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菊甘蓝多糖片的制备工艺及含量测定方法研究

吉林医药学院学报 2024年第1期45卷 33-36页

作者：桑野关皎潘旭朱鹤云冯波吉林医药学院药学院吉林吉林132013

目的制备含量均匀、性状稳定的菊甘蓝多糖片剂,并测定其含量。方法采用单因素试验筛选多糖片制备工艺及最优处方,并应用苯酚硫酸法测定多糖含量。结果最优处方如下:菊芋粗多糖10 g,甘草粗多糖3 g,绞股蓝粗多糖2 g,微晶纤维素4 g,羧甲基... 详细信息

目的制备含量均匀、性状稳定的菊甘蓝多糖片剂,并测定其含量。方法采用单因素试验筛选多糖片制备工艺及最优处方,并应用苯酚硫酸法测定多糖含量。结果最优处方如下:菊芋粗多糖10 g,甘草粗多糖3 g,绞股蓝粗多糖2 g,微晶纤维素4 g,羧甲基淀粉钠1 g,加入1.5%聚乙烯吡咯烷酮适量,湿法制粒,得干颗粒后,加约总量0.2%硬脂酸镁,多糖含量平均值为0.215 g/片。结论所得片剂性状稳定,片重差异、崩解时限、硬度均符合要求,本研究可为菊甘蓝多糖片的开发和工业化生产提供依据。

关键词：菊甘蓝多糖片制备工艺苯酚-硫酸法

超声法与闪式提取法提取刺五加中刺五加苷B的工艺对比研究

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中国饲料 2024年第11期 47-52页

作者：关皎丁思宇季玲玲胡子君王军民朱鹤云韩丽琴吉林医药学院药学院吉林吉林132013 吉林医药学院附属医院吉林吉林132013

本试验采用正交试验优化超声法和闪式提取法提取刺五加中刺五加苷B的提取工艺,并对两种提取方法的最佳工艺进行对比研究。以刺五加苷B的提取率为评价指标,设计L_(9)(3^(4))超声法和闪式提取法的正交试验,以高效液相色谱法测定刺五加苷B... 详细信息

本试验采用正交试验优化超声法和闪式提取法提取刺五加中刺五加苷B的提取工艺,并对两种提取方法的最佳工艺进行对比研究。以刺五加苷B的提取率为评价指标,设计L_(9)(3^(4))超声法和闪式提取法的正交试验,以高效液相色谱法测定刺五加苷B的含量。结果显示:超声法提取率高于闪式提取法,最佳提取工艺为提取溶剂30%乙醇,超声功率200 W,提取时间0.75 h,料液比1:5(g/mL)。本研究可为刺五加在饲料领域的开发和利用提供参考。

关键词：超声法闪式提取法刺五加刺五加苷B 高效液相色谱法

Synthesis of T-Extended Carbazoles via One-Pot C-c Coupling and Chlorination Promoted by FeCl3

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Chinese Journal of Chemistry 2020年第12期38卷 1538-1544页

作者： Yang Qian Jia Shang Zhen-Hua Lyu Xin Huang Ai-jiao guan Li-Jin Xu Han-Yuan Gong Department of Chemistry Renmin University of ChinaZhongguancundajie 59Beijing 100872China College of Chemistry Beijing Normal UniversityXinjiekouwaidajie 19Beijing 100875China Institute of Chemistry Chinese Academy of SciencesZhongguancunbeiyijie 2Beijing 100190China

of main observation and conclusion A facile synthesis,functionalization,and emission property of N-doped carbon-rich halogenated compound 3,6,12,15-tetrachloro-9-phenyl-9H-tetrabenzo[a,c,g#i]carbazole(ClCbz)was ***-effective FeCI3 catalyst serves to break eight C—H bonds of 1,2,3,4,5-pentaphenylpyrrole(1)and subsequently construct two C—C and four C—Cl bonds in one pot with a high yield of up to 75%.

