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Secure outsourcing of large matrix determinant computation

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Frontiers of Computer Science 2020年第6期14卷 141-152页

作者： jiayang liu Jingguo BI Mu LI Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China Beijing Research Institute of Telemetry Beijing 100094China Institute for Advanced Study Tsinghua UniversityBeijing 100084China Space Star Technology Co. LtdBeijing 100086China

Cloud computing provides the capability to con-nect resource-constrained clients with a centralized and shared pool of resources,such as computational power and storage on *** matrix determinant computation is almost ubiquitous in computer science and requires large-scale data ***,techniques for securely outsourcing matrix determinant computations to untrusted servers are of utmost importance,and they have practical value as well as theoretical significance for the scientific *** this study,we propose a secure outsourcing method for large matrix determinant *** em-ploy some transformations for privacy protection based on the original matrix,including permutation and mix-row/mix-column operations,before sending the target matrix to the *** results returned from the cloud need to be de-clypled anul verified U ubtainl te cullett ***1 comparison with previously proposed algorithms,our new al-gorithm achieves a higher security level with greater cloud *** experimental results demonstrate the efficiency and effectiveness of our algorithm.

关键词： cloud computing large-scale data computation matrix determinant computation secure outsourcing

市场激励型环境规制对企业环境信息披露的影响研究——以环境保护税征收为例

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唐山学院学报 2024年第3期37卷 37-47页

作者：杨洁张晓菡刘佳阳湖南工业大学经济与贸易学院湖南株洲412007 暨南大学伯明翰大学联合学院广州510006

文章以2010-2020年沪深A股上市的重污染企业为样本,以环境保护税征收为例,研究市场激励型环境规制对企业环境信息披露的影响。研究结果显示,环境保护税征收有助于促进企业环境信息披露,且相较于定性披露,其更有助于促进企业环境信息定... 详细信息

文章以2010-2020年沪深A股上市的重污染企业为样本,以环境保护税征收为例,研究市场激励型环境规制对企业环境信息披露的影响。研究结果显示,环境保护税征收有助于促进企业环境信息披露,且相较于定性披露,其更有助于促进企业环境信息定量披露;此外,环境保护税征收对环境信息披露的影响可以通过缓解融资约束压力、提高审计监督力度来实现。进一步研究发现,环境保护税征收对企业环境信息披露的影响呈现地区分布、企业性质与监控程度方面的异质性。基于以上结论,提出了相应的对策建议。

关键词：市场激励型环境规制环境保护税环境信息披露

Transformation of triclosan by a novel cold-adapted laccase from Botrytis sp. FQ

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Frontiers of Environmental Science & Engineering 2017年第3期11卷 79-86页

作者： Yuanyuan Shi Deyang Kong jiayang liu Junhe Lu Xiaoming Yin Quansuo Zhou College of Resources and Environmental Science Nanjing Agricultural University Nanjing 210095 China Nanjing Institute of Environmental Science Ministry of Environmental Protection of PRC Nanjing 210042 China School of Bioengineering Huanghuai University Zhumadian 463000 China

This work investigated the transformation of triclosan （TCS） by the laccase produced by a pathogen isolated from rotten tomato. The pathogen was characterized as Bot^tis sp. FQ, belonging to subphylum Deuteromw＇otina. The laccase exhibited cold-adaptation with relatively high activity at 20℃. The laccase could effectively transform TCS. Approximately 62% TCS could be removed at dose of 1.0 unit·mL^-1 in 120min. The reaction rate appeared to be pseudo-first-order to the concentration of the substrate, suggesting the laccase activity remained stable during the reaction. Transformation products of TCS were analyzed by mass spectrometry and it was revealed that TCS dimers were formed via radical coupling pathways. During this process, laccase catalyzed oxidation of TCS to form a radical intermediate is the rate limiting step. However, this step can be reversed by humic acid. Overall, the laccase showed great potential in the treatment of phenolic contaminants. Since laccase is widely presented in natural environment, this study also revealed an important pathway involved in the transformation of phenolic contaminants in the environment.

