检索结果-南通市图书馆

Electronic structural engineering of bimetallic Bi-Cu alloying nanosheet for highly-efficient CO_(2) electroreduction and Zn-CO_(2) batteries

引用

Nano Research 2024年第5期17卷 3684-3692页

作者： Wenbo Wu jiaye Zhu Yun Tong Shuangfei Xiang Pengzuo chen School of Chemistry and Chemical Engineering Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China

Regulating the electronic structure of Bi-based materials by alloying engineering is promising to promote the electrocatalytic activity,but it remains some challenges to be solved.In this study,a facile electrochemical co-deposition strategy is developed to synthesize the bimetallic Bi_(9)Cu_(1) alloy nanosheet on carbon cloth(Bi_(9)Cu_(1)/CC),which represents a novel self-supporting electrode for the electrocatalytic carbon dioxide(CO_(2))reduction reaction(CO_(2)RR).The Bi_(9)Cu_(1)/CC catalyst has achieved a remarkable catalytic performance with high Faradaic efficiencies(FE)of over 90%for formate at wide potentials from-0.7 to-1.2 V vs.reversible hydrogen electrode(RHE).Moreover,the reversible Zn-CO_(2) battery can be driven by Bi_(9)Cu_(1)/CC cathode with a largest power density of 1.4 mW·cm^(-2),and superior operating stability.The systematic characterizations and electrochemical results confirm that the improved catalytic active sites,the enhanced mass/charge transport and the optimal reaction kinetics of Bi nanosheet are realized for CO_(2)RR by Cu alloying.In situ attenuated total reflection infrared(ATR-IR)result confirms the bimetallic Bi-Cu active sites prefer to follow the^(*)OCHO conversion pathway.The density functional theory(DFT)calculations suggest that the Cu alloying contributes to the increased density of states near the Fermi surface of Bi and the optimized adsorption of^(*)OCHO intermediates on the Bi sites,resulting in the excellent catalytic performance.

关键词： electronic regulation bismuth nanosheet copper alloying CO_(2)electroreduction Zn-CO_(2)batteries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Single-cell and spatially resolved omics:Advances and limitations

引用

药物分析学报:英文版 2023年第8期13卷 833-835页

作者： jiaye chen Yongcheng Wang Jina Ko Liangzhu Laboratory Zhejiang UniversityHangzhou310058China Department of Bioengineering University of PennsylvaniaPhiladelphiaUSA

Recent advances in experimental and computational single-cell and spatially resolved omics have opened new avenues for research in biology and medicine.These technologies allow for the study of individual cells in unprecedented detail,providing insights into the heterogeneity within tissues and organs,and how different cells interact with each other.Humans and other eukaryotes are composed of billions of cells,each with vastly heterogeneous cell types and functional cell states determined by intrinsic and extrinsic factors.

关键词： organs spatially resolved

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Machine Learning Modeling of Protein-intrinsic Features Predicts Tractability of Targeted Protein Degradation

引用

Genomics, Proteomics & Bioinformatics 2022年第5期20卷 882-898页

作者： Wubing Zhang Shourya S.Roy Burman jiaye chen Katherine A.Donovan Yang Cao Chelsea Shu Boning Zhang Zexian Zeng Shengqing Gu Yi Zhang Dian Li Eric S.Fischer Collin Tokheim X.Shirley Liu Department of Data Science Dana-Farber Cancer InstituteBostonMA 02215USA Department of Biostatistics Harvard T.H.Chan School of Public HealthBostonMA 02115USA Department of Cancer Biology Dana-Farber Cancer InstituteBostonMA 02215USA Department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02115USA Department of Biomedical Informatics Harvard Medical SchoolBostonMA 02115USA Center of Growth Metabolismand AgingKey Laboratory of Bio-resource and Eco-environmentMinistry of EducationCollege of Life SciencesSichuan UniversityChengdu 610064China Research Scholar Initiative Graduate School of Arts and SciencesHarvard UniversityCambridgeMA 02138USA

Targeted protein degradation(TPD)has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery.However,the susceptibility of proteins for targeting by TPD approaches,termed“degradability”,is largely unknown.Here,we developed a machine learning model,model-free analysis of protein degradability(MAPD),to predict degradability from features intrinsic to protein targets.MAPD shows accurate performance in predicting kinases that are degradable by TPD compounds[with an area under the precision–recall curve(AUPRC)of 0.759 and an area under the receiver operating characteristic curve(AUROC)of 0.775]and is likely generalizable to independent non-kinase proteins.We found five features with statistical significance to achieve optimal prediction,with ubiquitination potential being the most predictive.By structural modeling,we found that E2-accessible ubiquitination sites,but not lysine residues in general,are particularly associated with kinase degradability.Finally,we extended MAPD predictions to the entire proteome to find964 disease-causing proteins(including proteins encoded by 278 cancer genes)that may be tractable to TPD drug development.

