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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang jiao Ming Li Xi Chen mei-Ze Xu Tian Ding Xiao-Ping Gong Zhuo-mei Li Xue-Yuan Liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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Embryo-Engineered Nonhuman Primate Models:Progress and Gap to Translational Medicine

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Research 2021年第1期2021卷 1627-1639页

作者： mei huang jiao Yang Peng Li Yongchang Chen Yunnan Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China State Key Laboratory of Primate Biomedical Research Kunming 650500China

Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic *** close relatives of humans,nonhuman primates(NHPs)play an increasingly indispensable role in advancing translational medicine *** this review,we summarized the progress of NHP models generated by embryo engineering,analyzed their unique advantages in mimicking clinical patients,and discussed the remaining gap between basic research of NHP models to translational medicine.

关键词： diseases Medicine translational

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浅析国际贸易政策中的政治化因素

山东行政学院山东省经济管理干部学院学报 2004年第2期 10-11页

作者：张艳红单美娇黄飞华东师范大学上海200062

进入20世纪九十年代以来,各国贸易政策中的政治化因素进一步加大,既有国内利益集团及政党政治家的需要,也有国际方面国家政治经济安全、国家地位和对外目标上的考虑。而这对WTO多边贸易体系的进程也产生了影响。

关键词：国际贸易政策管理贸易制度利益集团

A software architecture centric engineering approach for Internetware

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Science in China(Series F) 2006年第6期49卷 702-730页

作者： mei Hong huang Gang ZHAO Haiyan jiao Wenpin School of Electronics Engineering and Computer Science Peking University Beijing 100871 China

As a new software paradigm evolved by the Internet, Internetware brings many challenges for the traditional software development methods and techniques. Though architecture-based component composition （ABC） approach is originated in the traditional software paradigm, it supports the engineering of Internetware effectively due to its philosophy, rationales and mechanisms. ABC has three major contributions to the en- gineering of Internetware in detail. First, the feature oriented domain modeling method can structure the ＂disordered＂＂software entities＂ to ＂ordered Internetware＂ bottom-up in the problem space. Second, the architecture centric design and analysis method can support the development of self-adaptive Internetware. Third, the component operating platform is a reflective and self-adaptive middleware that not only provides Internetware with a powerful and flexible runtime infrastructure but also enables the self-adaptation of the structure and individual entities of Internetware.

关键词： internetware component software architecture feature model reflective middleware autonomous component

Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao LIU Rui ZHENG Liang DENG Jiahui ZHANG Wenzheng HUO Jinlu huang Li Shanghai Marine Diesel Engine Research Institute National Key Laboratory of Marine Engine Science and Technology Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong University

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm) and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC) with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT) imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： atomization dual-orifice nozzle nozzle structure spray flame asymmetry

Effect of Surface State on Nodular Corrosion Resistance of Zircaloy-4 Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第2期28卷 254-260页

作者： Chuan-Ming Chen Bang-Xin Zhou Shao-Qiu Gou jiao huang mei-Yi Yao Laboratory for Microstructures Shanghai University Institute of Materials Shanghai University

The effect of surface state on the nodular corrosion resistance of Zircaloy-4 alloy was investigated in super- heated steam at 500 ℃/10.3 MPa by autoclave tests. The microstructures of oxide films on the corroded specimens were observed by TEM and SEM. The results indicate that surface strained layer delays the appearance of nodular spots on the specimen surfaces and improves the nodular corrosion resistance. The columnar grains orientation of the oxide films formed on the specimens with surface strained layer was more consistent than that on the specimens without surface strained layer when a comparison was made on the same orientation of the grain surfaces. Such a kind of oxide micro- structure formed on the specimens with surface strained layer can hinder the diffusion of oxygen ions along the grain boundaries and delay the growth of oxide films, therefore retard the formation process of nodular spots. This indicates that the microstructure of the initial oxide films has an important influence on the subsequent growth of the oxide films.