关键词： bonds conclusion facile

The story of a decade:Genomics,functional genomics,and molecular breeding in Brassica napus

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Plant Communications 2024年第4期5卷 94-111页

作者： Jianwei Gu Zhilin guan Yushun jiao Kede Liu Dengfeng Hong National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070HubeiChina College of Life Science and Technology Hubei Engineering UniversityXiaogan 432100 HubeiChina Wuhan Botanical Garden Chinese Academy of SciencesWuhan 430074 HubeiChina Yazhouwan National Laboratory Sanya 572024 HainanChina These authors contributed equally to this article.

Rapeseed(Brassica napus L.)is one of the major global sources of edible vegetable oil and is also used as a feed and pioneer crop and for sightseeing and industrial *** in genome sequencing and molecular marker technology have fueled a boom in functional genomic studies of major agronomic characters such as yield,quality,flowering time,and stress ***,introgression and pyra-miding of key functional genes have greatly accelerated the genetic improvement of important *** we summarize recent progress in rapeseed genomics and genetics,and we discuss effective molecular breeding strategies by exploring thesefindings in *** insights will extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture throughout the world.

关键词： Brassica napus functional genomics genomics molecular breeding agronomic traits

血清人防御素-3、白细胞介素-12与股骨颈骨折患者髋关节置换术后感染的相关性

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中国医师进修杂志 2024年第9期47卷 797-802页

作者：孙铭霞孙艳斌关娇张利静延静蕾白冰承德市中心医院骨科承德067000

目的探讨股骨颈骨折(FNF)患者髋关节置换术后假体周围感染与术前血清人防御素-3(HBd-3)、白细胞介素-12(IL-12)水平的关系。方法采用前瞻性研究的方法,选取2020年4月至2022年4月在承德市中心医院接受髋关节置换术治疗的268例股骨颈骨折... 详细信息

目的探讨股骨颈骨折(FNF)患者髋关节置换术后假体周围感染与术前血清人防御素-3(HBd-3)、白细胞介素-12(IL-12)水平的关系。方法采用前瞻性研究的方法,选取2020年4月至2022年4月在承德市中心医院接受髋关节置换术治疗的268例股骨颈骨折患者,依据术后2周内患者是否发生假体周围感染将其分为感染组与未感染组,比较两组基线资料、术前实验室指标,重点分析术前血清HBd-3、IL-12水平与患者术后假体周围感染的关系。结果268例股骨颈骨折患者髋关节置换术后发生假体周围感染17例,感染率为6.34%(17/268);感染组患者体质量指数、手术时间、术后引流时间、IL-12高于未感染组[(23.75±2.18)kg/m^(2)比(21.86±1.95)kg/m^(2)、(124.82±15.93)min比(116.92±14.75)min、(57.41±7.81)min比(49.65±5.73)min、(64.82±11.59)ng/L比(54.23±9.55)ng/L],术前白蛋白、HBd-3低于未感染组[(32.56±4.63)g/L比(37.25±5.81)g/L、(38.03±6.74)μg/L比(46.84±8.93)μg/L],差异有统计学意义(P1,P0.70,具有一定的预测价值;采用样条函数与Logistic回归结合的限制性立方样条法分析结果显示,HBd-3、IL-12水平与股骨颈骨折患者髋关节置换术后假体周围感染的关联强度呈线性剂量反应关系(P<0.05)。结论术前血清HBd-3、IL-12水平与股骨颈骨折患者髋关节置换术后发生假体周围感染有关,且可作为发生感染的预测指标。

关键词：股骨颈骨折白细胞介素-12 髋关节置换术假体周围感染人防御素-3

Flow Field Characteristics of Multi-Trophic Artificial Reef Based on Computation Fluid Dynamics

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Journal of Ocean University of China 2024年第2期23卷 317-327页

