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Wideband diffusion metabsorber for perfect scattering field reduction

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Photonics Research 2022年第6期10卷 1361-1366页

作者： ZICHENG SONG PINGPING MIN jiaqi ZHU lei YANG FENG HAN LIN Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150080China School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Research Center of Analysis and Measurement Harbin Institute of TechnologyHarbin 150080China

Both absorption and diffuse reflection can effectively suppress microwave backward ***,the challenge of designing wideband absorptive elements with anti-phase reflection hinders the simultaneous working of the two *** aid of the wideband characteristic of bilateral complementary structure,we propose a strategy to design wideband absorptive elements with large reflection phase *** proof of concept,the proposed elements are arranged in a rectangular grid by optimizing scattering field *** proposed diffusion metabsorber achieves over 20-dB scattering field reduction in the range of 8.5–20.3 GHz with good polarization stability and high angular insensitivity of up to±40°,which has been verified by real ***,the proposed design strategy exhibits the potential to further reduce electromagnetic wave reflection,and the optical transparent characteristic is promising for window applications.

关键词： scattering diffusion perfect

Phylogeny of Seven Genomes of Monkeypox Virus—Anhui Province,China,2023

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China CDC weekly 2024年第46期6卷 1218-1222页

作者： Wanhang Lu Qingqing Chen Xiaomin Wu jiaqi Li Ming Li Yongkang Xiao lei Gong Yong Sun Anhui Provincial Center for Disease Control and Prevention Hefei CityAnhui ProvinceChina

What is already known about this topic?Monkeypox,first identified in Africa in 1958,is a zoonotic disease caused by monkeypox virus(MPXV).Since January 2022,a global outbreak of mpox has spread to over 100 non-endemic *** of June 30,2024,there have been 99,176 confirmed cases and 535 probable cases across 116 countries,resulting in 208 *** is added by this report?This report presents an analysis of the whole genome sequences of seven MPXVs from Anhui *** discovered that,compared to the reference sequence(NC_063383.1),these genomes exhibit 91 nucleotide substitutions and 42 amino acid *** are highly similar to genomes of MPXVs that emerged simultaneously in China,Japan,the Republic of Korea,and Portugal,and are classified within the IIb C.1.1 lineage,with multiple transmission chains and no new *** are the implications for public health practice?The MPXV in Anhui Province has undergone mutations in areas critical for viral replication,transcription,and immune escape,posing a risk of recurrent ***,vigilant mutation monitoring of MPXV is imperative.

关键词： Anhui branch chains

大鼠脂肪间充质干细胞及其外泌体的蛋白组学对比分析

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中国组织工程研究 2025年第13期29卷 2683-2689页

作者：张鑫瑞韩悦雷蕾刘建宇耿承奎云南中医药大学第二临床医学院云南中医药大学呈贡校区云南省昆明市650000 昆明医科大学附属延安医院骨科云南省昆明市650000

背景:从蛋白组学方面分析脂肪间充质干细胞及其来源外泌体促进组织修复的研究较多,但缺少二者之间的蛋白组学对比分析。目的:对脂肪间充质干细胞及其外泌体进行蛋白组学分析。方法:分离培养大鼠脂肪间充质干细胞,从细胞上清液中提取外... 详细信息

背景:从蛋白组学方面分析脂肪间充质干细胞及其来源外泌体促进组织修复的研究较多,但缺少二者之间的蛋白组学对比分析。目的:对脂肪间充质干细胞及其外泌体进行蛋白组学分析。方法:分离培养大鼠脂肪间充质干细胞,从细胞上清液中提取外泌体并进行鉴定;运用DIA蛋白组学分析大鼠脂肪间充质干细胞及其外泌体差异表达蛋白,对差异表达蛋白进行GO和KEGG分析。结果与结论:①脂肪间充质干细胞以长梭形为主,类似成纤维样;②经BCA法测定外泌体悬液的蛋白质量浓度为7.66 mg/mL;③外泌体呈典型的茶杯型,可见双层膜的囊泡结构,中央为低电子密度成分,外泌体粒径分布峰值为112.2 nm,浓度为7.5×10^(11)粒子/mL,平均直径在70-140 nm之间;④外泌体有表面标记蛋白CD9、TSG101高表达;⑤GO分析脂肪间充质干细胞及其外泌体的差异表达蛋白主要集中在细胞外基质和突触等位置,与离子结合和核糖体的结合能力相关,在细胞黏附和翻译过程中最为显著;⑥KEGG通路分析结果显示,差异表达蛋白主要参与细胞外基质受体交互、核糖体和细胞因子受体相互作用等,并且与胆固醇和甲状腺等多种代谢性疾病有关。

