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Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of Sz-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

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Chinese Chemical Letters 2024年第6期35卷 462-468页

作者： Yu Yan jiawei Song Dongdong Liu zihan Liu Jialing Cheng zhiyang Chen Yanfang Yang Weizhe Jiang Hongliang Wang Jun Ye Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China College of Pharmacy Guangxi Medical UniversityNanning 530021China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon and disrupted intestinal *** mori(Sangzhi)alkaloids(Sz-A),derived from twigs of mulberry,were approved by the National Medical Products Administration in 2020 for treating type 2 diabetes *** evidence has confirmed that Sz-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation,indicating its potential to address inflammation in ***,the treatment of UC faces challenges due to low drug delivery efficiency and short retention *** overcome these challenges,an injectable and adherent in-situ thermo-sensitive hydrogel containing Sz-A was developed for rectal drug delivery,utilizing the thermo-sensitive polymers Poloxamer 407and *** thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32±0.5℃,a short gelation time of 64 s,a p H range of 7-10,high moisturizing capability exceeding 90%,and moderate mechanical strength of 4-5 *** a rat model with UC,the in situ thermo-sensitive hydrogel significantly extended the retention time at the colonic site and enabled sustained release after rectal *** of UC were markedly reduced following rectal administration of Sz-A thermosensitive ***,the release of inflammatory factors,such as interleukin-1β(IL-1β),IL-6,IL-18,tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1),significantly decreased in the Sz-A thermo-sensitive hydrogel *** integrity of the colonic mucosal barrier was significantly enhanced following the application of Sz-A thermo-sensitive *** conclusion,rectal administration of Sz-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms,inhibited the secretion of inflammatory factors,and promoted the repair of the colonic mucosal *** approach holds promise as a potential treatment for UC.

关键词： Ulcerative colitis Sz-A Thermo-sensitive hydrogel Rectal administration Alleviation of inflammation Mucosal barrier repair

π-Fused Diazocines with Controllable Photoswitching Properties as Molecular Tweezers

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CCS Chemistry 2024年第9期6卷 2175-2185页

作者： Wei Yuan Mengjiao Wu Cheng Qian Jingjing Guo Yinglong Wu Ting He Haipeng Wei Xiaokai Chen Dongdong Wang jiawei Liu Yue z.ao Shihuai Wang Jie Yang zhongzheng zhang Yulan Chen Yanli z.ao School of Chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371 State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun 130012 Department of Chemistry National University of SingaporeSingapore 117543

Diazocines,a type of photoswitch molecules,are distinguished by their unique conformation and photochromic *** engineering of diazocines,especially theπ-extended ones,remains challenging due to limited synthetic ***,we developed threeπ-fused diazocines(BAzO-1,BAzO-2,and BAzO-3)via Bischler–Napieralski *** isomerizations(z⇆E)were switchable under visible light sources(427 and 630 nm).The size of theirπ-extension exerted a significant influence on the isomerization process,whereby the biggest fourfold ring-closure diazocine(BAzO-3)showed the fastest conversion rate(z→E).Notably,the half-life(t1/2)of the E isomer of BAzO-3 was 14.6 times higher than that of the twofold ring-closure ***,BAzO-3 acted as a molecular tweezer based on double N-embedded pyrene units,allowing it to bind to pyrene through supramolecular *** work may pave the way for designing novel photoswitches with long half-lives and lightcontrolled properties.

关键词： diazocine π-fused structure photochromism photoisomerization molecular tweezer

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面料性能对男士西服门襟造型的影响

现代纺织技术 2024年第1期32卷 100-107页

作者：孔媛劳稼玮浙江理工大学国际时装技术学院杭州310018 KNY男装有限公司杭州310018

西服门襟位于整件服装的视觉中心,是西服结构和造型的重要组成部分。除版型设计外,面料性能也会影响西服门襟的造型。以门襟倾斜度、重叠量作为门襟造型的客观评价指标,并以美观度、平整度作为门襟造型的主观评价指标,通过面料性能测试... 详细信息