作者： HUANG Junlin LI jiao LI Yan GONG Pihai guan Changtao XIA Xu School of Engineering Ocean University of ChinaQingdao 266100China Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesKey Laboratory of Sustainable Development of Marine FisheriesMinistry of Agriculture and Rural AffairsQingdao Key Laboratory for Marine Fish Breeding and BiotechnologyQingdao 266071China Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266071China

On the basis of computational fluid dynamics,the flow field characteristics of multi-trophic artificial reefs,including the flow field distribution features of a single reef under three different velocities and the effect of spacing between reefs on flow scale and the flow state,were *** indicate upwelling,slow flow,and eddy around a single *** velocity,height,and volume of upwelling in front of a single reef were positively correlated with inflow *** length and volume of slow flow increased with the increase in inflow *** were present both inside and backward,and vorticity was positively correlated with inflow *** between reefs had a minor influence on the maximum velocity and height of *** the increase in space from 0.5 L to 1.5 L(L is the reef lehgth),the length of slow flow in the front and back of the combined reefs increased *** the space was 2.0 L,the length of the slow flow *** four different spaces,eddies were present inside and at the back of each *** maximum vorticity was negatively correlated with space from 0.5 L to 1.5 L,but under 2.0 L space,the maximum vorticity was close to the vorticity of a single reef under the same inflow velocity.

关键词： artificial reef flow field characteristics computation fluid dynamics multi-trophic structure

3-D Tunnel Seismic Advance Prediction Method with Wide Illumination and High-Precision

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Journal of Earth Science 2024年第3期35卷 970-979页

作者： Peng guan Cuifa Shao Yuyong jiao Guohua Zhang Junpeng Zou Fei Tan Faculty of Engineering China University of GeosciencesWuhan 430074China

Tunnel seismic advance prediction can effectively reduce the construction risk during tunnel *** with the 2-D method,the 3-D method is more conducive to describing the spatial characteristics of the geological body by adding the seismic data in the vertical ***,some drawbacks still need improvement in the current 3-D tunnel seismic prediction method.(1)The geometry is complex,which is destructiveness,high cost,and time-consuming,and will delay the tunnel construction schedule.(2)Illumination of the anomalous body is insufficient,and the precision of migration imaging is low.(3)Shot points are far away from the tunnel face,the energy loss at the shot points is more serious.(4)The received signals at the tunnel wall have the surface wave with strong energy when the shot points are placed on the tunnel wall.(5)The geometry is not linear,so the directional filtering method cannot be used to extract the reflection *** overcome the drawbacks of the current prediction method,a new 3-D symmetrical tunnel seismic prediction method is *** geophones are installed on the tunnel wall,two on the left side,two on the right side,and two on the top ***-four shot points are placed on the tunnel face and near both sides of the tunnel wall,twelve shot points on the left side and twelve shot points on the right *** shot points will move along with the forward excavation of the *** wavefield analysis,illumination statistics,and 3-D reverse time migration imaging are used to evaluate the proposed *** result of modeled data indicates that the proposed 3-D geometry has some advantages:(1)the geometry is simple and the geophone installation time is short;(2)it has high illumination energy,wide illumination range,and can improve the prediction distance and imaging accuracy;(3)the proposed 3-D method can better estimate the velocity of surrounding rock and is more conducive to extracting the reflection wave with high resolut

关键词： tunnels excavation geophone shot points migration imaging method engineering ge-ology.

