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Incorporating Equity Concerns into Transportation Planning and Policies in Urban China: The Status Quo of Practice and Implications

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China City Planning Review 2019年第1期28卷 56-64页

作者： lin Xiongbin Liu jiayan(校) Department of Geography&Spatial Information Technology Ningbo UniversityNingboP.R.China 不详

Transportation equity is one of the most recent concerns toward sustainable urban development, which aims to help municipalities or local planning authorities incorporate equity issues into transportation planning and policies, avoiding multifaceted potential inequity outcomes. As for the urbanizing China, do the mainstream planning approaches fail to take equity issues into account? What are outcomes and the potential countermeasures based on Chinese cities' spatial and policy contexts? From the perspective of transportation equity, this article aims to examine the multidimensional effects related to equity concerns of urban transportation planning and policies in China. It suggests that the municipal government should enhance the service level of public transit and efficiently address the inequity issues of transportation systems. The potential measures include: building a multi-modal transit system, linking affordable housing to the transportation system, highlighting the role of non-motorized mode, and offering proper parking spaces around transit stations.

关键词： transit-oriented development transportation equity transportation planning and policy urban China

Silver-Mediated N-Trifluoromethylation of Amides and Peptides

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Chinese Journal of Chemistry 2020年第9期38卷 924-928页

作者： Zhenzhen Zhang jiayan He lin Zhu Haiwen Xiao Yewen Fang Chaozhong Li Key Laboratory of Organofluorine Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032China School of Materials and Chemical Engineering Ningbo University of Technology201 Fenghua RoadNingboZhejiang 315211China

Summary of main observation and conclusion We report herein the direct N-trifluoromethylation of N-H *** by AgOTf and 2-fluoro-pyridine,the reaction of a variety of amides with Selectfluor,TMSCF3 and CsF proceeds smoothly at room temperature leading to the corresponding N-trifluoromethylated products in satisfactory *** protocol is also applicable to amino acid derivatives,resulting in efficient and chemoselective W-trifluoromethylation of di-and tri-peptides with retention of configuration.A mechanism involving reductive elimination of Ag(Ⅲ)intermediates to form N—CF3 bonds is proposed.

关键词： smoothly bonds elimination

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急性胰腺炎继发胰周感染的危险因素分析

中国普通外科杂志 2018年第9期27卷 1148-1154页

作者：周书毅黄耿文申鼎成宁彩虹林嘉晏曹昕彤纪连栋魏伟陆晔斌中南大学湘雅医院胰胆外科湖南长沙410008

目的:探讨急性胰腺炎(AP)早期继发胰周感染的危险因素。方法:回顾性分析2010年1月—2016年10月间中南大学湘雅医院连续收治的、起病72 h内入院的826例AP患者资料,比较其中住院期间出现胰周感染与未出现胰周感染患者之间临床特点及入院2... 详细信息

目的:探讨急性胰腺炎(AP)早期继发胰周感染的危险因素。方法:回顾性分析2010年1月—2016年10月间中南大学湘雅医院连续收治的、起病72 h内入院的826例AP患者资料,比较其中住院期间出现胰周感染与未出现胰周感染患者之间临床特点及入院24 h血化验结果,分析胰周感染的危险因素,并单独分析急性重症胰腺炎(SAP)继发胰周感染的危险因素。结果:826例AP患者中,发生胰周感染患者30例(3.6%)。单因素与多因素Logistic回归分析结果显示,持续器官功能衰竭(>48 h)(OR=21.143,P1周)(OR=7.47,P=0.007)是SAP继发胰周感染的独立危险因素。结论:起病早期出现持续性器官功能衰竭,男性以及入院24 h内白蛋白减少是AP患者继发胰周感染的危险因素,且器官功能衰竭持续时间越长,发生胰周感染的风险越高。

关键词：胰腺炎胰腺炎急性坏死性感染危险因素

Arginine-mediated synthesis of cube-like platinum nanoassemblies as efficient electrocatalysts

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Nano Research 2015年第12期8卷 3963-3971页

