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基于CiteSpace的突发性聋伴耳鸣文献计量学分析及思考

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中华耳鼻咽喉头颈外科杂志 2024年第7期59卷 719-726页

作者：陈斯张剑宁霍岩凌雯琛吴佳倩赵鑫宇李明上海中医药大学附属岳阳中西医结合医院耳鼻喉科上海200437

目的探讨突发性聋(突聋)伴耳鸣的发生率、检查方案选择及治疗,为临床建立完善的突聋新指南提供参考。方法运用CiteSpace软件分析及数据挖掘,对计算机检索出的2011—2021年中国知网、万方以及Web of Science数据库收录的有关突聋伴耳鸣... 详细信息

目的探讨突发性聋(突聋)伴耳鸣的发生率、检查方案选择及治疗,为临床建立完善的突聋新指南提供参考。方法运用CiteSpace软件分析及数据挖掘,对计算机检索出的2011—2021年中国知网、万方以及Web of Science数据库收录的有关突聋伴耳鸣相关辅助检查和治疗的文章进行分析总结。结果本研究共检索随机对照研究207篇,其中中文121篇,英文86篇;最终纳入中文文献74篇,英文文献16篇。74篇中文文献中,伴随症状为耳鸣的64篇(86.5%),头晕/眩晕58篇(78.4%),耳闷25篇(33.8%),头痛10篇(13.5%),失眠4篇(5.4%),头晕耳鸣混杂4篇(5.4%),呕吐2篇(2.7%);16篇英文文献中伴随症状为耳鸣的15篇(93.8%),眩晕12篇(75.0%),耳闷1篇(6.3%),各种症状混杂1篇(6.3%)。64篇提及耳鸣的中文文献中,仅9篇提到了耳鸣匹配检查;1篇提到耳鸣伴随症状的治疗为声治疗及心理辅导。4种不同类型突聋伴耳鸣发生率由低到高依次为:低中频82.4%,中高频90.7%,全聋型92.4%,平坦型92.8%。结论耳鸣是突聋最常见的伴随症状,耳鸣匹配检查是有效评估手段。在建立科学、完善、全面、系统的突聋诊疗体系或指南的同时应重视耳鸣症状及其不良心理反应的诊疗,减少突聋康复后期耳鸣的发生率。

关键词：听觉丧失,突发性耳鸣耳鸣匹配检查 CiteSpace可视化分析

咪达唑仑与右美托咪定/丙泊酚对机械通气危重症患者镇静治疗有效性和安全性的Meta分析

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中国药房 2024年第3期35卷 353-360页

作者：吴佳骞苏丹邵腾皓于占彪赵聪聪王迎鑫河北大学附属医院重症医学科河北保定071030 河北医科大学附属第四医院重症医学科石家庄050035

目的系统评价咪达唑仑与右美托咪定/丙泊酚在机械通气危重症患者镇静治疗方面的有效性及安全性,为临床治疗提供循证参考。方法计算机检索PubMed、Embase、Web of Science、Cochrane图书馆、临床试验资料库(Clinical ***)、中国期刊全... 详细信息

目的系统评价咪达唑仑与右美托咪定/丙泊酚在机械通气危重症患者镇静治疗方面的有效性及安全性,为临床治疗提供循证参考。方法计算机检索PubMed、Embase、Web of Science、Cochrane图书馆、临床试验资料库(Clinical ***)、中国期刊全文数据库、中文科技期刊数据库、万方数据库、中国生物医学文献数据库,检索时限均为建库起至2023年3月31日,收集咪达唑仑与右美托咪定/丙泊酚在机械通气危重症患者镇静方面的疗效及安全性数据。对符合纳入标准的临床研究进行资料提取后,采用RevMan 5.3统计软件进行Meta分析。结果共纳入31篇文献,总计2 765例患者。Meta分析结果显示,咪达唑仑组患者机械通气时间[MD=14.13,95%CI(13.75,14.52),P<0.000 01]、重症监护病房住院时间[MD=0.92,95%CI(0.54,1.30),P<0.000 01]较右美托咪定/丙泊酚组更长;咪达唑仑组患者心动过缓发生率较右美托咪定/丙泊酚组更低[OR=0.60,95%CI(0.41,0.90),P=0.01],但两组低血压发生率[OR=0.69,95%CI(0.47,1.01),P=0.06]差异无统计学意义;咪达唑仑组患者谵妄[OR=3.88,95%CI(2.74,5.49),P<0.000 01]、呼吸机相关性肺炎[OR=2.32,95%CI(1.19,4.51),P=0.01]、呼吸抑制[OR=5.70,95%CI(3.09,10.52),P<0.000 01]发生率较右美托咪定/丙泊酚组更高。结论与右美托咪定/丙泊酚类药物比较,咪达唑仑在有效性方面增加了患者的机械通气时间和重症监护病房住院时间,在安全性方面增加了谵妄、肺部并发症的发生风险,但对心血管的影响更小。

