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Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial

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Cancer Biology & Medicine 2022年第7期19卷 1089-1099页

作者： Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan jiaqian yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang Cancer Research Institute Department of OncologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052HenanChina

Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was *** with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were *** R-FPD regimen consisted of rituximab(375 mg/m2 *** D0),fotemustine(100 mg/m2 *** D1),pemetrexed(600 mg/m2 *** D1),and dexamethasone(40 mg *** D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of ***:A total of 30 patients were *** 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL.

关键词： Rituximab primary central nervous system lymphoma pemetrexed fotemustine WBRT

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青藏高原多年冻土活动层厚度探测方法综述

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地质论评 2021年第S1期67卷 209-211页

作者：闫家倩王雯杰韩晨河北省煤田地质局水文地质队河北邯郸056200 中国地质科学院地球深部探测中心北京100037

青藏高原是世界上海拔最高、面积最大的高原,被称为"世界的屋脊"和"世界第三极",较高的海拔和严酷的气候发育出世界上中低纬度区海拔最高、面积最大、分布最广的多年冻土。

关键词：青藏高原多年冻土活动层厚度探测

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Towards Data-Driving Multi-View Evaluation Framework for Scratch

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Tsinghua Science and Technology 2024年第2期29卷 517-528页

作者： Xiaolin Chai yan Sun yan Gao Department of Computer Science Beijing University of Posts and TelecommunicationBeijing 100876China Intellectual Property Institute Shandong Polytechnic CollegeJining 272067China

As one of the most popular visual programming languages,Scratch has a lot of evaluation around *** evaluation can help programmers understand their projects *** the same time,it can also provide a reference for them to browse other projects in the online *** of the existing evaluations on Scratch are carried from three perspectives:Computational Thinking(CT)ability,visual presentation aesthetics,and code *** them,the assessment of CT and code quality is mainly carried out from the program script,while the evaluation of visual aesthetics is analyzed from the perspective of image sequences generated by project *** single-view evaluation focuses on the performance of a program in a certain aspect and is *** this paper,we propose a multi-view evaluation framework to integrate various evaluations using different *** quantitatively analyze the assessment of different views driven by *** with overall evaluations that represent human opinions,we analyze their differences and *** experiments,we determine the weights of different integration policies,the proposed multi-view evaluation method can generate evaluation results similar to human opinions.

关键词： Scratch Computational Thinking(CT) visual aesthetic static analysis integration policy machine learning

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河北省赤城县地质灾害易发性评价

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地质论评 2023年第S1期69卷 487-488页

作者：沈石凯张宏亮闫家倩河北省煤田地质局水文地质队河北邯郸056200

地质灾害已成为人类生存发展、工程建设甚至休闲活动无法回避的重要问题(刘传正等,2020)。地质灾害是由于自然因素和人为因素共同引起的。中国地质灾害发育频繁,尤以突发性地质灾害造成的人员伤亡和经济损失严重(殷坤龙等,2003)。所以... 详细信息

地质灾害已成为人类生存发展、工程建设甚至休闲活动无法回避的重要问题(刘传正等,2020)。地质灾害是由于自然因素和人为因素共同引起的。中国地质灾害发育频繁,尤以突发性地质灾害造成的人员伤亡和经济损失严重(殷坤龙等,2003)。所以地质灾害风险评估的重要性不言而喻,地质灾害风险评估是防灾减灾的项有力的措施.

关键词：地质灾害易发性评价 GIS

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Forward to the Special Topic on“Solving Differential Equations with Deep Learning”

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Journal of Systems Science & Complexity 2024年第2期37卷 389-390页

作者： yan Zhenya Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China

The concept of artificial intelligence(AI)was first presented at the Dartmouth SummerResearch Project on AI hosted by McCarthy and Minsky in *** that,the developmentof AI has experienced ups and downs due to some limited conditions including intelligentcomputing techniques,computer and hardware and software^([1,2]).In particular,with the rapidof deep artificial neural networks,machine learning(ML)and deep learning(DL)techniques^([3,4])have been applied in many fields of science and engineering,including machine translation,image recognition,genomics,scientific computing and atmospheric science,etc^([5]).

关键词： has artificial hardware

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强国背景下推进中国式职业教育现代化的时代趋向、逻辑取向与行动路向

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现代教育管理 2024年第4期 119-128页

作者：陈衍王佳倩浙江工业大学浙江杭州310023

在建设教育强国的时代趋向下,中国式职业教育现代化成为推动职业教育高质量发展的重要基础。中国式职业教育现代化具有独特而清晰的逻辑取向,包括职业教育制度化、职业教育数字化、职业教育终身化、职业教育国际化,其孕育在我国职业教... 详细信息

在建设教育强国的时代趋向下,中国式职业教育现代化成为推动职业教育高质量发展的重要基础。中国式职业教育现代化具有独特而清晰的逻辑取向,包括职业教育制度化、职业教育数字化、职业教育终身化、职业教育国际化,其孕育在我国职业教育的历史基础与改革实践中,并以解决我国发展过程中的实际问题为导向。为增强职业教育对我国现代社会的适应性,未来在推进中国式职业教育现代化进程中应着力深化现代职业教育体系改革,加快职业教育数字化转型,优化职业教育发展环境,完善中国特色职业教育理论。

