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Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis

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Chinese Chemical Letters 2024年第6期35卷 462-468页

作者： Yu Yan jiawei song Dongdong Liu Zihan Liu Jialing Cheng Zhiyang Chen Yanfang Yang Weizhe Jiang Hongliang Wang Jun Ye Yuling Liu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China College of Pharmacy Guangxi Medical UniversityNanning 530021China Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Ulcerative colitis(UC)is a chronic inflammatory bowel disease characterized by persistent inflammation of the colon and disrupted intestinal function.Ramulus mori(Sangzhi)alkaloids(SZ-A),derived from twigs of mulberry,were approved by the National Medical Products Administration in 2020 for treating type 2 diabetes mellitus.Accumulated evidence has confirmed that SZ-A also alleviates non-alcoholic fatty liver disease and ameliorates inflammation,indicating its potential to address inflammation in UC.However,the treatment of UC faces challenges due to low drug delivery efficiency and short retention time.To overcome these challenges,an injectable and adherent in-situ thermo-sensitive hydrogel containing SZ-A was developed for rectal drug delivery,utilizing the thermo-sensitive polymers Poloxamer 407and 188.The thermo-sensitive hydrogel system was designed with a moderate gelation temperature of 32±0.5℃,a short gelation time of 64 s,a p H range of 7-10,high moisturizing capability exceeding 90%,and moderate mechanical strength of 4-5 s.In a rat model with UC,the in situ thermo-sensitive hydrogel significantly extended the retention time at the colonic site and enabled sustained release after rectal administration.Symptoms of UC were markedly reduced following rectal administration of SZ-A thermosensitive hydrogel.Furthermore,the release of inflammatory factors,such as interleukin-1β(IL-1β),IL-6,IL-18,tumor necrosis factor-α(TNF-α),and transforming growth factor-β1(TGF-β1),significantly decreased in the SZ-A thermo-sensitive hydrogel group.The integrity of the colonic mucosal barrier was significantly enhanced following the application of SZ-A thermo-sensitive hydrogel.In conclusion,rectal administration of SZ-A in situ thermo-sensitive hydrogel effectively alleviated UC symptoms,inhibited the secretion of inflammatory factors,and promoted the repair of the colonic mucosal barrier.This approach holds promise as a potential treatment for UC.

关键词： Ulcerative colitis SZ-A Thermo-sensitive hydrogel Rectal administration Alleviation of inflammation Mucosal barrier repair

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Targeting the elabela/apelin-apelin receptor axis as a novel therapeutic approach for hypertension

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Chinese Medical Journal 2022年第9期135卷 1019-1026页

作者： jiawei song Jianqiong Tang Zhenzhou Zhang Ying Liu Jiuchang Zhong Heart Center and Beijing Key Laboratory of Hypertension Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Critical Care Medicine Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 201600China Beijing Institute of Respiratory Medicine Beijing 100020China.

Hypertension is the leading risk factor for global mortality and morbidity and those with hypertension are more likely to develop severe symptoms in cardiovascular and cerebrovascular system,which is closely related to abnormal renin-angiotensin system and elabela/apelin-apelin receptor(APJ)axis.The elabela/apelin-APJ axis exerts essential roles in regulating blood pressure levels,vascular tone,and cardiovascular dysfunction in hypertension by counterbalancing the action of the angiotensin II/angiotensin II type 1 receptor axis and enhancing the endothelial nitric oxide(NO)synthase/NO signaling.Furthermore,the elabela/apelin-APJ axis demonstrates beneficial effects in cardiovascular physiology and pathophysiology,including angiogenesis,cellular proliferation,fibrosis,apoptosis,oxidative stress,and cardiovascular remodeling and dysfunction during hypertension.More importantly,effects of the elabela/apelin-APJ axis on vascular tone may depend upon blood vessel type or various pathological conditions.Intriguingly,the broad distribution of elabela/apelin and alternative isoforms implicates its distinct functions in diverse cardiac and vascular cells and tissue types.Finally,both loss-of-function and gain-of-function approaches have defined critical roles of the elabela/apelin-APJ axis in reducing the development and severity of hypertensive diseases.Thus,targeting the elabela/apelin-APJ axis has emerged as a pre-warning biomarker and a novel therapeutic approach against progression of hypertension,and an increased understanding of cardiovascular actions of the elabela/apelin-APJ axis will help to develop effective interventions for hypertension.In this review,we focus on the physiology and biochemistry,diverse actions,and underlying mechanisms of the elabela/apelin-APJ axis,highlighting its role in hypertension and hypertensive cardiovascular injury and dysfunction,with a view to provide a prospective strategy for hypertensive disease therapy.