关键词： Zircaloy-4 Surface strained layer Nodular corrosion resistance Microstructures

Atom Probe Tomography Study of Fe Segregation at Phase Interface in Zr–2.5Nb Alloy

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Acta Metallurgica Sinica(English Letters) 2019年第10期32卷 1281-1286页

作者： Xue Liang Qiang Li jiao huang mei-Yi Yao Hui Li Qing-Dong Liu Institute of Materials Shanghai University Shanghai 200072 China Laboratory for Microstructures Shanghai University Shanghai 200444 China School of Materials Science and Engineering Inner Mongolia University of Technology Hohhot 010051. China School of Nuclear Science and Engineering Shanghai Jiaotong University Shanghai 200240 China

β-Nb is a typical second phase in Zr-Nb-based alloys used as fuel claddings in water-cooled nuclear reactors. The segregation of alloying element Fe may affect the corrosion resistance of Zr-Nb-based alloys. In this work, the Fe segregation at the interface between β-Nb phase and a-Zr matrix in Zr-2.5Nb alloy was studied using atom probe tomography and focused ion beam. The results suggested that the Fe concentration was much lower than Nb concentration in a-Zr matrix, while Fe selectively segregated at the β-Nb/a-Zr phase interface, leading to a Fe concentration peak at some interfaces. The peak Fe concentration varied from 0.4 to 1.2 at.% and appeared at the position where Zr concentration was approximately equal to Nb concentration. The selective segregation of Fe should be affected by the heat treatment and structure defects induced by cold rolling.

关键词： Zr-Nb alloy β-Nb phase Phase interface Segregation Atom probe tomography

Effects of cluster land reclamation projects on storm surge injiaojiang Estuary,China

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Water Science and Engineering 2017年第1期10卷 59-69页

作者： Zhi-lin Sun Sen-jun huang Jian-ge jiao Hui Nie mei Lu Ocean College Zhejiang UniversityHangzhou 310058China Science and Technology Department Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Zhejiang Province Ocean and Fisheries Bureau Hangzhou 310007China

Variations in coastline geometry caused by coastal engineering affect tides, storm surges, and storm tides. Three cluster land reclamation projects have been planned for construction in the jiaojiang Estuary during the period from 2011 to 2023. They will cause significant changes in coastline geometry. In this study, a surge-tide coupled model was established based on a three-dimensional finite-volume coastal ocean model （FVCOM）. A series of numerical experiments were carried out to investigate the effects of variations in coastline geometry on tides, storm surges, and storm tides. This model was calibrated using data observed at the Haimen and Ruian gauge stations and then used to reproduce the tides, storm surges, and storm tides in the jiaojiang Estuary caused by Typhoon Winnie in 1997. Results show that the high tide level, peak storm surge, and high storm tide level at the Haimen Gauge Station increased along with the completion of reclamation projects, and the maximum increments caused by the third project were 0.13 m, 0.50 m, and 0.43 m, respectively. The envelopes with maximum storm tide levels of 7.0 m and 8.0 m inside the river mouth appeared to move seaward, with the latter shifting 1.8 km, 3.3 km, and 4.4 km due to the first project, second project, and third project, respectively. The results achieved in this study contribute to reducing the effects of, and preventing storm disasters after the land reclamation in the jiaojiang Estuary.

关键词： Cluster land reclamation Coastline geometry variation Storm surge jiaojiang Estuary Typhoon Winnie

Microstructure of Bi-containing zirconium alloys

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Rare Metals 2022年第10期41卷 3566-3573页

作者： Han-Pei Zhao mei-Yi Yao jiao huang Jin-Long Zhang Jian-Chao Peng Bang-Xin Zhou Laboratory for Microstructure Shanghai UniversityShanghai200444China Institute of Materials Shanghai UniversityShanghai200072China

The effect of Bi addition(0.05 wt%-0.50 wt%)on the microstructure of zirconium alloys,including T5(Zr-0.7 S n-1.0 Nb-0.3 Fe-0.1 Cr),S5(Zr-0.8 Sn-0.35 Nb-0.4 Fe-0.1 Cr),Zr-4(Zr-1.5 Sn-0.2 Fe-0.1 Cr) and Zr-1 Nb,was investigated by transmission electron microscopy(TEM),energy-dispersive spectroscopy(EDS) and selected area electron diffraction(SAED).Results show that with the increase in Bi content,h-Zr(Fe,Cr,Nb)2,o-Zr(Fe,Sn,Bi)_(2) and Zr-Fe-Cr-Nb-Sn-Bi second-phase particles(SPPs) precipitate successively in the T5+xBi and S5+xBi alloys;in the Zr-4+xBi alloys,h-Zr(Fe,Cr)2,o-Zr(Fe,Sn,Bi)2,Zr-Fe-Cr-Sn-Bi and Zr-Fe-Cr-Bi SPPs are detected *** as for Zr-1 Nb+xBi alloys,Bi-free SPPs *** addition of Bi promotes the precipitation of SPPs with Sn in the *** concentration of Bi dissolved in α-Zr matrix increases with the decrease in Sn content in the *** reasonable Bi has little influence on the solid solution content of Nb in α-Zr matrix.

关键词： Zirconium alloy Bismuth Second-phase particles Microstructure