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Research progress in the treatment of diabetic kidney disease with Chinese medicine enema

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 205-215页

作者： Rui Wu jiaqi chen Zimengwei Ye Zhufeng Wang Guang'anmen Hospital China Academy of Chinese Medical SciencesBeijing102618China Chinese Medicine School Beijing University of Chinese MedicineBeijing102488China

Chinese medicine enema is an effective guiding method to treat diabetic kidney disease,a common chronic complication of diabetes,by regulating the function of the intestines to increase clearing and lower *** reviewed the treatment of diabetic kidney disease(DKD)with traditional Chinese medicine enemas and found that commonly used traditional Chinese medicines included Rhei Radix Et Rhizoma(Rheum palmatum L.),Ostrea concha(Ostrea gigas Thunberg),Taraxaci Herba(Taraxacum mongolicum Hand.-Mazz.),Astmgali Radix(Astragalus membranaceus ***(Bge.)Hsiao),Salviae Miltiorrhizae Radix Et Rhizoma(Salvia miltiorrhiza Bge.),and Aconiti Lateralis Radix Praeparata(Aconitum carmichaelii Debx).The mechanism of the adjuvant therapeutic effect on DKD may relate to regulating intestinal flora,inhibiting inflammation and oxidative stress and protecting against kidney injury.

关键词： Chinese medicine Enema Diabetic kidney disease

以人为本理念下基础化学实验室安全建设模式探究——以分析化学实验室为例

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大学化学 2024年第7期39卷 264-271页

作者：陈佳琪陈树伟任所财孙玥栾春晖吴旭太原理工大学化学学院太原030024 太原理工大学国有资产管理处太原030024

实验室安全建设是实验室高效有序运行的保障。大学生作为基础教学实验室运行的主力,他们的安全素养直接影响着实验室的安全状况。在实验教学过程中构建注重安全素养培养的“实验室管理人员、教师、学生——全员、全时三位一体实验教学... 详细信息

实验室安全建设是实验室高效有序运行的保障。大学生作为基础教学实验室运行的主力,他们的安全素养直接影响着实验室的安全状况。在实验教学过程中构建注重安全素养培养的“实验室管理人员、教师、学生——全员、全时三位一体实验教学模式”,并在分析化学实验教学中进行了具体实践。新的实验教学模式加强了实验室管理员、教师与学生之间的沟通,通过COOP与7S实验教学方案,使学生在学习的同时沉浸式参与实验环境维护及建设、根植安全理念。利用Partial Eta Squared(η2)检验和多元Logistic回归模型分析发现,实验过程操作规范性和操作区有序度对学生安全素养影响明显。实践证明,该模式有助于培养学生良好的实验习惯和安全素养,增加学生在实验室中的责任感和获得感,实现管教增质、教学相长、安全铸魂的教学目标,使实验室人员可以把安全时刻掌握在自己手中,实验室安全运行水平有效提升。

关键词：实验室安全以人为本安全素养分析化学实验

Tetrathiafulvalene esters with high redox potentials and improved solubilities for non-aqueous redox flow battery applications

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Green Energy & Environment 2024年第5期9卷 899-908页

作者： Weikang Hu jiaqi Xu Nanjie chen Zongcai Deng Yuekun Lai Dongyang chen College of Materials Science and Engineering Fuzhou UniversityFuzhou350116China College of Chemical Engineering Fuzhou UniversityFuzhou350116China

The exploitation of high performance redox-active substances is critically important for the development of non-aqueous redoxﬂow ***,three tetrathiofulvalene(TTF)derivatives with different substitution groups,namely TTF diethyl ester(TTFDE),TTF tetramethyl ester(TTFTM),and TTF tetraethyl ester(TTFTE),are prepared and their energy storage properties are *** has been found that the redox potential and solubility of these TTF derivatives in conventional carbonate electrolytes increases with the number of ester *** battery with a catholyte of 0.2 mol L^(-1) of TTFTE delivers a speciﬁc capacity of more than 10 Ah L^(-1) at the current density of 0.5 C with two discharge voltage platforms locating at as high as 3.85 and 3.60 V ***/Liþ.Its capacity retention can be improved from 2.34 Ah L^(-1) to 3.60 Ah L^(-1) after 100 cycles by the use of an anion exchange membrane to block the crossover of TTF *** excellent cycling stability of the TIF esters is supported by their well-delocalized electrons,as revealed by the density function theory ***,the introduction of more and larger electron-withdrawing groups is a promising strategy to simultaneously increase the redox-potential and solubility of redox-active ma-terials for non-aqueous redoxﬂow batteries.

