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Science China Chemistry 2016年第8期59卷 970-974页

作者： jiao-min lin Chun-Ting He Pei-Qin Liao Dong-Dong Zhou Jie-Peng Zhang Xiao-ming Chen Key Laboratory of Bioinorganic and Synthetic Chemistry Ministry of EducationSchool of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China

Solvothermal reaction of Zn（NO3）2, 4-（1H-pyrazol-4-yl）pyridine （Hpypz） and 1,3,5-benzenetricarboxylic acid （H3btc） in N,N-dimethylacetamide （DMA） produced a new porous coordination polymer [Zns（pypz）4（btc）2] （1）. Single-crystal X-ray diffraction study of 1 showed that deprotonated pypz^- ligands served as 1,2,4-triazolate-like ligands, linking Zn（II） ^＋ ions to form porous two-dimensional （2-D） sql-a layers {Zn（pypz）} , which were further connected by eight-legged pillars {Zn2（btc）4（H2O）2}8- based on the typical paddlewheel dinuclear Zn2（RCOO）4（H20）2 cluster to form a novel type of non-interpenetrated pillared-layer framework with 3-D intersecting pore system and large pore volume. Gas sorption measurements revealed that 1 possesses large BET surface area of 2061 m^2g^-1 and very high methane total uptake of 245 cm^3（STP） cm^-3 at 298 K and 65 bar.

关键词： metal-organic framework network topology eight-legged pillar methane storage

Advances in the Development of Gradient Scaffolds Made of Nano-Micromaterials for Musculoskeletal Tissue Regeneration

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NANO-MICRO LETTERS 2025年第1期17卷 1-46页

作者： Fang, Lei lin, Xiaoqi Xu, Ruian Liu, Lu Zhang, Yu Tian, Feng Li, jiao jiao Xue, Jiajia Beijing Univ Chem Technol Beijing Lab Biomed Mat Beijing 100029 Peoples R China Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing 100029 Peoples R China Univ Technol Sydney Fac Engn & IT Sch Biomed Engn Sydney NSW 2007 Australia

This review highlights the gradient variations in the structural composition of musculoskeletal tissues and comprehensively examines recent progress in the fabrication and application of biomimetic gradient scaffolds for musculoskeletal *** challenges and prospects of gradient scaffolds for clinical application are discussed. The intricate hierarchical structure of musculoskeletal tissues, including bone and interface tissues, necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered substitutes. This has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic outcomes. Building on the anatomical characteristics of bone and interfacial tissues, this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues, specifically focusing on methods used to construct compositional and structural gradients within the scaffolds. The latest applications of gradient scaffolds for the regeneration of bone, osteochondral, and tendon-to-bone interfaces are presented. Furthermore, the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed, as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

用于实现高性能热催化氧化还原反应的二茂铁功能化锆氧簇

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Science Bulletin 2024年第10期69卷 1418-1426页

作者：姚苏娟林焦敏董龙章李颖霖李宁刘江兰亚乾 School of Chemistry South China Normal UniversityGuangzhou 510006China

The Zr(Ⅳ)ions are easily hydrolyzed to form oxides,which severely limits the discovery of new structures and applications of Zr-based *** this work,three ferrocene(Fc)-functionalized Zr-oxo clusters(ZrOCs),Zr_(9)Fc_(6),Zr_(10)Fc_(6) and Zr_(12)Fc_(8) were synthesized through inhibiting the hydrolysis of Zr(Ⅳ)ions,which show increased nuclearity and regular structural *** importantly,these Fc-functionalized ZrOCs were used as heterogeneous catalysts for the transfer hydrogenation of levulinic acid(LA)and phenol oxidation reactions for the first time,and displayed outstanding catalytic *** particular,Zr_(12)Fc_(8) with the largest number of Zr active sites and Fc groups can achieve>95% yield for LAto-c-valerolactone within 4 h(130℃)and>98% yield for 2,3,6-trimethylphenol-to-2,3,5-trimethyl-pbenzoquinone within 30 min(80℃),showing the best catalytic *** characterization combined with theory calculations reveal that in the Fc-functionalized ZrOCs,the Zr active sites could serve as substrate adsorption sites,while the Fc groups could act as hydrogen transfer reagent or Fenton reagent,and thus achieve effectively intramolecular metal-ligand synergistic *** work develops functionalized ZrOCs as catalysts for thermal-triggered redox reactions.