关键词： Targeted protein degradation Degradability Protein-intrinsic feature Ubiquitination Machine learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Potential mechanisms of non-suicidal self-injury(NSSI)in major depressive disorder:a systematic review

引用

General Psychiatry 2023年第4期36卷 220-230页

作者： Baichuan Wu Huifeng Zhang Jinghong chen jiaye chen Zhifen Liu Yuqi cheng Tifei Yuan Daihui Peng Division of Mood Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina General Psychiatry Editorial Office Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry The First Hospital of Shanxi Medical UniversityTaiyuanShanxiChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnanChina

Background Non-suicidal self-injury(NSSI)is a frequent and prominent phenomenon in major depressive disorder(MDD).Even though its prevalence and risk factors are relatively well understood,the potential mechanisms of NSSI in MDD remain elusive.Aims To review present evidence related to the potential mechanisms of NSSI in MDD.Methods According to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines,articles for this systematic review were searched on Medline(through PubMed),Embase(through Elsevier),PsycINFO(through OVID)and Web of Science databases for English articles,as well as China National Knowledge Infrastructure(CNKI),SinoMed,Wanfang Data,and the Chongqing VIP Chinese Science and Technology Periodical(VIP)Databases for Chinese articles published from the date of inception to 2 August 2022.Two researchers(BW,HZ)independently screened studies based on inclusion and exclusion criteria and assessed their quality.Results A total of 25157 studies were searched.Only 25 of them were ultimately included,containing 3336 subjects(1535 patients with MDD and NSSI,1403 patients with MDD without NSSI and 398 HCs).Included studies were divided into 6 categories:psychosocial factors(11 studies),neuroimaging(8 studies),stress and hypothalamic-pituitary-adrenal(HPA)axis(2 studies),pain perception(1 study),electroencephalogram(EEG)(2 studies)and epigenetics(1 study).Conclusions This systematic review indicates that patients with MDD and NSSI might have specific psychosocial factors,aberrant brain functions and neurochemical metabolisms,HPA axis dysfunctions,abnormal pain perceptions and epigenetic alterations.

关键词： metabolism alterations mechanisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

鼓膜穿孔导致听力下降的有限元模型分析

引用

听力学及言语疾病杂志 2024年第3期32卷 258-264页

作者：丁家烨陈克光刘后广黄新生周雷复旦大学附属中山医院耳鼻咽喉头颈外科上海200032 中国矿业大学机电工程学院

目的探讨鼓膜穿孔导致听力下降的机制。方法通过有限元分析法(finite element analysis,FEA)构建全耳有限元模型并验证;参照实际鼓膜穿孔病例,创建个性化的鼓膜穿孔有限元模型,模拟鼓膜穿孔导致的听力损失;使用基底膜的位移响应与基线... 详细信息

目的探讨鼓膜穿孔导致听力下降的机制。方法通过有限元分析法(finite element analysis,FEA)构建全耳有限元模型并验证;参照实际鼓膜穿孔病例,创建个性化的鼓膜穿孔有限元模型,模拟鼓膜穿孔导致的听力损失;使用基底膜的位移响应与基线的差异来模拟听力损失情况,分析中耳各个组分对听力损失的贡献程度,探讨鼓膜穿孔导致听力下降的机制。结果如果将圆窗膜和中耳腔的耦合去掉,将导致低频约40 dB的听力下降,而高频段基本与基线情况下鼓膜穿孔所导致的听力损失持平;去除鼓膜内侧面和中耳腔气体的耦合,可部分减轻低频听力损失,而高频听力损失加重;切断外耳道气体和中耳腔气体之间的连续性,低频听力损失加重;但是去除圆窗膜和中耳腔之间耦合关系并且去除中耳腔气体和鼓膜内侧面的连接后,原先低频的40 dB听力损失将会恢复到10 dB左右;而去除中耳腔气体和听骨链之间的耦合,对听力损失无明显影响。结论鼓膜穿孔导致听力下降的主要机制是鼓膜穿孔本身所导致的传声效能降低,以及鼓膜内外声压差的降低;圆窗膜处声压的增加可以部分弥补鼓膜穿孔所导致的听力损失。

