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Global nonequilibrium energy criterion for predicting strength of 316L stainless steel under complex loadings:Theoretical modeling and experimental validation

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Science China(Physics,Mechanics & Astronomy) 2022年第4期65卷 62-71页

作者： Yanying Hu jiapeng chen Biao Wang Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China School of Physics Sun Yat-Sen UniversityGuangzhou 510275China

Classical strength criteria are developed based on some empirical assumptions and have been widely used in engineering to predict material strength owing to their simplicity. In some cases, however, considerable discrepancies arise between classicalstrength-criteria-based theoretical predictions and experimental results. Recently, a global nonequilibrium thermodynamics model has made important progress over classical models without resorting to any empirical assumptions. A prominent advance of this rational energy model is that it straightforwardly determines the dissipation energy density function, which is pertinent to inherent material ductility, through simple uniaxial and equi-biaxial tensions. In this study, a brief introduction of the nonequilibrium energy model was followed by systematic experimental investigation to determine the dissipation energy function and predict the material strength of pristine 316 L stainless steel-commonly used in engineering-under complex loadings. The results indicated that the strength contours predicted by the nonequilibrium energy criterion for complex loadings are consistent with the experimental results obtained for biaxial tension, implying that the nonequilibrium thermodynamics model is both reasonable and reliable. The prediction error was presumed to be induced by the anisotropy of the 316 L stainless steel sheets.

关键词： failure criterion nonequilibrium process 316L stainless steel strength prediction complex loading

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基于特征脂肪酸的中药海藻鉴别研究

中国药学杂志 2024年第10期59卷 887-895页

作者：耿玺承马善鹏陈嘉鹏陈璐晶林立东刘红兵中国海洋大学海洋药物教育部重点实验室山东青岛266003 海洋药物与生物制品功能实验室青岛海洋科学与技术试点国家实验室山东青岛266237 温州市洞头区海洋与渔业发展研究中心浙江温州325700 国家药品监督管理局海洋中药质量研究与评价重点实验室山东青岛266000

目的利用植物脂质组学和化学分类学开展羊栖菜与其同属易混马尾藻的鉴别研究。方法收集27批羊栖菜,靶向建立了脂肪酸气相色谱-质谱(GC-MS)指纹图谱;运用主成分分析、正交偏最小二乘判别分析等化学模式识别方法,比较了羊栖菜与同属其他8... 详细信息

目的利用植物脂质组学和化学分类学开展羊栖菜与其同属易混马尾藻的鉴别研究。方法收集27批羊栖菜,靶向建立了脂肪酸气相色谱-质谱(GC-MS)指纹图谱;运用主成分分析、正交偏最小二乘判别分析等化学模式识别方法,比较了羊栖菜与同属其他8种22批马尾藻,建立了海藻饮片判别模型;基于羊栖菜与其他马尾藻的差异脂肪酸,结合脂肪酸生合成途径分析,筛选质量标志物。结果指纹图谱共标定29个共有脂肪酸,相似度均大于0.96。化学模式识别法能够很好区分羊栖菜与同属其他8种22批马尾藻,以此建立的判别模型能够准确验证15批市售海藻饮片。结合差异脂肪酸与脂肪酸生合成途径分析,发现单不饱和脂肪酸在化学分类中的重要作用,提出比值C20∶1 n-9/C16∶1 n-7可作为羊栖菜鉴别的候选质量标志物,14批市售海藻饮片可被准确验证。结论本研究建立了羊栖菜与同属易混马尾藻的判别模型,发现了脂肪酸质量标志物,为中药海藻真伪鉴别方法的制定提供参考。

关键词：中药海藻羊栖菜脂肪酸化学分类学质量标志物

疫苗犹豫对北京市老年人新冠病毒疫苗接种情况影响

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中国公共卫生 2024年第4期40卷 446-449页

作者：郭娜陈佳鹏姜小峰李惠文朱萍白玥中国人口与发展研究中心北京100081 山东大学齐鲁医院济南250012 上海交通大学医学院附属瑞金医院上海200025 中国健康教育中心北京100011

