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China CDC weekly 2023年第12期5卷 259-265页

作者： Tao Li Xin Du jiaojie kang Dan Luo Xiaoqiu Liu Yanlin Zhao National Center for Tuberculosis Control and Prevention China CDCBeijingChina School of Public Health Peking UniversityBeijingChina Department of Public Health Hangzhou Medical CollegeHangzhou CityZhejiang ProvinceChina

Summary What is already known about this topic?The coronavirus disease(COVID-19)pandemic could have a damaging impact on access to tuberculosis(TB)diagnosis and *** is added by this report?The overall delay experienced by TB patients during the COVID-19 pandemic has shown a modest decrease in comparison to the period before the ***,higher patient delays were observed among agricultural workers and those identified through passive case-finding ***,the patient delay in eastern regions was shorter compared to western and central regions.

关键词： diagnosis Patients delay

Patient Delay in the Diagnosis of Pulmonary Tuberculosis in the Elderly—China,2015-2023

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China CDC weekly 2024年第42期6卷 1075-1079页

作者： Yushu Liu Mingkuan Fan Yuhong Li jiaojie kang Ybryim A Tianxin Yan Jun Cheng Hui Zhang National Center for Tuberculosis Control and Prevention ChineseCenter for Disease Control and PreventionBeijingChina Medical College of Xiangyang Polytechnic Xiangyang CityHubei ProvinceChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Patient delay in seeking medical care for pulmonary tuberculosis(PTB),especially among elderly individuals with weakened immune systems and mild symptoms,not only slows their recovery but also increases the risk of tuberculosis spread because cases are not identified *** is added by this report?In China,patient delays experienced by elderly PTB patients showed a modest decrease from 2015 to ***,longer patient delays were observed among agricultural workers and those identified through passive case-finding ***,the patient delay in the western regions was longer than in the eastern and central *** are the implications for public health practice?The study underscores the imperative of accessible healthcare for the elderly to minimize patient delay in pulmonary tuberculosis diagnosis and treatment.

关键词： tuberculosis diagnosis prompt

老年肺结核患者随访检查依从性及其影响因素分析

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中国医学前沿杂志（电子版） 2024年第3期16卷 22-27页

作者：康娇洁李玉红刘小秋李涛张慧中国疾病预防控制中心结核病预防控制中心北京102206 中国疾病预防控制中心传染病溯源预警与智能决策全国重点实验室北京102206

目的分析我国2019年年龄≥65岁肺结核患者随访检查依从性,为进一步规范患者治疗管理提供依据。方法通过“中国疾病预防控制信息系统”子系统“结核病管理信息系统”收集2019年全国登记治疗的年龄≥65岁且利福平敏感的初治肺结核患者的... 详细信息

目的分析我国2019年年龄≥65岁肺结核患者随访检查依从性,为进一步规范患者治疗管理提供依据。方法通过“中国疾病预防控制信息系统”子系统“结核病管理信息系统”收集2019年全国登记治疗的年龄≥65岁且利福平敏感的初治肺结核患者的病案信息,对患者的基本特征,治疗第2、5、6个月末随访检查完成率以及随访检查依从率进行描述性分析,采用二元多因素Logistic回归分析患者随访检查不依从的影响因素。结果 2019年我国老年利福平敏感初治肺结核患者治疗第2、5、6个月随访检查的完成率分别为95.5%、89.9%、86.0%,总体呈下降趋势(χ^(2)_(趋势)=-2.287,P=0.022)。患者随访检查的依从率为87.4%(48 834/55 888)。多因素logistic回归分析显示,女性、≥80岁、家务工作者、离退人员、其他职业、东部地区和西部地区、流动人口、有合并症、诊疗单位为综合医院、专科医院的患者随访检查不依从的风险较高,诊疗单位为社区卫生服务中心的患者随访检查不依从的风险较低。结论 2019年我国老年利福平敏感初治肺结核患者的随访检查工作成效显著,但仍需加强东、西部地区以及流动人口、专科医院诊疗患者管理和关怀工作,进一步规范治疗随访以提高患者的治愈率。

