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Numerical simulation of mesoscopic cracking of cement-treated base material based on random polygon aggregate model

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第3期10卷 454-468页

作者： Qiao Dong Xiaokang Zhao Xueqin Chen jiawei yuan Wei Hu Ahmad Jahanzaib School of Transportation Southeast UniversityNanjing 211189China National Demonstration Center for Experimental Road and Traffic Engineering Education Nanjing 211189China Department of Civil Engineering Nanjing University of Science and TechnologyNanjing 210094China Biotechnology Engineeringand Skilled Technologies DivisionWake Technical Community CollegeRaleighNC 27603USA

Cracking failure of cement-treated base(CTB)has always been the concern of highway constructors.Mesoscale cracking analysis is an important means to study the damage degradation mechanism,which is difficult to be characterized by experimental techniques alone.The objective of this paper is to develop a random aggregate modelling method to simulate the mesoscopic cracking of CTB material.A minimum rectangle area method was proposed to calculate the polygon aggregate size,which is closer to the sieving analysis than the average radius method.A buffer zone method was proposed to determine the distance between randomly generated polygon aggregates.Based on the proposed random algorithm,finite element method(FEM)was adopted to build the mesoscopic model of CTB including aggregate,mortar,interfacial transition zone(ITZ)and air voids.Laboratory tests were conducted to validate the numerical model.Then the sensitivity analyses were conducted to study the influencing factors on cracking behavior.The simulation results indicate that the higher aggregate content and the finer gradation lead to the increase of ITZ,thus reducing the cracking resistance of the CTB material.Low porosity content is able to significantly reduce the stress concentration and thus improves the cracking resistance.The research results of this paper could be used to guide the crack resistant design of CTB material.

关键词： Cement-treated base Random aggregate Mesoscopic structure Sensitivity analysis Finite element method

Hot deformation behavior and finite element simulation of Mg-8.3Gd-4.4Y-1.5Zn-0.8Mn alloy

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Journal of Rare Earths 2022年第5期40卷 831-839,I0006页

作者： Jiabin Fan Minglong Ma Kui Zhang Yongjun Li Xinggang Li Guoliang Shi jiawei yuan State Key Laboratory of Nonferrous Metals and Process GRINM Co.Ltd..Beijing 100088China GRIMAT Engineering Institute Co.Ltd Beijing 101407China General Research Institute for Nonferrous Metals Beijing 100088China

To study the hot deformation behavior of Mg-8.3 Gd-4.4 Y-1.5 Zn-0.8 Mn(wt%) alloy,hot compression tests were conducted using a Gleeble-3500 thermal simulator at temperatures ranging from 653 to773 K,true strain rates of 0.001-1 s^(-1),and a deformation degree of 60%.Results of hot compression experiments show that the flow stress of the alloy increases with the strain rate.The true stress-true strain curves are corrected by correcting the effect of temperature rise in the deformation process.Activation energy,Q,equal to 287380 J/mol and material constant,n,equal to 4.59 were calculated by fitting the true stress-true strain curves.Then,the constitutive equation was established and verified via finite element simulation.Results of the hot processing map show that the probability of material instability increases with the degree of deformation,which indicates that the material is not suitable for large deformation in a single pass.On the whole,the alloy is appropriate for multipass processing with small deformation and a suitable processing temperature and strain rate are 733 K and 0.01 s-1,respectively.

关键词： Mg-Gd-Y-Zn-Mn alloy Hot deformation Constitutive relationship Finite element simulation Processing map Rare earths

Josephin domain containing 2(JOSD2)promotes lung cancer by inhibiting LKB1(Liver kinase B1)activity

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Signal Transduction and Targeted Therapy 2024年第2期9卷 693-708页

作者： Tao yuan Chenming Zeng jiawei Liu Chenxi Zhao Fujing Ge Yuekang Li Meijia Qian Jiamin Du Weihua Wang Yonghao Li Yue Liu Xiaoyang Dai Jianya Zhou Xueqin Chen Shenglin Ma Hong Zhu Qiaojun He Bo Yang Institute of Pharmacology&Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 311199China Ministry of Education Key Laboratory of Chinese Medicinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese MedicineGuangzhou 510006China Center for Drug Safety Evaluation and Research of Zhejiang University Hangzhou 310058China Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310006China Department of Oncology Hangzhou Cancer HospitalHangzhou 310002China Cancer Center of Zhejiang University HangzhouChina Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHangzhouChina

