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Laser irradiation constructing all-in-one defective graphenepolyimide separator for effective restraint of lithium dendrites and shuttle effect

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Nano Research 2023年第10期16卷 12304-12314页

作者： jiawei Mu Mengdi Zhang Yanan Li Zhiliang Dong Yuanyuan Pan Bei Chen Zhengqiu He Haiqiu fang Shuoshuo Kong Xin Gu Han Hu Mingbo Wu State Key Laboratory of Heavy Oil Processing Advanced Chemical Engineering and Energy Materials Research CenterCollege of New EnergyChina University of Petroleum(East China)Qingdao 266580China College of Physics University-Industry Joint Center for Ocean Observation and Broadband CommunicationState Key Laboratory of Bio-Fibers and Eco TextilesQingdao UniversityQingdao 266071China

The commercialization of lithium-sulfur(Li-S)batteries faces several bottlenecks,and the major two of which are the shuttle effect of polysulfides and the wild growth of Li dendrites,responsible for fast capacity decay and severe safety *** an essential component of Li-S batteries,the structure and properties of the separators are closely related to the above problems,and the exploration of multifunctional separators is highly ***,an integrated separator composited of defective graphene and polyimide(DG-PI)was innovatively fabricated by electrospinning combined with the laser-induced carbonization *** all-in-one compact architecture with well-interconnected channels shows superior mechanical and thermal stability and *** importantly,the PI nanofibers containing N–/O–functional groups can induce the uniform deposition of lithium on the anode surface,while the DG framework with abundant pentagonal/heptagonal rings and vacancies can strongly trap polysulfides and accelerate polysulfide transformation on the cathode *** strong chemical interaction between the insulative PI layer and the conductive DG layer modulates the surface charge distribution of each other,leading to more prominent contributions to restraining lithium dendrites and shuttle ***,the Li-S batteries based on the integrated DG-PI separators afford an excellent performance in protecting lithium anode(stable cycles of 200 h at 5 mA·cm^(−2))and good cycling stability with a low capacity decay of 0.05%per cycle after 700 cycles at 1 *** work offers a new design concept of multifunctional Li-S battery separators and broadens the application scope of laser micro-nano fabrication technology.

关键词： lithium-sulfur batteries separators laser-induced graphene intrinsic carbon defects shuttle effect Li dendrites

医家一体化强化管理在2型糖尿病患者初次使用胰高糖素样肽-1受体激动剂中的应用研究

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护理与康复 2024年第7期23卷 36-39,46页

作者：王佳薇郑玲玉詹静董芳吕佳覃竞燕方倩林本庆谭擎缨中国人民解放军联勤保障部队第九〇三医院浙江杭州310013

目的观察医家一体化强化管理模式在初次使用胰高糖素样肽-1受体激动剂的2型糖尿病患者中的应用效果。方法选取2021年4月至7月在中国人民解放军联勤保障部队第九〇三医院内分泌科住院且出院后首次使用胰高糖素样肽-1受体激动剂治疗的81例... 详细信息

目的观察医家一体化强化管理模式在初次使用胰高糖素样肽-1受体激动剂的2型糖尿病患者中的应用效果。方法选取2021年4月至7月在中国人民解放军联勤保障部队第九〇三医院内分泌科住院且出院后首次使用胰高糖素样肽-1受体激动剂治疗的81例2型糖尿病患者为研究对象,按照随机数字表法分为观察组(41例)和对照组(40例)。两组在住院期间进行相同的糖尿病健康教育,出院后,对照组进行常规随访,观察组实施医家一体化强化管理模式随访,比较两组患者出院12周后的空腹血糖、HbA1C、BMI、腰围、治疗依从性及低血糖发生情况。结果空腹血糖干预前后差值观察组为2.85(1.99,5.46)mmol/L,对照组为2.30(1.01,3.72)mmol/L,Z=2.182,P=0.029;HbA1C干预前后差值观察组为1.80(1.10,2.75)%,对照组为0.98(0.13,2.74)%,Z=2.117,P=0.034;BMI干预前后差值观察组为1.40(0.90,2.25)kg/m^(2),对照组为0.55(0.20,0.98)kg/m^(2),Z=4.929,P<0.001;腰围干预前后差值观察组为7.00(5.50,10.00)cm,对照组为2.00(1.00,6.00)cm,Z=4.329,P<0.001。干预后治疗依从性总分观察组(26.96±6.44)分,对照组(23.49±3.61)分,t=2.996,P=0.004。出院12周内低血糖发生率观察组为29.27%,对照组为57.50%,P=0.014。结论医家一体化强化管理模式能提高初次使用胰高糖素样肽-1受体激动剂患者的治疗依从性,有效控制血糖,降低患者体脂指标水平。