关键词：结核肺老年人痰患者依从影响因素

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Direct interaction of DNMT inhibitors to PrP^C suppresses pathogenic process of prion

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Acta Pharmaceutica Sinica B 2019年第5期9卷 952-959页

作者： Dae-Hwan Kim Chunyan Ren Chongsuk Ryou jiaojie Li Institute of Pharmaceutical Science and Technology Hanyang UniversityAnsan15588Republic of Korea School of Undergraduate Studies College of Transdisciplinary StudiesDaegu Gyeongbuk Institute of Science and TechnologyDaegu42988Republic of Korea Boston Children’s Hospital Harvard Medical SchoolBostonMA02115USA Department of Pharmacy Hanyang UniversityAnsan15588Republic of Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea

The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-prion activity of SGI-1027 and its meta/meta analogue(M/M), previously known only as potent inhibitors of DNA methyltransferases(DNMTs). These compounds effectively decreased the level of Pr PSc in cultured cells with permanent prion infection, without affecting PrP^Cat the transcriptional or translational levels. Furthermore, SGI-1027 prevented effective prion infection of the cells. In a Pr P aggregation assay, both SGI-1027 and M/M blocked the formation of misfolded Pr P aggregates, implying that binding of these compounds hinders the Pr P conversion process. A series of binding and docking analyses demonstrated that both SGI-1027 and M/M directly interacted with the C-terminal globular domain of PrP^C, but only SGI-1027 bound to a specific region of PrP^C with high affinity, which correlates with its potent antiprion efficacy. Therefore, we report SGI-1027 and related compounds as a novel class of potential antiprion agents that preferentially function through direct interaction with PrP^C.

关键词： Prion DNMT Therapeutic compounds PrP^C Epigenetic regulation

Extracting Soil Moisture from Fengyun-3D Medium Resolution Spectral Imager-Ⅱ Imagery by Using a Deep Belief Network

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Journal of Meteorological Research 2020年第4期34卷 748-759页

作者： Wenwen WANG Chengming ZHANG Feng LI jiaojie SONG Peiqi LI Yuhua ZHANG College of Information Science and Engineering Shandong Agricultural UniversityTai’an 271000 Shandong Technology and Engineering Center for Digital Agriculture Tai’an 271000 Shandong Provincial Climate Center Jinan 25000

Obtaining continuous and high-quality soil moisture(SM) data is important in scientific research and applications,especially for agriculture, meteorology, and environmental monitoring. With the continuously increasing number of artificial satellites in China, the acquisition of SM data from remote sensing images has received increasing *** this study, we constructed an SM inversion model by using a deep belief network(DBN) to extract SM data from Fengyun-3 D(FY-3 D) Medium Resolution Spectral Imager-Ⅱ(MERSI-Ⅱ) imagery;we named this model *** SM-DBN consists of two subnetworks: one for temperature and the other for SM. In the temperature subnetwork, bands 1, 2, 3, 4, 24, and 25 of the FY-3 D MERSI-Ⅱ imagery, which are relevant to temperature, were used as inputs while land surface temperatures(LST) obtained from ground stations were used as the expected output value when training the model. In the SM subnetwork, the input data included LSTs generated from the temperature subnetwork, normalized difference vegetation index(NDVI), and enhanced vegetation index(EVI);and the SM data obtained from ground stations were used as the expected outputs. We selected the Ningxia Hui Autonomous Region of China as the study area and used selected MERSI-Ⅱ images and in-situ observation station data from 2018 to 2019 to develop our dataset. The results of the SM-DBN were validated by using in-situ SM data as a reference, and its performance was also compared with those of the linear regression(LR) and back propagation(BP) neural network models. The overall accuracy of these models was measured by using the root mean square error(RMSE) of the differences between the model results and in-situ SM observation data. The RMSE of the LR, BP neural network, and SM-DBN models were 0.101, 0.083, and 0.032, respectively. These results suggest that the SM-DBN model significantly outperformed the other two models.

