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益气活血/逐瘀类口服中成药干预冠状动脉微血管病的Meta分析及GRADE证据评价

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中国实验方剂学杂志 2025年第5期31卷 157-166页

作者：陈佳萍尚菊菊刘红旭李享来晓磊周慧文首都医科大学附属北京中医医院

目的：系统评价益气活血/逐瘀类口服中成药治疗冠状动脉微血管病(CMD)的有效性与安全性。方法：通过计算机检索PubMed、Cochrane图书馆、中国知网、万方、维普等数据库自建库至2023年12月31日期间收录的关于益气活血/逐瘀类口服中成药干... 详细信息

目的：系统评价益气活血/逐瘀类口服中成药治疗冠状动脉微血管病(CMD)的有效性与安全性。方法：通过计算机检索PubMed、Cochrane图书馆、中国知网、万方、维普等数据库自建库至2023年12月31日期间收录的关于益气活血/逐瘀类口服中成药干预CMD的随机对照试验。主要结局包括冠状动脉微血管阻力指数(IMR)、冠状动脉血流储备(CFR)、校正TIMI血流帧数(cTFC)；次要结局指标为症状疗效、左室射血分数(LVEF)、超敏C反应蛋白(hs-CRP)、一氧化氮(NO)、不良安全事件。使用Cochrane偏倚风险评估工具2.0(RoB 2.0)、Stata 17.0对纳入的文献进行文献质量评价及Meta分析，基于GRADE评价证据质量。结果：共纳入36项研究3 029例患者。在常规西医治疗基础上，联用益气活血/逐瘀类口服中成药可降低CMD患者的IMR[均数差(MD)=-5.93,95%置信区间(95%CI)[-8.73,-3.14],n=382,P<0.01]、cTFC(MD=-9.35,95%CI[-13.94,-4.76],n=618,P<0.01)和hs-CRP[标准均数差(SMD)=-1.50,95%CI[-1.90,-1.11],n=1 483,P<0.01]，提高CFR(SMD=1.14,95%CI[0.08,2.19],n=304,P=0.03)、症状改善疗效[相对危险度(RR)=1.36,95%CI[1.21,1.53],n=756,P<0.01]、LVEF(MD=4.39,95%CI[2.31,6.47],n=533,P<0.01)和NO(SMD=3.16,95%CI[2.07,4.25],n=946,P<0.01)。安全性方面，联用益气活血/逐瘀类中成药能减少CMD患者不良安全事件的发生(RR=0.49,95%CI[0.29,0.82],n=591,P=0.01)。GRADE分级显示不良安全事件为中等质量证据，cTFC、症状疗效、LVEF、NO为低质量证据，IMR、CFR、hs-CRP为极低质量证据。结论：基于微循环功能指标，联用益气活血/逐瘀类口服中成药可能改善CMD患者的冠状动脉微血管功能，且安全性较好，上述结论仍有必要在高质量临床研究基础上进一步验证。

关键词：中成药冠状动脉微血管病冠状动脉微血管阻力指数校正的TIMI帧数 Meta分析

Target Search and Navigation in Heterogeneous Robot Systems with Deep Reinforcement Learning

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Machine Intelligence Research 2025年第1期22卷 79-90页

作者： Yun chen jiaping Xiao Department of Mechanical Engineering University of AlabamaTuscaloosa35487USA School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore639798Singapore

Collaborative heterogeneous robot systems can greatly enhance the efficiency of target search and navigation *** this paper,we design a heterogeneous robot system consisting of an unmanned aerial vehicle(UAV)and an unmanned ground vehicle(UGV)for search and rescue missions in unknown *** system is able to search for targets and navigate to them in a maze-like mine environment with the policies learned through deep reinforcement learning *** the training process,if two robots are trained simultaneously,the rewards related to their collaboration may not be properly ***,we introduce a multi-stage reinforcement learning framework and a curiosity module to encourage agents to explore unvisited *** in simulation environments show that our framework can train the heterogeneous robot system to achieve the search and navigation with unknown target locations while existing baselines may *** UGV achieves a success rate of 89.1%in the mission within the original environment,and maintains a 67.6%success rate in untrained complex environments.

