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Improved computer-aided detection of pulmonary nodules via deep learning in the sinogram domain

Visual Computing for Industry,Biomedicine,and Art 2019年第1期2卷 129-137页

作者： Yongfeng Gao jiaxing tan Zhengrong Liang Lihong Li Yumei Huo Department of Radiology State University of New YorkStony BrookNY 11794USA Departments of Computer Science City University of New York/CSIStaten IslandNY 10314USA Engineering and Environmental Science City University of New York/CSIStaten IslandNY 10314USA

Computer aided detection(CADe)of pulmonary nodules plays an important role in assisting radiologists’diagnosis and alleviating interpretation burden for lung *** CADe systems,aiming at simulating radiologists’examination procedure,are built upon computer tomography(CT)images with feature extraction for detection and *** visual perception in CT image is reconstructed from sinogram,which is the original raw data acquired from CT *** this work,different from the conventional image based CADe system,we propose a novel sinogram based CADe system in which the full projection information is used to explore additional effective features of nodules in the sinogram *** the challenges of limited research in this concept and unknown effective features in the sinogram domain,we design a new CADe system that utilizes the self-learning power of the convolutional neural network to learn and extract effective features from *** proposed system was validated on 208 patient cases from the publicly available online Lung Image Database Consortium database,with each case having at least one juxtapleural nodule *** results demonstrated that our proposed method obtained a value of 0.91 of the area under the curve(AUC)of receiver operating characteristic based on sinogram alone,comparing to 0.89 based on CT image ***,a combination of sinogram and CT image could further improve the value of AUC to *** study indicates that pulmonary nodule detection in the sinogram domain is feasible with deep learning.

关键词： Computer-aided detection Computed tomography Deep learning Lung Sinogram

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Neuroimage-Based Consciousness Evaluation of Patients with Secondary Doubtful Hydrocephalus Before and After Lumbar Drainage

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Neuroscience Bulletin 2020年第9期36卷 985-996页

作者： Jiayu Huo Zengxin Qi Sen Chen Qian Wang Xuehai Wu Di Zang tanikawa Hiromi jiaxing tan Lichi Zhang Weijun tang Dinggang Shen Institute for Medical Imaging Technology Shanghai Jiao Tong UniversityShanghai 200030China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200030China Neurosurgical Institute of Fudan University Shanghai Clinical Medical Center of NeurosurgeryShanghai Key Laboratory of Brain Function Restoration and Neural RegenerationShanghai 200030China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science School of Basic Medical Sciences and Institutes of Brain ScienceFudan UniversityShanghai 200030China Department of Radiology Huashan HospitalFudan UniversityShanghai 200030China Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Brain and Cognitive Engineering Korea UniversitySeoul 02841Republic of Korea

Hydrocephalus is often treated with a cerebrospinal fluid shunt(CFS) for excessive amounts of cerebrospinal fluid in the ***,it is very difficult to distinguish whether the ventricular enlargement is due to hydrocephalus or other causes,such as brain atrophy after brain damage and *** non-trivial evaluation of the consciousness level,along with a continuous drainage test of the lumbar cistern is thus clinically important before the decision for CFS is *** studied 32 secondary mild hydrocephalus patients with different consciousness levels,who received T1 and diffusion tensor imaging magnetic resonance scans before and after lumbar cerebrospinal fluid *** applied a novel machine-learning method to find the most discriminative features from the multi-modal ***,we built a regression model to regress the JFK Coma Recovery Scale-Revised(CRS-R) scores to quantify the level of *** experimental results showed that our method not only approximated the CRS-R scores but also tracked the temporal changes in individual *** regression model has high potential for the evaluation of consciousness in clinical practice.

关键词： Hydrocephalus Disorder of consciousness Structural imaging Feature selection Regression

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裂缝性储层PDC钻头随钻响应特征实验研究

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钻采工艺 2023年第1期46卷 1-7页

作者：毛敏杨毅张立刚姬建飞薛东阳李浩苗振华谭甲兴中法渤海地质服务有限公司提高油气采收率教育部重点实验室·东北石油大学油气钻完井技术国家工程研究中心

裂缝性储层的裂缝预测难度大,研究裂缝性地层PDC钻头钻进响应特征对裂缝性储层随钻识别具有重要意义。文章利用水泥石材料制备的无裂缝水泥石试件、填充裂缝水泥石试件和张开裂缝水泥石试件开展了微PDC钻头钻进实验,监测不同裂缝类型的... 详细信息

裂缝性储层的裂缝预测难度大,研究裂缝性地层PDC钻头钻进响应特征对裂缝性储层随钻识别具有重要意义。文章利用水泥石材料制备的无裂缝水泥石试件、填充裂缝水泥石试件和张开裂缝水泥石试件开展了微PDC钻头钻进实验,监测不同裂缝类型的水泥石试件在钻进过程中的钻压、转速、扭矩、钻时等直接参数,通过计算机械比能、机械比能异常因子、机械比能波动因子和扭矩波动因子等衍生参数,揭示了不同裂缝类型的试件在PDC钻头钻进时的响应特征,构建了无缝、填充裂缝、张开裂缝在PDC钻头钻进时的特征图谱、评价指标体系和分类标准。并在渤中19-6气田进行了现场应用,与测井解释符合率达到了82%以上。该项研究成果为裂缝性储层的随钻识别诊断提供了实验依据。

