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水中痕量重金属元素测定的影响因素研究

皮革制作与环保科技 2024年第15期5卷 11-13页

作者：叶嘉琪广东科旭检测评价技术服务有限公司东莞分公司广东东莞523000

在分析痕量水中重金属时,应选择合适的器皿、化学试剂、实验用水等,可有效减少系统误差。本文对试剂纯度、容器材质、实验用水以及针孔滤膜处理方式进行实验论证。结果表明:使用聚丙烯材质的容器、高纯度试剂、一级水以及针孔滤膜过滤... 详细信息

在分析痕量水中重金属时,应选择合适的器皿、化学试剂、实验用水等,可有效减少系统误差。本文对试剂纯度、容器材质、实验用水以及针孔滤膜处理方式进行实验论证。结果表明:使用聚丙烯材质的容器、高纯度试剂、一级水以及针孔滤膜过滤时弃去前面2 mL的滤液,检测痕量重金属时所引入的杂质较少,产生的干扰较少,使分析结果更准确、数据更可靠。

关键词：痕量分析水检测重金属元素

血清脂蛋白相关磷脂酶A2对老年稳定性冠心病患者远期预后的预测价值

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中华老年心脑血管病杂志 2024年第5期26卷 495-498页

作者：庄建芬叶佳琦陈海晓姜英钱烨晟张清南通市第一人民医院(南通大学第二附属医院)全科医学科 226001 南通市第一人民医院(南通大学第二附属医院)心血管内科 226001

目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)对老年稳定性冠心病患者远期预后的预测价值。方法回顾性收集2016年1月至2018年12月南通市第一人民医院收治的老年稳定性冠心病患者198例,对患者随访5年,根据患者5年内是否发生不良心血管事件,... 详细信息

目的探讨血清脂蛋白相关磷脂酶A2(Lp-PLA2)对老年稳定性冠心病患者远期预后的预测价值。方法回顾性收集2016年1月至2018年12月南通市第一人民医院收治的老年稳定性冠心病患者198例,对患者随访5年,根据患者5年内是否发生不良心血管事件,将患者分为不良心血管事件组42例和对照组156例,比较2组患者临床特征和Lp-PLA2差异,同时分析Lp-PLA2对老年稳定性冠心病患者5年内发生不良心血管事件的预测价值。结果与对照组比较,不良心血管事件组患者年龄[(74.95±7.02)岁vs(70.17±6.30)岁,P=0.000]、糖尿病(54.76%vs 27.56%,P=0.001)、冠状动脉狭窄≥75%(69.05%vs 47.44%,P=0.013)、左心室射血分数<50%(50.00%vs 28.21%,P=0.008)、Lp-PLA2[(478.38±187.54)U/L vs(308.17±126.73)U/L,P=0.000]显著增高。年龄和Lp-PLA2曲线下面积分别为0.683(95%CI:0.590~0.776,P<0.01)和0.763(95%CI:0.677~0.848,P=0.763)。多因素logistics回归分析显示,年龄、糖尿病、冠状动脉狭窄≥75%、左心室射血分数<50%和Lp-PLA2是老年稳定性冠心病患者5年内发生不良心血管事件的独立影响因素(P<0.05,P<0.01)。结论Lp-PLA2增高与稳定性冠心病患者5年内发生不良心血管事件相关。

关键词：冠心病 1-烷基-2-乙酰甘油磷酸胆碱酯酶预后预测主要不良心血管事件

层粘连蛋白与老年急性心肌梗死病人主要不良心血管事件的相关性

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实用老年医学 2024年第2期38卷 149-151页

作者：章颖谢玲叶佳琦羌文慧严晓云姜英张清南通市第一人民医院全科医学科江苏省南通市226000

目的分析层粘连蛋白(laminin,LN)预测老年急性心肌梗死(acute myocardial infarction,AMI)病人住院期间主要不良心血管事件(major adverse cardiovascular events,MACE)的价值。方法回顾性分析在我院接受治疗的132例老年AMI病人资料,... 详细信息

目的分析层粘连蛋白(laminin,LN)预测老年急性心肌梗死(acute myocardial infarction,AMI)病人住院期间主要不良心血管事件(major adverse cardiovascular events,MACE)的价值。方法回顾性分析在我院接受治疗的132例老年AMI病人资料,根据住院期间是否出现MACE分为事件组和非事件组,观察比较2组LN水平,并分析LN对MACE的预测价值。结果 132例老年AMI病人中,37例(28.03%)发生MACE,事件组LN水平较非事件组高(P<0.01)。Logistic回归分析显示,高LN水平是老年AMI病人住院期间发生MACE的独立危险因素(OR=1.010,95%CI:1.001~1.020)。ROC曲线显示,LN预测老年AMI病人发生MACE的AUC为0.819。结论 LN升高与老年AMI病人院内发生MACE有关。