关键词：脂肪间充质干细胞外泌体蛋白组学对比分析组织修复

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黄土边坡微生物矿化加固及植被恢复试验

水土保持研究 2025年第1期32卷 227-234+242页

作者：雷磊王良樊成虎刘子瑞宋洋薛倩楠田堪良段金贵国网陕西省电力有限公司电力科学研究院国网(西安)环保技术中心有限公司国网陕西省电力有限公司国网陕西省电力有限公司安康水力发电公司国网陕西省电力有限公司西安供电公司西北农林科技大学水土保持研究所中国科学院水利部水土保持研究所黄河水利委员会西峰水土保持科学试验站

[目的]研究黄土边坡微生物矿化加固及植被恢复，为黄土边坡的加固及坡面土壤侵蚀防治提供新方法和新技术。[方法]采用微生物诱导碳酸钙沉淀(Microbially Induced Calcite Precipitation, MICP)技术对黄土边坡进行矿化加固处理，并在固... 详细信息

[目的]研究黄土边坡微生物矿化加固及植被恢复，为黄土边坡的加固及坡面土壤侵蚀防治提供新方法和新技术。[方法]采用微生物诱导碳酸钙沉淀(Microbially Induced Calcite Precipitation, MICP)技术对黄土边坡进行矿化加固处理，并在固化黄土边坡上进行植被恢复，利用扫描电子显微镜(SEM)和光学显微镜，从微观角度探究MICP技术对黄土边坡矿化加固的作用机制，并统计分析了固化黄土边坡的植被恢复效果。[结果]采用MICP技术对黄土边坡进行固化处理后，在坡面上生成的固化层将松散且相邻的土壤颗粒胶结在一起，使黄土坡面形成一个整体，固化层最大厚度为0.23 cm,平均厚度为0.21 cm;固化黄土边坡恢复植被后第60天，A1,A2,B1,B2,A1B1,A2B2各区域内植被成活率比A0,B0,A0B0各区域分别显著提高26.66%,20%,37.5%,25%,33.33%,25%(p<0.05),第60天后，各区域内植被的成活率均差异显著，而且固化后加保水剂的A1,B1,A1B1各区域内植被的成活率最高；固化后加保水剂的B1和A1B1区域内紫穗槐高度和地径的生长变化量最大，且固化后加保水剂的A1,B1,A1B1各区域内麦冬草和紫穗槐的生长状况最好。[结论]采用MIC技术可以有效固化黄土坡面，与植被恢复技术相结合，既能防治土壤侵蚀，又能恢复生态环境。这种综合防治措施为黄土边坡水土流失防治与生态修复提供了良好的技术支持。

关键词：黄土边坡微生物矿化加固技术植被恢复边坡防护

Structural diversification of bioactive bibenzyls through modular co-culture leading to the discovery of a novel neuroprotective agent

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Acta Pharmaceutica Sinica B 2023年第4期13卷 1771-1785页

作者： Yuyu Liu Xinnan Li Songyang Sui Jingshu Tang Dawei Chen Yuying Kang Kebo Xie Jimei Liu jiaqi Lan lei Wu Ridao Chen Ying Peng Jungui Dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugsand NHC Key Laboratory of Biosynthesis of Natural ProductsInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological ***,due to the low abundance in nature,uncontrollable and environmentally unfriendly chemical synthesis processes,these compounds are not readily ***,one high-yield bibenzyl backbone-producing Escherichia coli strain was constructed by using a highly active and substrate-promiscuous bibenzyl synthase identified from Dendrobium officinale in combination with starter and extender biosynthetic *** types of efficiently postmodifying modular strains were engineered by employing methyltransferases,prenyltransferase,and glycosyltransferase with high activity and substrate tolerance together with their corresponding donor biosynthetic *** different bibenzyl derivatives were tandemly and/or divergently synthesized by co-culture engineering in various combination ***,a prenylated bibenzyl derivative(12)was found to be an antioxidant that exhibited potent neuroprotective activity in the cellular and rat models of ischemia ***-seq,quantitative RT-PCR,and Western-blot analysis demonstrated that 12 could up-regulate the expression level of an apoptosis-inducing factor,mitochondria associated 3(Aifm3),suggesting that Aifm3 might be a new target in ischemic stroke *** study provides a flexible plug-and-play strategy for the easy-to-implement synthesis of structurally diverse bibenzyls through a modular co-culture engineering pipeline for drug discovery.