关键词：职业教育现代化中国式技能

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一种选择单粒子瞬态脉冲敏感结点的方法

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常州工学院学报 2018年第2期31卷 37-41页

作者：宋依青严佳倩常州工学院计算机信息工程学院江苏常州213032

逻辑电路中NMOS管或者PMOS管受到高能粒子撞击,会产生单粒子瞬态脉冲错误。针对这种现象,提出一种识别和选择电路中敏感结点的新方法,并与门的逻辑掩蔽效应加权综合考虑,对所选择的结点通过增大恢复管的尺寸来加固,以减小单粒子效应导... 详细信息

逻辑电路中NMOS管或者PMOS管受到高能粒子撞击,会产生单粒子瞬态脉冲错误。针对这种现象,提出一种识别和选择电路中敏感结点的新方法,并与门的逻辑掩蔽效应加权综合考虑,对所选择的结点通过增大恢复管的尺寸来加固,以减小单粒子效应导致的软错误率。

关键词：单粒子瞬态脉冲逻辑掩蔽软错误率单粒子加固

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Large eddy simulation study of 3D wind field in a complex mountainous area under different boundary conditions

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第7期25卷 541-556页

作者： yan LI Lei yan Xuhui HE School of Civil Engineering Central South UniversityChangsha410075China National Engineering Research Center for High-speed Railway Construction Changsha410075China Hunan Provincial Key Laboratory for Disaster Prevention and Mitigation of Rail Transit Engineering Structures Changsha410075China

Large eddy simulations generally are used to predict 3D wind field characteristics in complex mountainous *** simulation boundary conditions,such as the height and length of the computational domain or the characteristics of inflow turbulence,can significantly impact the quality of *** this study,we examined these boundary conditions within the context of the mountainous terrain around a long-span cable-stayed bridge using a wind tunnel *** sizes of computational domains and turbulent incoming wind velocities were used in large eddy *** results show that when the height of the computational domain is five times greater than the height of the terrain model,there is minimal influence from the top wall on the wind field characteristics in this complex mountainous *** the length of the wake region of the computational domain has negligible effects on the wind *** in the inlet boundary reduces the length of the wake region on a leeward hill with a low slope,but has less impact on the mean wind velocity of steep hills.

关键词： Large eddy simulation(LES) Spectral representation method Recycling method High mountainous canyon Wind characteristics Atmospheric boundary layer Computational domain

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Electromagnetic characteristic analysis and design of a linear motor used for ultra-high-speed EMS maglev train

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Science China(Technological Sciences) 2024年第6期67卷 1957-1973页

作者： GAO Han SHI TingNa GAO XinMai LEI yanXiao yan Dong GUO Liyan yan yan College of Electrical Engineering Zhejiang UniversityHangzhou310027China Zhejiang University Advanced Electrical Equipment Innovation Center Hangzhou311107China State Key Laboratory of High-speed Maglev Transportation Technology Qingdao266100China CRRC Qingdao Sifang Co.Ltd. Qingdao266111China

The operating speed of the commercial electromagnetic suspension(EMS)maglev train has been over 430 km/h,making it the fastest means of land *** the increasing demands of people traveling,it is necessary to further improve the operating speed of maglev *** to examine whether the existing EMS system can meet the requirements of ultra-highspeed operation(more than 600 km/h),the electromagnetic characteristics of an EMS linear motor under the operating speed of 600–1000 km/h fed by a square-wave voltage supply is investigated in this ***,an electromagnetic field model of the EMS system under the square-wave voltage supply is established to investigate its electromagnetic performance,e.g.,the characteristics of phase current,the magnetic flux density,and the electromagnetic ***,the relationship between the harmonic components of the air-gap magnetic flux density and electromagnetic force is investigated using the two-dimensional fast Fourier transform(2D-FFT)to reveal the mechanism of electromagnetic force ***,to address the issues of excessive armature current density and significant electromagnetic force ripple,the linear motor is re-designed by enlarging the stator slot area and reshaping the mover's main magnetic ***,the Taguchi method is used to further improve the electromagnetic characteristics of the linear electric ***,the effectiveness of the proposed optimal design is validated by the finite-element analysis(FEA)based co-simulation.

关键词： ultra-high-speed maglev transportation electromagnetic suspension(EMS) linear motor electromagnetic force ripple suppression

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Thermal and mechanical behavior of casting copper alloy wheel during wheel and belt continuous casting process

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China Foundry 2024年第1期21卷 82-90页

作者： Kun Gao yan Peng School of Mechanical Engineering Yanshan UniversityQinhuangdao 066004HebeiChina

To investigate the thermal and mechanical behavior of casting wheel,a two-dimensional thermoelastic-plastic finite element model was used to predict the temperature,stress and distortion distribution of the casting wheel during the wheel and belt continuous casting *** effects of grinding thickness and casting speed on the thermal and mechanical behaviors of the center of the hot face of the casting wheel were discussed in *** each rotation,the casting wheel passes through four different spray *** results show that the temperature distribution of the casting wheel in different spray zones is similar,the temperature of the hot face is the highest and the temperature reaches the peak in the spray zoneⅢ.The stress and distortion depend on the temperature distribution,and the maximum stress and distortion of the hot face are 358.2 MPa and 1.82 mm,*** temperature at the center of the hot face decreases with increasing grinding thickness and increases with increasing casting speed.

关键词： casting wheel finite element model grinding thickness casting speed hot face spray zones

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