关键词：层粘连蛋白急性心肌梗死主要不良心血管事件

Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping Li Xin Li jiaqi Meng Weier Bao Shuang Wang Peng ye Xiao-Dong Gao Wei Wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

Effects of Potassium-Solubilizing Bacteria on Growth, Antioxidant Activity and Expression of Related Genes in Fritillaria taipaiensis P. Y. Li

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 789-806页

作者： jiaqi Lang Mingyan ye Ya Luo Yueheng Wang Zhifen Shi Xiaotian Kong Xuan Li Nong Zhou Chongqing Engineering Laboratory of Green Planting and Deep Processing of Famous-Region Drug in the Three Gorges Reservoir Region College of Biology and Food EngineeringChongqing Three Gorges UniversityChongqing404120China College of Modern Chinese Medicine Industry Chengdu University of Traditional Chinese MedicineChengdu611130China College of Pharmacy Dali UniversityDali671000China

This study aimed to examine the effects of inoculating Fritillaria taipaiensis *** leaves with different strains ofpotassium-solubilizing bacteria (KSB), or combinations thereof, focusing on aspects of photosynthesis and physiologicaland biochemical characteristics. At present, some studies have only studied the rhizosphere microbialcommunity characteristics of F. taipaiensis and have not discussed the effects of different microbial species on thegrowth promotion of F. taipaiensis. This paper will start from the perspective of potassium-solubilizing bacteria toconduct an in-depth study. Seed cultivation commenced at the base with three different KSBs in early October2022. The growth of F. taipaiensis leaves was observed after different treatments. Both single-plant and compoundinoculations were executed. A total of eight treatment groups were established, with aseptic fertilizer and sterilizedsoil functioning as the control group. The results reveal that intercellular CO_(2) concentration (Ci), stomatal conductance(Gs), and transpiration rate (Tr) were at their apex in the S7 group. Most treatment groups exhibited anincrease in leaf area, photosynthetic pigment content, soluble sugar, soluble protein, Superoxide Dismutase(SOD), Peroxidase (POD), Catalase (CAT) activities, and proline content. The expression levels of POD, SOD,and CAT genes were evaluated, following inoculation with different KSB. The highest was the S7 group. Theinoculation with various KSB, or combinations thereof, appears to bolster the growth and development of F. *** composite inoculation group S7, comprising Bacillus cereus, Burkholderia cepacia, and Bacillus subtilis,manifested the most favorable impact on the diverse indices of F. taipaiensis, thereby furnishing valuableinsights for the selection of bacterial fertilizer in the artificial cultivation of F. taipaiensis.

关键词： Fritillaria taipaiensis bacteria antioxidant enzyme genes leaf physiology and biochemistry photosynthetic characteristics

Influence of hydraulic retention time on behavior of antibiotics and antibiotic resistance genes in aerobic granular reactor treating biogas slurry

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Frontiers of Environmental Science & Engineering 2019年第3期13卷 59-67页

作者： Jie Liao Chaoxiang Liu Lin Liu Jie Li Hongyong Fan jiaqi ye Zhichao Zeng Key Laboratory of Environmental Biotechnology Fujian Province University Xiamen University of Technology Xiamen 361024 China Key Laboratory of Urban Pollutant Conversion Institute of Urban Environment Chinese Academy of Sciences Xiamen 361021 China Fujian Institute of Innovation Chinese Academy of Sciences Fuzhou 350002 China

The behavior of antibiotics and the corresponding resistance genes in aerobic granular reactors for treating biogas slurry under different hydraulic retention times (10.7 h, Rl;8 h, R2) was investigated in this study. The results indicated that the hydraulic retention time could affect the effluent concentrations and removal efficiencies of sulfonamides. The average removal rates of tetracyclines, fluoroquinolones, and sulfonamides were 63%, 46%, and 90% in Rl, and 62%, 46%, and 86% in R2, respectively. Although the removal efficiencies of tetracyclines and fluoroquinolones were similar in both reactors, the respective accumulated concentrations of tetracyclines and fluoroquinolones in R1 were 7.00 and 11.15μg/g SS, which were lower than those in R2 (8.92 and 13.37μg/g SS, respectively). The difference in the relative abundance of target antibiotic resistance genes between both reactors was not significant, yet the average relative abundances of all target resistance genes in R1 were higher than those in R2 after 45 days of operation. The results of this study suggested that a longer hydraulic retention time could enhance the antibiotic removal ability of aerobic granular sludge, yet it may also increase the risk of surplus sludge utilization from a resistance genes point of view.