Non-small cell lung cancer(NSCLC)ranks as one of the leading causes of cancer-related deaths worldwide.Despite the prominence and effectiveness of kinase-target therapies in NSCLC treatment,these drugs are suitable for and beneficial to a mere~30%of NSCLC patients.Consequently,the need for novel strategies addressing NSCLC remains pressing.Deubiquitinases(DUBs),a group of diverse enzymes with well-defined catalytic sites that are frequently overactivated in cancers and associated with tumorigenesis and regarded as promising therapeutic targets.Nevertheless,the mechanisms by which DUBs promote NSCLC remain poorly understood.Through a global analysis of the 97 DUBs’contribution to NSCLC survival possibilities using The Cancer Genome Atlas(TCGA)database,we found that high expression of Josephin Domain-containing protein 2(JOSD2)predicted the poor prognosis of patients.Depletion of JOSD2 significantly impeded NSCLC growth in both cell/patient-derived xenografts in vivo.Mechanically,we found that JOSD2 restricts the kinase activity of LKB1,an important tumor suppressor generally inactivated in NSCLC,by removing K6-linked polyubiquitination,an action vital for maintaining the integrity of the LKB1-STRAD-MO25 complex.Notably,we identified the first small-molecule inhibitor of JOSD2,and observed that its pharmacological inhibition significantly arrested NSCLC proliferation in vitro/in vivo.Our findings highlight the vital role of JOSD2 in hindering LKB1 activity,underscoring the therapeutic potential of targeting JOSD2 in NSCLC,especially in those with inactivated LKB1,and presenting its inhibitors as a promising strategy for NSCLC treatment.

关键词： LKB1 inhibiting removing

基于零序信号全波形识别的小电流接地系统故障选线方法

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电网技术 2024年第2期48卷 839-850页

作者：袁嘉玮焦在滨西安交通大学电气工程学院陕西省西安市710049

小电流接地系统发生单相接地故障时,故障电流微弱,暂态特征复杂,导致现有选线方法正确率偏低,可靠性较差。该文提出了一种基于零序信号全波形识别的选线方法。首先,介绍了基于故障信号全波形识别的通用方法,指出从波形的角度认识并识别... 详细信息

小电流接地系统发生单相接地故障时,故障电流微弱,暂态特征复杂,导致现有选线方法正确率偏低,可靠性较差。该文提出了一种基于零序信号全波形识别的选线方法。首先,介绍了基于故障信号全波形识别的通用方法,指出从波形的角度认识并识别信号,可以充分利用信号的全部故障信息;其次,选取母线电压和所有馈线电流波形作为待识别信号,并根据电流波形分布特征自适应捕捉信号中特征差异最明显的波形进行故障识别,提出了基于故障信号全波形识别的选线方法;然后,利用改进后的全卷积神经网络来识别不同信号波形,并基于Dice系数对识别出的故障信号波形进行可信赖性评价。最后,PSCAD仿真和真型实验测试结果表明该方法具有很高的选线正确率和可靠性。

关键词：波形长度自适应技术可信度评价故障选线语义分割波形识别

Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes

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Genes & Diseases 2024年第4期11卷 134-137页

作者： Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng yuan Jianwei Zhu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China Jecho Laboratories Inc.FrederickMD 21704USA Jecho Institute Co. Ltd.Shanghai 200240China

The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal antibodies can be efficacious in preventing and treating SARSCoV-1 and SARS-CoV-2 infections.Using a phage display platform,we have identified dozens of monoclonal antibodies that bind to diverse epitope groups on the SARS-CoV-2 spike protein.Many of them bound to the receptor binding domain(RBD)and inhibited ACE2-RBD interaction.

关键词： antibodies inhibited monoclonal

Textbook outcome in gallbladder carcinoma after curative-intent resection:a 10-year retrospective single-center study

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Chinese Medical Journal 2023年第14期136卷 1680-1689页

作者： Qi Li Hengchao Liu Qi Gao Feng Xue Jialu Fu Mengke Li jiawei yuan Chen Chen Dong Zhang Zhimin Geng Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710061China Department of Pediatric Surgery The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China

Background:Textbook outcome(TO)can guide decision-making among patients and clinicians during preoperative patient selection and postoperative quality improvement.We explored the factors associated with achieving a TO for gallbladder carcinoma(GBC)after curative-intent resection and analyzed the effect of adjuvant chemotherapy(ACT)on TO and non-TO patients.Methods:A total of 540 patients who underwent curative-intent resection for GBC at the Department of Hepatobiliary Surgery of the First Affiliated Hospital of Xi’an Jiaotong University from January 2011 to December 2020 were retrospectively analyzed.Multivariable logistic regression was used to investigate the factors associated with TO.Results:Among 540 patients with GBC who underwent curative-intent resection,223 patients(41.3%)achieved a TO.The incidence of TO ranged from 19.0%to 51.0%across the study period,with a slightly increasing trend over the study period.The multivariate analysis showed that non-TO was an independent risk factor for prognosis among GBC patients after resection(P=0.003).Age≤60 years(P=0.016),total bilirubin(TBIL)level≤34.1 mmol/L(P<0.001),well-differentiated tumor(P=0.008),no liver involvement(P<0.001),and T1-2 stage disease(P=0.006)were independently associated with achieving a TO for GBC after resection.Before and after propensity score matching(PSM),the overall survival outcomes of non-TO GBC patients who received ACT and those who did not were statistically significant;ACT improved the prognosis of patients in the non-TO group(P<0.05).Conclusion:Achieving a TO is associated with a better long-term prognosis among GBC patients after curative-intent resection,and ACT can improve the prognosis of those with non-TO.

