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Composition regulates dissolved organic matter adsorption onto iron (oxy)hydroxides and its competition with phosphate: Implications for organic carbon and phosphorus immobilization in lakes

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Journal of Environmental Sciences 2024年第10期144卷 159-171页

作者： ShuaiLong Wen JingJing Liu YueHan Lu jiaru dai XiuLin Huang ShiLin An Erik Jeppesen ZhengWen Liu YingXun Du State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Molecular Eco-Geochemistry(MEG)Laboratory Department of Geological SciencesThe University of Alabama2017th AveTuscaloosaAL 35485USA School of Environmental Science and Engineering Nanjing Tech UniversityNanjing 210008China School of Environmental and Chemical Engineering Chongqing Three Gorges UniversityChongqing 404020China Department of Ecoscience Aarhus UniversitySilkeborg 8600Denmark Sino-Danish Centre for Education and Research University of Chinese Academy of SciencesBeijing 101408China Limnology Laboratory Department of Biological Sciences and Centre for Ecosystem Research and ImplementationMiddle East Technical UniversityAnkara 06800Turkey

Dissolved organicmatter(DOM)is a heterogeneous pool of compounds and exhibits diverse adsorption characteristics with or without phosphorous(P)*** impacts of these factors on the burial and mobilization of organic carbon and P in aquatic ecosystems remain *** this study,an algae-derived DOM(ADOM)and a commercially available humic acid(HA)with distinct compositions were assessed for their adsorption behaviors onto iron(oxy)hydroxides(FeOx),both in the absence and presence of *** contained less aromatics but more protein-like and highly unsaturated structures with oxygen compounds(HUSO)than *** adsorption capacity of FeOx was significantly greater for ADOM than for ***-like and HUSO compounds in ADOM and humic-like compounds and macromolecular aromatics in HA were preferentially adsorbed by ***,ADOM demonstrated a stronger inhibitory effect on phosphate adsorption than *** observation suggests that the substantial release of autochthonous ADOM by algae could elevate internal P loading and pose challenges for the restoration of restore eutrophic *** presence of phosphate suppressed the adsorption of protein-like compounds in ADOM onto FeOx,resulting in an increase in the relative abundance of protein-like compounds and a decrease in the relative abundance of humic-like compounds in post-adsorption *** contrast,phosphate exhibited no discernible impact on the compositional fractionation of ***,our results show the source-composition characters of DOM influence the immobilization of both DOM and P in aquatic ecosystems through adsorption *** preferential adsorption of proteinaceous compounds within ADOM and aromatics within HA highlights the potential for the attachment with FeOx to diminish the original source-specific signatures of DOM,thereby contributing to the shared DOM characteristics observed across diverse aquatic environments.

关键词： Algal dissolved organic matter Humic acid Adsorption Phosphate Fractionation FT-ICR MS

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Trehalose ameliorates autophagy dysregulation in aged cortex and acts as an exercise mimetic to delay brain aging in elderly mice

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Food Science and Human Wellness 2022年第4期11卷 1036-1044页

作者： Shanyao Pan Shanshan Guo jiaru dai Yanrong Gu Guoxiang Wang Yulong Wang Zhenghong Qin Li Luo School of Physical Education and Sports Science Soochow UniversitySuzhou 215021China School of Life Sciences Fudan UniversityShanghai 200032China Department of Rehabilitation Shenzhen Second People's HospitalThe First Affi liated HospitalShenzhen University School of MedicineShenzhen 518035China Department of Pharmacology and Laboratory of Aging and Nervous Diseases Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-DiseasesCollege of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China

Exercise is recognized as an effective strategy to delay brain aging, which is related to the activation of autophagy. Trehalose is a natural compound that can activate autophagy and exert beneficial effects in delaying brain aging. In this study, we investigated whether trehalose may exert neuroprotection similar to those of exercise in delaying age-related cognitive decline. Fifteen-month-old male C57BL/6 mice underwent swim exercise and/or were treated with 2% trehalose for 12 weeks. Trehalose, exercise and the combination of exercise and trehalose intervention improved the learning and memory of aged mice. They also improved the ratio of LC3-II/LC3-I, the protein level of LC3-II, Bnip3L, and Parkin respectively. Additionally, both exercise and trehalose increased the phosphorylation of AMPK. Exercise decreased cortical phosphorylation of m TOR and S6k, whereas trehalose did not change these cortical levels. These data indicated that exercise and trehalose might modulate autophagy through m TOR-dependent or m TOR-independent pathways, respectively. However, a combination of exercise and trehalose did not play a synergistic role in improving cognitive function and modulation of autophagy. Taken together, our findings suggest that trehalose exerts similar effects to those of exercise in delaying age-related cognitive decline and that it may thus represent an exercise mimetic to delay brain aging.