关键词：鼓膜穿孔有限元分析听力下降

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

敬畏与助人的关系:自我-他人重叠的中介作用

引用

心理发展与教育 2024年第4期40卷 499-509页

作者：王国芳田淑萍胥子健陈嘉晔杨敏齐中国政法大学社会学院北京100088 国家移民管理局北京100018 承德医学院心理学系承德067000 郑州大学教育学院郑州450001 郑州大学马克思主义学院郑州450001

为探索特质性敬畏与状态性敬畏与助人之间的关系及其心理机制,研究一采用问卷法探讨了特质性敬畏与助人行为的关系及自我-他人重叠的中介作用;研究二采用实验法探讨了状态性敬畏对助人行为的影响及自我-他人重叠的中介作用。结果表明:(1... 详细信息

为探索特质性敬畏与状态性敬畏与助人之间的关系及其心理机制,研究一采用问卷法探讨了特质性敬畏与助人行为的关系及自我-他人重叠的中介作用;研究二采用实验法探讨了状态性敬畏对助人行为的影响及自我-他人重叠的中介作用。结果表明:(1)个体的特质性敬畏水平越高,其助人行为水平也越高;(2)自我-他人重叠在特质性敬畏情绪与助人行为间起不完全中介作用;(3)与中性情绪相比,状态性敬畏能显著增加个体的金钱助人行为,但对时间助人行为没有显著影响;(4)自我-他人重叠在状态性敬畏与时间助人行为间起中介作用。研究从自我-他人之间联系的角度揭示了敬畏影响助人的作用机制,拓展了敬畏与社会行为的关系研究。

关键词：特质性敬畏状态性敬畏自我-他人重叠助人行为

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metal oxides heterojunction derived Bi-In hybrid electrocatalyst for robust electroreduction of CO_(2) to formate

引用

能源化学:英文版 2023年第8期83卷 180-188,I0007页

作者： Runze Ye jiaye Zhu Yun Tong Dongmei Feng Pengzuo chen School of Chemistry and Chemical Engineering Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018ZhejiangChina

Electrochemical reduction of Bi-based metal oxides is regarded as an effective strategy to rationally design advanced electrocatalysts for electrochemical CO_(2)reduction reaction(CO_(2)RR).Realizing high selectivity at high current density is important for formate production,but remains challenging.Herein,the BiIn hybrid electrocatalyst,deriving from the Bi2O3/In2O3heterojunction(MOD-Biln),shows excellent catalytic performance for CO_(2)RR.The Faradaic efficiency of formate(FEHCOO-) can be realized over 90% at a wide potential window from-0.4 to-1.4 V vs.RHE,while the partial current density of formate(jHCOO-) reaches about 136.7 mA cm^(-2)at-1.4 V in flow cell without IR-compensation.In additio n,the MOD-Biln exhibits superior stability with high selectivity of formate at 100 mA cm^(-2).Systematic characterizations prove the optimized catalytic sites and interface charge transfer of MOD-Biln,while theoretical calculation confirms that the hybrid structure with dual Bi/In metal sites contribute to the optimal free energy of*H and*OCHO intermediates on MOD-Biln surface,thus accelerating the formation and desorption step of*HCOOH to final formate production.Our work provides a facile and useful strategy to develop highly-active and stable electrocatalysts for CO_(2)RR.

