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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang ai-ai Gao Cheng Zhu Tao He James G Herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

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Feasible strategy for the nitrogen fixation and humification quality improvement by spent mushroom substrate as conditioning agent

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 235-240页

作者： Shuang ai Yuanbei Zhang Guoxiang Zheng College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Swine Facilities Engineering Ministry of Agriculture and Rural AffairsHarbin 50030China Heilongjiang Key Laboratory of Technology and Equipment for the Utilization of Agricultural Renewable Resources Harbin 150030China

There is an overlooked problem which increasing microbial abundance while reducing nitrogen loss during *** study investigated the viability of spent mushroom substrate(SMS)as conditioners in the aerobic composting of kitchen waste(KW)with cattle manure(CM).The variation of temperature,pH,C/N,organic matter,cellulose,hemicelluloses,germination index(GI),and microflora structure were explored to evaluate the potential in accelerating maturity and nitrogen fixation by SMS *** results showed that the addition of SMS accelerated the heating rate,prolonged the high temperature time,and decreased organic matter,hemicellulose,and cellulose by 17.49%,23.61%,and 18.62%,*** GI reached 105.86%with SMS addition,while 74.17%was found in control treatment after *** changed the microbial community composition and increased the species ***,Clostridium XI and Azomonas were dominant bacteria,which increased the retention of nitrogen,promoted organic matter degradation and reduce compost *** study can provide a feasible strategy for nitrogen fixation in the field of organic waste recycling.

关键词： spent mushroom substrate conditioning agent nitrogen fixation humification quality aerobic composting

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Runout prediction of potential landslides based on the multi-source data collaboration analysis on historical cases

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China Geology 2024年第2期7卷 264-276页

作者： Jun Sun Yu Zhuang ai-guo Xing Guizhou Geology and Mineral Engineering Construction Co. LtdGuiyang 550000China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Long runout landslides involve a massive amount of energy and can be extremely hazardous owing to their long movement distance,high mobility and strong destructive *** methods have been widely used to predict the landslide runout but a fundamental problem remained is how to determine the reliable numerical *** study proposes a framework to predict the runout of potential landslides through multi-source data collaboration and numerical analysis of historical landslide ***,for the historical landslide cases,the landslide-induced seismic signal,geophysical surveys,and possible in-situ drone/phone videos(multi-source data collaboration)can validate the numerical results in terms of landslide dynamics and deposit features and help calibrate the numerical(rheological)***,the calibrated numerical parameters can be used to numerically predict the runout of potential landslides in the region with a similar geological setting to the recorded *** of the runout prediction approach to the 2020 Jiashanying landslide in Guizhou,China gives reasonable results in comparison to the field *** numerical parameters are determined from the multi-source data collaboration analysis of a historical case in the region(2019 Shuicheng landslide).The proposed framework for landslide runout prediction can be of great utility for landslide risk assessment and disaster reduction in mountainous regions worldwide.

关键词： Landslide runout prediction Drone survey Multi-source data collaboration DAN3D numerical modeling Jianshanying landslide Guizhou Province Geological hazards survey engineering

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Constitutive Behavior of the Interface between UHPC and Steel Plate without Shear Connector:From Experimental to Numerical Study

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1863-1888页

作者： Zihan Wang Boshan Zhang Hui Wang Qing ai Xingchun Huang School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Bridge Engineering Tongji UniversityShanghai200092China

The application of ultra-high performance concrete(UHPC)as a covering layer for steel bridge decks has gained widespread *** employing a connection without a shear connector between the steel plate and UHPC,namely,the sandblasted interface and the epoxy adhesive with sprinkled basalt aggregate interface,the installation cannot only be simplified but also the stress concentration resulting from the welded shear connectors can be *** study develops constitutive models for these two interfaces without shear connectors,based on the interfacial pull-off and push-out *** validation,three-point bending tests on the steel-UHPC composite plates are *** results indicated that the proposed bilinear traction-separation model for the sandblasted interface and the trapezoidal traction-separation model for the epoxy adhesive with sprinkled basalt aggregate interface can generally calibrate the interfacial ***,the utilization of the experimentally determined pure shear strength underestimates the load-carrying capacity of the composite plates in the case of three-point bending *** recalling the Mohr-Coulomb criterion,this underestimation is attributed to the enhancement of the interface shear strength by the presence of normal stress.