关键词： Exercise Trehalose Cognitive function Autophagy

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A deterministic model for homologous antibody dependant enhancement on influenza infection

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Infectious Disease Modelling 2024年第4期9卷 1265-1275页

作者： Shilian Xu jiaru Yang Department of Environment and Genetics School of AgricultureBiomedicine and EnvironmentLa Trobe UniversityBundooraVIC3086Australia Department of Mathematical and Physical Sciences La Trobe UniversityBundooraVIC3086Australia Department of Biochemistry and Molecular Biology Biomedicine Discovery InstituteMonash UniversityClaytonVIC3800Australia The Institute for Tropical Medicine School of Basic Medical SciencesKunming Medical UniversityKunming650500China

Antibody dependant enhancement refers that viral infectivity was unexpectedly enhanced at low antibody concentration compared to when antibodies were absent,such as Dengue,Zika and influenza *** mathematically describe switch from enhancement to neutralisation with increase of antibody concentration,one hyperbolic tangent variant is used as switching function in existed ***,switching function with hyperbolic tangent contains four parameters,and does not always increase with antibody *** address this problem,we proposed a monotonically increasing Logistical function variant as switching function,which only contains position parameter and magnitude *** influenza viral titre estimated from 21 focus reduction assay(FRA)datasets from neutralisation group(viral titre lower than negative control on all serial dilutions)and 20 FRA dataset from enhancement group(viral titre higher than negative control on high serial dilution),switching function with Logistic function performs better than existed model independent of both groups and exhibited different behaviour/character;specifically,magnitude parameter estimated from enhancement group is lower,but position parameter estimated from enhancement group is higher.A lower magnitude parameter refers that enhancement group more rapidly switches from enhancement to neutralisation with increase of antibody concentration,and a higher position parameter indicates that enhancement group provides a larger antibody concentration interval corresponding to *** estimated neutralisation kinetics with viral replication,we demonstrated that antibody-induced bistable influenza kinetics exist independent of both ***,comparing with neutralisation group,enhancement group provides higher threshold value of antibody concentration corresponding to influenza *** explains the observed phenomenon that antibody dependent enhancement enhances susceptibility,severity,a

关键词： Antibody dependent enhancement Logistical function Switching function Influenza virus

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Construction of novel P-Si/TiO_(2)/HfO_(2)/MoS_(2)/Pt heterophotocathode for enhanced photoelectrochemical water splitting

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Nano Research 2024年第5期17卷 4428-4436页

作者： jiaru Li Jiayu Bai Songjie Hu Wenyu Yuan Yuyu Bu Xiaohui Guo Key Lab of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education Shaanxi Key Laboratory for Carbon Neutral TechnologyThe College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710069China Key Lab of Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi’an 710071China Key Lab of Macromolecular Science of Shaanxi Province Key Laboratory of Applied Surface and Colloid ChemistryMinistry of EducationSchool of Chemistry&Chemical EngineeringShaanxi Normal UniversityXi'an 710062China

Photoelectrochemical devices have been developed to enable the conversion of solar ***,their commercial potential is restricted by the limited stability of the materials *** enhance the stability of photocathode and its solar water splitting performance,a P-Si/TiO_(2)/HfO_(2)/MoS_(2)/Pt composite photocathode is developed in this *** novel TiO_(2)/HfO_(2)/MoS_(2) serial nanostructure provides excellent stability of the photocathode,and optimizes the interface energy barrier to further facilitate the transfer process of photogenerated carriers within the *** best P-Si/TiO_(2)/HfO_(2)/MoS_(2)/Pt photocathode demonstrates an initial potential of 0.5 V(***)and a photocurrent density of-29 mA/cm^(2) at 0 V(***).Through intensity modulated photocurrent spectroscopy and photoluminescence test,it is known that the enhanced water splitting performance is attributed to the optimized carrier transfer *** findings provide a feasible strategy for the stability and photon quantum efficiency enhancement of silicon-based photocathode devices.

关键词： photoelectrochemical water splitting stability surface/interface engineering HfO_(2)layer

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Magnetically responsive manipulation of droplets and bubbles

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Droplet 2024年第2期3卷 73-94页

作者： Shaojun Jiang Dong Wu Jiawen Li jiaru Chu Yanlei Hu CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefeiChina

Droplets and bubbles have a wide range of applications in industry,agriculture,and daily life,and their controllable manipulation is of significant scientific and technological *** magnetically responsive manipulation strategies have been developed to achieve precise control over droplets and *** manipulate nonmagnetic droplets or bubbles with magnetic fields,the presence of magnetic medium is *** additives can be added to the surface or interior of droplets and bubbles,allowing for on-demand manipulation by direct magnetic ***,magnetically responsive elastomer substrates can be used to actuate droplets and bubbles by controlling the deformation of microstructures on the substrates through magnetic *** strategy is based on untethered magnetic devices,which enables free mobility,facilitating versatile manipulation of droplets and bubbles in a flexible *** paper reviews the advances in magnetically responsive manipulation strategies from the perspective of droplets and *** overview of the different classes of magnetic medium,along with their respective corresponding droplet/bubble manipulation methods and principles,is first ***,the applications of droplet/bubble manipulation in biomedicine,microchemistry,and other fields are ***,the remaining challenges and future opportunities related to regulating droplet/bubble behavior using magnetic fields are discussed.