关键词：裂缝性储层微PDC钻头钻进响应特征随钻识别

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基于Fluent分层注水工具过桥短节的压力损失数值模拟

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石油化工高等学校学报 2021年第6期34卷 64-69页

作者：张立刚娄绢平温晓红陈喜田刘照义孙道坤谭甲兴东北石油大学石油工程学院黑龙江大庆163318 中国石油集团科学技术研究院有限公司北京100083

分层注水工具是分层注水系统中的核心部件,对分层注水开发具有十分重要的意义。为研究不同管道粗糙度、不同流量对分层注水工具过桥短节摩阻压耗的影响,利用Fluent软件进行模拟分析。结果表明,分层注水工具过桥短节流量为500~2000 m^(3... 详细信息

分层注水工具是分层注水系统中的核心部件,对分层注水开发具有十分重要的意义。为研究不同管道粗糙度、不同流量对分层注水工具过桥短节摩阻压耗的影响,利用Fluent软件进行模拟分析。结果表明,分层注水工具过桥短节流量为500~2000 m^(3)/d工况下,外管压耗为1.90×10^(4)~6.16×10^(5)Pa,内管压耗为3.61×10^(5)~4.03×10^(6)Pa;当粗糙度不变时,液体流量越大,引起的局部阻力越大,引起的分层注水工具摩阻压耗越大,管道粗糙度对摩阻压耗的影响较小,可以忽略不计。以上研究结果为新分层注水管道设计及参数的选择提供了依据。

关键词： Fluent 分层注水工具过桥短节流量

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塑化剂迁移量测定和迁移模型研究进展

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数学建模及其应用 2014年第1期3卷 28-34,40页

作者：李广宇谭嘉星诸世豪佘良李红军北京林业大学理学院北京100083

综述国内外塑化剂迁移量测定和迁移模型研究进展,从创新实验测定方法和实验误差分析的角度简要评述了迁移量测定的研究成果;从数学模型的角度对微分方程模型、统计模型和计算机模拟3类重要迁移模型进行评述。最后指出,测定实验和迁移模... 详细信息

综述国内外塑化剂迁移量测定和迁移模型研究进展,从创新实验测定方法和实验误差分析的角度简要评述了迁移量测定的研究成果;从数学模型的角度对微分方程模型、统计模型和计算机模拟3类重要迁移模型进行评述。最后指出,测定实验和迁移模型相结合来研究塑化剂迁移问题是未来一个值得重视的方法。

关键词：迁移模型迁移量塑化剂测定数学模型

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反循环热洗有杆泵井井筒温度场数值模拟

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东北石油大学学报 2020年第5期44卷 82-88,I0005,I0006页

作者：张立刚谭甲兴陶泽俊王倩颖李浩娄绢平孙道坤薛东阳东北石油大学提高油气采收率教育部重点实验室黑龙江大庆163318 大庆钻探工程公司井下作业工程公司吉林松原138000 大庆油田有限责任公司第二采油厂黑龙江大庆163414

以有杆泵抽油井为例,引入井筒温度场计算的热流耦合模型和数值模拟方法,计算不同工况下采液过程和热洗过程中的油套环空和油管内的温度场分布。结果表明:采液过程中,随产液量和含水率增加,油管内各点温度逐渐升高,当产液量为0~85 t/d时... 详细信息

以有杆泵抽油井为例,引入井筒温度场计算的热流耦合模型和数值模拟方法,计算不同工况下采液过程和热洗过程中的油套环空和油管内的温度场分布。结果表明:采液过程中,随产液量和含水率增加,油管内各点温度逐渐升高,当产液量为0~85 t/d时,温升速率较快;当产液量超过85 t/d时,温度变化趋于平缓。热洗过程中,油套环空温度自上而下逐渐降低,油管内温度逐渐升高,随洗井温度和洗井排量增大,井下各点温度升高,但温升速率不同。井筒内温度数值模拟结果与实测结果符合率为96.59%~99.74%。该结果为反循环热洗油井清蜡提供指导。

关键词：反循环热洗有杆泵热流耦合温度场清蜡

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DARBOUX EQUATIONS AND ISOMETRIC EMBEDDING OF RIEMANNIAN MANIFOLDS WITH NONNEGATIVE CURVATURE IN R

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Chinese Annals of Mathematics,Series B 1999年第2期20卷 123-136页

作者： HONG jiaxing Fudan Univ Inst Math Shanghai 200433 Peoples R China

The present paper is concerned with the existence of golbal smooth solutions for the homogeneous Dirichlet boundary value problem of the Darboux equation and the case degenerate onthe boundary is contained As some app... 详细信息

