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Long-Term Performance and Microstructural Characterization of Dam Concrete in the Three Gorges Project

Engineering 2024年第2期33卷 237-262页

作者： Chen Lyu Cheng Yu Chao Lu li Pan Wenwei li jiaping liu School of Materials Science and Engineering Southeast UniversityNanjing 211189China State Key Laboratory of High Performance Civil Engineering Materials Sobute New Materials Co.Ltd.Nanjing 211103China China Three Gorges Corporation Wuhan 430010China

This study investigates the long-term performance of laboratory dam concrete in different curing environments over ten years and the microstructure of 17-year-old laboratory concrete and actual concrete cores drilled from the Three Gorges Dam.The mechanical properties of the laboratory dam concrete,whether cured in natural or standard environments,continued to improve over time.Furthermore,the laboratory dam concrete exhibited good resistance to diffusion and a refined microstructure after 17 years.However,curing and long-term exposure to the local natural environment reduced the frost resistance.Microstructural analyses of the laboratory concrete samples demonstrated that moderate-heat cement and fine fly ash(FA)particles were almost fully hydrated to form compact micro structures consisting of large quantities of homogeneous calcium(alumino)silicate hydrate(C-(A)-S-H)gels and a few crystals.No obvious interfacial transition zones were observed in the microstructure owing to the longterm pozzolanic reaction.This dense and homogenous microstructure was the crucial reason for the excellent long-term performance of the dam concrete.A high FA volume also played a significant role in the microstructural densification and performance growth of dam concrete at a later age.The concrete drilled from the dam surface exhibited a loose microstructure with higher microporosity,indicating that concrete directly exposed to the actual service environment suffered degradation caused by water and wind attacks.In this study,both macro-performance and microstructural analyses revealed that the application of moderate-heat cement and FA resulted in a dense and homogenous microstructure,which ensured the excellent long-term performance of concrete from the Three Gorges Dam after 17 years.Long-term exposure to an actual service environment may lead to microstructural degradation of the concrete surface.Therefore,the retained long-term dam concrete samples need to be further researched to better understand its microstructural evolution

关键词： Three Gorges Dam Long-term performance Microstructural analysis Moderate-heat cement Fly ash

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Magnetically responsive nanofibrous ceramic scaffolds for on-demand motion and drug delivery

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Bioactive Materials 2022年第9期7卷 372-381页

作者： Yonggang Zhang jiaping li Pamela Habibovic Department of Instructive Biomaterials Engineering Maastricht UniversityMERLN Institute for Technology-Inspired Regenerative MedicineUniversiteitssingel 406229 ERMaastrichtthe Netherlands Department of Complex Tissue Regeneration Maastricht UniversityMERLN Institute for Technology-Inspired Regenerative MedicineUniversiteitssingel 406229 ERMaastrichtthe Netherlands

Smart biomaterials,featuring not only bioactivity,but also dynamic responsiveness to external stimuli,are desired for biomedical applications,such as regenerative medicine,and hold great potential to expand the boundaries of the modern clinical practice.Herein,a magnetically responsive three-dimensional scaffold with sandwich structure is developed by using hydroxyapatite(HA)nanowires and ferrosoferric oxide(Fe_(3)O_(4))nanoparticles as building blocks.The magnetic HA/Fe_(3)O_(4) scaffold is fully inorganic in nature,but shows polymeric hydrogel-like characteristics including a 3D fibrous network that is highly porous(>99.7%free volume),deformable(50%deformation)and elastic,and tunable stiffness.The magnetic HA/Fe3O4 scaffold has been shown to execute multimodal motion upon exposure to an external magnetic field including shape transformation,rolling and somersault.In addition,we have demonstrated that the magnetic scaffold can serve as a smart carrier for remotely controlled,on-demand delivery of compounds including an organic dye and a protein.Finally,the magnetic scaffold has exhibited good biocompatibility,supporting the attachment and proliferation of human mesenchymal stromal cells,thereby showing great potential as smart biomaterials for a variety of biomedical applications.

关键词： Hydroxyapatite Magnetic Responsive Drug delivery Cell culture

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Influences of chemical reactions on polysulfide reduction reaction process on promotor surface in li-S batteries

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Nano Research 2024年第4期17卷 2712-2718页

作者： Yufeng Luo Zhenhan Fang Zixin Hong Shaorong Duan Haitao liu Hengcai Wu Qunqing li Yuegang Zhang Shoushan Fan Wenhui Duan jiaping Wang Tsinghua-Foxconn Nanotechnology Research Center Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Frontier Science Center for Quantum Information Tsinghua UniversityBeijing 100084China

