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A Novel Method for the Prenatal Diagnosis of Cleft Palate Based on Amniotic Fluid Metabolites

Chinese Journal Of Plastic and Reconstructive Surgery 2020年第2期2卷 93-102页

作者： Wancong ZHANG Lewen JIANG Zhiwei SHEN jiasheng chen Xiaoping ZHONG Weiping ZENG Jianda ZHOU Zhihao HE Shijie TANG Department of Plastic Surgery and Burn Center Second Affiliated HospitalShantou University Medical CollegeShantouGuangdongChina Department of Plastic Surgery Shenzhen Longgang District Maternity&Child Health care HospitalShenzhenGuangdongChina Department of Medical Imaging Second Affiliated Hospital of Shantou University Medical CollegeShantouGuangdongChina Department of Plastic and Reconstructive Surgery Central South University Third Xiangya HospitalChangshaHunanChina

Background and purpose The prenatal diagnosis of cleft palate is an important component of sequential therapy,but the relevant diagnostic methods are still limited.We aimed here,to explore the possibility of an early prenatal diagnosis of cleft palate by assessing metabolites in pregnant mice.Methods Twenty-four inseminated females were randomly divided into retinoic acid(RA)-treated(treated with retinoic acid at 10.5 gestation days)and control groups.The metabolites of the embryonic palatal tissue,maternal amniotic fluid,and serum were characterized using 9.4T magnetic resonance spectroscopy in vitro.Then,a predictive model was established through the principal component analysis(PCA),and the correlations between the metabolites of amniotic fluid and palatal tissue were explored using orthogonal-2 partial least squares(O2-PLS).Results The incidences of cleft palate were 100%and 0%in the RA-treated and control groups,respectively.A predictive PCA model with a high specificity and sensitivity was established for the early prenatal diagnosis of isolated cleft palate using amniotic fluid metabolic data.Between RA-treated and control mice,we found that two metabolites in the amniotic fluid and palatal tissue were correlated.Creatinine showed the same trend in the palatal tissue and amniotic fluid,while choline showed opposite trends in the two tissues.However,the data for serum metabolites could not be used to establish a prediction model.Conclusion This study indicates that assessing the metabolites of amniotic fluid is a potential approach for the prenatal diagnosis of isolated cleft palate.

关键词： Metabolism Amniotic Fluid Serum Cleft Palate Prenatal Diagnosis

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Sigmatropic rearrangements of B(MIDA)-propargylic alcohols towards the diverse synthesis of α-functionalized organoborons

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Science China Chemistry 2024年第2期67卷 568-575页

作者： jiasheng Qian Li-Cai Liu Zhi-Hao chen Yuan Liu Yin Li Qingjiang Li Honggen Wang Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China

α-Functionalized organoborons are useful building blocks and key structural elements in functional molecules.Their previous synthesis relied on the famous Matteson reaction or the late-stage borylative modification of alkynes or alkenes.Recently,the synthetic transformation of borylated building blocks offers another useful strategy and is currently actively explored.We report herein that B(MIDA)-propargylic alcohols(BPAs) are a useful type of borylated building blocks.Bearing two complementary functional group handles(alkyne and hydroxyl) in close proximity,the redox-neutral [3,3] and [2,3] sigmatropic rearrangements of BPAs allow the efficient synthesis of several types of α-functionalized boronates,including α,β-unsaturated acylborons,α-S/P-substituted allenylborons,boryl-substituted thiazoles and a borylated α,β-unsaturated hydrazine,some of which are otherwise challenging targets using other synthetic methods.

关键词： organoboron diverse synthesis sigmatropic rearrangement heteroarene amide

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Design and optimization of fluid lubricated bearings operated with extreme working performances——a comprehensive review

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International Journal of Extreme Manufacturing 2024年第2期6卷 325-376页

作者： Guohua Zhang Ming Huang Gangli chen jiasheng Li Yang Liu Jianguo He Yueqing Zheng Siwei Tang Hailong Cui Institute of Machinery Manufacturing Technology China Academy of Engineering PhysicsMianyangSichuan 621999People’s Republic of China

Fluid lubricated bearings have been widely adopted as support components for high-end equipment in metrology,semiconductor devices,aviation,strategic defense,ultraprecision manufacturing,medical treatment,and power generation.In all these applications,the equipment must deliver extreme working performances such as ultraprecise movement,ultrahigh rotation speed,ultraheavy bearing loads,ultrahigh environmental temperatures,strong radiation resistance,and high vacuum operation,which have challenged the design and optimization of reliable fluid lubricated bearings.Breakthrough of any related bottlenecks will promote the development course of high-end equipment.To promote the advancement of high-end equipment,this paper reviews the design and optimization of fluid lubricated bearings operated at typical extreme working performances,targeting the realization of extreme working performances,current challenges and solutions,underlying deficiencies,and promising developmental directions.This paper can guide the selection of suitable fluid lubricated bearings and optimize their structures to meet their required working performances.