关键词： Bibenzyls Modular co-culture engineering Promiscuous enzymes Neuroprotective agent Aifm3 Dendrobium officinale

Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis

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Acta Pharmaceutica Sinica B 2023年第2期13卷 577-597页

作者： Yujun Zhou Jingshu Tang jiaqi Lan Yong Zhang Hongyue Wang Qiuyu Chen Yuying Kang Yang Sun Xinhong Feng lei Wu Hongtao Jin Shizhong Chen Ying Peng State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Department of Neurology Beijing Tsinghua Changgung HospitalSchool of Clinical MedicineTsinghua UniversityBeijing 102218China New Drug Safety Evaluation Center Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China NMPA Key Laboratory for Safety Research and Evaluation of Innovative Drug Beijing 100050China

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease affecting both upper and lower motor neurons(MNs)with large unmet medical *** pathological mechanisms are considered to contribute to the progression of ALS,including neuronal oxidative stress and mitochondrial ***(HNK)has been reported to exert therapeutic effects in several neurologic disease models including ischemia stroke,Alzheimer’s disease and Parkinson’s *** we found that honokiol also exhibited protective effects in ALS disease models both in vitro and in *** improved the viability of NSC-34 motor neuron-like cells that expressed the mutant G93A SOD1 proteins(SOD1-G93A cells for short).Mechanistical studies revealed that honokiol alleviated cellular oxidative stress by enhancing glutathione(GSH)synthesis and activating the nuclear factor erythroid 2-related factor 2(NRF2)-antioxidant response element(ARE)***,honokiol improved both mitochondrial function and morphology via fine-tuning mitochondrial dynamics in SOD1-G93A ***,honokiol extended the lifespan of the SOD1-G93A transgenic mice and improved the motor *** improvement of antioxidant capacity and mitochondrial function was further confirmed in the spinal cord and gastrocnemius muscle in ***,honokiol showed promising preclinical potential as a multiple target drug for ALS treatment.

关键词： Amyotrophic lateral sclerosis Glutathione Honokiol Mitochondrial biogenesis Mitochondrial dynamics NRF2 Oxidative stress SOD1-G93A

Human activity during the late Pleistocene in the Lop Nur region, northwest China： Evidence from a buried stone artifact

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Science China Earth Sciences 2018年第11期61卷 1659-1668页

作者： Kangkang LI Xiaoguang QIN Xiaoyan YANG Bing XU lei ZHANG Guijin MU Dong WEI Chunxue WANG Yong WU Xiaohong TIAN Yongchong LIN Wen LI jiaqi LIU Yinxin JIAO Key Laboratory of Cenozoic Geology and Environment Institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 China Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China School of Archaeology Jilin University Changchun 130012 China Xinjiang Institute of Archaeology Urumqi 830011 China Bureau of Cultural Heritage of Ruoqiang County Ruoqiang 841800 China

The Lop Nur region, in the east part of Tarim Basin, was an important transportation junction between west and east,north and south Eurasia. However, previous studies on prehistoric human activity have concentrated mostly on the Bronze Age,whereas that during the Stone Age remains largely unresearched. Here, we present a new direct evidence of human activity in the late Pleistocene, recorded on a grinding stone buried in a lacustrine sediment section of the Lop Nur region. The grain size distribution of the sediment section indicates that the site was probably in the center of a lake with weak hydrodynamic environment. Therefore, the stone artifact can only be carried to here by people instead of river and it was never move as soon as left here. Results of radiocarbon dating, the evident stratigraphic relations between the stone artifact and the sedimentary formation, indicate that the human activity could extend to approximately 13 ka BP. Furthermore, the results of starch-grain and use-wear analyses suggest that ancient humans gathered seeds of Triticeae, roots, and tubers and used the grinding stone to simply process selected plant as plant foodstuffs during this period. It implies that the environmental conditions in the river delta of the Lop Nur were inhabitable during the late Pleistocene.