Polar promotors have been proven effective in catalyzing the polysulfide(PS)reduction reaction(PSRR)process in lithium-sulfur(li-S)batteries.However,the promotor surface tends to be poisoned due to the accumulation of insoluble discharging products of lithium disulfide(li_(2)S_(2))and lithium sulfide(li_(2)S)during li-S battery operation.Herein,we investigate the detailed PSRR mechanism on the surface of manganese sulfides(MnS)as a representative promoter by performing in-situ Raman mapping measurements.The catalytic ability of MnS enables thorough electrochemical reduction of PSs to li_(2)S_(2) and li_(2)S on the MnS surface.The generated li_(2)S_(2) and li_(2)S then adsorb the dissolved PSs via chemical reactions among sulfur species during the subsequent PSRR process.This phenomenon mitigates promotor poisoning and continuously improves the reversible capacity.Consequently,the assembled li-S cell demonstrates excellent electrochemical performance after introducing a conductive interlayer containing a thin piece of carbon nanotube film and MnS promotors.

关键词： promotors polysulfides chemical reactions catalytic ability in-situ Raman measurements

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Tetrahedral DNA nanostructures synergize with MnO_(2) to enhance antitumor immunity via promoting STING activation and M1 polarization

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2494-2505页

作者： Siping liang Jiaying li Zhengyu Zou Miao Mao Siqi Ming Fan lin Ziyan Zhang Can Cao Jinyu Zhou Yuanqing Zhang jiaping li Minhao Wu Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Department of Laboratory Medicine Guangdong Second Provincial General HospitalGuangzhou 510317China Guangdong Key Laboratory of Chiral Molecule and Drug Discovery School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Interventional Oncology The First Afﬁliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Stimulator of interferon genes(STING) is a cytosolic DNA sensor which is regarded as a potential target for antitumor immunotherapy. However, clinical trials of STING agonists display limited anti-tumor effects and dose-dependent side-effects like inflammatory damage and cell toxicity. Here,we showed that tetrahedral DNA nanostructures(TDNs) actively enter macrophages to promote STING activation and M1 polarization in a size-dependent manner, and synergized with Mn^(2+) to enhance the expressions of IFN-β and iNOS, as well as the co-stimulatory molecules for antigen presentation. Moreover, to reduce the cytotoxicity of Mn^(2+),we constructed a TDN-MnO_(2) complex and found that it displayed a much higher efficacy than TDN plus Mn^(2+) to initiate macrophage activation and anti-tumor response both in vitro and in vivo. Together, our studies explored a novel immune activation effect of TDN in cancer therapy and its synergistic therapeutic outcomes with MnO_(2).These findings provide new therapeutic opportunities for cancer therapy.

关键词： Tetrahedral DNA nanostructure Manganese MnO_(2) STING M1 polarization Antigen presentation Anti-tumor immunity Cancer therapy

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面向高光谱异常检测的背景记忆模型

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遥感学报 2024年第3期28卷 717-729页

作者：谢卫莹钟佳平李云松西安电子科技大学综合业务网理论及关键技术国家重点实验室西安710071

高光谱图像具有丰富的连续光谱信息,覆盖从可见光到红外波长范围内数百个波段。此数据特性使得高光谱数据在图像处理中有挖掘光谱内在特征的独特优势,从而有利于充分利用空间和光谱信息,检测感兴趣区域中的目标。但是由于高光谱数据的... 详细信息

高光谱图像具有丰富的连续光谱信息,覆盖从可见光到红外波长范围内数百个波段。此数据特性使得高光谱数据在图像处理中有挖掘光谱内在特征的独特优势,从而有利于充分利用空间和光谱信息,检测感兴趣区域中的目标。但是由于高光谱数据的高维性、实际场景的复杂性以及有标签样本数量的有限性,高光谱异常检测仍面临背景和异常不易区分和检测精度低的问题。为了解决以上问题,本文提出一种面向高光谱异常检测的背景记忆模型。首先,通过无监督的基于密度估计的粗检方法,获得伪背景和伪异常向量。其次,设计基于异常突出正则项约束的背景记忆生成对抗网络模型,扩大伪背景和伪异常间的距离,并采用弱监督—伪标签的训练方式,使得网络具有较强的背景生成能力,同时弱化其对于异常的重构效果,减少对于背景和异常重构的泛化性,增强输出检测结果中背景和异常的差异和辨别度。此外,在特征域和图像域进行对抗学习,提高样本生成能力,更好地学习到输入样本的分布情况,提高网络对背景的生成能力。最后,使用非线性背景抑制方法减小虚警率,进一步提升检测精度。实验结果表明,本文方法相比其他检测算法在不同数据集上具有更好的检测效果。

关键词：遥感生成对抗网络高光谱异常检测弱监督学习无监督学习

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血清β_(2)-微球蛋白水平对尿毒症维持性血液透析动静脉内瘘失功的诊断价值

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郑州大学学报（医学版） 2024年第2期59卷 269-274页