关键词： fluid lubricated bearings structural design performance optimization extreme working performances

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线粒体在芥子气损伤中的作用研究进展

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广西医科大学学报 2024年第5期41卷 780-785页

作者：王雨润张鑫月刘俊宏陈佳胜谢璐泽孙铭学孟文琪海军军医大学海军医学系防化医学教研室上海200433 郑州市疾病预防控制中心郑州450042

芥子气(SM)是一种难防难治的化学战剂,可引起多个组织器官不可逆转的损伤,包括皮肤、眼睛、肺和神经系统等,迄今为止SM的中毒机制尚不明确。已有SM中毒机制研究表明,氧自由基大量产生、谷胱甘肽耗竭、NAD^(+)的消耗、钙离子超载以及细... 详细信息

芥子气(SM)是一种难防难治的化学战剂,可引起多个组织器官不可逆转的损伤,包括皮肤、眼睛、肺和神经系统等,迄今为止SM的中毒机制尚不明确。已有SM中毒机制研究表明,氧自由基大量产生、谷胱甘肽耗竭、NAD^(+)的消耗、钙离子超载以及细胞凋亡等都与线粒体关系密切。本综述拟从线粒体形态、功能以及膜电位,氧化应激,线粒体DNA,NAD^(+),凋亡、自噬等方面对线粒体在SM损伤中的作用进行总结,并展望了未来的研究方向。

关键词：芥子气线粒体 NAD+消耗氧化应激凋亡

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腹腔镜下前列腺癌根治术联合保留最大尿道长度和膀胱颈的尿道重建术治疗高危前列腺癌的早期控尿和控瘤效果

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现代泌尿外科杂志 2024年第7期29卷 612-616页

作者：郑坤胡晓勇傅强李望王营曹乃龙陈加生杨冉星上海交通大学医学院附属第六人民医院泌尿外科上海200233

目的探讨联合施行保留最大尿道长度(MULP)和膀胱颈(BNP)的尿道重建术与腹腔镜下前列腺癌根治术(LRP)或机器人辅助腹腔镜下前列腺癌根治术(RALP)治疗高危前列腺癌(HRPC)的早期控尿及控瘤效果。方法回顾性分析上海交通大学医学院附属第六... 详细信息

目的探讨联合施行保留最大尿道长度(MULP)和膀胱颈(BNP)的尿道重建术与腹腔镜下前列腺癌根治术(LRP)或机器人辅助腹腔镜下前列腺癌根治术(RALP)治疗高危前列腺癌(HRPC)的早期控尿及控瘤效果。方法回顾性分析上海交通大学医学院附属第六人民医院泌尿外科2022年5月—2024年1月收治的23例HRPC患者的临床资料,所有患者均行LRP(包括RALP),并采用联合MULP和BNP的尿道重建技术。收集并分析患者的术前基线资料包括年龄、身体质量指数、临床T分期、Gleason评分、前列腺重量和体积、前列腺特异性抗原;术中变量包括手术方式、手术时间、术中出血量和术中输血患者数;术后变量包括住院时间、尿管留置时间、切缘阳性数、生化复发数、并发症发生率及术后早期尿控率。结果所有患者均顺利完成手术,无中转开放。手术时间(108±31)min,出血量(112±45)mL,无患者术中输血,住院时间(5.5±1.5)d,尿管留置时间(12.6±1.8)d。术后拔除尿管即刻及1、3、6个月的控尿率分别为39.1%、65.2%、73.9%和91.3%。术后2例患者切缘阳性,均为血管神经束切缘。术后无患者出现尿路梗阻或尿瘘等手术相关并发症。结论联合MULP和BNP的尿道重建术在HRPC患者行LRP治疗中可在不增加控瘤风险的前提下,有效提高患者的早期控尿率,改善患者的术后生活质量。

关键词：前列腺癌腹腔镜下前列腺癌根治术机器人辅助腹腔镜下前列腺癌根治术尿控最大尿道长度膀胱颈膀胱尿道吻合术尿道重建术

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Trade-offs between the accumulation of cuticular wax and jasmonic acid-mediated herbivory resistance in maize

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Journal of Integrative Plant Biology 2024年第1期66卷 143-159页