作者： Gengtao Fu Qian Zhang jiayan Wu Dongmei Sun lin Xu Yawen Tang Yu Chen Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Meterials Science Nanjing Normal University Nanjing 210023 China Key Laboratory of Macromolecular Science of Shaanxi Province School of Materials Science and Engineering Shaanxi Normal University Xi'an 710062 China

Controllable self-assembly of noble metal nanocrystals is of broad interest for the development of highly active electrocatalysts. Here we report an efficient arginine-mediated hydrothermal approach for the high-yield synthesis of cube-like Pt nanoassemblies （Pt-CNAs） with porous cavities and rough surfaces based on the self-assembly of zero dimensional Pt nanocrystals. In this process, arginine acts as the reductant, structure directing agent, and linker between adjacent nanocrystals. Interestingly, the Pt-CNAs exhibit single-crystal structures with dominant {100} facets, as evidenced by X-ray diffraction. Based on electrocatalytic studies, the as-synthesized Pt-CNAs exhibit improved electrocatalytic activity as well as good stability and CO tolerance in the methanol oxidation reaction. The Pt-CNA＇s good performance is attributed to their unique morphology and surface structure. We believe that the synthetic strategy outlined here could be extended to other rationally designed monometallic or bimetallic nanoassemblies for use in high performance fuel cells.

关键词： platinum nanoassemblies cube self-assembly arginine electrocatalysis

Dendritic platinum-copper bimetallic nanoassemblies with tunable composition and structure： Arginine-driven self-assembly and enhanced electrocatalytic activity

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Nano Research 2016年第3期9卷 755-765页

作者： Gengtao Fu Huimin Liu Nika You jiayan Wu Dongmei Sun lin Xu Yawen Tang Yu Chen Key Laboratory of Macromolecular Science of Shaanxi Province School of Materials Science and Engineering Shaanxi Normal University Xi'an 710062 China Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School ot Chemistry and Materials Science Nanjing Normal University Nanjing 210023 China Materials Science and Engineering Program & Texas Materials Institute The University of Texas atAustin Austin Texas 78712 USA

Novel self-assembled architectures have received a growing amount of attention and have significant potential for application in catalysis/electrocatalysis. Herein, we take advantage of the unique coordination and self-assembly properties of arginine for the preparation of dendritic PtCu bimetallic nanoassemblies with tunable chemical composition and structure. Strong interactions between the arginine molecules are key in driving the self-assembly of primary nanocrystals. In addition, the strong coordination interactions between arginine and metal ions is responsible for the formation of Pt-Cu alloys. We also investigated the electrocatalytic activity of various dendritic PtCu bimetallic nanoassemblies towards the methanol oxidation reaction. PtBCUl nanoassemblies exhibited excellent electrocatalytic activity and stability in comparison with other PtCu bimetallic nanoassemblies （PtlCu3, PtlCu~） and commercial Pt black, due to their unique dendritic structures and the synergistic effect between the Pt and Cu atoms.

关键词： platinum-copper nanoassemblies arginine molecules electrocatalysis methanol oxidation

TwoMADS-boxgenes regulate vascularcambium activity and secondary growth by modulating auxin homeostasis in Populus

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Plant Communications 2021年第5期2卷 120-131页

作者： Shuai Zheng Jiajia He Zengshun lin Yingying Zhu jiayan Sun Laigeng Li National Key Laboratory of Plant Molecular Genetics and CAS Center for Excellence in Molecular Plant Sciences Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of the Chinese Academy of Sciences Beijing 100049China Hunan Agricultural University Hunan 4101287China Lanzhou University Lanzhou730000China

In trees,stem secondary growth depends on vascular cambium proliferation activity and subsequent cell differentiation,in which an auxin concentration gradient across the cambium area plays a crucial role in regulating the ***,the underlying molecular mechanismfor the establishment of auxin concentration is not fully *** this study,we identified two function-unknown MADS-box genes,VCM1 and VCM2,which are expressed specifically in the vascular cambium and modulate the subcellular homeostasis of *** knockdown of both VCM1 and VCM2 enhanced vascular cambium proliferation activity and subsequent xylem *** of VCM1 suppressed vascular cambium activity and wood formation by regulating PIN5 expression,which tuned the soluble auxin concentration in the vascular cambium *** study reveals the role of VCM1 and VCM2 in regulating the proliferation activity of the vascular cambium and secondary growth by modulating the subcellular auxin homeostasis in Populus.