关键词： Laccase Botrytis cinerea cinerea Triclosan Transformation Kinetics

Doxorubicin-loaded bacterial outer-membrane vesicles exert enhanced anti-tumor efficacy in non-small-cell lung cancer

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Acta Pharmaceutica Sinica B 2020年第8期10卷 1534-1548页

作者： Kudelaidi Kuerban Xiwen Gao Hui Zhang jiayang liu Mengxue Dong Lina Wu Ruihong Ye Meiqing Feng Li Ye Minghang Hospital&Department of Biological Medicines at School of Pharmacy Fudan UniversityShanghai 201100China Shanghai Engineering Research Center of ImmunoTherapeutics School of PharmacyFudan UniversityShanghai 201203China TOF-PET/CT/MR Center the 4th Affiliated HospitalHarbin Medical UniversityHarbin 150028China Department of Pharmaceutical Engineering School of PharmacyHubei University of Chinese MedicineWuhan 430070China

More efficient drug delivery system and formulation with less adverse effects are needed for the clinical application of broad-spectrum antineoplastic agent doxorubicin(DOX). Here we obtained outer-membrane vesicles(OMVs), a nano-sized proteoliposomes naturally released by Gram-negative bacteria, from attenuated Klebsiella pneumonia and prepared doxorubicin-loaded O0MVs(DOX-OMV). Confocal microscopy and in vivo distribution study observed that DOX encapsulated in OMVs was efficiently transported into NSCLC A549 cells. DOX-OMV resulted in intensive cytotoxic effects and cell apoptosis in vitro as evident from MTT assay, Western blotting and flow cytometry due to the rapid cellular uptake of DOX. In A549 tumor-bearing BALB/c nude mice, DOX-OMV presented a substantial tumor growth inhibition with favorable tolerability and pharmacokinetic profile, and TUNEL assay and H&E staining displayed extensive apoptotic cells and necrosis in tumor tissues. More importantly, OMVs’ appropriate immunogenicity enabled the recruitment of macrophages in tumor microenvironment which might synergize with their cargo DOX in vivo. Our results suggest that OMVs can not only function as biological nanocarriers for chemotherapeutic agents but also elicit suitable immune responses, thus having a great potential for the tumor chemoimmunotherapy.

关键词： nude loaded outer

高校财经类交叉学科课程思政教学研究——以“保险会计学”为例

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开封文化艺术职业学院学报 2024年第1期44卷 75-79页

作者：王铭利刘家养谢强强王靖涵广西财经学院金融与保险学院广西南宁530007

高校财经类交叉学科课程兼具两个甚至多个学科特点,增加了课程思政建设和提升思政教学效果的难度。为此,首先以“保险会计学”为例阐明了财经类交叉学科课程思政建设的新特征。其次,从目标导向、具体内容、实现路径等方面对“保险会计... 详细信息

高校财经类交叉学科课程兼具两个甚至多个学科特点,增加了课程思政建设和提升思政教学效果的难度。为此,首先以“保险会计学”为例阐明了财经类交叉学科课程思政建设的新特征。其次,从目标导向、具体内容、实现路径等方面对“保险会计学”课程思政建设进行了实践探索。再次,根据“保险会计学”课程思政实践经验提出推动财经类交叉学科课程思政建设发展的建议。高校需要高度重视财经类交叉学科课程思政建设,形成学科交叉相融的思政教学氛围,不断优化教师的跨专业教学能力,创新教学形式,从而实现课程思政教学目标。

关键词：财经类交叉学科保险会计学课程思政教学设计

The risk factors and threshold level of subchronic inhalation exposure of reclaimed water

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Journal of Environmental Sciences 2024年第3期137卷 639-650页

作者： jiayang Kong Yun Lu Yunru Ren Menghao Chen Gang liu Liangliang Shi State Key Joint Laboratory of Environment Simulation and Pollution Control State Environment Protection Key Laboratory of Microorganism Application and Risk ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China

Inhalation of reclaimed water is known to cause lung infammation,and free endotoxins have been shown to be a major risk factor for acute *** exposure has also been shown to induce infammatory responses with visible tissue ***,subchronic risk factors have yet to be identified,and a threshold for the protection of occupational populations during urban reuse is *** this study,potential risk factors in reclaimed water were examined by subchronic exposure with fractionated reclaimed water,and the health risk threshold was tested with a series of diluted reclaimed ***,following a 12-week exposure,macromolecules and microorganisms were found to be two major risk factors in reclaimed water that could cause pulmonary infammation,including increased proportion of polymorphonuclear leukocytes in bronchoalveolar fuid,formation of inducible bronchus-associated lymphoid tissue,and elevation of Immunoglobulin A ***,infammation persisted after a 4-week recovery *** calculated threshold of reclaimed water exposure for mice was 31.8 Endotoxin Unit(EU)/(kg·day)under when exposed to 50%additional relative humidity from reclaimed water at 25℃ for 2 hr/***,the subchronic threshold estimate for humans under the same exposure conditions was found to be 12.2 EU/(kg·day),corresponding to endotoxin levels of 61.7 EU/mL in reclaimed *** threshold level of endotoxin was lower than that in most non-potable reclaimed *** findings of this study suggest that occupational exposure of reclaimed water can serve as a potential risk to workers.