关键词： Aerobic granules Swine wastewater Tetracyclines Fluoroquinolones Sulfonamides

Effects of Inoculation with Phosphate Solubilizing Bacteria on the Physiology,Biochemistry,and Expression of Genes Related to the Protective Enzyme System of Fritillaria taipaiensis ***

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Phyton-International Journal of Experimental Botany 2024年第2期93卷 247-260页

作者： Zhifen Shi Fumei Pan Xiaotian Kong jiaqi Lang Mingyan ye Qian Wu Guangzhi Wang Liang Han Nong Zhou College of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611130China College of Pharmacy Dali UniversityDali671000China College of Food and Biological Engineering Chongqing Three Gorges UniversityChongqing404120China Diqing Tibetan Autonomous Prefecture Institute of Plateau Biology Diqing674400China Chongqing Institute of Medicinal Plant Cultivation Chongqing408435China

Fritillaria taipaiensis *** is a widely used medicinal herb in treating pulmonary *** recent years,its wild resources have become scarce,and the demand for efficient artificial cultivation has significantly *** article is the first to apply phosphate solubilizing bacteria isolated from the rhizosphere soil of *** *** to the cultivation process of *** *** aim is to identify suitable reference strains for the artificial cultivation and industrial development of *** *** by examining the effects of various phosphate solubilizing bacteria and their combinations on photosynthesis,physiological and biochemical properties,and gene expression related to the protective enzyme system in *** *** experiment,conducted in pots at room temperature,included a control group(CK)and groups inoculated with inorganic phosphorussolubilizing bacteria:W1(Bacillus cereus),W2(Serratia plymuthica),W12(Bacillus cereus and Serratia plymuthica),and groups inoculated with organophosphorus-solubilizing bacteria:Y1(Bacillus cereus),Y2(Bacillus cereus),Y12(Bacillus cereus and Bacillus cereus),totaling seven *** to CK,most growth indices in the bacterial addition groups showed significant differences,with W12 achieving the highest values in all indices except the leaf area *** content of photosynthetic pigments,photosynthetic parameters,and osmoregulatory substances increased variably in each bacterial treatment group.W12 exhibited the highest content of chlorophyll a and soluble protein,while W1 had the highest free proline *** activities of peroxidase(POD),superoxide dismutase(SOD),and catalase(CAT)in all inoculated groups were higher than in CK,with significant changes in SOD and CAT *** malondialdehyde(MDA)content in all inoculated groups was lower than in CK,with Y12 being the lowest,at approximately 30%of *** expression corresponding to these three enzymes also increased var

关键词： Fritillaria taipaiensis P.Y.Li phosphate solubiliozing bacteria photosynthesis physiology and biochemistry protective enzymes

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探讨心肌桥与冠心病的相关性

临床心血管病杂志 2020年第11期36卷 1057-1060页

作者：叶佳琦鲁翔南京医科大学第二附属医院老年医学科南京210009

心肌桥是一种先天性的冠状动脉(冠脉)异常,表现为部分冠脉走行在心肌内。大多数患者无临床表现,是一种良性病变。部分患者有心肌缺血、左室功能障碍、房室传导阻滞、猝死等冠心病的症状。本文对心肌桥与冠心病的关系作一综述。

关键词：心肌桥冠心病动脉粥样硬化冠状动脉痉挛内皮功能障碍

Investigations of Water Flow Behaviors Induced by Local Temperature Variations through a Single Rough Fracture for the Enhanced Geothermal Systems

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Journal of Thermal Science 2024年第3期33卷 1055-1064页

作者： LI Jiawei ye Lin Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China School of Power and Energy Northwestern Polytechnical UniversityXi’an710072China

In recent years,Enhanced Geothermal System(EGS)technologies have been applied to the geothermal resources production in the Hot Dry Rock(HDR).The core of EGS technologies is to adopt hydraulic fracturing in the reservoir to create a connected network of discrete fractures with the consideration of water as a working fluid for hydraulic fracturing and heat *** paper investigates the characteristics of water flow behaviors through a single rough fracture under different temperature and pressure conditions.A single fracture model with rough fracture surfaces is constructed and then characterized,and influences of the anisotropic factor on the average tortuosity and frictional resistance coefficient of water flow through a single fracture with rough surfaces have been compared and *** consideration of other impacting factors(temperature,pressure,fracture roughness),the impact of mass flow rate has also been *** simulation results present that changes of average tortuosity for water flow through a single rough facture are mainly affected by *** can be observed that higher temperature leads to larger average tortuosity but the frictional resistance coefficient shows an opposite *** for pressure conditions,it is found that effects of pressure on average tortuosity and frictional resistance coefficient is very small,which can be neglected under high pressure ***,the average tortuosity shows a progressively linear relationship with the mass flow *** the contrary,the frictional resistance coefficient has a negative relationship with the mass flow *** is revealed that when the mass flow rate reaches a critical point,the influences of temperature on the frictional resistance coefficient will be *** of single rough fractures with different anisotropic factors show that values of average tortuosity and frictional resistance coefficient have positive relationships with the increase

关键词： single rough fracture tortuosity frictional resistance enhanced geothermal system