关键词： Cohesive zone model interfacial behavior finite element simulation UHPC steel plate

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Construction personnel dress code detection based on YOLO framework

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CAai Transactions on Intelligence Technology 2024年第3期9卷 709-721页

作者： Yunkai Lyu Xiaobing Yang ai Guan Jingwen Wang Leni Dai College of Information Engineering China Jiliang UniversityHangzhouChina College of Integrated Circuit Science and Engineering Nanjing University of Posts and TelecommunicationsNanjingChina China Jiliang University HangzhouZhejiangChina Department of Mathematics University of California San DiegoLa JollaCaliforniaUSA

It is important for construction personnel to observe the dress code,such as the correct wearing of safety helmets and reflective vests is conducive to protecting the workers'lives and safety of construction.A YOLO network-based detection algorithm is proposed for the construction personnel dress code(YOLO-CPDC).Firstly,Multi-Head Self-Attention(MHSA)is introduced into the backbone network to build a hybrid back-bone,called Convolution MHSA Network(CMNet).The CMNet gives the model a global field of view and enhances the detection capability of the model for small and obscured ***,an efficient and lightweight convolution module is *** is named Ghost Shuffle Attention-Conv-BN-SiLU(GSA-CBS)and is used in the neck *** GSANeck network reduces the model size without affecting the ***,the SIoU is used in the loss function and Soft NMS is used for *** results on the self-constructed dataset show that YOLO-CPDC algorithm has higher detection accuracy than current ***-CPDC achieves a mAP50 of 93.6%.Compared with the YOLOv5s,the number of parame-ters of our model is reduced by 18%and the mAP50 is improved by 1.1%.Overall,this research effectively meets the actual demand of dress code detection in construction scenes.

关键词： artificial intelligence computer vision deep learning deep neural networks

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Self-actuating protection mechanisms for safer lithium-ion batteries

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Journal of Energy Chemistry 2024年第7期94卷 181-198页

作者： Yang Luo Chunchun Sang Kehan Le Hao Chen Hui Li Xinping ai Hubei Key Lab of Electrochemical Power Sources College of Chemistry&Molecular ScienceWuhan UniversityWuhan 430072HubeiChina state Key Laboratory of New Textile Materials&Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200HubeiChina

Safety issue is still a problem nowadays for the large-scale application of lithium-ion batteries(LIBs)in electric vehicles and energy storage *** unsafe behaviors of LIBs arise from the thermal run-away,which is intrinsically triggered by the overcharging and *** improve the safety of LIBs,various protection strategies based on self-actuating reaction control mechanisms(SRCMs)have been proposed,including redox shuttle,polymerizable monomer additive,potential-sensitive separator,thermal shutdown separator,positive-temperature-coefficient electrode,thermally polymerizable addi-tive,and reversible thermal phase transition *** build-in protection mechanisms,these meth-ods can sensitively detect either the temperature change inside battery or the potential change of the electrode,and spontaneously shut down the electrode reaction at risky conditions,thus preventing the battery from going into thermal *** their advantages in enhancing the intrinsic safety of LIBs,this paper overviews the research progresses of SRCMs after a brief introduction of thermal runaway mechanism and limitations of conventional thermal runaway mitigating *** importantly,the current states and issues,key challenges,and future developing trends of SRCTs are also discussed and outlined from the viewpoint of practical application,aiming at providing insights and guidance for developing more effective SRCMs for LIBs.

关键词： Li-ion battery Safety Thermal runaway Thermal protection Overcharge protection

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Chiral mesostructured hematite with temperature-independent magnetism due to spin confinement

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Nano Research 2024年第3期17卷 2019-2024页

作者： Baiwen Zhang Jing ai Yingying Duan Te Bai Lu Han Shunai Che School of Physics Science and Engineering Tongji UniversityShanghai 200092China School of Chemistry and Chemical Engineering Tongji UniversityShanghai 200092China Wuxi Vocational College of Science and Technology Wuxi 214028China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesState Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Hematite(α-Fe_(2)O_(3))is known to undergo conversion from weak ferromagnetic to antiferromagnetic as the temperature decreases below the Morin temperature(TM=250 K)due to spin moment rotation occurring during the Morin transition(MT).Herein,we endowed hematite with mesostructured chirality to maintain weak ferromagnetism without *** mesostructured hematite(CMH)nanoparticles were prepared by a hydrothermal method with glutamic acid(Glu)as the symmetry-breaking *** triangular bipyramidal CMH nanoparticles were composed of helically cleaved nanoflakes with twisted crystal ***-cooled(FC)magnetization measurements showed that the magnetic moments of CMH were stabilized without MT within the temperature range of 10–300 *** loop measurements confirmed the weak ferromagnetism of *** enhanced Dzyaloshinskii–Moriya interaction(DMI)was speculated to be responsible for the temperature-independent weak ferromagnetism,in which the spin configuration would be confined with canted antiferromagnetic coupling due to the mesostructured chirality of CMH.