关键词：咪达唑仑右美托咪定丙泊酚镇静机械通气危重症患者疗效安全性

Alternative splicing: An important mechanism in stem cell biology

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World Journal of Stem Cells 2015年第1期7卷 1-10页

作者： Kenian Chen Xiaojing Dai jiaqian wu The Vivian L Smith Department of Neurosurgery The Center for Stem Cell and Regenerative Medicine University of Texas Medical School at HoustonHouston TX 77030 United States

Alternative splicing(AS) is an essential mechanism in post-transcriptional regulation and leads to protein diversity. It has been shown that AS is prevalent in metazoan genomes, and the splicing pattern is dynamically regulated in different tissues and cell types, including embryonic stem cells. These observations suggest that AS may play critical roles in stem cell biology. Since embryonic stem cells and induced pluripotent stem cells have the ability to give rise to alltypes of cells and tissues, they hold the promise of future cell-based therapy. Many efforts have been devoted to understanding the mechanisms underlying stem cell selfrenewal and differentiation. However, most of the studies focused on the expression of a core set of transcription factors and regulatory RNAs. The role of AS in stem cell differentiation was not clear. Recent advances in highthroughput technologies have all owed the profiling of dynamic splicing patterns and cis-motifs that are responsible for AS at a genome-wide scale, and provided novel insights in a number of studies. In this review, we discuss some recent findings involving AS and stem cells. An emerging picture from these findings is that AS is integrated in the transcriptional and post-transcriptional networks and together they control pluripotency maintenance and differentiation of stem cells.

关键词： Alternative splicing Stem cell Pluripotency Differentiation Splicing factor

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基于LLE和PSO的快速虹膜图像重构算法

华南理工大学学报（自然科学版） 2018年第1期46卷 97-102页

作者：沃焱吴嘉茜华南理工大学计算机科学与工程学院广东广州510006

虹膜特征码Iriscode具有高效的识别性能,被广泛应用于虹膜识别系统中.随着人们对生物特征安全问题的重视,如何从Iriscode重构虹膜图像以评判虹膜识别系统的安全性已成为一个研究热点.文中对Iriscode重构虹膜图像问题进行了分析,构建了... 详细信息

虹膜特征码Iriscode具有高效的识别性能,被广泛应用于虹膜识别系统中.随着人们对生物特征安全问题的重视,如何从Iriscode重构虹膜图像以评判虹膜识别系统的安全性已成为一个研究热点.文中对Iriscode重构虹膜图像问题进行了分析,构建了虹膜重构优化模型,并提出两阶段的快速虹膜重构算法.将提取Iriscode的过程视为距离保持的降维过程,在第一阶段中根据待测Iriscode的近邻,采用局部线性嵌入算法重构出若干非精确的虹膜重构图像;第二阶段利用粒子群优化算法,将前一阶段获得的非精确虹膜图像作为初始粒子进行迭代搜索,以获得精确结果.实验表明,本算法获得的重构虹膜图像能够通过虹膜识别系统,达到伪造攻击的目的.相比于其他重构算法,在时间及伪造成功率上都有提高.

关键词：虹膜图像重构局部线性嵌入算法粒子群优化算法虹膜特征码

PRR11 induces filopodia formation and promotes cell motility via recruiting ARP2/3 complex in non-small cell lung cancer cells

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Genes & Diseases 2022年第1期9卷 230-244页

作者： Zhili Wei Ru Wang Xun Yin lian Zhang Yunlong Lei Ying Zhang Yi Li jiaqian wu Youquan Bu Guoxiang Jin Chundong Zhang Department of Biochemistry and Molecular Biology Chongqing Medical UniversityChongqing 400016PR China Molecular Medicine and Cancer Research Center Chongqing Medical UniversityChongqing 400016PR China Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhouGuangdong 510080PR China