作者：谢嘉平曾莉成都医学院第二附属医院·核工业四一六医院肾内科成都610051

目的:探讨血清β_(2)-微球蛋白(β_(2)-MG)水平对尿毒症维持性血液透析动静脉内瘘失功的诊断价值。方法:选取2019年1月至2022年4月我院采用动静脉内瘘为血管通路进行维持性血液透析治疗的患者202例,根据动静脉内瘘功能分为失功组(48例)... 详细信息

目的:探讨血清β_(2)-微球蛋白(β_(2)-MG)水平对尿毒症维持性血液透析动静脉内瘘失功的诊断价值。方法:选取2019年1月至2022年4月我院采用动静脉内瘘为血管通路进行维持性血液透析治疗的患者202例,根据动静脉内瘘功能分为失功组(48例)和对照组(154例)。采集患者上机前外周静脉血,采用Immulite 2000全自动化学发光免疫分析仪检测血清β_(2)-MG水平,同时检测其他实验室指标如血浆超敏-C反应蛋白(hs-CRP)、血浆D-二聚体(D-D)水平等。行肱动脉超声检查,观察血管壁钙化、血栓形成情况,计算肱动脉血流量、搏动指数和阻力指数。采用Logistic回归分析动静脉内瘘失功的影响因素。绘制ROC曲线,分析β_(2)-MG对动静脉内瘘失功的诊断价值。结果:失功组血hs-CRP、D-D和β_(2)-MG水平均高于对照组(P<0.05);失功组肱动脉血流量低于对照组,肱动脉搏动指数、阻力指数和血管壁钙化、血栓形成发生率高于对照组(P<0.05)。Logistic回归分析结果显示血清β_(2)-MG水平、肱动脉血流量和肱动脉阻力指数为动静脉内瘘失功的影响因素,OR(95%CI)分别为1.446(1.211~1.726)、0.994(0.991~0.996)、1.158(1.034~1.298)。血清β_(2)-MG水平诊断维持性血液透析动静脉内瘘失功的ROC曲线下面积(95%CI)为0.705(0.654~0.864),以15.81 mg/L为截断值时敏感度为0.75,特异度为0.63。结论:血清β_(2)-MG水平是维持性血液透析动静脉内瘘失功的重要影响因素,对判断动静脉内瘘失功具有一定参考价值。

关键词：尿毒症维持性血液透析 β_(2)-微球蛋白动静脉内瘘失功

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Analysis on Climatic Characteristics of High Temperature Weather in Longdong Region

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Meteorological and Environmental Research 2023年第4期14卷 12-16页

作者： Meiyu li jiaping li Jiaqi liU Zhengning County Meteorological Bureau of Gansu Province Zhengning 745300China

Using meteorological data from 8 national basic meteorological observation stations in Qingyang City of Longdong region from 1972 to 2021,the causes and change characteristics of high-temperature weather were analyzed,and targeted countermeasures and suggestions were proposed for residents' production,life,and energy security supply affected by high-temperature weather.The results showed that①affected by global warming,the annual average temperature,annual average maximum temperature,annual extreme maximum temperature,days of daily maximum temperature≥30℃,and days of daily maximum temperature≥35℃in Longdong region were all showing an upward trend;②due to the different terrain and soil properties of the underlying surface,the increase in high temperature weather varied in different regions.Due to the influence of desert and hilly terrain,the frequency and days of high temperature occurrence were relatively high in the central and northern parts of Qingyang City.Due to the climate regulation of the Ziwuling Mountains,the days of high temperature in the central and southern parts was significantly less than that in the central and northern parts;③if the warm high pressure ridge on the Qinghai-Tibet Plateau developed strongly in summer,the temperature of the closed warm center reached 0-4℃on the 500 hPa of high-altitude weather map.If the warm air mass developed eastward,it often led to sustained high temperature weather in Longdong region;④when the El Nino phenomenon occurred,the subtropical high in the western Pacific developed strongly in summer,with a center located northward,which was stable,with little movement.It was dry,sunny,hot,and rainless in Longdong region,and the high temperature weather was more significant than that in normal years.

关键词： High temperature weather Climate change Characteristics analysis

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Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1^(high)CD11b^(+)cells elimination in hepatocellular carcinoma

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Acta Pharmaceutica Sinica B 2023年第2期13卷 632-647页

作者： Jizhou Tan Ting liu Wenzhe Fan Jialiang Wei Bowen Zhu Yafang liu lingwei liu Xiaokai Zhang Songling Chen Haibiao lin Yuanqing Zhang jiaping li Department of Interventional Oncology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Stomatology the First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Laboratory Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangdong Provincial Hospital of TraditionalChinese MedicineGuangzhou 510120China Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510006China School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China