关键词： Metal oxide derivation Hybrid electrocatalyst Dual metal sites Electrocatalytic CO_(2)RR Formate product

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

化工“三废”处理技术及其发展趋势研究

引用

山东化工 2024年第5期53卷 261-262,266页

作者：金亮章留留陈佳业扬州联博药业有限公司江苏扬州225000

化工废水、废气和固废,合称为化工“三废”,是由工业化进程中产生的有害废物,会对环境和人类健康构成严重威胁。本文介绍了化工“三废”的来源,在此基础上,分别探讨了废水、废气以及固废等处理技术,并进一步展望了化工“三废”处理技术... 详细信息

化工废水、废气和固废,合称为化工“三废”,是由工业化进程中产生的有害废物,会对环境和人类健康构成严重威胁。本文介绍了化工“三废”的来源,在此基础上,分别探讨了废水、废气以及固废等处理技术,并进一步展望了化工“三废”处理技术的未来发展趋势,即精细化、绿色化以及微化工等,进而为化工“三废”的有效处理提供一定的参考。

关键词：化工三废处理

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mono-dispersed Ag nanoparticles decorated graphitic carbon nitride:An excellent lubricating additive as PPESK composite film

引用

Friction 2022年第5期10卷 717-731页

作者： Beibei chen Mengjie ZHANG Kan ZHANG Zhe DONG jiaye LI Gai ZHAO School of Materials and Science Engineering Institute for Advanced MaterialsJiangsu UniversityZhenjiang 212013China State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Studies show that two dimensional(2D)nanomaterial and its hybrid have a great promise in tribology for the special laminar microstructure.However,the majority of performed investigations about 2D graphitic carbon nitride(g-C_(3)N_(4))nanosheets are most focused on energy storage,catalysis,adsorption,rarely tribology.In the present study,g-C_(3)N_(4) supporting mono-dispersed Ag nanoparticle hybrid(g-C_(3)N_(4)/Ag)is prepared,and its microstructure and chemical composition are determined.More specifically,the tribological performance as the lubricating additive of poly phthalazinone ether sulfone ketone(PPESK)composite is investigated using the ball-on-disc friction tester.Moreover,the corresponding enhancement mechanism is well proposed based on the experimental analysis and theoretical simulation.Obtained results show that Ag nanoparticles with a size of about 10-20 nm are homogeneously anchored on g-C_(3)N_(4) nanosheets,favoring for good compatibility between g-C_(3)N_(4)/Ag and PPESK.It is found that when 0.3 wt%of g-C_(3)N_(4)/Ag is added to PPESK,the friction coefficient and wear rate of PPESK decrease by 68.9%and 97.1%,respectively.These reductions are mainly attributed to the synergistic self-lubricating effect of Ag nanoparticles and g-C_(3)N_(4) nanosheet,the formation of transfer film,as well as the limited effect of g-C_(3)N_(4)/Ag on the shear deformation of PPESK composite film.Furthermore,it is found that the proposed g-C_(3)N_(4)/Ag-PPESK composite still keeps reasonable friction-reducing and wear-resistant properties under heavy loads and high rotating speeds.The present study demonstrates that the proposed g-C_(3)N_(4)/Ag hybrid is an excellent lubricating additive for polymer composites.

关键词： g-C_(3)N_(4)/Ag hybrid poly phthalazine ether sulfone ketone(PPESK)composite film friction wear theoretical simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

工作频率可重构的多层超表面设计

引用

电子测量技术 2024年第7期47卷 28-33页

作者：王哲飞张晋滔陈鹏飞王佳锋周加烨南京信息工程大学南京210044

为应对现代通信系统日益复杂的通信环境需求以及充分利用有限的频谱资源,提出了一种采用超表面结构与有源器件PIN二极管和变容二极管结合的设计,以实现双极化功能频率独立可重构的多模式特性。与传统多模式结构不同,该设计利用PIN二极... 详细信息

为应对现代通信系统日益复杂的通信环境需求以及充分利用有限的频谱资源,提出了一种采用超表面结构与有源器件PIN二极管和变容二极管结合的设计,以实现双极化功能频率独立可重构的多模式特性。与传统多模式结构不同,该设计利用PIN二极管独立调控双极化波的透射和反射状态,并利用变容二极管实现对双极化波透射窗口的动态调频,可实现9种工作模式的切换。本设计在静态状态下,能够独立调控TE和TM极化波的透射和反射;在切换到动态状态时,除了调控极化波外,还增加了独立调谐TE或TM极化波透射窗口偏移的功能。各个模式之间相互独立,模式兼容性良好。此外,在0°~45°入射角度范围,本设计表现出良好的角度稳定性。通过使用电磁仿真软件CST进行实验验证,证明了本设计的可靠性,显示其在天线罩和信号多频传输方面具有广泛的应用前景。

关键词：超表面多模式可重构可调频天线罩

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：