Filopodia, a finger-like structure and actin-rich plasma-membrane protrusion at the leading edge of the cell, has important roles in cell motility. However, the mechanisms of filopodia generation are not well-understood via the actin-related protein 2/3 (ARP2/3) complex in Non-Small Cell Lung Cancer (NSCLC) cells. We previously have demonstrated that PRR11 associates with the ARP2/3 complex to regulate cytoskeleton-nucleoskeleton assembly and chromatin remodeling. In this study, we further demonstrate that PRR11 involves in filopodia formation, focal adhesion turnover and cell motility through ARP2/3 complex. Cell phenotype assays revealed that the silencing of PRR11 increased cellular size and inhibited cell motility in NSCLC cells. Mechanistically, PRR11 recruited and co-localized with Arp2 at the membrane protrusion to promote filopodia formation but not lamellipodia formation. Notably, PRR11 mutant deletion of the proline-rich region 2 (amino acid residues 185–200) abrogated the effect of filopodia formation. In addition, PRR11-depletion inhibited filopodial actin filaments assembly and increased the level of active integrin β1 in the cell surface, whereas reduced the phosphorylation level of focal adhesion kinase (FAKY397) to repress focal adhesion turnover and cell motility in NSCLC cells. Taken together, our findings indicate that PRR11 has critical roles in controlling filopodia formation, focal adhesion turnover and cell motility by recruiting ARP2/3 complex, thus dysregualted expression of PRR11 potentially facilitates tumor metastasis in NSCLC cells.

关键词： ARP2/3 complex Cell motility FAK Filopodia Focal adhesion Integrin NSCLC cells PRR11

不同性别梨形环棱螺形态性状对体质量性状影响效果分析

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大连海洋大学学报 2024年第4期39卷 622-633页

作者：吴佳倩周康奇张彩群韦小凯叶华彭金霞林勇覃俊奇陈忠罗辉韦嫔媛何苹萍潘贤辉西南大学水产学院重庆402460 广西壮族自治区水产科学研究院广西水产遗传育种与健康养殖重点实验室广西南宁530021

为探究雄、雌梨形环棱螺(Bellamya purificata)形态性状与体质量性状的相关性,从广西南繁水产良种基地采集了1007只梨形环棱螺,鉴定性别并测量其体质量、壳宽、壳高等11个性状,并对其进行相关分析、通径分析及多元回归分析。结果表明:... 详细信息

为探究雄、雌梨形环棱螺(Bellamya purificata)形态性状与体质量性状的相关性,从广西南繁水产良种基地采集了1007只梨形环棱螺,鉴定性别并测量其体质量、壳宽、壳高等11个性状,并对其进行相关分析、通径分析及多元回归分析。结果表明:梨形环棱螺各形态性状与各质量性状的相关性均达到极显著性水平(P<0.05);雄性、雌性梨形环棱螺全湿质量均主要受到壳高影响,通径系数均为0.927;雄性梨形环棱螺的软体质量主要受壳高影响(0.904),而雌性主要受壳宽影响(0.899);雄性梨形环棱螺肌肉质量主要受体螺层高的影响(0.899),雌性主要受到壳宽、壳口宽、体螺层高、螺旋部高的共同影响;壳高对雄、雌梨形环棱螺全湿质量和雄螺软体质量的单独决定系数最大,分别为0.489、0.281、0.561;壳宽对雌性梨形环棱螺软体质量、肌肉质量单独决定系数最大,分别为0.190、0.080;体螺层高对雄性梨形环棱螺的肌肉质量单数决定系数最大,为0.601。研究表明,雄、雌梨形环棱螺的全湿质量、软体质量、肌肉质量均具有良好的选育潜力;在选育更高全湿质量、软体质量时,应选择壳高作为关键形状;当肌肉质量作为选育目标时,雄螺应以体螺层高为主要选择性状,雌螺则应综合考虑壳宽、壳口宽、体螺层高的影响。本研究通过逐步多元回归对雄、雌梨形环棱螺的全湿质量、软体质量、肌肉质量建立了较优的方程式,为后续的梨形环棱螺良种选育提供了重要参考依据。

关键词：梨形环棱螺形态性状通径分析回归分析

基于自然语言处理(NLP)的医学知识挖掘探索与实践

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健康教育与健康促进 2024年第2期19卷 155-157,217页