小剂量右美托咪定在急性缺血性脑卒中患者取栓术中的应用效果及对血清S100β蛋白、CCNI蛋白的影响

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中国急救复苏与灾害医学杂志 2024年第1期19卷 42-46页

作者：赵振儒王孟楠关娇王莉萍任建华曾丹承德市中心医院麻醉科河北承德067000 承德市中心医院神经诊断科河北承德067000 承德市中心医院手术室河北承德067000

目的探讨小剂量右美托咪定在急性缺血性脑卒中(AIS)患者机械取栓术中的应用效果及对血清中枢神经特异性蛋白(S100β)及血浆中富含半胱氨酸蛋白61(CCNI)水平的影响。方法选取自2018年1月—2021年12月收治的行介入机械取栓术治疗的AIS患... 详细信息

目的探讨小剂量右美托咪定在急性缺血性脑卒中(AIS)患者机械取栓术中的应用效果及对血清中枢神经特异性蛋白(S100β)及血浆中富含半胱氨酸蛋白61(CCNI)水平的影响。方法选取自2018年1月—2021年12月收治的行介入机械取栓术治疗的AIS患者89例,随机分为三组,对照组、小剂量组、大剂量组。小剂量组(30例)、大剂量组(30例)在麻醉诱导前10 min均静脉泵注右美托咪定1.0μg/(kg·h)后维持剂量分别为0.4、0.8μg/(kg·h),直至气管拔管,对照组(29例)静脉泵注等容量生理盐水。于入室给药前(T0)、麻醉诱导后(T1)、维持剂量持续泵注右美托咪定10 min(T2)、术毕带管恢复自主呼吸(T3)时对三组血清S100β蛋白、CCNI蛋白进行检测,并对比三组术后24 h镇静、NIHSS评分、穿刺-血管再通(PTR)时间、苏醒时间的差异以及躁动、谵妄发生率。结果对照组T1~T3时血清S100β蛋白、CCNI蛋白与T0时的数值相比较差异无统计学意义(P>0.05),小剂量组与大剂量组T1~T3时血清S100β蛋白、CCNI蛋白均明显低于T0时的数值(P0.05);T1~T3时,小剂量组与大剂量组血清S100β蛋白、CCNI蛋白均明显低于对照组,且小剂量组显著低于大剂量组(P0.05)。小剂量组、大剂量组躁动、谵妄的发生率明显低于对照组(P0.05)。大剂量组低血压、心动过缓的发生率明显高于小剂组与对照组(P0.05)。结论在AIS患者机械取栓术中大、小剂量右美托咪定均可降低S100β蛋白、CCNI蛋白水平,而1.0μg/(kg·h)输注,小剂量[0.4μg/(kg·h)]维持麻醉时镇静作用明显,可显著减轻神经功能的损伤,且不增加不良反应。

关键词：急性缺血性脑卒中右美托咪定取栓术中枢神经特异性蛋白富含半胱氨酸蛋白61

Splenectomy does not affect mouse behaviors

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Neural Regeneration Research 2023年第8期18卷 1789-1794页

作者： jiao-Qiong guan Pei-Sen Zhang Wen-Chao Zhang Bing-Qian Zhang Hai-Tao Wu Yue Lan Ti-Fei Yuan Department of Rehabilitation Medicine Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouGuangdong ProvinceChina Shanghai Key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina College of Life Science and Technology Beijing University of Chemical TechnologyBeijingChina Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijingChina Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina guangzhou Key Laboratory of Aging Frailty&Neurorehabilitation GuangzhouGuangdong ProvinceChina

The spleen is critical for *** is the largest immune organ and immune center in the peripheral *** the relationship between behavior and immunity has been demonstrated in physiology and diseases,the role of the spleen in behavior is not *** investigate the effects of the spleen on behaviors,we performed a refined splenectomy procedure on C57BL/6J mice and performed an open field test,circadian rhythm test,elevated plus maze,sucrose preference test,and Barnes maze *** did not induce changes in general locomotion,circadian rhythms,learning and memory,or depression/anxiety-related *** further investigate the effects of spleen on stress susceptibility,we established mouse models of depression through chronic unpredictable mild *** behavioral performances of mice subjected to splenectomy showed no differences from control *** findings suggest that splenectomy does not cause changes in baseline behavioral performance in mice.

关键词： anxiety chronic unpredictable mild stress circadian rhythms depression immunity learning locomotion memory spleen splenectomy