关键词： deep learning deep belief network(DBN) Fengyun-3D(FY-3D) Medium Resolution Spectral Imager-Ⅱ(MERSI-Ⅱ)Imagery data fitting soil moisture(SM) Ningxia

A Synergistic Strategy for Nanoparticle/Nanofiber Composites Towards p-Nitrophenol Catalytic Hydrogenation

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Chemical Research in Chinese Universities 2015年第6期31卷 1012-1017页

作者： WANG Wei WANG Ke HE jiaojie ZHANG Xintong WANG Ce ZHAO Zhiwei CUI Fuyi State Key Laboratory of Urban Water Resource and Environment(SKLUWRE) School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 P. R. China Alan G. Macdiarmid Institute Jilin University Changchun 130012 P. R. China Department of National Defense Construction Planning and Environmental Engineering Logistical Engineering University Chongqing 401311 P R. China

Nanoparticle（NP）/nanofiber（NF） composites based on Ag/hydrostable-polyvinyl alcohol were fabricated by a green synergistic strategy via electrospinning. The electrospun NFs served as an in situ reducing agent for the metal salt precursors and a protecting agent for the resulting NPs. Additionallly, during the fomation of the NPs, the water-soluble NFs were in situ oxidized and catalyzed by the metal ions to achieve chemical crosslinking. This two-in-one process achieves polymer curing and metal nanoparticles reducing/protecting synergistically. It eliminates the usage of organic electrospinning solvents, conventional chemical reducing agents and stabilizers, as well as harmful chemical crosslinking agents during the whole process. By the absolutely green synergistic electrospinning, nanoparticle/nanofiber composites with super-hydrophilicity, good hydrostability, as well as uniform and thin particle sizes were obtained. They exhibited enhanced activities when used for catalytic hydrogenation ofp-nitrophenol in water.

关键词： Electrospirming Supported narloparticle Nanofiber Ag

Influence of overnight orthokeratology lens fitting decentration on corneal topography reshaping

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Eye and Vision 2018年第1期5卷 48-58页

作者： jiaojie Chen Wei Huang Rong Zhu Jun Jiang Yiyu Li School of Optometry and Ophthalmology WenZhou Medical UniversityWenZhouZheJiangChina Eye Hospital of Wenzhou Medical University 270 West Xueyuan RoadWenzhouZhejiang 325027China

Background:This retrospective study was designed to investigate the sole influence of orthokeratology(OK)lens fitting decentration on the Zernike coefficients of the reshaped anterior corneal ***:This study comprised a review of 106 right eyes and measurements of corneal topography both before OK and at 1-month follow-up visit.A routine was designed to calculate local corneal surface astigmatism and assist the determination of OK lens fitting decentration from pupil *** pupil-centered corneal Zernike coefficients of baseline(PCCB)and post-treatment(PCCP)were ***,the OK-lens-centered corneal Zernike coefficients of post-treatment(OCCP)were also calculated and considered as the presumptive ideal fitting group without *** between lens fitting decentration and the change of Zernike coefficients including(PCCP−PCCB)and(PCCP−OCCP)were ***:Patients with a mean age of 11±2.36 years old had an average spherical equivalent refractive error of−3.52±1.06 D before *** month after treatment,OK lens fitting decentration from pupil center was 0.68±0.35 *** of 3rd-order(P0.05).For the high order corneal Zernike coefficients in(PCCP–OCCP),radial distance of decentration was correlated with C^(−1)_(3)(r=−0.296,P<0.05),C^(1)_(3)(r=−0.396,P<0.001),and C^(0)_(4)(r=0.449,P<0.001),horizontal decentration was significantly correlated with C^(1)_(3)(r=0.901,P<0.001)and C^(1)_(5)(r=0.340,P<0.001),and vertical decentration was significantly correlated with C^(−1)_(3)(r=0.904,P<0.001).Conclusions:OK lens fitting decentration within 1.5 mm hardly influenced the change of corneal spherical power for myopia correction,but significantly induced additional corneal

关键词： Orthokeratology Lens fitting decentration Zernike coefficients Contact lens Corneal topography

Variations of alkenone temperature in the Sea of Japan during the last 170 ka and its paleoceanographic implications

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Chinese Science Bulletin 2014年第33期59卷 4498-4509页