作者： Jiong Liu Lu Li Zhilong Xiong Christelle AMRobert Baozhu Li Shan He Wenjie chen jiasheng Bi Guanqing Zhai Siyi Guo Hui Zhang Jieping Li Shutang Zhou Xi Zhang Chun‐Peng Song School of Life Sciences Henan UniversityKaifeng 475004China State Key Laboratory of Crop Stress Adaptation and Improvement Henan UniversityKaifeng 475004China State Key Laboratory of Cotton Bio‐Breeding and Integrated Utilization Henan UniversityKaifeng 475004China Sanya Institute of Henan University Sanya 572025China Institute of Plant Sciences University of BernBern 3013Switzerland

Plants have evolved complex physical and chemical defense systems that allow them to withstand herbivory infestation.Composed of a complex mixture of very-long-chain fatty acids(VLCFAs)and their derivatives,cuticular wax constitutes the first physical line of defense against herbivores.Here,we report the function of Glossy 8(ZmGL8),which encodes a 3-ketoacyl reductase belonging to the fatty acid elongase complex,in orchestrating wax production and jasmonic acid(JA)-mediated defenses against herbivores in maize(Zea mays).The mutation of GL8 enhanced chemical defenses by activating the JA-dependent pathway.We observed a trade-off between wax accumulation and JA levels across maize glossy mutants and 24 globally collected maize inbred lines.In addition,we demonstrated that mutants defective in cuticular wax biosynthesis in Arabidopsis thaliana and maize exhibit enhanced chemical defenses.Comprehensive transcriptomic and lipidomic analyses indicated that the gl8 mutant confers chemical resistance to herbivores by remodeling VLCFA-related lipid metabolism and subsequent JA biosynthesis and signaling.These results suggest that VLCFA-related lipid metabolism has a critical role in regulating the trade-offs between cuticular wax and JA-mediated chemical defenses.

关键词： cuticular wax fall armyworm herbivore resistance jasmonic acid maize plant-herbivore interactions

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家校互动的类型表征及其对青少年自我效能感的影响——基于“中国教育追踪调查”的实证研究

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教育发展研究 2022年第22期42卷 51-58页

作者：陈嘉晟张文明华东师范大学社会发展学院上海200241 华东师范大学国家教育宏观政策研究院上海200062

何种类型的家校互动更有助于青少年成长?基于中国教育追踪调查(2014-2015年)追访数据,运用潜在类别分析(LCA)与增强逆概率加权模型(AIPW),探讨了家校互动的普遍类型及不同类型中青少年自我效能感的差异。研究发现,初中阶段的家校互动呈... 详细信息

何种类型的家校互动更有助于青少年成长?基于中国教育追踪调查(2014-2015年)追访数据,运用潜在类别分析(LCA)与增强逆概率加权模型(AIPW),探讨了家校互动的普遍类型及不同类型中青少年自我效能感的差异。研究发现,初中阶段的家校互动呈现出“家校疏离型”、“家庭行动型”、“家校共育型”与“学校组织型”四种典型类型并在自我效能感上存在明显的差异性表征,并且这种差异对青少年的自我效能感有显著影响。其中,家校共育型互动更有利于青少年自我效能感的培养,也有助于减缓弱势家庭社会经济地位带来的“劣势”。随着“双减”政策与《家庭教育促进法》的落实,更应积极关注自我疏离的弱势家庭与缺乏家校活动的学校,协助其激活潜在资源并建立有效的家校互动平台。这不仅有利于青少年全面发展,也对促进教育公平大有裨益。

关键词：家校互动自我效能感潜在类别分析增强逆概率加权

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中小学生肥胖问题研究:校际差异及时间分配表征

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华东师范大学学报（教育科学版） 2022年第2期40卷 43-56页

作者：张文明陈嘉晟华东师范大学社会发展学院上海200241 华东师范大学国家教育宏观政策研究院上海200241

学校是否会形塑学生身体?为回答这一问题,基于“中小学生学习情况及学习环境调查(2020)”数据,通过“以个体为中心”的研究视角,运用潜在剖面分析、多层次次序Logistic回归,探讨基础教育阶段学校层面的校际差异与个体层面的时间分配模... 详细信息