西服门襟位于整件服装的视觉中心,是西服结构和造型的重要组成部分。除版型设计外,面料性能也会影响西服门襟的造型。以门襟倾斜度、重叠量作为门襟造型的客观评价指标,并以美观度、平整度作为门襟造型的主观评价指标,通过面料性能测试及门襟造型主客观评价实验,根据SPSS数据分析结果探究面料性能对西服门襟造型的影响,通过回归分析分别建立了门襟倾斜度、重叠量、美观度、平整度与面料性能关系的回归方程。研究表明:克重、厚度、悬垂系数、抗弯刚度、断裂强度和伸长率等面料性能指标会对门襟造型产生影响,主观评价指标与客观评价指标间存在较大的相关性,门襟的倾斜度小,重叠量大,门襟的美观度和平整度较好。

关键词：西服门襟服装造型面料性能美观性评价

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Diagnose and treatment for Type D congenital esophageal atresia with tracheoesophageal fistula

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Pediatric Investigation 2024年第1期8卷 37-43页

作者： Dingding Wang Yong z.ao Yanan zhang Kaiyun Hua Yichao Gu Shuangshuang Li Junmin Liao Shen Yang Ting Yang jiawei z.ao Jinshi Huang Department of Neonatal Surgery Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Type D esophageal atresia(EA)with tracheoesophageal fistula(TEF)is characterized by EA with both proximal and distal *** is a rare congenital anomaly with a very low ***:To investigate diagnostic and treatment strategies for this rare ***:We retrospectively reviewed the clinicopathological features of patients with EA/TEF treated at our institution between January 2007 and September ***:Among 386 patients with EA/TEF,14(3.6%)had type D EA/*** two patients were diagnosed with proximal TEF *** patients were diagnosed *** patients were missed for diagnosis during the initial surgery but was later confirmed by *** the neonatal period,seven patients underwent a one-stage repair of proximal and distal TEF via thoracoscopy or *** to missed diagnosis and other reasons,the other 7 patients underwent two-stage surgery for repair of the proximal TEF,including cervical incision and *** of the 14 patients experienced postoperative complications including anastomotic leakage,pneumothorax,esophageal stricture,and *** who underwent one-stage repair of distal and proximal TEF during the neonatal period showed a higher incidence of anastomotic leak(4/7).In contrast,only one of seven patients with two-stage repair of the proximal TEF developed an anastomotic ***:Type D EA/TEF is a rare condition,and proximal TEFs are easily *** may aim to diagnose and determine the correct surgical approach.A cervical approach may be more suitable for repairing the proximal TEF.

关键词： Diagnosis Therapy Tracheoesophageal fistula Type D congenital esophageal atresia

基于激光诱导荧光的土壤石油污染物荧光仿真研究

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中国激光 2024年第5期51卷 213-221页

作者：谢贝贝周炫宇赵佳伟王智翀燕山大学信息科学与工程学院河北秦皇岛066004 河北省计算机虚拟技术与系统集成重点实验室河北秦皇岛066004

激光诱导荧光(LIF)技术是一种主动式的遥感光学探测技术。土壤是常见的天然多孔介质,与石油混合后油滴会进入其孔隙内部,其独特的结构可以使光线发生多次反射和吸收,这种现象导致LIF探测土壤石油污染物获得的荧光分布具有差异性。笔者... 详细信息

