检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

红细胞分布宽度在肺癌转移中的应用价值

中华检验医学杂志 2014年第6期37卷 444-446页

作者：徐阳颺朱晓娄加陶上海交通大学附属胸科医院检验科 200030

目的：探讨红细胞分布宽度（ RDW）在提示肺癌患者转移中的临床应用价值。方法回顾性分析上海市胸科医院2012年1月至2013年7月525例初诊肺癌患者的病历资料和全血RDW数据。对全部525例患者根据分期、有无转移等分组，并进一步对其中405... 详细信息

目的：探讨红细胞分布宽度（ RDW）在提示肺癌患者转移中的临床应用价值。方法回顾性分析上海市胸科医院2012年1月至2013年7月525例初诊肺癌患者的病历资料和全血RDW数据。对全部525例患者根据分期、有无转移等分组，并进一步对其中405例有转移者根据转移程度及其中246例有远端转移者根据远端转移器官数分别分组。多组间计量资料的比较用Kruskal-Wallis H检验，RDW与临床参数间的相关性用Spearman相关性分析。结果肺癌转移患者外周血RDW水平为14.5（13.0～15.4）％，显著高于未转移者[12.7（12.3～13.0）％]，差异有统计学意义（U＝8597.500，P＜0.05）。对于不同分期的肺癌患者，Ⅲ期、Ⅳ期组的 RDW[14.6（12.9～15.4）％]显著高于Ⅰ、Ⅱ期组[12.6（12.2～13.1）％]，差异有统计学意义（U＝8549.000，P＜0.05）。 RDW与分期、是否转移有一定相关性（r＝0.508、0.470，P均＜0.05）。 ROC曲线分析表明，RDW鉴别诊断肺癌是否发生转移、远端转移的曲线下面积（AUC）分别为0.823（95％ CI：0.787～0.859）和0.710（95％CI：0.655～0.765）。以Youden指数最大时的切点作为诊断肺癌转移的cut-off值（14.25％），此时敏感度为56.8％，特异度为98.3％，具有一定准确性。结论 RDW值的变化对判断肺癌患者转移情况有一定的应用价值。（中华检验医学杂志，2014，37：444-446）

关键词：肺肿瘤肿瘤转移红细胞指数

Ren-integrable and ren-symmetric integrable systems

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第3期76卷 62-69页

作者： S Y lou School of Physical Science and Technology Ningbo UniversityNingbo315211China

A new type of symmetry,ren-symmetry,describing anyon physics and corresponding topological physics,is ***-symmetry is a generalization of super-symmetry which is widely applied in super-symmetric physics such as super-symmetric quantum mechanics,super-symmetric gravity,super-symmetric string theory,super-symmetric integrable systems and so *** and Grassmann numbers are,in some sense,dual conceptions,and it turns out that these conceptions coincide for the ren situation,that is,a similar conception of ren-number(R-number)is devised for *** particular,some basic results of the R-number and ren-symmetry are exposed which allow one to derive,in principle,some new types of integrable systems including ren-integrable models and ren-symmetric integrable *** examples of ren-integrable KdV-type systems and ren-symmetric KdV equations are explicitly given.

关键词： symmetries integrable systems anyon physics extended supersymmetry ren-symmetry

DNA Methylation Analysis of the SHOX2 and RASSF1A Panel in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis

在线全文

学校读者我要写书评

暂无评论

DNA Methylation Analysis of the SHOX2 and RASSF1A Panel in B...

Nickel Sulfide Modified NiCu Nanoalloy with Excellent Oxygen Evolution Reaction Properties Prepared through Electrospinning and Heat Treatment

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Chenzi Zhang Wenjun Yu Lin Wang Mingna Zhao Qiaomei Guo Shaogang Lv Xiaomeng Hu jiatao lou Department of Laboratory Medicine Shanghai Chest HospitalShanghai Jiao Tong University

Introduction: Currently the majority of lung cancer patients are diagnosed as advanced diseases for no sensitive and specific biomarkers exist, noninvasive biomarkers with high sensitivity and specificity are urgently needed in lung cancer diagnosis. Bronchoscopy is a standard procedure of the diagnostic work-up of patients with suspected lung cancer despite of the limited diagnostic accuracy. Besides, epigenetic changes through DNA methylation play an important role in tumorigenesis. Thus, we examined the aberrant methylation of the SHOX2 and RASSF1A in bronchoalveolar lavage fluid (BALF) in comparing with conventional cytology examination and serum CEA in order to evaluate the new diagnostic method.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2024年第2期39卷 320-326页