关键词： Elabela Apelin APJ Hypertension Renin-angiotensin system

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Unmanned Aerial Vehicles:Control Methods and Future Challenges

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IEEE/CAA Journal of Automatica Sinica 2022年第4期9卷 601-614页

作者： Zongyu Zuo Cunjia Liu Qing-Long Han jiawei song IEEE the Seventh Research Division Beihang University(BUAA) the Department of Aeronautical and Automotive Engineering Loughborough University the School of Science Computing and Engineering TechnologiesSwinburne University of Technology

With the rapid development of computer technology,automatic control technology and communication technology,research on unmanned aerial vehicles(UAVs)has attracted extensive attention from all over the world during the last decades.Particularly due to the demand of various civil applications,the conceptual design of UAV and autonomous flight control technology have been promoted and developed mutually.This paper is devoted to providing a brief review of the UAV control issues,including motion equations,various classical and advanced control approaches.The basic ideas,applicable conditions,advantages and disadvantages of these control approaches are illustrated and discussed.Some challenging topics and future research directions are raised.

关键词： Aircraft control disturbance rejection path-following trajectory tracking unmanned aerial vehicle

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Evaluating provincial-level employment challenge during the coal transition in China

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Advances in Climate Change Research 2022年第5期13卷 729-737页

作者： Caitlin HAMILTON jiawei song Ryna CUI Colin OLSON Diyang CUI Center for Global Sustainability School of Public PolicyUniversity of MarylandCollege Park 20742USA

As China works to move away from coal in its energy system as a critical strategy to achieve carbon neutrality before 2060,there are several challenges which will affect the coal transition.One challenge that has not been fully explored is the impact on coal employment.There are millions of people employed in various sectors along the coal supply chain,including mining,processing,transport,and power generation.In this study,we developed a framework to understand the magnitude and characteristics of the employment challenges associated with the coal transition across provinces.Specifically,the magnitude and characteristics of the challenges are evaluated from multiple dimensions,including existing coal sector employment,coal production,coal consumption,GDP contribution from the coal industry,and coal mining productivity,to explore how the transition of the coal industry will likely affect different provinces.The results showed that provinces with large total coal employment today are often those with high coal production and consumption,high GDP contribution from the coal industry,and low productivity of coal mining.We found that employment impacts of a coal transition will not be equally distributed in China,as both the magnitude and characteristics of the employment challenges vary substantially across all provinces.It is therefore important to develop a tailored strategy to tackle specific needs for each province.

关键词： Coal transition Just transition Coal employment Province China

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Simultaneous integrated dose reduction intensity-modulated radiotherapy effectively reduces cardiac toxicity in limited-stage small cell lung cancer

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Cancer Biology & Medicine 2023年第6期20卷 452-464页