激光诱导荧光(LIF)技术是一种主动式的遥感光学探测技术。土壤是常见的天然多孔介质,与石油混合后油滴会进入其孔隙内部,其独特的结构可以使光线发生多次反射和吸收,这种现象导致LIF探测土壤石油污染物获得的荧光分布具有差异性。笔者根据土壤含油量的多少以及分布特点,将土壤石油污染物分为油泥与含油土壤,基于蒙特卡罗方法和多孔介质的隐函数表示法,分别建立油泥和含油土壤的荧光仿真模型,采用荧光转换效率(接收荧光功率与发射激光功率的比值)表征荧光强度,从不同出射方向分析发射出土壤的荧光分布情况。通过模拟不同油品污染的油泥和含油土壤在不同入射天顶角、孔隙率、孔隙密度下的荧光转换效率,分析不同油品、LIF系统参数和土壤因素对荧光分布的影响。仿真结果表明:对于同种石油污染的油泥和含油土壤,油泥因较高的含油量导致荧光信号强于含油土壤;当激光垂直入射时,LIF系统收集的荧光信号强度最高,入射角度增大会导致荧光信号强度逐渐减弱;土壤石油污染物的荧光强度会随着孔隙率的增大而增大,随着孔隙密度的增大而减小;在激光照射下,轻质原油污染的土壤由于吸收系数较低,产生的荧光信号要弱于重质石油污染的土壤。本研究为LIF探测陆地溢油污染提供了理论和技术支持。

关键词：光谱学激光诱导荧光蒙特卡罗多孔介质土壤石油污染物荧光仿真

低载波比牵引系统的感应电机特征根离散化模型研究

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电工技术学报 2024年第2期39卷 434-444,454页

作者：张钦培李健卢阳吴凌豪杨凯孙佳伟强电磁工程与新技术国家重点实验室(华中科技大学电气与电子工程学院) 武汉430074 华中科技大学电气与电子工程学院新型电机与特种电磁装备教育部工程研究中心武汉430074 中车大连电力牵引研发中心有限公司大连116052

在大功率和高速电机驱动领域,电机控制系统将运行于低载波比工况。传统的一阶欧拉、二阶双线性等降阶离散化模型在低载波比下由于离散化误差过大,对应的状态观测将出现幅值和相位的稳态误差,严重时甚至出现发散不收敛现象。针对上述问题... 详细信息

在大功率和高速电机驱动领域,电机控制系统将运行于低载波比工况。传统的一阶欧拉、二阶双线性等降阶离散化模型在低载波比下由于离散化误差过大,对应的状态观测将出现幅值和相位的稳态误差,严重时甚至出现发散不收敛现象。针对上述问题,该文提出了感应电机特征根离散化模型。通过构建感应电机的复矢量模型状态空间方程,将满秩的状态转移矩阵进行对角化,得到状态转移矩阵的精确离散化结果,该模型在低载波比时仍具有较高的离散化精度。同时,提出了一种基于伯德图的离散化误差定量分析方法,通过定量对比不同离散化模型和连续域模型之间观测变量的幅值和相位误差,从理论上证明了提出方法的优越性。最后,通过仿真和实验验证了上述感应电机特征根离散化模型在低载波比下均具有良好的稳态精度与暂态跟随性能。

关键词：感应电机离散化模型传递函数伯德图低载波比

Mo含量对激光熔覆CoCrFeNiW_(0.6)Mo_(x)高熵合金涂层组织与性能的影响

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表面技术 2024年第3期53卷 170-178页

作者：杨佳伟牛伟孙荣禄张连旺马世忠蒋廷普天津工业大学机械工程学院天津300387 天津市现代机电装备技术重点实验室天津300387

目的研究Mo含量的变化对激光熔覆CoCrFeNiW_(0.6)高熵合金涂层的影响。方法使用RFL-C1000光纤激光器,在45钢基体表面制备CoCrFeNiW_(0.6)Mo_(x)(x=0,0.2,0.4,0.6,0.8)高熵合金涂层,并利用Leica DVM6光学显微镜、扫描电镜(SEM)、X射线衍射仪(XRD)、能谱仪、显微硬度仪、电化学工作站对熔覆层的宏观形貌与稀释率、相结构、微观组织结构、硬度、耐腐蚀性能进行测试与分析。结果加入Mo元素后,结合状态与表面形貌良好,当x=0~0.4时,涂层微观组织主要呈树枝晶形态,且晶粒逐渐变细。当x≥0.6时,涂层表面开始有裂纹产生。随着Mo元素的添加,涂层逐渐析出σ相,晶粒尺寸逐渐减小。当x=0.8时,有共晶组织形成。涂层显微硬度随Mo元素的增加而增加,但由于x=0.8时出现较多裂纹,裂纹的出现影响了涂层硬度,导致x=0.8时的硬度减小。当x=0.6时,涂层平均显微硬度最高,达到了959.69HV0.3,约为CoCrFeNiW_(0.6)涂层平均硬度的20.32%。当x=0~0.6时,涂层耐腐蚀性能随着Mo元素含量的增加逐渐提升。当x=0.8时,耐腐蚀性能变差,其原因是裂纹的出现以及σ相的形成使得涂层耐腐蚀性变差。在x=0.6时,涂层耐腐蚀性能最好。结论Mo元素的加入使得涂层微观组织出现σ相,同时有细化晶粒的作用,可以显著改善涂层的硬度以及耐腐蚀性。