作者： Yanguang Liu jiaojie Chen Jinxia Chen Lei Xing Jianjun Zou Zhengquan Yao Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of Oceanography State Oceanic Administration Key Laboratory of Marine Chemistry Theory and Technology Ministry of Education/Qingdao Collaborative Innovation Center of Marine Science and Technology Ocean University of China

Two sediment cores, KCES1 and ODP797,which were recovered from the Sea of Japan(JS), were measured for alkenone-derived sea surface temperatures(UK037-SSTs). Our results revealed that the SSTs closely follow the glacial-interglacial cycles during the last 170 ka,except in the last glacial maximum(LGM), during which the SST was higher than in the Holocene. The anomalous high temperature in the LGM is considered as an effect of the intrusion of a low salinity water mass into the JS when the sea level was almost below 130 m. On the glacialinterglacial to orbital timescale, the UK037-SSTs record in the JS correlated well with the benthic foraminiferal d18 O record and solar insolation, which suggests the dominant control of solar insolation and its related sea ice development on the SST in the JS. On the sub-orbital/millennial timescale, reduced SST corresponds to an enhanced east asian winter monsoon(EAWM) during the last glacial period(MIS3 and MIS4), indicating the dominant control of sea ice expansion due to the enhanced EAWM on the SST in the JS. In contrast, during the last interglacial period(MIS5), the SST in the JS was controlled by variations in the east Asian summer monsoon. These results highlight the key role of solar insolation and associated glacialinterglacial conditions in the variations of the SST in the JS since the last 170 ka.

关键词：海表温度日本海古海洋学烯酮末次间冰期太阳辐射 SST 末次盛冰期

Multifunctional polymeric micelle-based chemo-immunotherapy with immune checkpoint blockade for efficient treatment of orthotopic and metastatic breast cancer

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Acta Pharmaceutica Sinica B 2019年第4期9卷 819-831页

作者： jiaojie Wei Yang Long Rong Guo Xinlei Liu Xian Tang Jingdong Rao Sheng Yin Zhirong Zhang Man Li Qin He Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of Pharmacy Sichuan University

Immunotherapy has become a highly promising paradigm for cancer treatment. Herein, a chemo-immunotherapy was developed by encapsulating chemotherapeutic drug doxorubicin(DOX) and Toll-like receptor 7 agonist imiquimod(IMQ) in low molecular weight heparin(LMWH)-D-α-tocopheryl succinate(TOS) micelles(LT). In this process, LMWH and TOS were conjugated by ester bond and they were not only served as the hydrophilic and hydrophobic segments of the carrier, but also exhibited strong anti-metastasis effect. The direct killing of tumor cells mediated by DOX-loaded micelles(LT-DOX)generated tumor-associated antigens, initiating tumor-specific immune responses in combination with IMQ-loaded micelles(LT-IMQ). Furthermore, the blockade of immune checkpoint with programmed cell death ligand 1(PD-L1) antibody further elevated the immune responses by up-regulating the maturation of DCs as well as the ratios of CD8+ CTLs/Treg and CD4+ Teff/Treg. Therefore, such a multifunctional strategy exhibited great potential for inhibiting the growth of orthotopic and metastatic breast cancer.

关键词： Checkpoint blockade Immunotherapy Immunogenic cell death Anti-metastasis Nanoparticle

Customized design and efficient machining of astigmatism-minimized progressive addition lens

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Chinese Optics Letters 2018年第11期16卷 75-79页

作者： Yiyu Li Wei Huang Haihua Feng jiaojie Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027China The Eye Hospital of Wenzhou Medical University Wenzhou 325027China Corresponding author： liyiyu@***

Astigmatism is inevitable and inherent to progressive addition lenses （PALs）, which are typically distributed in the lateral areas on both sides of the progressive corridor. In this study, we took into account the spectacle frame for the customized freeform PAL design with the variational-diffcrence numerical approach. The PAL surface with minimized astigmatism, approximately equal to 84% of the added power, was numerically resolved without expending the zone for clear vision. We validated our approach by experimentally demonstrating the procedure from tool path generation to surface power measurement, thus providing an efficient solution to the personalization of astigmatism-minimized PAL design and manufacture.

关键词： Astigmatism Surface measurements Vision