关键词： deformation bubble versatile

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Scalable synthesis of lipid nanoparticles for nucleic acid drug delivery using an isometric channel-size enlarging strategy

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Nano Research 2024年第4期17卷 2899-2907页

作者： Zesen Ma Haiyang Tong Sijin Lin Li Zhou Demeng Sun Baoqing Li Changlin Tian jiaru Chu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of ChinaHefei 230027China Science Island Branch Graduate SchoolUniversity of Science and Technology of ChinaHefei 230026China Anhui Provincial Key Laboratory of High Field Magnetic Resonance Imaging High Magnetic Field LaboratoryHefei Institute of Physical ScienceChinese Academy of SciencesHefei 230031China Anhui Provincial Engineering Laboratory of Peptide Drugs University of Science and Technology of ChinaHefei 230027China School of Biomedical Engineering Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaSuzhou 215127China

Lipid nanoparticles(LNPs)have emerged as highly effective delivery systems for nucleic acid-based ***,the broad clinical translation of LNP-based drugs is hampered by the lack of robust and scalable synthesis techniques that can consistently produce formulations from early development to clinical *** this work,we proposed a method to achieve scalable synthesis of LNPs by scaling inertial microfluidic mixers isometrically in three ***,a theoretical predictive method,which controls the mixing time to be equal across different chips,is developed to ensure consistent particle size and size distribution of the synthesized *** loaded with small interfering RNA(siRNA)were synthesized at different flow rates,exhibiting consistent physical properties,including particle size,size distribution and encapsulation *** work provides a practical approach for scalable synthesis of LNPs consistently,offering the potential to accelerate the transition of nucleic acid drug development into clinical application.

关键词： lipid nanoparticles nucleic acid delivery microfluidics scalable synthesis consistent particle size

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Dynamic knowledge graph approach for modelling the decarbonisation of power

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Energy and AI 2024年第3期17卷 48-64页

作者： Wanni Xie Feroz Farazi John Atherton jiaru Bai Sebastian Mosbach Jethro Akroyd Markus Kraft Department of Chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCambridge CB30ASUK CARES Cambridge Centre for Advanced Research and Education in Singapore1 Create WayCREATE Tower#05-05Singapore138602Singapore School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang DriveSingapore637459Singapore The Alan Turing Institute LondonNW12DBUK

This paper presents a dynamic knowledge graph approach that offers a reusable,interoperable,and extensible framework for modelling power *** ontologies have been developed to support a linked data representation of infrastructure data,socio-demographic data,areal attributes like demand,and models describing power *** knowledge graph links the data with a hierarchical representation of administrative regions,supporting geospatial queries to retrieve information about the population within the vicinity of a power plant,the number of power plants,total generation capacity,and demand within specific *** agents were developed to operate on the knowledge *** agents performed tasks including data uploading,updating,retrieval,processing,model construction and scenario analysis.A derived information framework was used to track the provenance of information calculated by agents involved in each *** knowledge graph was populated with data describing the UK power *** alternative models of the transmission grid with different levels of structural resolution were instantiated,providing the foundation for the power system simulation and optimisation tasks performed by the *** application of the dynamic knowledge graph was demonstrated via a case study that investigates clean energy transition trajectories based on the deployment of Small Modular Reactors in the UK.

关键词： Power system modelling Decarboni sation Dynanic knowledge graph Ontology and Semantic Web

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Active Micro-Nano-Collaborative Bioelectronic Device for Advanced Electrophysiological Recording

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Nano-Micro Letters 2024年第7期16卷 244-264页

作者： Yuting Xiang Keda Shi Ying Li Jiajin Xue Zhicheng Tong Huiming Li Zhongjun Li Chong Teng jiaru Fang Ning Hu Department of Chemistry Zhejiang-Israel Joint Laboratory of Self-Assembling Functional MaterialsZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 310058People’s Republic of China School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053People’s Republic of China General Surgery Department Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Children’s HealthHangzhou 310052People’s Republic of China Department of Lung Transplantation and General Thoracic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003People’s Republic of China Department of Orthopedics The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322005People’s Republic of China School of Electronics and Information Technology Sun Yat-Sen UniversityGuangzhou 510006People’s Republic of China Department of Obstetrics and Gynecology The Tenth Affiliated HospitalSouthern Medical UniversityDongguan 523059People’s Republic of China Dongguan Key Laboratory of Major Diseases in Obstetrics and Gynecology Dongguan 523059People’s Republic of China