关键词：高熵合金激光熔覆涂层 CoCrFeNi Mo 微观组织显微硬度耐腐蚀性能

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SVM strategy and analysis of a three-phase quasi-z-source inverter with high voltage transmission ratio

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Science China(Technological Sciences) 2023年第10期66卷 2996-3010页

作者： CHEN DaoLian z.ao jiawei QIN ShuRan School of Electrical Engineering Qingdao UniversityQingdao 266071China

Herein,we propose a novel three-phase quasi-z-source inverter with a high voltage transmission ratio to address challenges such as high switching loss and sizeable magnetic components in the basic quasi-z-source *** proposed circuit topology,control strategy,and related analysis are *** circuit topology of the inverter comprises a quasi-z-source network with an integrated magnetic inductor,an active clamp circuit,a three-phase inverter bridge,and an output LC filter,all of which are connected in *** improved 12-sector space vector modulation scheme is proposed based on the root-mean-square value of the voltage and the instantaneous value of the ***,analyses of the inverter voltage transmission ratio,resonant process,and parametric design guidelines for integrated magnetic inductor and zero-voltage switching conditions are *** results on a 1-kVA prototype inverter demonstrate that the proposed inverter exhibits a higher transmission ratio and efficiency than existing inverters;thus,the proposed inverter would have broad prospects in low-voltage DC-AC applications.

关键词： quasi-z-source inverter three-phase inverter zero-voltage-switching magnetically integrated inductor space vector modulation

Harnessing cytokine-induced killer cells to accelerate diabetic wound healing:an approach to regulating post-traumatic inflammation

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Regenerative Biomaterials 2024年第2期3卷 88-99页

作者： Yixi Yang Cheng zhang Yuan Jiang Yijun He iawei Cai Lin Liang z.aohuan Chen Sicheng Pan Chu Hua Keke Wu Le Wang zhiyong zhang Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University Guangdong Province Engineering Research Center for Biomedical EngineeringState Key Laboratory of Respiratory DiseaseDepartment of Orthopaedic SurgeryMedical Technology and Related Equipment Research for Spinal Injury TreatmentCity Key LaboratoryThe Third Affliated Hospital of Guangzhou Medical UniversitySchool of Biomedical EngineeringGuangzhou MedicalUniversityGuangzhouGuangdong510150P.R.China Department of Osteoarthropathy and Sports Medicine Panyu Central HospitalGuangzhou 511400P.R.China

Impaired immunohomeostasis in diabetic wounds prolongs infiammation and cytokine dysfunction,thus,delaying or pre-venting wound-surface *** clinical studies have been conducted on cytokine-induced killer(CIK)cells recently,as they can be easily proliferated using a straightforward,inex-pensive ***,the function of CIK cells in regulat-ing inflammatory environments has been drawing attention for clinical *** the current investigation,we discovered the regenerative capacity of these cells in the chal-lenging environment of wounds that heal poorly due to *** demonstrated that the intravenous injection of CIK cells can re-establish a proregenerative inflammatory *** *** accelerateskin healing in diabetic *** results indicated that CIK cell treatment affects macrophage polarization and restores the function regenerative cells under hyperglycemic *** novel cellular therapy offers a promising intervention for clinical applic tions through specific inflammatory regulation functions.

关键词： macrophage diabetic wound post-traumatic inflammation cytokine-induced killer cells vascularization