关键词：糖尿病疾病管理医家一体化依从性

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复方苍术挥发油微乳的制备工艺研究

广东化工 2024年第7期51卷 49-51,10页

作者：李睿刘謦蔚王芸芸沈佳伟万芳荆楚理工学院湖北荆门448000

目的:对复方苍术挥发油微乳的处方进行筛选,考察其制备工艺条件。方法:根据复方苍术挥发油与油相、乳化剂、助乳化剂的互溶现象进行初步筛选,然后通过绘制伪三元相图,综合考虑微乳区域面积、微乳的外观、稳定性,最终确定处方组成,并在... 详细信息

目的:对复方苍术挥发油微乳的处方进行筛选,考察其制备工艺条件。方法:根据复方苍术挥发油与油相、乳化剂、助乳化剂的互溶现象进行初步筛选,然后通过绘制伪三元相图,综合考虑微乳区域面积、微乳的外观、稳定性,最终确定处方组成,并在此基础上进一步对微乳的制备温度、搅拌速度、搅拌时间进行比较研究,测定微乳粒径。结果:复方苍术挥发油微乳的制备工艺为:将EL-40与异丙醇按3∶1的质量比混合,制得混合乳化剂,再取等质量复方苍术挥发油与油酸乙酯混合为油相,将混合乳化剂与油相按8∶2的质量比混合,在300 r/min,30±5℃条件下,加入蒸馏水搅拌10~15 min至澄清透明的微乳形成。微乳平均粒径为20.71 nm,分散系数为0.019。结论:复方苍术挥发油微乳的制备工艺简单可行,微乳澄清透明,粒径小、分布均匀,稳定性良好。

关键词：复方苍术挥发油微乳伪三元相图稳定性处方组成制备工艺

Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist

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Science China Chemistry 2019年第10期62卷 1371-1378页

作者： Chao Zuo Wei-Wei Shi Xiao-Xu Chen Marie Glatz Bernd Riedl Ingo Flamme Elisabeth Pook jiawei Wang Ge-Min fang Donald Bierer Lei Liu Tsinghua-Peking Center for Life Sciences Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyCenter for Synthetic and Systems BiologyDepartment of ChemistryTsinghua UniversityBeijing 100084China School of Life Science Institutes of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Bayer AG Department of Medicinal ChemistryAprather Weg 18A42096 WuppertalGermany Bayer AG Cardiovascular Research42096 WuppertalGermany Bayer AG Lead Discovery42096 WuppertalGermany

Blockade of the interaction of anaphylatoxin C5a with its receptor C5aR1 has been actively studied as a potential treatment for many inflammatory diseases;but current C5a antagonists exhibit inadequate potency and poor species cross-reactivity, and novel biochemical tools are needed to investigate whether the core region of C5a contains important interaction epitopes that can explain these limitations. Herein, we report the development of chimeric protein C5a probes containing both the complete core region of rat or human C5a, and the small-molecule antagonist PMX53-1. These probes were chemically synthesized through hydrazide-based native chemical ligation of a linear peptide hydrazide with the requisite cyclopeptidic antagonist, both of which were made by solid-phase synthesis. Quasi-racemic X-ray crystallography established that attachment of PMX53-1 did not affect the structure of the core region of C5a. Subsequent C5aR1 activity assays demonstrated the probes can provide valuable insights into the development of C5a antagonists;for example, they exhibited significantly better binding affinity and much improved species cross-reactivity than PMX53-1, supporting the notion that the effect of some epitopes outside the C-terminus of C5a should be taken into consideration when designing better C5a antagonists. Surprisingly, the core region of C5a was found to partially agonize C5aR1, suggesting the presence of more than one agonistic interaction in the binding of C5a to C5aR1. This study exemplifies the value of chemical protein synthesis in developing novel receptor probes for drug discovery research.