关键词： hematite chiral mesostructure Dzyaloshinskii–Moriya interaction weak ferromagnetism antiferromagnetic material temperature-independent magnetism

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Spatiotemporal Evolution of Urban Heat Islands and Optimization of Spatial Network Construction in the Central Urban Area of Fuzhou City, China

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Chinese Geographical Science 2024年第5期34卷 917-930页

作者： ZHAO Qiuyue YU Kunyong GENG Jianwei LIN Jiqing ai Jingwen LIU Jian College of Landscape Architecture Fujian Agriculture and Forestry UniversityFuzhou 350002China University Key Lab for Geomatics Technology and Optimize Resources Utilization in Fujian Province Fujian Agriculture and Forestry UniversityFuzhou 350002China

Although accelerated urbanization has led to economic prosperity,it has also resulted in urban heat island ***,identifying methods of using limited urban spaces to alleviate heat islands has become an urgent *** this study,we assessed the spatiotemporal evolution of urban heat islands within the central urban area of Fuzhou City,China from 2010 to *** assessment was based on a morphological spatial pattern analysis(MSPA)model and an urban thermal environment spatial network constructed us-ing the minimum cumulative resistance(MCR)*** measures for the spatial network were proposed to provide a theor-etical basis for alleviating urban heat *** results show that the heat island area within the study area gradually increased while that of urban cold island area gradually *** core area was the largest of the urban heat island patch landscape elements with a significant impact on other landscape elements,and represented an important factor underlying urban heat island network *** thermal environment network revealed a total of 197 thermal environment corridors and 93 heat island *** locations were then optimized according to the current land use,which maximized the potential of 1599.83 *** based on current land use led to an increase in climate resilience,with effective measures showing reduction in thermal environment spatial network structure and function,contributing to the mitigation of urban heat *** findings support the use of current land use patterns during urban heat island mitigation measure planning,thus providing an important reference basis for alleviating urban heat island effects.

关键词： urban heat island spatiotemporal analysis circuit theory post optimization evaluation climate mitigation Fuzhou City,China

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Two-Staged Method for Ice Channel Identification Based on Image Segmentation and Corner Point Regression

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China Ocean Engineering 2024年第2期38卷 313-325页

作者： DONG Wen-bo ZHOU Li DING Shi-feng WANG ai-ming Cai Jin-yan School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Identification of the ice channel is the basic technology for developing intelligent ships in ice-covered waters,which is important to ensure the safety and economy of *** the Arctic,merchant ships with low ice class often navigate in channels opened up by *** in the ice channel often depends on good maneuverability skills and abundant experience from the captain to a large *** ship may get stuck if steered into ice fields off the *** this circumstance,it is very important to study how to identify the boundary lines of ice channels with a reliable *** this paper,a two-staged ice channel identification method is developed based on image segmentation and corner point *** first stage employs the image segmentation method to extract channel *** the second stage,an intelligent corner regression network is proposed to extract the channel boundary lines from the channel region.A non-intelligent angle-based filtering and clustering method is proposed and compared with corner point regression *** training and evaluation of the segmentation method and corner regression network are carried out on the synthetic and real ice channel *** evaluation results show that the accuracy of the method using the corner point regression network in the second stage is achieved as high as 73.33%on the synthetic ice channel dataset and 70.66%on the real ice channel dataset,and the processing speed can reach up to 14.58frames per second.

关键词： ice channel ship navigation identification image segmentation corner point regression

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Detection method of forward-scatter signal based on Rényi entropy

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Journal of Systems Engineering and Electronics 2024年第4期35卷 865-873页

作者： ZHENG Yuqing ai Xiaofeng YANG Yong ZHAO Feng XIAO Shunping State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System National University of Defense TechnologyChangsha 410073China

The application scope of the forward scatter radar(FSR)based on the Global Navigation Satellite System(GNSS)can be expanded by improving the detection ***,the forward-scatter signal model when the target crosses the baseline is ***,the detection method of the for-ward-scatter signal based on the Rényi entropy of time-fre-quency distribution is proposed and the detection performance with different time-frequency distributions is ***-tion results show that the method based on the smooth pseudo Wigner-Ville distribution(SPWVD)can achieve the best ***,combined with the geometry of FSR,the influence on detection performance of the relative distance between the target and the baseline is ***,the proposed method is validated by the anechoic chamber measurements and the results show that the detection ability has a 10 dB improvement compared with the common constant false alarm rate(CFAR)detection.

关键词： forward scatter radar(FSR) Global Navigation Satellite System(GNSS) time-frequency distribution Rényi entropy signal detection

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