目的了解疫苗犹豫对北京市老年人新型冠状病毒疫苗(简称“新冠病毒疫苗”)接种情况的影响,为更好落实国家关于推进老年人新冠病毒疫苗接种策略提供政策建议。方法于2020年10月采用分层随机抽样方法在北京市抽取800名≥60岁老年人进行问... 详细信息

目的了解疫苗犹豫对北京市老年人新型冠状病毒疫苗(简称“新冠病毒疫苗”)接种情况的影响,为更好落实国家关于推进老年人新冠病毒疫苗接种策略提供政策建议。方法于2020年10月采用分层随机抽样方法在北京市抽取800名≥60岁老年人进行问卷调查,并采用多因素非条件logistic回归模型分析疫苗犹豫对北京市老年人新冠病毒疫苗接种情况的影响。结果最终纳入分析的720名北京市老年人中,接种新冠病毒疫苗第一剂次者541人,新冠病毒疫苗第一剂次接种率为75.14%;北京市老年人疫苗犹豫5C量表的信心、自满、约束、计算和集体责任维度得分分别为(8.94±1.39)、(1.92±2.26)、(1.46±1.94)、(7.44±2.63)和(8.10±1.68)分,经正负向转换后合成的疫苗犹豫5C量表总分为(4.84±1.06)分;疫苗犹豫程度高者240人(33.33%),疫苗犹豫程度中等者232人(32.22%),疫苗犹豫程度低者248人(34.44%);在调整了性别、年龄、文化程度、婚姻状况、家庭人均月收入、是否吸烟、是否饮酒、过去1个月是否参加过社交活动和是否患慢性病后,多因素非条件logistic回归分析结果显示,集体责任得分较高的北京市老年人的新冠病毒疫苗接种率较高(OR=1.21,95%CI=1.00~1.46),自满(OR=0.76,95%CI=0.64~0.92)、约束(OR=0.83,95%CI=0.69~0.99)和计算(OR=0.72,95%CI=0.58~0.89)得分较高的北京市老年人新冠病毒疫苗接种率较低,疫苗犹豫程度中等(OR=2.19,95%CI=1.44~3.33)和低(OR=4.03,95%CI=2.51~6.45)的北京市老年人新冠病毒疫苗接种率较高。结论北京市老年人的新冠病毒疫苗接种率较低,疫苗犹豫程度较低老年人新冠病毒疫苗的接种率较高。

关键词：疫苗犹豫新型冠状病毒疫苗(新冠病毒疫苗) 接种影响老年人

南沙地区海堤迎海侧堤岸生态防护结构体系研究

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广东水利水电 2024年第2期 52-56页

作者：陈佳鹏王艳秦茂洁广东省水利电力勘测设计研究院有限公司广州510635

南沙区位于珠三角的河网地带,全区整体防洪(潮)体系基础骨干框架已形成,但绝大部分海堤为传统海堤,需按照国家级自贸区的建设要求进一步进行生态化改造。根据南沙地区各水道的水文规律,按照设计洪潮水位、多年平均高潮位、多年平均低潮... 详细信息

南沙区位于珠三角的河网地带,全区整体防洪(潮)体系基础骨干框架已形成,但绝大部分海堤为传统海堤,需按照国家级自贸区的建设要求进一步进行生态化改造。根据南沙地区各水道的水文规律,按照设计洪潮水位、多年平均高潮位、多年平均低潮位等特征洪潮水位,以及区域动植物群落分布与海堤迎海侧堤岸的相对竖向关系进行生态结构分层,不同的分层采用不同的生态防护结构,形成适用于南沙地区的独特海堤生态防护结构体系。在不同的海堤建设条件和不同的水位条件下,可以组合运用,形成南沙独特的海堤生态风貌风格,冀可为以后该地区海堤生态化建设能提供借鉴。