关键词： vascular cambium secondary growth auxin xylem tree

肠内营养制剂在急性淋巴细胞白血病患儿诱导治疗期的营养支持作用及对化疗并发症的影响

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中华实用儿科临床杂志 2019年第17期34卷 1335-1339页

作者：王超栗达林巍张元元范佳于娇乐张瑞东吴颖漆佩静陆继冉李静林嘉衍郑雪岭闫洁郑胡镛国家儿童医学中心首都医科大学附属北京儿童医院血液肿瘤中心儿童血液病与肿瘤分子分型北京市重点实验室儿科学国家重点学科儿科重大疾病研究教育部重点实验室北京100045 国家儿童医学中心首都医科大学附属北京儿童医院营养科北京100045

目的通过在儿童急性淋巴细胞白血病(ALL)患儿诱导治疗期给予肠内营养支持,观察该段时间内患儿营养学指标的变化及对化疗并发症的影响,并观察肠内营养制剂的安全性。方法选择2016年11月至2017年9月在北京儿童医院血液肿瘤中心的60例初诊... 详细信息

目的通过在儿童急性淋巴细胞白血病(ALL)患儿诱导治疗期给予肠内营养支持,观察该段时间内患儿营养学指标的变化及对化疗并发症的影响,并观察肠内营养制剂的安全性。方法选择2016年11月至2017年9月在北京儿童医院血液肿瘤中心的60例初诊ALL患儿为研究对象,采用简单随机化方法平行分为试验组和对照组,每组各30例。试验组在常规低脂饮食的基础上,给予高热卡、优质蛋白、高中链三酰甘油型肠内营养制剂,持续时间为ALL患儿诱导治疗期间,对照组则按常规给予低脂饮食。通过分析诱导化疗前(D0)、化疗第15天(D15)及化疗第33天(D33)的相关指标,了解2组患儿营养状态变化及对化疗并发症的影响。结果2组患儿体质量指数(BMI)及肱三头肌皮褶厚度在化疗前后无明显变化,差异均无统计学意义(均P>0.05),但试验组化疗后上臂围上升[治疗前:(15.80±2.63) cm,治疗后(16.27±2.57) cm],对照组较化疗前下降[化疗前:(17.19±3.71) cm,化疗后:(17.15±3.64) cm],差异均有统计学意义(均P0.05)。元素锌与对照组比较差异无统计学意义。ALL患儿化疗后中性粒细胞缺乏症发生率较高(37/60例,61.67%),试验组化疗后中性粒细胞缺乏症恢复情况优于对照组。化疗后试验组贫血程度轻于对照组,输血人次、人均输血次数均少于对照组(54人次比74人次,2.45次比3.08次),输注血制品人次少于对照组(78人次比101人次),但差异无统计学意义(P>0.05)。试验组化疗后肝损程度下降,对照组无明显变化。试验组初始活化部分凝血酶原时间(APTT)延长人数多于对照组(5例比3例),化疗后少于对照组(0例比1例)。试验组化疗期间发热人数少于对照组(6例比8例),平均发热时间短于对照组(2.8 d比4.1 d),但差异均无统计学意义(均P>0.05)。化疗过程中试验组发生胰腺炎0例,对照组发生胰腺炎1例。2组化疗D15、D33缓解率差异无统计学意义(P>0.05)。结论ALL患儿经初期诱导化疗后营养状态有所下降,采用高热卡、优质蛋白、高中链三酰甘油型肠内营养支持有助于维持患儿化疗初期的营养状态,肠内营养支持可提高血液系统对化疗的耐受性并减少并发症发生。

关键词：淋巴细胞白血病,急性儿童肠内营养支持化疗并发症

Spinel MnCo2O4 nanoparticles cross-linked with two-dimensional porous carbon nanosheets as a high-efficiency oxygen reduction electrocatalyst