作者：李涛凌帅 ZHONG Shujie lou Qiongyue Department of Materials Engineering School of Mechanical EngineeringChengdu UniversityChengdu 610106China

Ni^(2+)/Cu^(2+)/SO_(4)^(2-)/polyvinyl alcohol precursor fibers with uniform diameters were prepared through ***-based composite nanoalloys containing Ni,Cu,and S were prepared through heat treatment in an Ar *** experimental results show that the main components of the prepared nanoalloys are NiCu,Ni_(3)S_(2),Ni,and *** nanoalloys exhibit fine grain sizes about 200-500 nm,which can increase with increasing heat treatment *** test results show that the nickel sulfidemodified NiCu nanoalloy composites exhibit excellent oxygen evolution reaction properties,and the oxygen evolution reaction properties gradually improve with the increasing heat treatment *** sample prepared at 1 000℃ for 40 min show a low overpotential of 423 mV and a small Tafel slope of 134 mV·dec^(-1) at a current density of 10 mA·cm^(-2).

关键词： NiCu nanoalloy Ni_(3)S_(2) structure transformation oxygen evolution reaction

Decomposition solutions and Bäcklund transformations of the B-type and C-type Kadomtsev-Petviashvili equations

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第6期76卷 34-44页

作者： Xiazhi Hao S Y lou College of Science Zhejiang University of TechnologyHangzhou 310014China School of Physical Science and Technology Ningbo UniversityNingbo 315211China

This paper introduces a modified formal variable separation approach,showcasing a systematic and notably straightforward methodology for analyzing the B-type Kadomtsev-Petviashvili(BKP)*** the application of this approach,we successfully ascertain decomposition solutions,Bäcklund transformations,the Lax pair,and the linear superposition solution associated with the aforementioned ***,we expand the utilization of this technique to the C-type Kadomtsev-Petviashvili(CKP)equation,leading to the derivation of decomposition solutions,Bäcklund transformations,and the Lax pair specific to this *** results obtained not only underscore the efficacy of the proposed approach,but also highlight its potential in offering a profound comprehension of integrable behaviors in nonlinear ***,this approach demonstrates an efficient framework for establishing interrelations between diverse systems.

关键词： decomposition solution Backlund transformation Lax pair linear superposition solution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

循环肿瘤细胞检测对非小细胞肺癌的诊断价值

中华检验医学杂志 2016年第8期39卷 589-594页

作者：郭巧梅乔理华王琳娄加陶上海市胸科医院检验科 200030

目的评估循环肿瘤细胞检测对非小细胞肺癌（NSCLC）的诊断价值。方法采用非干预型临床研究，选择2014年10月至2015年4月就诊于上海市胸科医院胸外科的162例NSCLC患者（其中I期83例、Ⅱ期16例、Ⅲ期27例、Ⅳ期36例），119例肺部良性疾病... 详细信息

目的评估循环肿瘤细胞检测对非小细胞肺癌（NSCLC）的诊断价值。方法采用非干预型临床研究，选择2014年10月至2015年4月就诊于上海市胸科医院胸外科的162例NSCLC患者（其中I期83例、Ⅱ期16例、Ⅲ期27例、Ⅳ期36例），119例肺部良性疾病患者，以及同期接受体检的52名健康人。采用基于叶酸受体的PCR方法检测外周血循环肿瘤细胞（CTC）水平，流式荧光发光法检测CEA、CYFRA21—1，化学发光微粒子免疫法检测SCC，多组比较采用Kruskal—Wallis检验，两组比较采用Mann—WhitneyU检验，阳性率比较采用卡方检验，并绘制ROC曲线分析。结果NSCLC患者的CTC中位数为11．90CTCUnits／3ml，显著高于肺部良性疾病患者（6．72CTCUnits／3m1）和健康人（5．82CTCUnits／3m1），差异有统计学意义（x2=125．990，P〈0．01）；ROC曲线下面积为0．8532（95％CI：0．8095～0．8969），临界值（cut—off值）为8．74CTCUnits／3ml，对应的灵敏度为77．16％，特异度为90．06％。临床I期NSCLC患者的CTC阳性率为68．7％，明显高于多联肿瘤标志物（CEA＋CYFRA21—1＋SCC）的阳性率（19．4％），差异有统计学意义（0=32．98，P〈0．01）。结论CTC检测对NSCLC诊断具有较好的灵敏度和特异度，可能有一定的临床应用价值。

关键词：癌,非小细胞肺肿瘤细胞,循环肿瘤标记,生物学

MicroRNA-34a functions as a tumor suppressor in non-small celllung cancer H1299 cell line by targeting TGFγR2

在线全文

学校读者我要写书评

暂无评论

MicroRNA-34a functions as a tumor suppressor in non-small ce...