关键词： Gallbladder neoplasms Textbook outcome Curative-intent resection Adjuvant chemotherapy Prognosis Nomogram

Enhancing strength and ductility in back extruded WE71 magnesium alloy cylindrical parts by introduction of multi-direction forging process

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Journal of Rare Earths 2023年第3期41卷 462-470,I0006页

作者： Dehao Bu Ting Li Xiaolei Han Zhiwei Du jiawei yuan Kui Zhang Yongjun Li Yonggang Peng Zheng Pang Chunlei Zhao National Center of Analysis and Testing for Nonferrous Metals and Electronic Materials GRINM Group Co.Ltd.Beijing 100088China Guobiao(Beijing)Testing&Certification Co. Ltd.China United Test&Certification Co.Ltd.Beijing 100088China General Research Institute for Nonferrous Metals Beijing 100088China State Key Laboratory for Fabrication and Processing of Non-Ferrous Metals GRIMAT Engineering Institute Co.Ltd.Beijing 101407China Gaona Aero Material Co. Ltd.Beijing 100081China

Magnesium cylindrical parts have relatively poor mechanical properties and distinct anisotropy of microstructure,which hinder their application as structural components.To improve the performance of WE71 cylindrical parts,multi-direction forging(MDF)was introduced before back extrusion,and the microstructure and mechanical properties were investigated.Results of microstructure show that the grain size in the outer of the cylindrical bottom is refined from 30.1 to 27.7μm,the micro structure is more uniform and the dislocation density is higher.The bimodal grain structure is formed in the outer of the cylindrical wall,which is ascribed to the formation of MgsRE phases along grain boundaries.These phases result in the Zener pinning effect on grain boundaries and the reduction of DRX volume fraction.The texture type of the cylindrical bottom is‖ED and the cylindrical wall is‖ED,and the maximum pole intensity is 1.986 and 1.664,respectively.Results of the tensile test at room temperature show that combined improved strength and ductility of the cylindrical part is attained after introducing the MDF process.The ultimate tensile strength(UTS),yield strength(YS)and elongation are279 MPa,185 MPa and 12%at the bottom and 299 MPa,212 MPa and 20%at the wall.

关键词： WE71 magnesium alloy Multi-direction forging Backward extrusion Bimodal grain structure Rare earths

飞机维修路径研究热点与前沿——基于CiteSpace的可视化分析

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航空工程进展 2024年第2期15卷 66-76页

作者：袁媛于佳伟沈阳航空航天大学经济与管理学院沈阳110136

近年来,随着民航运输业的飞速发展,飞机维修路径规划研究越来越受到重视。为了探究飞机维修路径规划问题的研究现状、研究热点以及前沿趋势,以中国知网(CNKI)和Web of Science核心数据库2000年1月—2022年12月收录的国内外飞机维修路径... 详细信息

近年来,随着民航运输业的飞速发展,飞机维修路径规划研究越来越受到重视。为了探究飞机维修路径规划问题的研究现状、研究热点以及前沿趋势,以中国知网(CNKI)和Web of Science核心数据库2000年1月—2022年12月收录的国内外飞机维修路径规划研究的相关文献作为分析数据,将CiteSpace V软件作为辅助研究工具,分析飞机维修路径规划研究领域的研究人员、研究机构及其合作关系,结合知识图谱与文献内容总结该领域的研究热点与研究前沿。考虑国内的飞机维修路径规划研究情况,针对我国在该领域的研究趋势及重点研究内容提出研究建议,为今后飞机维修路径规划研究提供参考。

关键词：飞机维修路径规划飞机排班 CiteSpace 知识图谱分析研究热点

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面料性能对男士西服门襟造型的影响

现代纺织技术 2024年第1期32卷 100-107页

作者：孔媛劳稼玮浙江理工大学国际时装技术学院杭州310018 KNY男装有限公司杭州310018

西服门襟位于整件服装的视觉中心,是西服结构和造型的重要组成部分。除版型设计外,面料性能也会影响西服门襟的造型。以门襟倾斜度、重叠量作为门襟造型的客观评价指标,并以美观度、平整度作为门襟造型的主观评价指标,通过面料性能测试... 详细信息

西服门襟位于整件服装的视觉中心,是西服结构和造型的重要组成部分。除版型设计外,面料性能也会影响西服门襟的造型。以门襟倾斜度、重叠量作为门襟造型的客观评价指标,并以美观度、平整度作为门襟造型的主观评价指标,通过面料性能测试及门襟造型主客观评价实验,根据SPSS数据分析结果探究面料性能对西服门襟造型的影响,通过回归分析分别建立了门襟倾斜度、重叠量、美观度、平整度与面料性能关系的回归方程。研究表明:克重、厚度、悬垂系数、抗弯刚度、断裂强度和伸长率等面料性能指标会对门襟造型产生影响,主观评价指标与客观评价指标间存在较大的相关性,门襟的倾斜度小,重叠量大,门襟的美观度和平整度较好。

关键词：西服门襟服装造型面料性能美观性评价