关键词： anaphylatoxin C5a PMX53 quasi-racemic X-ray crystallography native chemical ligation

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《活人事证方》(前后集)养生思想探析

中华中医药杂志 2024年第7期39卷 3276-3279页

作者：吕佳蔚王振国杨金萍鞠芳凝陈战山东中医药大学中医文献与文化研究院济南250355 山东中医药大学外国语学院济南商250355

《活人事证方》(前后集)是南宋一部较有影响的医药专著,作者为士人刘信甫。该书记录了日常生活中的各类实用方药,其中包含的大量养生方剂,不仅多以韵文形式呈现,且来源颇广,反映了儒士的治学特色。通过研究《活人事证方》(前后集)养生文... 详细信息

《活人事证方》(前后集)是南宋一部较有影响的医药专著,作者为士人刘信甫。该书记录了日常生活中的各类实用方药,其中包含的大量养生方剂,不仅多以韵文形式呈现,且来源颇广,反映了儒士的治学特色。通过研究《活人事证方》(前后集)养生文本,可以发现其重视草木服食、导引行气,以及个人卫生和仪容修饰的思想特点。文章通过考证《活人事证方》(前后集)的作者与成书,在医儒结合的时代背景下把握其养生思想。

关键词：《活人事证方》刘信甫养生文本思想文献研究

生活方式对高危孕妇发生妊娠期糖尿病的预防作用

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武汉大学学报（医学版） 2024年第5期45卷 594-597页

作者：徐嘉蔚林萱房莹崔静李智田丽槟郭红艳卢新妍丁家豪柯璐吴嘉慧武汉科技大学附属华润武钢总医院内分泌科湖北武汉430080 武汉科技大学医学院湖北武汉430062

目的:探讨采用生活方式干预来预防高危孕妇发生妊娠期糖尿病(GDM)的可行性。方法:自2020年12月至2022年2月,在武汉市共招募251名有GDM高危因素的孕妇,并随机分配其到干预组(n=128)与对照组(n=123)。对干预组进行生活方式干预,干预措施... 详细信息

目的:探讨采用生活方式干预来预防高危孕妇发生妊娠期糖尿病(GDM)的可行性。方法:自2020年12月至2022年2月,在武汉市共招募251名有GDM高危因素的孕妇,并随机分配其到干预组(n=128)与对照组(n=123)。对干预组进行生活方式干预,干预措施包括饮食建议、健康教育及体重管理,对照组定期孕期体检。所有孕妇在孕24~28周接受GDM筛查。结果:孕24~28周,干预组和对照组的GDM发生率分别为16.4%(21/128)和30.9%(38/123)(P<0.01)。干预组空腹血糖[(4.31±0.37)mmol/L]、服糖后1 h血糖[(7.10±1.73)mmol/L]、服糖后2 h血糖[(5.92±1.33)mmol/L]均低于对照组的(4.53±0.42)mmol/L、(7.53±1.68)mmol/L、(6.37±1.24)mmol/L(P<0.05)。结论:对高危孕妇进行生活方式干预能够预防GDM的发生。

关键词：生活方式干预妊娠期糖尿病预防

Association between soft drink consumption types and risk of lung cancer and all-cancer: A prospective study of PLCO data

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The Journal of Biomedical Research 2022年第6期36卷 390-400页