Infinitely Many Solutions for a Class of Quasi-linear Elliptic Problem

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

作者： zhongliang ma pinpin hou yanli li detao wang jiali wei botao zhao jiatao lou xintaizhao yan jin youxin jin School of life sciences Shanghai University School of Life Sciences Shanghai University Department of Laboratory Medicine Shanghai Chest Hospital affiliated to Shanghai Jiaotong University

MicroRNAs(MiRNAs) are small non-coding RNA molecules which act as important regulatorsof post-transcriptional gene expression by binding 3′-untranslated region(3′-UTR) oftarget mRNA. In this study, we analyzed miRNA-34a(miR-34a) as a tumor suppressor innon-small cell lung cancer(NSCLC) H1299 cell line. The expression level of miR-34 a in fourdifferent NSCLC cell lines, H1299, A549, SPCA-1 and HCC827 was significantly lower thanthat in the normal bronchial epithelium cell line BEAS-2B. In human NSCLC tissues, miR-34 a expression level was also down-regulated in pT2-4 compared with the correspondingnon-tumor tissues. Moreover, miR-34 a mimics could inhibit the proliferation and triggeredapoptosis in H1299 cells. Luciferase assays revealed that miR-34 a inhibited TGFβR2 expressionby targeting one binding site in the 3′-UTR of TGFβR2 mRNA. Quantitative real-timePCR(qRT-PCR) and western blot assays verified that miR-34 a reduced TGFβR2 expressionat both mRNA and protein levels. The expression level of miR-34 a and its target geneTGFβR2 was inverted corresponding in human NSCLC tissues and NSCLC cell lines. Furthermore,down-regulation TGFβR2 by siRNA showed the same effects on the proliferation andapoptosis as miR-34 a mimics in H1299 cells. Our results demonstrated that miR-34 a could inhibit the proliferation and promote the apoptosis of H1299 cells partially through the down-regulation of its target gene TGFβR2.

关键词： miR-34a non-small cell lung cancer apoptosis TGFβR2

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2024年第3期40卷 728-743页

作者： Xiao-yao JIA Zhen-luo lou School of Economics and Management Zhongyuan University of TechnologyZhengzhou 450007China Mathematics and Statistics School Henan University of Science and TechnologyLuoyang 471023China

In this paper,we study the following quasi-linear elliptic equation:■where Ω?R^(N) is a bounded domain,λ>0 is a *** function ψ(|t|)t is the subcritical term,and φ(|t|)t is the critical Orlicz-Sobolev growth term with respect to φ.Under appropriate conditions on φ,ψ and φ,we prove the existence of infinitely many weak solutions for quasi-linear elliptic equation,for λ∈(0,λ_(0)),where λ_(0)> 0 is a fixed constant.

关键词： quasi-linear elliptic equations variational methods Orlicz-Sobolev spaces

Hydrochemical insights on the signatures and genesis of water resources in a high-altitude city on the Qinghai-Xizang Plateau, South-west China

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2024年第7期18卷 123-140页

作者： Jiutan Liu Kexin lou Zongjun Gao Menghan Tan College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

Water resources have crucial implications for the steady development of the urban social *** study investigated the hydrochemical signatures and genesis of water resources in the urban area of Lhasa City(UALC).To this end,several analyses,such as ion ratio analysis and correlation analysis,were performed by comprehensively applying mathematical statistics and integrated hydrochemical *** results show relatively low concentrations of major ions in the groundwater and surface water(GSW)of the *** primary anions and cations are HCO3-and Ca2+,reflecting the HCOg-Ca water ***,groundwater exhibits higher concentrations of key chemical components compared to surface *** are weakly alkaline,with pH values of 7.78 and 7.61,respectively,and they have low salinity with average concentrations of total dissolved solids being 190.74 and 112.17 mg/L,*** inputs have minimal influence on the hydrochemical features of GSw,whereas rock weathering is the dominant controlling ***,cation *** a significant *** influencing their hydrochemical *** to the isotope analysis(H and 180),the primary source of recharge for GSW is atmospheric precipitation,with some input from melted ice and ***,GSW samples from the UALC show relatively similar 2H and 18O isotopic compositions,indicating the existence of a discernible hydraulic connection linking the two water *** research findings can serve as a valuable scientific reference and foundation for the sustainable development,effective utilization,and proper safeguarding of regional water resources in high-altitude areas.

关键词： Groundwater and surface water Hydrochemical features Genesis mechanism Water quality Urban area of Lhasa City