关键词： Non-aqueous redox flow batteries Tetrathiofulvarene Redox potential Solubility Substituent effect

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东海岛重化工厂周围土壤重金属生态风险评价

高师理科学刊 2024年第1期44卷 78-84,104页

作者：陈梓欣陈碧珊杨福宁李烨俊纪婉薇陈家琪岭南师范学院地理科学学院广东湛江524048

为了解东海岛重化工厂对周围土壤环境的影响,在工厂周围共采集26个土壤样品,采用地累积指数法和潜在生态风险指数法对样品中8种重金属的质量浓度特征进行分析.结果表明,除Cr外,其余重金属As,Cd,Cu,Hg,Ni,Pb,Zn的最大质量浓度分别为15.6,... 详细信息

为了解东海岛重化工厂对周围土壤环境的影响,在工厂周围共采集26个土壤样品,采用地累积指数法和潜在生态风险指数法对样品中8种重金属的质量浓度特征进行分析.结果表明,除Cr外,其余重金属As,Cd,Cu,Hg,Ni,Pb,Zn的最大质量浓度分别为15.6,0.116,53.8,0.055,76.1,31.6,103mg·kg^(-1),均未达到国家规定的风险筛选值,表明东海岛重化工厂周围土壤主要受Cr污染.8种重金属平均地累积指数都小于0,为无污染.通过综合潜在风险指数分析得出,研究区为轻微至中等生态风险程度.东海岛工业发展虽然对周围土壤重金属的影响较小,但仍需进行长期监测.

关键词：东海岛重化工厂重金属污染生态风险评价

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小鼠小肠类器官炎症模型的构建

天津医药 2024年第1期52卷 16-21页

作者：陈浩李蕊易菲周丽陈嘉琪朱璠管城艳吴娜江西中医药大学药学院 330004 江西中医药大学附属医院药学部江西中医药大学计算机学院江西中医药大学临床医学院江西中医药大学附属医院消化一科

目的建立体外小肠类器官培养体系,探讨脂多糖(LPS)对小肠类器官生长和炎性因子分泌的影响。方法体外无菌分离并收集C57BL/6小鼠小肠隐窝细胞团,使用类器官基质胶进行包埋,并在完全培养基的支撑下,培养形成具有小肠上皮样结构的立体多叶... 详细信息

目的建立体外小肠类器官培养体系,探讨脂多糖(LPS)对小肠类器官生长和炎性因子分泌的影响。方法体外无菌分离并收集C57BL/6小鼠小肠隐窝细胞团,使用类器官基质胶进行包埋,并在完全培养基的支撑下,培养形成具有小肠上皮样结构的立体多叶结构的小肠类器官。小肠类器官培养5~7 d或类器官中央区域变黑时传代,传代后3 d将小肠类器官随机分为不同质量浓度LPS组(0、150、175、200、225、250、275、300 mg/L)。在LPS诱导24 h和48 h后观察小肠类器官生长和形态特征变化;用CCK-8法检测不同时间和质量浓度LPS对小肠类器官诱导炎症后增殖活力的影响;采用酶联免疫吸附试验检测4种不同质量浓度LPS(0、175、200、225 mg/L)在不同时间对类器官培养上清液中粒细胞-巨噬细胞集落刺激因子(GM-CSF)、白细胞介素(IL)-1α、IL-6、IL-10水平的影响。结果初步构建了小鼠小肠类器官培养体系。不同时间和质量浓度LPS作用小肠类器官诱导炎症后,通过形态学观察到小肠类器官会有不同程度的膨胀和内腔凋亡现象的发生,受损的肠上皮中隐窝或肠干细胞的增殖分化和出芽数量也受到不同程度的抑制。小肠类器官在175~225 mg/L的LPS诱导24 h和48 h后,其增殖活力呈现不同程度的降低(P<0.05),但细胞活力仍大于50%。200 mg/L和225 mg/L的LPS诱导24 h和48 h后,IL-1α、IL-6和GM-CSF水平部分升高(P<0.05);200 mg/L的LPS诱导24 h和48 h后,IL-10水平降低(P<0.05)。结论本研究初步构建了不同质量浓度和时间的LPS诱导小肠类器官体外肠道炎症损伤模型,为今后肠道疾病的机制研究和有效药物的筛选提供了更为可靠的研究平台。

关键词：小肠类器官脂多糖类生物因子隐窝

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Untangling the contributions of meteorological conditions and human mobility to tropospheric NO2 in Chinese mainland during the COVID-19 pandemic in early 2020

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National Science Review 2021年第11期8卷 121-132页

作者： Yuxiang Zhang Haixu Bo Zhe Jiang Yu Wang Yunfei Fu Bingwei Cao Xuewen Wang jiaqi chen Rui Li School of Earth and Space Sciences University of Science and Technology of China Comparative Planetary Excellence Innovation Center Frontiers Science Center for Planetary Exploration and Emerging Technologies Chinese Academy of Sciences State Key Laboratory of Fire Science University of Science and Technology of China Jiangxi Ecological Environment Monitoring Center Green Earth Science and Education Service

In early 2020,unprecedented lockdowns and travel bans were implemented in Chinese mainland to fight COVID-19,which led to a large reduction in anthropogenic *** provided a unique opportunity to isolate the effects from emission and meteorology on tropospheric nitrogen dioxide（NO;2;）.Comparing the atmospheric NO;2;in 2020 with that in 2017,we found the changes of emission have led to a49.3±23.5% reduction,which was～12% more than satellite-observed reduction of 37.8±16.3%.The discrepancy was mainly a result of changes of meteorology,which have contributed to an 8.1±14.2%increase of NO;2;.We also revealed that the emission-induced reduction of NO;2;has significantly negative correlations to human mobility,particularly that inside the *** intra-city migration index derived from Baidu Location-Based-Service can explain 40.4%±17.7% variance of the emission-induced reduction of NO;2;in 29 megacities,each of which has a population of over 8 million in Chinese mainland.