关键词： Reclaimed water Inhalation exposure Risk factor Threshold Infammation Endotoxin

工学一体背景下的《精细有机合成实验》教学探索

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广东化工 2024年第1期51卷 147-148,129页

作者：代坤任兰正王金秀祝英忠刘家扬孙轶民滁州学院安徽滁州239000 南京工大开元环保科技(滁州)有限公司安徽滁州239050

基于创建地方应用型高水平大学、产学研融合的办学目标和应用化学专业培养目标,我们针对《精细有机合成实验》课程实验内容与企业生产脱钩、工艺设计环节较少、安全环保意识淡薄等问题,进行更新实验内容、融合生产实例、增强工艺设计和... 详细信息

基于创建地方应用型高水平大学、产学研融合的办学目标和应用化学专业培养目标,我们针对《精细有机合成实验》课程实验内容与企业生产脱钩、工艺设计环节较少、安全环保意识淡薄等问题,进行更新实验内容、融合生产实例、增强工艺设计和强化安全环保意识等教学探索,以期提高《精细有机合成实验》教学质量,培养高素质应用型人才,更好地服务于地方区域经济发展。

关键词：产学研融合应用化学精细有机合成实验教学探索应用型人才

Self-healable gels in electrochemical energy storage devices

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Nano Research 2024年第4期17卷 3302-3323页

作者： Yang Li PeiPei Ding Yuzhe Gu Sheng Qian Yuncong Pang Lele Wang jiayang Feng Baoguang liu Qi Wan Ping Li Zhiwei liu College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts&Telecommunications(NJUPT)Nanjing 210023China State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China College of Materials Science&Engineering Beijing University of TechnologyBeijing 100124China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Pillar of Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

In the green energy and carbon-neutral technology,electrochemical energy storage devices have received continuously increasing attention ***,due to the unavoidable volume expansion/shrinkage of key materials or irreversible mechanical damages during application,the stability of energy storage and delivery as well as the lifetime of these devices are severely shortened,leading to serious performance degradation or even safety ***,the utilization of self-healable gels into electrochemical energy storage devices,such as electrodes,binders,and electrolytes,is proven as an effective method to realize long-term stable operation of these devices via the self-repairing of mechanical and electrochemical ***,this review first summarizes the feature and fabrication of different gels,paying special attention to hydrogels,organohydrogels,and ***,basic concepts and figure of merit of self-healable gels are analyzed with a detailed discussion at the healing mechanisms,from reversible dynamic bonds to physical molecular diffusion,and to external healing *** we introduce all the important parts of electrochemical energy storage devices,which could be replaced by healable gels to enhance the durability,including electrodes,binders,and ***,the critical challenges and future perspectives regarding the future development of healable gels based high-performance electrochemical energy storage devices or electronics are provided.

关键词： self-healable gels healing mechanisms electrodes binders gel electrolytes

基于Logistic回归及ROC曲线研究卒中患者120急救入院的影响因素

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临床医学研究与实践 2024年第9期9卷 25-29页

作者：厉倬学林富李归宿刘佳阳赵智丽李艳凤深圳市龙华区人民医院药学部广东深圳518000 深圳市龙华区人民医院神经内科广东深圳518000

目的探讨卒中患者选择120急救入院的影响因素,为更加精准的溶栓临床药学干预提供证据。方法选取2019年12月至2022年12月在深圳市龙华区人民医院神经内科住院的患者为研究对象,将93例完成完整调查的120急救入院患者纳入病例组,将同期255... 详细信息

目的探讨卒中患者选择120急救入院的影响因素,为更加精准的溶栓临床药学干预提供证据。方法选取2019年12月至2022年12月在深圳市龙华区人民医院神经内科住院的患者为研究对象,将93例完成完整调查的120急救入院患者纳入病例组,将同期255例完成完整调查的非120急救入院患者纳入对照组。通过临床药师结构式访谈获取患者的人口学资料、溶栓态度、疾病情况、FAST卒中症状知晓情况、卒中分型知晓情况及药物种类知晓情况。分析卒中患者120急救入院的影响因素。结果两组的独居、婚况、听说过溶栓、愿意溶栓、担心何种溶栓风险、知晓3 h溶栓时间窗、既往血管病史、言语含糊或听不懂别人说话、卒中分型知晓度及药物种类知晓度比较,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,愿意溶栓、听说过溶栓、担心何种溶栓风险、知晓3 h溶栓时间窗是卒中患者120急救入院的影响因素(P<0.05)。结论卒中患者的溶栓知识与积极信念是其选择120急救入院的重要影响因素,这为更加精准的临床药学干预服务提供了依据。

关键词：卒中溶栓 120急救临床药学