关键词： Darboux equation Isometric embedding Riemannian manifold Nonnegative curvature

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Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment

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Nano Research 2022年第4期15卷 3556-3568页

作者： Qingsi Wu Jiading Wang Yuanfang Wang Ling Xiang Yulu tan jiaxing Feng Zhirong Zhang Ling Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyNo.17Block 3Southern Renmin RoadChengdu 610041China College of Polymer Science and Engineering Sichuan UniversityNo.24South Block 1First Ring RoadChengdu 610065China Med-X Center for Materials Sichuan UniversityNo.14 Section 3 South Renmin RoadJinjiang DistrictChengdu 610000China

The etiology of chronic kidney disease(CKD)is complex and diverse,which could be briefly categorized to glomerular-or ***,the final outcomes of CKD are mainly glomerular sclerosis,endothelial dysfunction and injury,and chronic ***,targeted delivery of drugs to the glomeruli in order to ameliorate glomerular endothelial damage may help alleviate CKD and help enrich our *** herb tripterygium wilfordii shows therapeutic effect on kidney disease,and celastrol(CLT)is one of its active ingredients but with strong ***,based on the unique structure and pathological characteristics of the glomerulus,we designed a targeted delivery system named peptides coupled CLT-phospholipid lipid nanoparticles(PC-PLNs)to efficiently deliver CLT to damaged endothelial cells and podocytes in the glomerulus for CKD treatment and ***-PLNs could effectively inhibit inflammation,reduce endothelial damage,alleviate CKD severity,and reduce the toxicity of *** also studied the mechanism of CLT in the treatment of nephropathy and found that CLT can increase the level of NO by increasing eNOS while inhibiting the expression of VCAM-1,thus provides an anti-inflammatory ***,our study not only offered an efficient CKD drug formulation for further development,but also provided new medical knowledge about CKD.

关键词： celastrol chronic kidney disease(CKD) glomerulus endothelial cells VCAM-1

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A Note for Estimation About Average Differential Entropy of Continuous Bounded Space-Time Random Field

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Chinese Journal of Electronics 2022年第5期31卷 793-803页

作者： SONG Zhanjie ZHANG jiaxing Georgia Tech Shenzhen Institute Tianjin University Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin University School of Mathematics Tianjin University

In this paper, we mainly study the discrete approximation about average differential entropy of continuous bounded space-time random field. The estimation of differential entropy on random variable is a classic problem, and there are many related studies. Space-time random field is a theoretical extension of adding random variables to space-time parameters, but studies on discrete estimation of entropy on space-time random field are relatively few. The differential entropy forms of continuous bounded space-time random field and discrete estimations are discussed, and three estimation forms of differential entropy in the case of random variables are generated in this paper. Furthermore, it is concluded that under the condition that the entropy estimation formula after space-time segmentation converges with probability1, the average entropy in the bounded space-time region can also converge with probability 1, and three generalized entropies are verified respectively. In addition, we also carried out numerical experiments on the convergence of average entropy estimation based on parameters,and the numerical results are consistent with the theoretical results, which indicting further study of the average entropy estimation problem of space-time random fields is significant in the future.

关键词： average differential entropy differential entropy forms average entropy estimation problem random processes entropy estimation formula random variable approximation theory space-time segmentation space-time parameters bounded space-time region entropy continuous bounded space-time random field

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Constant charge method or constant potential method:Which is better for molecular modeling of electrical double layers?

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Journal of Energy Chemistry 2024年第7期94卷 54-60页

作者： Liang Zeng Xi tan Xiangyu Ji Shiqi Li Jinkai Zhang jiaxing Peng Sheng Bi Guang Feng State Key Laboratory of Coal Combustion Schoolof Energy and PowerEngineeringHuazhong Universityof Science and Technology(HUST)Wuhan 430074HubeiChina Sorbonne Universite CNRSPhysico-chimie des Electrolytes et Nanosystemes InterfaciauxPHENIXF-75005 ParisFrance

In molecular modeling of electrical double layers(EDLs),the constant charge method(CCM)is prized for its computational efficiency but cannot maintain electrode equipotentiality like the more resourceintensive constant potential method(CPM),potentially leading to *** certain scenarios,CCM can yield results identical to ***,there are no clear guidelines to determine when CCM is sufficient and when CPM is ***,we conduct a series of molecular simulations across various electrodes and electrolytes to present a comprehensive comparison between CCM and CPM under different charging *** reveal that CCM approximates CPM effectively in capturing equilibrium EDL and current-driven dynamics in open electrode systems featuring ionic liquids or regular concentration aqueous electrolytes,while CPM is indispensable in scenarios involving organic and highly concentrated aqueous electrolytes,nanoconfinement effects,and voltage-driven *** work helps to select appropriate methods for modeling EDL systems,prioritizing accuracy while considering computationalefficiency.

关键词： Electrochemical interface Molecular dynamics Electrode polarization modeling Nanoconfinement effect

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