关键词： Heterogeneous intelligent systems deep reinforcement learning multiagent systems robot learning target search

Adaptation of migratory Tibetan antelope to infrastructure development

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Ecosystem Health and Sustainability 2021年第1期7卷 81-86页

作者： Tong Wu Xinming Lian Hongqi Li Dong Wang jiaping chen Ziyan Miao Tongzuo Zhang Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXiningPR China University of Chinese Academy of Sciences BeijingPR China Qinghai Provincial Key Laboratory of Animal Ecological Genomics XiningPR China Environmental Engineering Assessment Center of Qinghai Province XiningPR China

Background:The Tibetan antelope(Pantholops hodgsonii)is a migratory ungulate species that inhabits the Qinghai-Tibet *** recent years,the population of Tibetan antelope has steadily increased owing to rigorous protection measures to safeguard the species from commercial ***,infrastructure development,competition with domestic livestock,and predation are the principal factors threatening the survival of Tibetan ***:Our study found that migratory Tibetan antelope can adapt to the development of infrastructure over time,decreasing the potential negative impacts of such ***:We,therefore,urge infrastructure development companies to incorporate wildlife corridors that enable free movement of wildlife populations,particularly for migratory species.

关键词： Pantholops hodgsonii migration infrastructure human disturbance wildlife corridors

Comparison of survival outcomes between transthoracic and transabdominal surgical approaches in patients with Siewert-Ⅱ/Ⅲesophagogastric junction adenocarcinoma:a single-institution retrospective cohort study

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Chinese Journal of Cancer Research 2016年第4期28卷 413-422页

作者： Weihan Zhang Xinzu chen Kai Liu Kun Yang Xiaolong chen Ying Zhao Yongfan Zhao jiaping chen Longqi chen Jiankun Hu Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041China Institute of Gastric Cancer State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Department of Discipline Construction West China HospitalSichuan UniversityChengdu 610041China Department of Thoracic Surgery West China HospitalSichuan UniversityChengdu 610041China

Objective： To compare the survival outcomes of transabdominal （TA） and transthoracic （TT） surgical approaches in patients with Siewert-II/III esophagogastric junction adenocarcinoma. Methods： This retrospective study was conducted in patients with Siewert-II/III esophagogastric junction adenocarcinoma who underwent either TT or TA operations in the West China Hospital between January 2006 and December 2009. Results： A total of 308 patients （109 in the TT and 199 in the TA groups） were included in this study with a follow-up rate of 87.3%. The median （P25, P75） number of harvested perigastric lymph nodes was 8 （5, 10） in the TT group and 23 （16, 34） in the TA group （P〈0.001）, and the number of positive perigastric lymph nodes was 2 （0, 5） in the TT group and 3 （1, 8） in the TA group （P〈0.004）. The 5-year overall survival （OS） rate was 36% in the TT group and 51% in the TA group （P=0.005）. Subgroup analysis by Siewert classification showed that 5-year OS rates for patients with Siewert II tumors were 38% and 48% in TT and TA groups, respectively （P=0.134）, whereas the 5-year OS rate for patients with Siewert III tumors was significantly lower in the TT group than that in the TA group （33% vs. 53%; P=0.010）. Multivariate analysis indicated that N2 and N3 stages, RI/R2 resection and a TT surgical approach were prognostic factors for poor OS. Conclusions： Improved perigastric lymph node dissection may be the main reason for better survival outcomes observed with a TA gastrectomy approach than with TT gastrectomy for Siewert III tumor patients.

关键词： Siewert classification adenocarcinoma of esophagogastric junction transthoracic transabdominal prognosis

Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population

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Chinese Journal of Cancer Research 2013年第5期25卷 565-571页

作者： jiaping chen Zhenzhen Qin Shandong Pan Jie Jiang Li Liu Jibin Liu Xiaojun chen Zhibin Hu Hongbing Shen State Key Laboratory of Reproductive Medicine Department of Epidemiology and BiostatisticsSchool of Public HealthNanjing Medical University Section of Clinical Epidemiology Jiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentCancer CenterNanjing Medical University Tumor Hospital of Nantong City

Objective：Recent evidence indicates that dysregulation of microRNA （miRNA） biogenesis is implicated in cancer development and *** on the important role of miRNA biogenesis genes in carcinogenesis,we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical ***：We identified three single nucleotide polymorphisms （SNPs） located in the 3＇-untranslated regions （3＇-UTR） of of miRNA biogenesis key genes （rs1057035 in DICER,rs3803012 in RAN and rs10773771 in HIWI） and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and 1,549 cancer-free controls in Chinese ***：Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk [rs3803012 in RAN AG/GG *** adjusted OR =1.104,95 ％ confidence interval （CI）：0.859-1.419; rs1057035 in DICER CT/CC *** adjusted OR =0.962,95％ CI：0.805-1.149;rs10773771 in HIWICT/CC *** adjusted OR =0.963,95％ CI：0.826-1.122].Conclusions：The findings did not suggest that genetic variants in the 3＇-UTR of RAN,DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population.