The development of precise and sensitive electrophysiological recording platforms holds the utmost importance for research in the fields of cardiology and *** recent years,active micro/nano-bioelectronic devices have undergone significant advancements,thereby facilitating the study of *** distinctive configuration and exceptional functionality of these active micro-nano-collaborative bioelectronic devices offer the potential for the recording of high-fidelity action potential signals on a large *** this paper,we review three-dimensional active nano-transistors and planar active micro-transistors in terms of their applications in electroexcitable cells,focusing on the evaluation of the effects of active micro/nano-bioelectronic devices on electrophysiological *** forward to the possibilities,challenges,and wide prospects of active micro-nano-devices,we expect to advance their progress to satisfy the demands of theoretical investigations and medical implementations within the domains of cardiology and neuroscience research.

关键词： Active micro/nano collaborative bioelectronic device Three-dimensional active nano-transistor Planar active microtransistor Electrophysiology

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Fasn involved in the nephrotoxicity induced by polystyrene nanoplastics and the intervention of melatonin through intestinal microbiota-mediated lipid metabolism disorder

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Nano Research 2024年第8期17卷 7365-7375页

作者： Huiwen Kang Danyang Huang jiaru Jing Wei Zhang Lei Zhang Jingyu Wang Ziyan Liu Lin Han Ziyan Wang Lefeng Zhang Ai Gao Department of Occupational Health and Environmental Health School of Public HealthCapital Medical UniversityBeijing 100069China Beijing Key Laboratory of Environmental Toxicology Capital Medical UniversityBeijing 100069China

Nanoplastics(NPs)can accumulate in the kidney and cause kidney injury,but the multi-organ interaction mechanism and preventive measures of kidney injury are still *** this study,in vivo(60μg/day,42 days)and in vitro(0.4μg/μL,24 h)exposure models of polystyrene nanoplastics(PS-NPs,80 nm)in mice and human kidney cortex proximal tubule epithelial cells(HK-2 cells)were established,*** study revealed that PS-NPs caused obvious pathological changes and impaired renal function in mice,which were related to lipid metabolism disorders mediated by intestinal ***-fatty acid synthase(Fasn)-docosahexaenoic acid(DHA)pathway may be one of the mechanisms of kidney injury in ***,we also found that melatonin attenuates PS-NPs-induced nephrotoxicity by modulating lipid metabolism disorders(represented by DHA)and affects Fasn *** conclusion,our study revealed the important role of intestinal flora-mediated lipid metabolism in PS-NPs-induced nephrotoxicity and preliminarily provided potential key gene targets and effective preventive measures for PS-NPs-induced nephrotoxicity.

关键词： nanoplastics nephrotoxicity lipid metabolism fatty acid synthase(Fasn) melatonin

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High-performance liquid metal electromagnetic actuator fabricated by femtosecond laser

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International Journal of Extreme Manufacturing 2024年第2期6卷 511-521页

作者： Yiyu Chen Hao Wu Rui Li Shaojun Jiang Shuneng Zhou Zehang Cui Yuan Tao Xinyuan Zheng Qianqian Zhang Jiawen Li Guoqiang Li Dong Wu jiaru Chu Yanlei Hu CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefei 230027People’s Republic of China Key Laboratory of Testing Technology for Manufacturing Process of Ministry of Education Southwest University of Science and TechnologyMianyang 621010People’s Republic of China Department of Mechanical Engineering The University of Hong KongHong Kong Special Administrative Region of ChinaPeople’s Republic of China

Small-scale electromagnetic soft actuators are characterized by a fast response and simplecontrol,holding prospects in the field of soft and miniaturized *** use of liquid metal(LM)to replace a rigid conductor inside soft actuators can reduce the rigidity and enhance the actuation performance and *** research efforts,challenges persist in the flexible fabrication of LM soft actuators and in the improvement of actuation *** address these challenges,we developed a fast and robust electromagnetic soft microplate actuator based on a laser-induced selective adhesion transfer *** with unprecedentedly thin LM circuit and customized low Young’s modulus silicone rubber(1.03 kPa),our actuator exhibits an excellent deformation angle(265.25?)and actuation bending angular velocity(284.66 rad·s^(-1)).Furthermore,multiple actuators have been combined to build an artificial gripper with a wide range of *** actuator presents new possibilities for designing small-scaleartificial machines and supports advancements in ultrafast soft and miniaturized robotics.

关键词： soft actuators femtosecond laser liquid metal

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