关键词：南沙海堤生态防护结构

Existence criteria and validity of plate models for graphene-like materials

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Science China(Physics,Mechanics & Astronomy) 2019年第5期62卷 84-98页

作者： jiapeng chen Biao Wang School of Electronics and Information Technology Sun Yat-Sen University School of Physics Sun Yat-Sen University Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen University

Graphene-like(GL) materials have enriched the application prospects of two-dimensional materials by virtue of their various structures and properties. However, the following theoretical issues remain unsolved: how can stable GL materials exist and is plate idealization valid for any GL materials? Here we answer these questions based on an atomistic potential-based *** existence criteria for GL materials with three common structures, including planar honeycomb(PH), buckled honeycomb(BH), and honeycomb MX_2(2 H-MX_2) structures, were established. Moreover, the validity of classic linear-elastic plate models for these materials was examined. A validity factor, which represents the validity of using thin plate models to investigate the overall mechanical response of GL sheets, was defined. We determined that 2 H-MX_2 sheets can approximately be modeled as thin plates for arbitrary loadings, unlike PH and BH sheets.

关键词： grapheme-like material existence criterion plate idealization

Electrochemical CO_(2)reduction to C_(2+)products over Cu/Zn intermetallic catalysts synthesized by electrodeposition

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Frontiers in Energy 2024年第1期18卷 80-88页

作者： Ting DENG Shuaiqiang JIA Shitao HAN Jianxin ZHAI jiapeng JIAO Xiao chen cheng XUE Xueqing XING Wei XIA Haihong WU Mingyuan HE Buxing HAN School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200062China Institute of Eco-Chongming Shanghai 202162China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Chemistry Chinese Academy of SciencesBeijing 100190China

Electrocatalytic CO_(2)reduction(ECR)offers an attractive approach to realizing carbon neutrality and producing valuable chemicals and fuels using CO_(2)as the ***,the lack of cost-effective electrocatalysts with better performances has seriously hindered its ***,a one-step co-electrodeposition method was used to introduce Zn,a metal with weak^(*)CO binding energy,into Cu to form Cu/Zn intermetallic catalysts(Cu/Zn IMCs).It was shown that,using an H-cell,the high Faradaic efficiency of C_(2+)hydrocarbons/alcohols()could be achieved in ECR by adjusting the surface metal components and the applied *** suitable conditions,FEC_(2+)and current density could be as high as 75%and 40 mA/cm^(2),*** with the Cu catalyst,the Cu/Zn IMCs have a lower interfacial charge transfer resistance and a larger electrochemically active surface area(ECSA),which accelerate the ***,the^(*)CO formed on Zn sites can move to Cu sites due to its weak binding with*CO,and thus enhance the C–C coupling on the Cu surface to form C_(2+)products.

关键词： carbon dioxide electroreduction electrochemistry co-electrodeposition intermetallic catalysts value-added chemicals

Targeting FAPα-positive lymph node metastatic tumor cells suppresses colorectal cancer metastasis

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Acta Pharmaceutica Sinica B 2024年第2期14卷 682-697页

作者： Shuran Fan Ming Qi Qi Qi Qun Miao Lijuan Deng Jinghua Pan Shenghui Qiu Jiashuai He Maohua Huang Xiaobo Li Jie Huang jiapeng Lin Wenyu Lyu Weiqing Deng Yingyin He Xuesong Liu Lvfen Gao Dongmei Zhang Wencai Ye Minfeng chen State Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan UniversityGuangzhou 510632China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China School of Medicine Jinan UniversityGuangzhou 510632China School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510630China The First Affiliated Hospital of Jinan University Guangzhou 510632China State Key Laboratory of Chemical Oncogenomics Guangdong Provincial Key Laboratory of Chemical BiologyTsinghua Shenzhen International Graduate SchoolShenzhen 518055China