作者： Dongfang You Hongyang Xu Xin Chen jiawei Zhou Yaqian Wu Yingdan Tang Zhongtian Wang Yang Zhao fang Shao Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Critical Care Medicine Wuxi People's Hospital Affiliated to Nanjing Medical UniversityWuxiJiangsu 214023China China International Cooperation Center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjingJiangsu 211166China The Center of Biomedical Big Data and the Laboratory of Biomedical Big Data Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Diet/sugar-free soft drinks are considered to be healthier than regular soft ***,few studies have examined the relationship between the types of soft drinks(regular and diet/sugar-free)and lung cancer(LC)/all-cancer(AC)*** this study,we comprehensively assessed the influence of the type of soft drink consumption on LC/AC risk based on the Prostate,Lung,Colorectal,and Ovarian(PLCO)Cancer Screening *** Cox proportional hazards and competing risks Fine-Gray regression models adjusted for relevant confounders were used to estimate hazard ratios(HRs)and subdistribution HRs for different types of soft drink *** the PLCO population,female subgroup,and the ever/current smoker subgroup,consumption of both regular and diet soft drinks was associated with a significantly reduced risk of LC compared with no soft drinks at *** the non-lung cancer(NLC)risk,consumption of only diet soft drinks had a significant positive association for the total population and female *** on our findings,it was suggested that partial replacement of regular soft drinks with diet soft drinks might be beneficial to LC prevention,especially for females and ever/current ***,completely replacing regular soft drinks with diet soft drinks might be detrimental to NLC prevention,especially for females.

关键词： soft drink diet/sugar-free drink lung cancer all-cancer PLCO trial

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基于改进蚁群算法的计量物资供应多目标调度

电子器件 2024年第4期47卷 1081-1086页

作者：徐嘉伟范彩兄金顺安王克荣方侃罗仲全国网青海省电力公司电力科学研究院青海西宁810000

针对计量物资调度任务分工不协调的问题,提出了计量物资供应多目标调度优化模型。分析了电力计量物资供应的需求和特点,说明了物资供应流程的环节特性。建立了以物资满意度和时间成本为目标的多目标物资调度模型,考虑物资平衡约束、供... 详细信息

针对计量物资调度任务分工不协调的问题,提出了计量物资供应多目标调度优化模型。分析了电力计量物资供应的需求和特点,说明了物资供应流程的环节特性。建立了以物资满意度和时间成本为目标的多目标物资调度模型,考虑物资平衡约束、供应点约束、转运点约束、紧急需求点约束等,利用主观和客观赋权方法得到综合权重,再利用改进蚁群优化方法进行模型求解。利用IEEE33节点模型进行仿真分析,说明了确定运输节点和供应流程环节能够获得物资满意度和时间满意度,论证了所提模型和方法的有效性。

关键词：计量物资多目标优化物资供应改进蚁群算法

煅烧条件对溶胶-凝胶法合成超细ZrB_(2)粉体的影响

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材料开发与应用 2024年第3期39卷 77-81页

作者：孟佳伟吕艳红崔唐茵白丽徐海森方惠一王鹏山东理工大学材料科学与工程学院山东淄博255000 中国建材检验认证集团淄博有限公司山东淄博255000 山东工业陶瓷研究设计院山东淄博255000 山东硅元新型材料股份有限公司山东淄博255000 国防科技大学新型陶瓷纤维及其复合材料重点实验室湖南长沙410073

ZrB_(2)基陶瓷材料在超高温领域具有广阔的应用前景,为研究煅烧条件对ZrB_(2)粉体的影响,本研究分别以正丙醇锆、蔗糖和硼酸为Zr源、C源和B源,采用溶胶-凝胶法制备ZrB_(2)粉体,研究了煅烧温度、保温时间及氩气流量对ZrB_(2)粉体合成的... 详细信息

ZrB_(2)基陶瓷材料在超高温领域具有广阔的应用前景,为研究煅烧条件对ZrB_(2)粉体的影响,本研究分别以正丙醇锆、蔗糖和硼酸为Zr源、C源和B源,采用溶胶-凝胶法制备ZrB_(2)粉体,研究了煅烧温度、保温时间及氩气流量对ZrB_(2)粉体合成的影响。结果表明,随着煅烧温度的升高,生成物中的杂质相含量逐渐降低,ZrB_(2)相含量逐渐增加。B∶Zr∶C摩尔比为2.85∶1∶7的前驱体粉体在氩气气氛、1550℃下分别保温30、60和120 min后均得到了纯ZrB_(2)粉体。由Scherrer公式计算得到的ZrB_(2)平均晶粒尺寸远小于SEM观测的粒径,表明制得的ZrB_(2)粉体由小晶粒组成。煅烧过程中通入的氩气流量会影响B_(2)O_(3)的挥发程度,进而影响产物的物相组成。

关键词： ZrB_(2) 溶胶-凝胶法煅烧温度显微形貌 B_(2)O_(3)挥发