonist called *** with YY001 alone demonstrated a significant reduction in gastric cancer growth and inhibited tumor metastasis to the lungs in a mouse ***,adminis-tration of YYo01 stimulated a robust immune response within the tumor microenvironment,characterized by increased infiltration of antigen-presenting cells,T cells,and M1 ***,our research revealed that YYo01 exhibited remarkable synergistic ef-fects when combined with the PD-1 antibody and the clinically targeted drug apatinib,rather than *** findings suggest that YYo01 holds great promise as a potential therapeutic strategy for gastric cancer,whether used as a standalone treatment or in combination with other drugs.

关键词： EP4 Immunomodulation Synergy Tumor microenvironment YY001

Time-Periodic Solutions to Quasilinear Hyperbolic Systems on General Networks

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 41-72页

作者： peng QU School of Mathematical Sciences Fudan UniversityShanghai 200433China

For quasilinear hyperbolic systems on general networks with time-periodic boundary-interface conditions with a dissipative structure,the existence and stability of the time-periodic classical solutions are discussed.

关键词： Time-periodic solution Quasilinear hyperbolic system General net-work Classical solution Asymptotic stability