Lymphatic metastasis is the main metastatic route for colorectal cancer, which increases the risk of cancer recurrence and distant metastasis. The properties of the lymph node metastatic colorectal cancer(LNM-CRC) cells are poorly understood, and effective therapies are still lacking. Here, we found that hypoxia-induced fibroblast activation protein alpha(FAPα) expression in LNM-CRC cells. Gain-or loss-function experiments demonstrated that FAPα enhanced tumor cell migration, invasion, epithelial-mesenchymal transition, stemness, and lymphangiogenesis via activation of the STAT3 pathway. In addition, FAPα in tumor cells induced extracellular matrix remodeling and established an immunosuppressive environment via recruiting regulatory T cells, to promote colorectal cancer lymph node metastasis(CRCLNM). Z-GP-DAVLBH, a FAPα-activated prodrug, inhibited CRCLNM by targeting FAPα-positive LNM-CRC cells. Our study highlights the role of FAPα in tumor cells in CRCLNM and provides a potential therapeutic target and promising strategy for CRCLNM.

关键词： Lymphaticmetastasis Colorectal cancer Fibroblastactivation proteinα FAPα-activated prodrug Epithelial-mesenchymal

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工程经济辅助法在城乡河涌综合整治中的运用

小水电 2022年第5期 46-48,54页

作者：陈佳鹏广东省水利电力勘测设计研究院有限公司广东广州510610

工程经济辅助法是工程项目按照相关规程规范、规划文件要求进行设计,在满足了防洪、排涝、生态、景观等功能之外,为更好地对工程进行运行管理,在建设中融入经济辅助措施,使周围居民能从工程中获取经济利益,从而自发对工程进行维护管理... 详细信息

工程经济辅助法是工程项目按照相关规程规范、规划文件要求进行设计,在满足了防洪、排涝、生态、景观等功能之外,为更好地对工程进行运行管理,在建设中融入经济辅助措施,使周围居民能从工程中获取经济利益,从而自发对工程进行维护管理的一种新型设计理念。从城镇和乡村两个方面的河涌整治实例中,对工程经济辅助法的运用进行了详细阐述。图1幅。

关键词：城乡河涌整治工程经济辅助法运用

Meridional deflection of global eddy propagation derived from tandem altimetry: Mechanism and implication

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Science China Earth Sciences 2024年第3期67卷 811-825页

作者： Ge chen Xiaoyan chen Frontiers Science Center for Deep Ocean Multispheres and Earth System School of Marine TechnologyOcean University of ChinaQindao 266100China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQindao 266237China

A common view on meridional deflection of eddy propagation is poleward for cyclones and equatorward for anticyclones. This widely accepted polarity-sensitive pattern has been increasingly undermined given that it is systematically violated on both zonal and regional scales as recently reported. Here, we approach the problem by exploring these violations in terms of eddy effects of spatiotemporal geostrophy, thermal fading, and flow dragging, yielding the following main conclusions.(1) The polarity-dependent deflection discrepancy is a pseudo feature resulting from a biased fit to the normalized eddy tracks which are spatially asymmetric(though azimuthally symmetric) between the two signs;Instead, the primary pattern of eddy deflection appears to be geographically correlated and polarity independent.(2) Geostrophic adjustment plays a critical role in defining the meridional movement of an eddy. Specifically, a consistent poleward(equatorward) trajectory bending of spatially(temporally) ageostrophic eddies is observed irrespective of their polarity.(3) The mechanism of eddy deflection is also determined by its zonal propagation direction. Westward propagating eddies are substantially affected by thermal fading, while opposite ones by flow dragging. A realistic and comprehensive understanding of eddy deflection mechanisms serves as a significant contribution to the prediction of eddy trajectory, and the protection of ocean environment.

关键词： Mesoscale eddies Eddy propagation Eddy meridional deflection Satellite observation Geostrophic adjustment

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