关键词： Zirconium-oxo cluster Metal-ligand synergitic thermalcatalysis Crystalline coordination compound Hydrogen transfer Fenton reagent

锆/铪氧簇中硫原子导向的金属-配体协同高效催化胺氧化反应

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Science Bulletin 2024年第4期69卷 492-501页

作者：孙胜男牛倩林焦敏何莉玲石景文黄青刘江兰亚乾 School of Chemistry South China Normal UniversityGuangzhou 510006China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China

The performance applications(e.g.,photocatalysis)of zirconium(Zr)and hafnium(Hf)based complexes are greatly hindered by the limited development of their structures and the relatively inert metal *** this work,we constructed two ultrastable Zr/Hf-based clusters(Zr_(9)-TC4A and Hf_(9)-TC4A)using hydrophobic 4-tert-butylthiacalix[4]arene(H4TC4A)ligands,in which unsaturated coordinated sulfur(S)atoms on the TC4A^(4-)ligand can generate strong metal–ligand synergy with nearby active metal Zr/Hf *** a result,these two functionalized H4TC4A ligands modified Zr/Hf-oxo clusters,as catalysts for the amine oxidation reaction,exhibited excellent catalytic activity,achieving very high substrate conversion(>99%)and product selectivity(>90%).Combining comparative experiments and theoretical calculations,we found that these Zr/Hf-based cluster catalysts accomplish efficient amine oxidation reactions through synergistic effect between metals and ligands:(i)The photocatalytic benzylamine(BA)oxidation reaction was achieved by the synergistic effect of the dual active sites,in which,the naked S sites on the TC4A^(4-)ligand oxidize the BA by photogenerated hole and oxygen molecules are reduced by photogenerated electrons on the metal active sites;(ii)in the aniline oxidation reaction,aniline was adsorbed by the bare S sites on ligands to be closer to metal active sites and then oxidized by the oxygen-containing radicals activated by the metal sites,thus completing the catalytic reaction under the synergistic catalytic effect of the proximity metal–*** this work,the Zr/Hf-based complexes applied in the oxidation of organic amines have been realized using active S atom-directed metal–ligand synergistic catalysis and have demonstrated very high reactivity.

关键词： Zirconium/hafnium-oxo clusters Amine oxidation reaction Photocatalytic reaction Synergistic catalysis

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-min lin Mai Xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Efficacy and safety of Huaiqihuang granule as adjuvant treatment for primary nephrotic syndrome in children: a meta-analysis and systematic review

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World Journal of Pediatrics 2021年第3期17卷 242-252页

作者： jiao lin Li-min Huang Jing-Jing Wang Jian-Hua Mao Department of Nephrology National Clinical Research Center For Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310003China

Background Huaiqihuang(HQH)granule is a traditional Chinese herbal complex that has been used as an adjuvant treatment in clinics for the primary nephrotic syndrome(PNS)for many ***,the effectiveness and safety of HQH have not been systematically *** review aimed to evaluate the effectiveness and safety of HQH in paediatric patients with *** The following databases were searched from inception to Mar 2019:MEDlinE,Cochrane Library,EMBASE,CNKI,Wanfang Database,the Chinese Scientific Journal Database and the Chinese biomedical literature service *** the randomized controlled trials(RCTs)eligible for inclusion were *** primary outcomes were relapse,infection,remission and adverse *** secondary outcomes included serum immunoglobulin levels(IgA,IgG or IgM),T-lymphocyte subtype(CD3+,CD4+,CD8+,CD4+/CD8+),IL-10,TNF-α,TNF-γ,total cholesterol and time of proteinuria turning *** Fourteen RCTs(885 patients)were *** with HQH reduced the chance of relapse[relative risk(RR):0.47;95%CI:0.34,0.66;P<0.001]and infections(RR:0.47;95%Cl:0.35,0.62;P<0.001).No significant difference was found in adverse *** also increased the serum levels of IgA[weighted mean difference(WMD):0.40;95%Cl:0.20,0.60;P<0.001]and IgG(WMD:1.58;95%Cl:1.38-1.78;P<0.001),as well as CD4+[standard mean difference(SMD):0.90;95%Cl:0.12-1.68;P=0.02],CD3+(WMD:4.04;95% CI:3.27-4.82;P<0.001),and the CD4^(+)/CD8^(+)ratio(WMD:0.31;95% CI:0.21-0.41;P<0.001),but decreased the level of CD8+cells(WMD:-3.39;95% CI:-5.73-1.05;P=0.004).No statistically significant difference was found in IgM(WMD:0.05;95% CI:-0.13,0.24;P=0.57).Conclusions HQH could reduce the rate of relapse and the frequency of infection in children with *** apparent adverse effects were ***,the beneficial influence of HQH may act through *** multi-center,large-sample,high-quality studies are needed to confirm the effectiveness and safety of

关键词： Children Huaiqihuang Nephrotic syndrome Meta-analysis

A Stability Criterion for Singular Systems with Two Additive Time-varying Delay Components

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International Journal of Automation and computing 2013年第1期10卷 39-45页

作者： Jian-min jiao Department of Mathematics Baoji University of Arts and Sciences

The problem of stability for singular systems with two additive time-varying delay components is investigated. By constructing a simple type of Lyapunov-Krasovskii functional and utilizing free matrix variables in approximating certain integral quadratic terms, a delay-dependent stability criterion is established for the considered systems to be regular, impulse free, and stable in terms of linear matrix inequalities （LMIs）. Based on this criterion, some new stability conditions for singular systems with a single delay in a range and regular systems with two additive time-varying delay components are proposed. These developed results have advantages over some previous ones in that they have fewer matrix variables yet less conservatism. Finally, two numerical examples are employed to illustrate the effectiveness of the obtained theoretical results.