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Nano Research 2016年第7期9卷 2110-2122页

作者： Gengtao Fu Zhenyuan Liu Jingfei Zhang jiayan Wu lin Xu Dongmei Sun Jubing Zhang Yawen Tang Pei Chen Jiangsu Key Laboratory of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 China Key Laboratory of Applied Surface and Colloid Chemistry (MOE) School of Materials Science and Engineering Shaanxi Normal University Xi'an 710062 China Materials Science and Engineering Program & Texas Materials Institute the University of Texas atAustin Austin Texas 78712 USA

Catalysts for the oxygen reduction reaction （ORR） play an important role in fuel cells. Alternative non-precious metal catalysts with comparable ORR activity to Pt-based catalysts are highly desirable for the development of fuel cells. In this work, we report for the first time a spinel MnC0204/C ORR catalyst consisting of uniform MnC0204 nanoparticles cross-linked with two-dimensional （2D） porous carbon nanosheets （abbreviated as porous MnC0204/C nanosheets）, in which glucose is used as the carbon source and NaC1 as the template. The obtained porous MnCo204/C nanosheets present the combined properties of an interconnected porous architecture and a large surface area （175.3 m2-g-1）, as well as good electrical conductivity （1.15 x 102 ***-1）. Thus, the as-prepared MnC0204/C nanosheets efficiently facilitate electrolyte diffusion and offer an expedite transport path for reactants and electrons during the ORR. As a result, the as-prepared porous MnC0204/C nanosheet catalyst exhibits enhanced ORR activity with a higher onset potential and current density than those of its counterparts, including pure MnC0204, carbon nanosheets, and Vulcan XC-72R carbon. More importantly, the porous MnC0204/C nanosheets exhibit a com- parable electrocatalytic activity but superior stability and tolerance toward methanol crossover effects than a high-performance Pt/C catalyst in alkaline medium. The synthetic strategy outlined here can be extended to other non- precious metal catalysts for application in electrochemical energy conversion.

关键词： spinel SnCo2O4 carbon porous nanosheets electrocatalysis oxygen reduction reaction

Combining mannose receptor mediated nanovaccines and gene regulated PD-L1 blockade for boosting cancer immunotherapy

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Bioactive Materials 2022年第1期7卷 167-180页

作者： Jie Chen Huapan Fang Yingying Hu jiayan Wu Sijia Zhang Yuanji Feng lin lin Huayu Tian Xuesi Chen Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022PR China University of Science and Technology of China Hefei230026PR China Jilin Biomedical Polymers Engineering Laboratory Changchun130022PR China Institute of Functional Nano and Soft Materials(FUNSOM) Jiangsu Key Laboratory for CarbonBased Functional Materials&DevicesSoochow UniversitySuzhou215123JiangsuPR China

Tumor nanovaccines have potential applications in the prevention and treatment of malignant ***,it remains a longstanding challenge in exploiting efficient nanocarriers for inducing potent specifically cellular immune *** this objective,we herein explore an intensive tumor immunotherapeutic strategy by combining mannosylated nanovaccines and gene regulated PD-L1 blockade for immune stimulation and killing ***,we fabricate a mannose modified PLL-RT(Man-PLL-RT)mediated nanovaccines with dendritic cells(DCs)targeting ***-PLL-RT is capable of co-encapsulating with antigen(ovalbumin,OVA)and adjuvant(unmethylated cytosine-phosphate-guanine,CpG)by electrostatic *** positively charged Man-PLL-RT/OVA/CpG nanovaccines can facilitate the endocytosis,maturation and cross presentation in ***,the nanovaccines arouse limited inhibition of tumor growth,which is mainly due to the immunosuppressed microenvironment of *** tumor nanovaccines with gene regulated PD-L1 blockade leads to an obvious tumor remission in B16F10 melanoma bearing *** collaborative strategy provides essential insights to boost the benefits of tumor vaccines by regulating the checkpoint blockade with gene therapy.

关键词： Gene delivery PD-L1 blockade Targeted vaccine Nanovaccines Tumor immunotherapy