Cryoablation(CRA)and microwave ablation(MWA)are two main local treatments for hepatocellular carcinoma(HCC).However,which one is more curative and suitable for combining with immunotherapy is still controversial.Herein,CRA induced higher tumoral PD-L1 expression and more T cells infiltration,but less PD-L1^(high)CD11b^(+)myeloid cells infiltration than MWA in HCC.Furthermore,CRA had better curative effect than MWA for anti-PD-L1 combination therapy in mouse models.Mechanistically,anti-PD-L1 antibody facilitated infiltration of CD8^(+)T cells by enhancing the secretion of CXCL9 from cDC1 cells after CRA therapy.On the other hand,anti-PD-L1 antibody promoted the infiltration of NK cells to eliminate PD-L1^(high)CD11b^(+)myeloid cells by antibody-dependent cell-mediated cytotoxicity(ADCC)effect after CRA therapy.Both aspects relieved the immunosuppressive microenvironment after CRA therapy.Notably,the wild-type PD-L1 Avelumab(Bavencio),compared to the mutant PD-L1 atezolizumab(Tecentriq),was better at inducing the ADCC effect to target PD-L1^(high)CD11b^(+)myeloid cells.Collectively,our study uncovered the novel insights that CRA showed superior curative effect than MWA in combining with anti-PD-L1 antibody by strengthening CTL/NK cell immune responses,which provided a strong rationale for combining CRA and PD-L1 blockade in the clinical treatment for HCC.

关键词： Hepatocellular carcinoma Immunotherapy Cryoablation Microwave ablation CXCL9 NK cells Antibody-dependent cell-mediated cytotoxicity Immunosuppressive microenvironment

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超大直径盾构下穿施工引起既有地铁隧道变形分析及控制要点

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城市轨道交通研究 2024年第S1期27卷 79-83页

作者：周群邵华李家平上海地铁维护保障有限公司上海200235 上海地铁监护管理有限公司上海200070 上海岩土与地下空间综合测试工程技术研究中心上海200093

[目的]随着城市地下空间利用率不断提高,新建隧道穿越施工对既有隧道的扰动不可避免。上海市北横通道超大直径盾构近距离下穿上海轨道交通11号线工程项目情况较为复杂,需针对性分析对既有隧道变形的影响。[方法]基于上海轨道交通11号线... 详细信息

[目的]随着城市地下空间利用率不断提高,新建隧道穿越施工对既有隧道的扰动不可避免。上海市北横通道超大直径盾构近距离下穿上海轨道交通11号线工程项目情况较为复杂,需针对性分析对既有隧道变形的影响。[方法]基于上海轨道交通11号线上下行线隧道的实时监测数据,分析了北横通道超大直径盾构下穿隧道影响区域时,11号线上下行线隧道垂直位移情况;提出了下穿施工期间控制既有地铁隧道变形的技术要点。[结果及结论]盾构下穿施工对既有地铁隧道垂直位移影响主要发生在正投影区域,且垂直位移曲线呈现“火山口状”;在正常下穿施工阶段上方既有地铁隧道表现为上抬,而在管片拼装阶段则表现为下沉。应基于“少扰动、小扰动”的原则采取控制既有地铁隧道变形的技术措施。

关键词：地铁隧道超大直径盾构近距离下穿变形影响

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椰壳纤维加筋土遗址生态注浆材料的性能

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建筑材料学报 2024年第1期27卷 90-98页

作者：芦苇骆望李东波刘秦龙刘加平西安建筑科技大学西部绿色建筑国家重点实验室陕西西安710055 西安建筑科技大学理学院陕西西安710055 西安建筑科技大学建筑学院陕西西安710055

为提升土遗址注浆料的力学性能,以椰壳纤维掺和糯米浆、烧料礓石以及黄土改性注浆料为研究对象,研究了椰壳纤维长度和掺量(质量分数)对土遗址注浆料流动性、收缩性、抗压强度和抗折强度的影响.结果表明:椰壳纤维的掺量和长度越大,浆体... 详细信息

为提升土遗址注浆料的力学性能,以椰壳纤维掺和糯米浆、烧料礓石以及黄土改性注浆料为研究对象,研究了椰壳纤维长度和掺量(质量分数)对土遗址注浆料流动性、收缩性、抗压强度和抗折强度的影响.结果表明:椰壳纤维的掺量和长度越大,浆体的流动性越低,而椰壳纤维的长度与浆体的收缩率无明显相关性;椰壳纤维良好的桥接能力可以有效提高浆体固化后的抗压强度、抗折强度和延性;椰壳纤维的长度和掺量均存在最优值,建议最优配比为纤维长度6 mm、掺量0.5%~0.6%,此时浆体固化后的抗压强度、抗折强度分别提升49.09%和32.08%;过多、过长的椰壳纤维易发生弯折、团聚,导致浆体的流动性和强度大幅降低.

关键词：椰壳纤维土遗址生态注浆材料力学性能增强机理

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