关键词： Lop Nur Late Pleistocene Stone artefact Human activity Paleo-enviroument

骨关节炎软骨细胞中hsa-miR-3202的生物信息分析与功能验证

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中国组织工程研究 2025年第12期29卷 2458-2465页

作者：张佳琪刘艳虹梁慧婷周晶晶王雅雯许憬瑜李煜爽雷立健胡晓琴山西医科大学公共卫生学院流行病学教研室山西省太原市030001

背景:软骨细胞增殖与凋亡的失衡在骨关节炎发生发展中起着重要作用,已有研究发现hsa-miR-3202参与调节多种细胞的增殖和凋亡过程,然而尚未有研究探讨hsa-miR-3202与骨关节炎的相关性。目的:探讨hsa-miR-3202在骨关节炎软骨细胞中的表达... 详细信息

背景:软骨细胞增殖与凋亡的失衡在骨关节炎发生发展中起着重要作用,已有研究发现hsa-miR-3202参与调节多种细胞的增殖和凋亡过程,然而尚未有研究探讨hsa-miR-3202与骨关节炎的相关性。目的:探讨hsa-miR-3202在骨关节炎软骨细胞中的表达及其对软骨细胞增殖与凋亡能力的影响。方法:①通过生物信息分析筛选骨关节炎软骨细胞中差异表达的microRNA,基于国内外研究现状,选择hsa-miR-3202进行后续研究,采用GO功能富集和KEGG通路富集对其进行靶基因预测。②选择对数生长期的人正常软骨细胞系C28/I2,随机分4组培养:正常组加入普通培养基培养24 h,更换普通培养基培养6 h,更换普通培养基继续培养;脂多糖组加入含脂多糖的培养基培养24 h,更换普通培养基培养6 h,更换普通培养基继续培养;脂多糖+NC组加入含脂多糖的培养基培养24 h,加入has-miR-3202 mimics对照转染6 h,更换普通培养基继续培养;脂多糖+hsa-miR-3202 mimics组加入含脂多糖的培养基培养24 h,加入has-miR-3202 mimics转染6 h,更换普通培养基继续培养。继续培养48 h后,采用RT-qPCR检测细胞hsa-miR-3202表达,流式细胞术检测细胞凋亡;继续培养0-72 h,采用CCK-8检测细胞增殖活力。结果与结论:①生物信息分析结果显示,hsa-miR-3202表达在骨关节炎软骨细胞中显著下调;GO功能富集与KEGG通路富集结果显示,hsa-miR-3202靶基因功能与细胞生长、凋亡密切相关。②体外细胞实验结果显示,与正常组比较,脂多糖组软骨细胞hsa-miR-3202表达与细胞增殖能力下降(P<0.05),细胞凋亡率增加(P<0.05);与脂多糖组比较,脂多糖+hsa-miR-3202 mimics组软骨细胞hsa-miR-3202表达与细胞增殖能力升高(P<0.05),细胞凋亡率减少(P<0.05)。③结果表明,hsa-miR-3202在骨关节炎软骨细胞中表达下调,其表达下调可抑制细胞增殖并促进细胞凋亡,进而影响骨关节炎疾病的发生和发展。

关键词： has-miR-3202 骨关节炎生物信息学软骨细胞炎症细胞增殖细胞凋亡老年人

Overview of the development history of China’s typhoon research and operational work in the past century

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Science China Earth Sciences 2020年第3期63卷 362-383页

作者： Xiaotu lei Shanghai Typhoon Institute of China Meteorological Administration Shanghai Meteorological Bureau

Because typhoons are one of the most major natural disasters in the southeastern coastal areas of China,great attention has been paid to the prevention and mitigation of the disasters caused by *** the past century,significant progress has been made in typhoon-related scientific research and operational work in China,including the construction of a network of typhoon monitoring stations,the establishment of forecasting operation systems,early warning and prevention of typhoon-related disasters,and the research of basic theories of typhoon behaviors and key forecasting *** paper briefly reviews the milestones in the development history of typhoon research in China over the past century and a half in order to commemorate the predecessors,especially those who made historical contributions to the advancement of typhoon research since the economic and cultural reforms known as the"Opening of China",who provided historical references which enabled China to become an international leader in the field of typhoon science and technology.

关键词： Typhoon Scientific research and operations Development history Review