作者： Jing Luo jiawei song Li Xiao Jiajia Zhang Yipeng Cao Jun Wang Ping Wang Lujun Zhao Ningbo Liu Department of Immunology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerKey Laboratory of Cancer Immunology and BiotherapyTianjin 300060China Department of Oncology Ganyu District People's Hospital of Lianyungang CityLianyungang 222100China Department of Oncology Hebei Province Cangzhou Hospital of Integrated Traditional and Western MedicineCangzhou 061000China Department of Radiation Oncology Yantai Yuhuangding HospitalYantai 264000China Department of Radiation Oncology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Objective:To assess the clinical outcomes and toxicities of once daily(QD)simultaneous dose reduction intensity-modulated radiotherapy(SDR-IMRT-QD;SDR-QD)versus conventional QD IMRT(C-QD)and twice daily(BID)IMRT in patients with limited-stage small cell lung cancer(LS-SCLC).Methods:After propensity score matching(PSM),a retrospective analysis involving 300 patients with LS-SCLC treated using SDR-QD,C-QD,or BID was performed from January 1,2014 to December 31,2019.The prescribed irradiation dose in the SDR-QD cohort was 60 Gy/PGTV and 54 Gy/PTV QD.The radiation dose was 60 Gy for both PGTV and PTV QD in the C-QD cohort.The radiation dose was 45 Gy for both PGTV and PTV in the BID cohort.Toxicities,short-term effects,and survival outcomes were recorded.A meta-analysis on the protective effects of pharmaceuticals for cardiac toxicities induced by anti-tumor therapy was performed.Results:The median overall survival time(MST)in the 3 cohorts were 32.7 months(SDR-QD),26.3 months(C-QD),and 33.6 months(BID);the differences between groups were statistically significant.Lower toxicities and doses to organs-at-risk(OARs)occurred in the SDR-QD and BID cohorts.Further,the cardiac dose dosimetric parameter Vheart40 was negatively associated with survival(r=-0.35,P=0.007).A Vheart40 value of 16.5%was recommended as a cut-off point,which yielded 54.7%sensitivity and 85.7%specificity for predicting negative survival outcomes.The meta-analysis indicated that pharmaceuticals significantly reduced the cardiac toxicities induced by chemotherapy,but not radiotherapy.Conclusions:SDR-QD was shown to have similar toxicities and survival compared with BID,but fewer toxicities and better survival than C-QD.In addition,cardiac dose exposure was negatively associated with survival.Thus,16.5%of the cardiac dosimetric parameter Vheart40 is recommended as the cut-off point,and a Vheart40>16.5%predicts poor survival.

关键词： cardiac radiotherapy doses

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最小依赖隐藏的屏摄鲁棒水印方法

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中国图象图形学报 2024年第2期29卷 408-418页

作者：宋佳维刘春晓张心怡浙江工商大学计算机科学与技术学院杭州310018

目的现有屏摄水印方法无法有效平衡计算复杂度、嵌入水印后的图像质量以及水印鲁棒性3项指标,同时广泛使用透视畸变矫正预处理,大大限制了屏摄水印的实际商业使用。本文在重新设计噪声层的基础上,提出了一种最小依赖载体图像隐藏水印... 详细信息

目的现有屏摄水印方法无法有效平衡计算复杂度、嵌入水印后的图像质量以及水印鲁棒性3项指标,同时广泛使用透视畸变矫正预处理,大大限制了屏摄水印的实际商业使用。本文在重新设计噪声层的基础上,提出了一种最小依赖载体图像隐藏水印信息的屏摄鲁棒水印,将屏摄水印对于载体图像的依赖控制在最小。方法为了保证水印的嵌入效率,极大简化依赖深度隐藏网络框架中的编码网络,达成对载体图像的最小依赖,大大减小计算复杂度;为了平衡网络深度减小所导致的网络提取能力损失,加入Sobel算子,引入载体图像的边缘信息;在噪声层中加入缩放攻击操作,并由此去除了限制屏摄水印应用范围的透视畸变矫正预处理,进一步拓宽了应用范围;为了训练网络的屏摄鲁棒性,重新定义了噪声层,改进原有噪声层的设计结构,对噪声层图像扰动类型和参数进行随机选择,使得解码网络的输入数据具有更高的样本均衡性和多样性。结果在DIV2K(DIVerse 2K)数据集上与其他的3种方法进行了对比实验,本文方法获得了最高的PSNR(peak signal-to-noise ratio)和SSIM(structural similarity index measure)指标,并比排名第2的通用深度隐藏方法提高了12 dB的PSNR值和0.006的SSIM值;在有无攻击两种环境下,本文方法均能保持很高的ACC(accuracy)和F1指标,在攻击环境下比排名第2位的StegaStamp(steganography stamp)方法提高了0.262的F1分数。与同网络框架下的已有噪声层相比,在无攻击环境下,本文算法提高了0.124的ACC和0.284的F1分数;在有攻击环境下,本文算法提高了0.316的ACC和0.524的F1分数,水印提取的准确性更高。结论本文算法在图像质量和水印鲁棒性方面获得了更优的效果,摆脱了透视畸变矫正的限制,拓宽了屏摄水印的应用范围。