作者：沈红崔子禕曾淑君金小蕾盛妤朱思燕张莹吴佳倩上海市徐汇区疾病预防控制中心上海200237 上海智臻智能网络科技股份有限公司上海201803

目的通过对医学健康知识的挖掘,为人工智能等的健康科普知识支撑提供实践经验。方法采用基于自然语言处理(NLP)技术对徐汇区疾病预防控制中心2010年1月—2021年1月积累的科普文章进行结构拆分、阅读理解、实体识别等,处理流程包括文档... 详细信息

目的通过对医学健康知识的挖掘,为人工智能等的健康科普知识支撑提供实践经验。方法采用基于自然语言处理(NLP)技术对徐汇区疾病预防控制中心2010年1月—2021年1月积累的科普文章进行结构拆分、阅读理解、实体识别等,处理流程包括文档预处理、特征提取、段落筛选、阅读理解、答案排序、审核和发布。结果通过直接文档结构拆分,得到5395条问答;通过阅读理解,得到857条问答;通过抽取数字问答,得到1668条,初步形成问答形式的医学健康知识库。结论自然语言处理(NLP)技术为人工智能技术需要的大量语料素材提供了有效制作方法。

关键词：自然语言处理医学知识语料人工智能

A Retrospective Analysis of Glucagon-Like Peptide 1 Receptor Agonists in Treating Type 2 Diabetes Mellitus Complicated by Nonalcoholic Fatty Liver Disease

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Journal of Biosciences and Medicines 2024年第3期12卷 16-24页

作者： jiaqian Chen Hongyan wu Department of Endocrinology The First Affiliated Hospital of Yangtze University Jingzhou China

Background: The objective of this study was to compare and analyze the variations in clinical indices before and after treatment of type 2 mellitus (T2DM) combined with nonalcoholic fatty liver disease (NAFLD) that were treated with glucagon-like peptide 1 receptor agonists (GLP-1RAs). Methods: The electronic medical record system was utilized to search for a total of 16 patients with type 2 diabetes complicated by NAFLD who were hospitalized at the First Affiliated Hospital of Yangtze University from October 2022 to April 2023 and treated with GLP-1RA for the first time. The clinical indices were compared before and after 12 weeks of treatment with GLP-1RA. Results: The liver-spleen CT ratio (L/S), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in all patients treated with GLP-1RA after 12 weeks were significantly different (P 0.05). The patients were categorized into two groups based on the types of GLP-1RAs. The changes in L/S, TC, TG, and LDL-C in the long-acting group after treatment were statistically significant (P Conclusions: GLP-1RAs can improve liver function, regulate lipid metabolism, and reduce the severity of fatty liver in patients with T2DM complicated by NAFLD, which demonstrates the importance of clinical applications.

关键词： Glucagon-Like Peptide 1 Receptor Agonists Nonalcoholic Fatty Liver Disease Type 2 Diabetes Mellitus

The switch triggering the invasion process:Lipid metabolism in the metastasis of hepatocellular carcinoma

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Chinese Medical Journal 2024年第11期137卷 1271-1284页

作者： jiaqian Zhang Zhicheng Zhang Zhangfan wu Yufei Wang Zerui Zhang Limin Xia Department of Gastroenterology Institute of Liver and Gastrointestinal DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032China

In humans,the liver is a central metabolic organ with a complex and unique histological *** carcinoma(HCC),which is a highly aggressive disease with a poor prognosis,accounts for most cases of primary liver *** an emerging hallmark of cancers,metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs,including the ***,rewiring of the liver metabolic microenvironment,including lipid metabolism,is driven by HCC cells,propelling the phenotypes of HCC cells,including dissemination,invasion,and even metastasis in *** resulting formation of this vicious loop facilitates various malignant behaviors of HCC ***,few articles have comprehensively summarized lipid reprogramming in HCC ***,we have reviewed the general situation of the liver microenvironment and the physiological lipid metabolism in the liver,and highlighted the effects of different aspects of lipid metabolism on HCC metastasis to explore the underlying *** addition,we have recapitulated promising therapeutic strategies targeting lipid metabolism and the effects of lipid metabolic reprogramming on the efficacy of HCC systematical therapy,aiming to offer new perspectives for targeted therapy.

关键词： Hepatocellular carcinoma Invasion Metastasis Lipid metabolism Tumor microenvironment