关键词： atmospheric nitrogen dioxide anthropogenic emissions meteorology conditions human mobility COVID-19 quarantine

传统村落风貌韧性评价体系研究——以潮州凤山楼村为例

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城市建筑 2024年第9期21卷 96-100页

作者：金文灿陈佳琪何韶颖郭健铭广东工业大学建筑与城市规划学院

城镇化快速推进下的传统村落发展面临着脆弱性和不确定性持续增强的局面,而韧性理论为其风貌可持续发展研究提供了新的视角。从韧性评估视角切入,利用层次分析法构建了潮州传统村落风貌韧性评价指标体系及其评价函数,通过对潮州市凤山... 详细信息

城镇化快速推进下的传统村落发展面临着脆弱性和不确定性持续增强的局面,而韧性理论为其风貌可持续发展研究提供了新的视角。从韧性评估视角切入,利用层次分析法构建了潮州传统村落风貌韧性评价指标体系及其评价函数,通过对潮州市凤山楼村的风貌韧性评价,研究村落风貌演变过程中的扰动因素及作用机制,并提出村落风貌保护传承与适应性演进的策略建议。研究成果可为村落风貌保护与发展工作提供技术支持,更可为地方政府相关工作提供科学的决策依据,对实现村落文化振兴具有重要的社会价值。

关键词：传统村落风貌韧性评价指标体系

Treatability of volatile chlorinated hydrocarbon-contaminated soils of different textures along a vertical profile by mechanical soil aeration：A laboratory test

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Journal of Environmental Sciences 2017年第4期29卷 328-335页

作者： Yan Ma Yi Shi Deyi Hou Xi Zhang jiaqi chen Zhifen Wang Zhu Xu Fasheng Li Xiaoming Du School of Chemical and Environmental Engineering China University of Mining &Technology Beijing 100083 China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences Beijing 100012 China School of Environment Tsinghua University Beijing 100084 China BGI Engineering Consultants Ltd. Beijing 100038 China School of Environment and Energy Peking University Shenzhen 518055 China

Mechanical soil aeration is a simple, effective, and low-cost soil remediation technology that is suitable for sites contaminated with volatile chlorinated hydrocarbons（VCHs）. Conventionally, this technique is used to treat the mixed soil of a site without considering the diversity and treatability of different soils within the site. A laboratory test was conducted to evaluate the effectiveness of mechanical soil aeration for remediating soils of different textures（silty,clayey, and sandy soils） along a vertical profile at an abandoned chloro-alkali chemical site in China. The collected soils were artificially contaminated with chloroform（TCM） and trichloroethylene（TCE）. Mechanical soil aeration was effective for remediating VCHs（removal efficiency 〉 98%）. The volatilization process was described by an exponential kinetic *** the early stage of treatment（0–7 hr）, rapid contaminant volatilization followed a pseudofirst order kinetic model. VCH concentrations decreased to low levels and showed a tailing phenomenon with very slow contaminant release after 8 hr. Compared with silty and sandy soils, clayey soil has high organic-matter content, a large specific surface area, a high clay fraction, and a complex pore structure. These characteristics substantially influenced the removal process, making it less efficient, more time consuming, and consequently more expensive. Our findings provide a potential basis for optimizing soil remediation strategy in a cost-effective manner.

关键词： Contaminated site Texture of soil profile Particle-size fraction Volatile chlorinated hydrocarbons(VCHs) Mechanical soil aeration Treatability test

Single-atom Co alloyed Ru for electrocatalytic nitrite reduction to ammonia

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Nano Research 2024年第5期17卷 3660-3666页

作者： Fuzhou Wang jiaqi Xiang Guike Zhang Kai chen Ke Chu School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

Electrochemical converting NO_(2)^(-)into NH_(3)(NO_(2)RR)holds an enormous prospect to attain efficient NH_(3) electrosynthesis and polluted NO_(2)^(-)***,we report single-atom Co alloyed Ru(Co_(1)Ru)as an efficient and durable NO_(2)RR *** experimental and theoretical investigations reveal that single-atom Co alloying of Ru enables the construction of Co_(1)-Ru heteronuclear active sites to synergistically promote NO_(2)^(-)activation/hydrogenation while suppressing the competitive H_(2) evolution,rendering the greatly enhanced activity and selectivity of Co_(1)Ru towards the NO_(2)***,Co_(1)Ru assembled within a flow cell exhibits an impressive NH_(3) yield rate of 2379.2μmol·h^(-1)·cm^(-2) with an NH_(3)-Faradaic efficiency of 92%at a high current density of 415.9 mA·cm^(-2),which is among the highest NO_(2)RR performances reported to date.

关键词： electrochemical converting NO_(2)-into NH3 single-atom alloys theoretical computations industrial-level current density