关键词：数字水印屏摄信道全卷积网络依赖隐藏噪声层

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噪声特性对言语可懂度评价的影响

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噪声与振动控制 2024年第1期44卷 234-241页

作者：宋嘉炜祝培生刘曦东刘浩成大连理工大学建筑与艺术学院辽宁大连116024

言语可懂度是语言声房间和厅堂音质评价的重要指标,噪声特性是影响言语可懂度评价结果的重要因素之一。基于国内外相关文献就噪声特性对言语可懂度评价的影响进行系统研究,结果表明,噪声特性对言语可懂度的评价结果有显著影响(:1)噪声... 详细信息

言语可懂度是语言声房间和厅堂音质评价的重要指标,噪声特性是影响言语可懂度评价结果的重要因素之一。基于国内外相关文献就噪声特性对言语可懂度评价的影响进行系统研究,结果表明,噪声特性对言语可懂度的评价结果有显著影响(:1)噪声在时域上的波动起伏有利于言语理解,但会导致个体间差异增大并降低评价结果的稳定性;噪声频率范围和频谱分布与语言声越接近,在低频区的噪声量越大,对言语可懂度的影响越大;言语噪声能够导致额外的信息掩蔽,影响程度与言语噪声的数量、噪声和目标语之间的相似程度以及听者的个体因素等有关。(2)将当前基于稳态噪声的言语可懂度客观评价方法用于其他噪声时,可能造成对言语可懂度的低估或高估。非稳态噪声情况下的可懂度客观评价仍存在一些不确定的地方。结合当前的研究现状,进一步提出该领域的下一步研究方向。相关内容可为噪声环境中的言语可懂度主、客观评价提供参考。

关键词：声学综述噪声特性言语可懂度主观评价客观评价

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茶树喷灌防霜中植株储水/冰量动态变化与影响因素研究

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农业机械学报 2024年第2期55卷 180-187页

作者：潘庆民鹿永宗张志金矿宋佳伟胡永光江苏大学农业工程学院镇江212013

喷灌是园艺作物有效的防霜技术之一。为确定茶树喷灌防霜需水量和节约水资源,需研究喷灌过程中植株的储水/冰量动态变化及影响因素。本文设计了一种防滴落、茎杆水收集及称量组合装置,可直接精确获取整株茶树的储水/冰量;试验分析非冻... 详细信息

喷灌是园艺作物有效的防霜技术之一。为确定茶树喷灌防霜需水量和节约水资源,需研究喷灌过程中植株的储水/冰量动态变化及影响因素。本文设计了一种防滴落、茎杆水收集及称量组合装置,可直接精确获取整株茶树的储水/冰量;试验分析非冻结和冻结、微量和摇臂2类喷头条件下储水/冰量变化的异同;最后探究了冻结下微量喷头喷灌时长对储冰量和茎杆水量的影响。研究结果表明,非冻结条件下,茶树储水量变化经历积累、动平衡和干燥3个阶段;冻结条件下的储冰量随喷灌进行持续增加,并在停喷后较长时间内保持不变,即积累和保持阶段,随后依次经历融化流失和干燥阶段;相同喷灌压力和时长下,微量喷头的储水量和储冰量分别是摇臂喷头的1.2倍和2.0倍;微量喷头喷灌时长对最大储水量无明显影响,约为0.22 kg,最大储冰量则随喷灌时长的增加而显著增加,1.5 h的储冰量是0.5 h的2.9倍。微量喷头作用的茎杆水量,在非冻结和冻结条件下也较高,分别是摇臂喷头的3.0倍和2.7倍。本文研究了茶树植株表面储水/冰量变化及影响因素,改进了灌木类植物冠层截留量的测量方法,为提升防霜效果和实现精准喷灌奠定了基础。