关键词： Singular systems additive delay components stability Lyapunov-Krasovskii functional linear matrix inequality (LMI)

Robust Stability and Stabilization of Discrete Singular Systems with Interval Time-varying Delay and linear Fractional Uncertainty

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International Journal of Automation and computing 2012年第1期9卷 8-15页

作者： Jian-min jiao Department of Mathematics Baoji University of Arts and Sciences Baoji 721013 PRC

The robust stability and robust stabilization problems for discrete singular systems with interval time-varying delay and linear fractional uncertainty are discussed. A new delay-dependent criterion is established for the nominal discrete singular delay systems to be regular, causal and stable by employing the linear matrix inequality （LMI） approach. It is shown that the newly proposed criterion can provide less conservative results than some existing ones. Then, with this criterion, the problems of robust stability and robust stabilization for uncertain discrete singular delay systems are solved, and the delay-dependent LMI conditions are obtained. Finally, numerical examples are given to illustrate the effectiveness of the proposed approach.

关键词： Discrete singular systems time-varying delay linear fractional uncertainty robust stability robust stabilization linear matrix inequality (LMI).

Preparation of Ferrioxalate Submicrorods/Graphene Composites and Their Photocatalytic Properties

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Journal of Materials Science & Technology 2014年第2期30卷 117-122页

作者： min Fu Yun Zhao Qingze jiao School of Chemical Engineering and the Environment Beijing Institute of Technology

Ferrioxalate submicrorods/graphene composites were synthesized through a simple solvothermal process in a mixture of ethylene glycol and water. The in situ growth of ferrioxalate submicrorods and the reduction of graphene oxide （GO） were completed in a one-step reaction. Fourier transform infrared and Raman spectroscopy confirmed the reduction of GO. Uniform rod-like ferrioxalates with diameter of about 600 nm and length of several micrometers were well distributed on the graphene sheets. As-obtained composites exhibited better photocatalytic properties than pure ferrioxalate submicrorods. The influence of different contents of GO on photocatalytic performance was also investigated. A possible photocatalytic mechanism of ferrioxalate submicrorods/graphene composites was proposed.

关键词： Ferrioxalate submicrorods Graphene Photocatalysis

Comparison of the anti-apoptotic effects of 15-and 35-minute suspended moxibustion after focal cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2018年第2期13卷 257-264页

作者： Ai-jiao Xiao lin He Xin Ouyang Jie-min Liu ming-ren Chen School of Basic Medical Science Jiangxi University of Traditional Chinese Medicine School of Moxibustion Jiangxi University of Traditional Chinese Medicine

Heat-sensitive suspended moxibustion has a neuroprotective effect against focal cerebral ischemia/reperfusion injury, but the underly- ing mechanisms remain unclear. The duration of heat-sensitive suspended moxibustion （usually from 30 minutes to 1 hour） is longer than traditional suspended moxibustion （usually 15 minutes）. However, the effects of 15- and 35-minute suspended moxibustion in rats with cerebra/ischemia/reperfusion injury are poorly understood. In this study, we performed 15- or 35-minute suspended moxibustion at acupoint Dazhui （GV14） in an adult rat model of focal cerebral ischemia/reperfusion injury. Infarct volume was evaluated with the 2,3,5-triphenyltetrazolium chloride assay. Histopathological changes and neuronal apoptosis at the injury site were assessed by hematoxy- lin-eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Caspase-9 and caspase-3 expression at the in- jury site was detected using immunofluorescent staining. Bax and Bcl-2 expression at the injury site was assessed using western blot assay. In the 35-minute moxibustion group, infarct volume was decreased, neuronal apoptosis was reduced, caspase-9, caspase-3 and Bax expres- sion was lower, and Bcl-2 expression was increased, compared with the 15-minute moxibustion group. Our findings show that 35-minute moxibustion has a greater anti-apoptotic effect than 15-minute moxibustion after focal cerebral ischemia/reperfusion injury.

关键词： nerve regeneration suspended moxibustion middle cerebral artery occlusion cerebral ischemia/reperfusion injury infarct volume apoptosis Bcl-2 Bax caspase-9 caspase-3 neural regeneration traditional Chinese medical therapy