学校是否会形塑学生身体?为回答这一问题,基于“中小学生学习情况及学习环境调查(2020)”数据,通过“以个体为中心”的研究视角,运用潜在剖面分析、多层次次序Logistic回归,探讨基础教育阶段学校层面的校际差异与个体层面的时间分配模式是否对中小学生的肥胖程度产生影响。研究发现:(1)在小学阶段和初中阶段,学校评级与学校性质分别会对小学生与初中生的肥胖程度造成影响;高中阶段学校因素的影响不显著。(2)肥胖程度在时间分配模式上呈现出两种不同表征并随学段发生变化。在小学与初中阶段,作业型、均衡型与游戏型3种较多静态时间分配模式的学生更容易发胖。(3)中小学生肥胖的时间分配随着校际差异存在异质性表征,初中阶段尤为明显。相较于民办初中,公办初中的学生更容易因时间分配的不均衡而“致胖”。因此,在学校及学生健康政策制定中应当充分考虑中小学生肥胖的结构性特征,通过对作业、手机(游戏)、运动以及睡眠的时间进行政策性干预,进而从影响肥胖的外部因素角度有效遏制超重、肥胖现象的发生。

关键词：肥胖以个体为中心校际差异时间分配模式

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Integrated and holistic knowledge map of phase change materials for pavement: A scientometric analysis and bibliometric review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： jiasheng Dai Feng Ma Zhen Fu chen Li Yingjie Hou Yalu Wen Yanzhe Zou Dongdong Yuan Wenhao Dong Ke Shi Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an University School of Material and Science Engineering Chang'an University

Elevated pavement temperatures contribute to the urban heat island effect and pose a risk of thermal damage to pavement. Thus， regulating pavement temperature is paramount to ensure its longevity， enhance traffic safety， and preserve the environment. Phase change materials (PCMs) with the latent heat characteristic can store and release thermal energy via phase transitions. PCMs can effectively control pavement structure temperatures within a relatively narrow range， mitigating thermal stress on asphalt pavements. This research aims to explore the current status and emerging trends in PCM Integrated Pavement Engineering (PCMIPE) using the CiteSpace visual analysis tool. Relevant publications were systematically curated from the Web of Science core database， spanning 2011 to 2023. Subsequently， the co-authorships network maps (country， institution， author)， co-cited network maps (co-cited journals， authors， and references)， and keyword co-occurrence network maps were constructed to analyze the principal contributions in the PCMIPE field comprehensively. This analysis provides an understanding of the field's strengths， research domains， and knowledge structure and identifies current research focal points and emerging frontiers. The findings reveal that research within the PCMIPE field is still in its early stages， with a predominant emphasis on material design and performance assessment. Additionally， future research is anticipated to expand into economic analyses and exploration of environmental effects when integrating PCMs into pavement engineering. Furthermore， there is an emerging interest in investigating the synergy of PCMs with other functional pavement technologies. These results underscore the potential of the PCMIPE field and emphasize the importance of future research endeavors.

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The magnetic properties of Serbian loess and its environmental significance

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Chinese Science Bulletin 2013年第33期58卷 353-363页

作者： LIU XiuMing LIU Zhi Lü Bin MARKOVI S B chen jiasheng GUO Hui MA MingMing ZHAO GuoYong FENG Hua Research School of Arid Environment & Climate Change Lanzhou University School of Geographical Sciences Fujian Normal University Department of Environment and Geography Macquarie UniversitySydney NSW 2109Australia Chair of Physical Geography Faculty of SciencesUniversity of Novi SadTrg Dositeja Obradovi a 321000 Novi SadSerbia

This paper reports a loess-paleosol sequence located in the Danube River basin,Serbia,which formed at least since the latest part of the early Pleistocene,and before the paleomagnetic B/M boundary.Various magnetic parameters of the Serbian V-L1-V-S4 loess-paleosol sequence have been measured and analyzed in the Titel Loess Plateau.These parameters show a very similar magnetic behavior compared with that of the Chinese loess.There is a general positive relationship between magnetic susceptibility() and pedogenesis.The main contributors to are the magnetic grains of SP(superparamagnetic) and SD(single domain) magnetic domains,while MD(multi domain) contributes only a small percentage.The difference in between loess and paleosol mainly is caused by pedogenesis.The very fine magnetic minerals increase gradually with increasing soil development(from loess to soil),and they lead to higher.The thermomagnetic curves show thatmagnetic minerals in the loess layers are magnetite and maghemite,both providing a major contribution to.In contrast the paleosol layers mainly are composed of magnetite,with almost no or a very small amount of maghemite,as implied by a reversible thermomagnetic behavior.This indicates that pedogenic conditions during V-S3 and V-S4 strong soil development have resulted in maghemite that is no longer stable,and has been resolved or converted to other stable phase minerals.This likely indicates that soil moisture during V-S3 and V-S4 development exceeded a critical condition of maghemite stability.

关键词：黄土高原塞尔维亚环境意义磁学性质古土壤序列磁赤铁矿成土作用磁性矿物

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