关键词：茶树防霜喷灌冠层截留储水量储冰量

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封闭体系内丁烷-空气预混气体爆炸的试验研究

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爆破器材 2024年第1期53卷 51-56页

作者：张宇庭徐振洋闫祎然宋家威秦涛辽宁科技大学矿业工程学院辽宁鞍山114051

为研究不同浓度丁烷-空气预混气体在封闭管道内的燃爆特性,利用方形密闭爆炸试验管道对不同体积分数的丁烷-空气预混气体进行爆炸试验。结果表明:气体爆炸先后经历了压力上升第一阶段、压力上升第二阶段和压力下降阶段;随着丁烷气体浓... 详细信息

为研究不同浓度丁烷-空气预混气体在封闭管道内的燃爆特性,利用方形密闭爆炸试验管道对不同体积分数的丁烷-空气预混气体进行爆炸试验。结果表明:气体爆炸先后经历了压力上升第一阶段、压力上升第二阶段和压力下降阶段;随着丁烷气体浓度的上升,爆炸压力上升速率、最大火焰速度、火焰加速度都呈先升高、后降低的趋势;其中,当丁烷体积分数为5%时,上述参数均达到峰值;含水管道中,气相与液相的爆炸压力趋势基本一致,但相较于无水管道中的压力变化更为平缓,并且最大爆炸压力及升压速率都较低。为可燃气体燃爆问题研究提供理论参考。

关键词：预混气体封闭管道爆炸压力火焰速度

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产前超声诊断胎儿口腔寄生胎并X连锁巨角膜1例

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中华超声影像学杂志 2024年第2期33卷 174-176页

作者：宋佳伟唐中锋高富华杨磊赵玉娜徐元哲甘肃省妇幼保健院超声医学中心兰州730050 甘肃省妇幼保健院产前诊断中心兰州730050 暨南大学口腔医学院广州510000

孕妇, 35岁, 怀孕4次, 生育2次, 自然流产2次, 2016、2019年行剖宫产分娩2女婴, 体健。孕25+4周外院超声提示:胎儿口咽部囊实性肿块, 多考虑来源于胎儿口腔。于孕27+1周, 来甘肃省妇幼保健院行针对性超声进一步检查, 超声所见:胎儿口腔... 详细信息

孕妇, 35岁, 怀孕4次, 生育2次, 自然流产2次, 2016、2019年行剖宫产分娩2女婴, 体健。孕25+4周外院超声提示:胎儿口咽部囊实性肿块, 多考虑来源于胎儿口腔。于孕27+1周, 来甘肃省妇幼保健院行针对性超声进一步检查, 超声所见:胎儿口腔无法闭合, 口腔内见一混合回声团块向外突出, 动态观察与胎儿咽喉部相连, 大小11.57 cm×8.41 cm×8.65 cm, 大小较外院检查时增大, 边界清, 形态不规则, 内部回声不均匀, 内可见大小不等的无回声及多发短条状强回声后方伴声影。受包块遮挡, 胎儿颜面部无法显示。彩色多普勒血流显像(CDFI)示团块内见动、静脉血流信号, 可见滋养血管来自于颅内。胎儿腹部散在多发的强回声斑;胃泡、胆囊、膀胱未显示。羊水无回声区最大深度11.68 cm, 羊水指数38.87 cm。超声提示:①胎儿口咽部混合回声占位, 多考虑口腔寄生胎;②胎儿腹部散在多发强回声斑;③胎儿胃泡、胆囊、膀胱未显示;④羊水过多(图1)。充分告知患儿父母双方病情后, 患儿父母要求入院引产, 于2 d后生下一女婴, 外观见口鼻部膨出一14 cm×10 cm大小不规则样膨出物, 外部可见一层膜包裹, 边缘可见部分肠管外漏, 该肿物来源于胎儿口腔上腭。最后经病理诊断为胎儿口腔寄生胎。

关键词：患儿父母混合回声口咽部羊水过多省妇幼保健院强回声胃泡上腭

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