关键词： miRNA biogenesis gene genetic variant cervical cancer

U-shaped association between telomere length and esophageal squamous cell carcinoma risk： a case-control study in Chinese population

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Frontiers of Medicine 2015年第4期9卷 478-486页

作者： Jiangbo Du Wenjie Xue Yong Ji Xun Zhu Yayun Gu Meng Zhu cheng Wang Yong Gao Juncheng Dai Hongxia Ma Yue Jiang jiaping chen Zhibin Hu Guangfu Jin Hongbing Shen Department of Epidemiology and Biostatistics School of Public Health Nanjing Medical University Nanjing 211166 China Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing 211166 China Department of Cardiothoracic Surgery the Affiliated Wuxi People's Hospital of Nanjing Medical University Wuxi 214043 China Department of Medical Oncology the Affiliated Huai 'an First People 's Hospital of Nanjing Medical University Huai'an 223300 China

Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma （ESCC） was still uncertain. Several telomere length-related single nucleotide polymorphisms （TL- SNPs） in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study （1045 ESCC cases and 1433 controls） to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length （RTL）（median： 1.34） than controls （median： 1.50, P 〈 0.001）. More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk （P 〈 0.001）, with odds ratios （95% confidence interval） equal to 2.40 （1.84- 3.14）, 1.36 （1.03-1.79）, 1.01 （0.76-1.35）, and 1.37 （1.03-1.82） for individuals in the 1st （the shortest）, 2nd, 3rd, and 5th （the longest） quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.

关键词： esophageal squamous cell carcinoma telomere length genetic variants susceptibility genome-wide association study

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新马克思主义视角下中国新城空间演变研究

城市规划学刊 2013年第4期 18-26页

作者：陈嘉平中山大学地理科学与规划学院广州市城市规划勘测设计研究院

首先指出建国以后出现的一波接一波的新城/工业区建设热潮,之后将其置于新马克思主义的视角下理解,探讨中国新城/工业区在建国以来的在中国资本积累进程中所承担的角色。通过对建国以来资本积累循环与新城空间演变历程的梳理,指出新中... 详细信息

首先指出建国以后出现的一波接一波的新城/工业区建设热潮,之后将其置于新马克思主义的视角下理解,探讨中国新城/工业区在建国以来的在中国资本积累进程中所承担的角色。通过对建国以来资本积累循环与新城空间演变历程的梳理,指出新中国建立后存在一个资本积累循环不断调整的过程,这个过程受到国内外政治经济形势及国家相应作出的制度与政策调整的影响。资本积累循环的调整过程具体体现为国内资本类型的变化,主要积累回路的转换以及金融和国家机构在循环中的角色与作用的变动。中国新城以新兴工业城市、开发区、新城区为代表成为资本积累循环中盈余资本进行空间修复的主要载体。由于资本积累循环内部结构的调整,新城呈现出不同的类型、空间分布与结构特征。

关键词：资本积累资本积累循环中国新城空间演变

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基于中部崛起的区域旅游合作动力机制研究

地域研究与开发 2010年第5期29卷 64-67页

作者：陈佳平河南职业技术学院郑州450046

在经济全球化和区域经济一体化的背景下,区域旅游合作是重要的发展趋势之一,也是未来影响世界各国旅游业竞争力的重点领域。在中部崛起的宏观背景下中部六省区域旅游合作已经启动,具有极大的发展前景。通过空间生长力、政府调控力和市... 详细信息

在经济全球化和区域经济一体化的背景下,区域旅游合作是重要的发展趋势之一,也是未来影响世界各国旅游业竞争力的重点领域。在中部崛起的宏观背景下中部六省区域旅游合作已经启动,具有极大的发展前景。通过空间生长力、政府调控力和市场驱动力3个层面对中部区域旅游合作的动力机制进行研究,对于中部六省区域旅游合作的实践具有重要意义。

关键词：中部崛起区域旅游合作动力机制中部六省

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郑州城市生态旅游空间构建与发展策略研究

地域研究与开发 2013年第4期32卷 94-97页

作者：陈佳平河南职业技术学院郑州450046

随着城市发展进程的加快,城市生态环境急剧恶化,给城市旅游发展带来了障碍。因此,寻找一种基于生态和谐的旅游方式显得尤为重要。通过分析郑州城市生态旅游发展的意义、优势条件和旅游空间结构,从网络、板块以及环城游憩带3个方面构建... 详细信息

随着城市发展进程的加快,城市生态环境急剧恶化,给城市旅游发展带来了障碍。因此,寻找一种基于生态和谐的旅游方式显得尤为重要。通过分析郑州城市生态旅游发展的意义、优势条件和旅游空间结构,从网络、板块以及环城游憩带3个方面构建郑州城市生态旅游的基本体系,并提出发展郑州城市生态旅游必须注重加大城市生态环境建设力度、实施城市旅游承载量管理、增强城市生态保护意识、进行旅游与其他资源整合、打造生态旅游精品等具体策略。

关键词：城市生态旅游旅游空间结构策略郑州市