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Lipid droplets in the nervous system:involvement in cell metabolic homeostasis

Neural Regeneration Research 2025年第3期20卷 740-750页

作者： Yuchen Zhang Yiqing Chen Cheng Zhuang Jingxuan Qi Robert Chunhua Zhao jiao wang School of Life Sciences Shanghai UniversityShanghaiChina School of Medicine Shanghai UniversityShanghaiChina Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic MedicinePeking Union Medical CollegeBeijingChina Center of Excellence in Tissue Engineering Chinese Academy of Medical SciencesBeijingChina Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy BeijingChina

Lipid droplets serve as primary storage organelles for neutral lipids in neurons,glial cells,and other cells in the nervous *** droplet formation begins with the synthesis of neutral lipids in the endoplasmic ***,lipid droplets were recognized for their role in maintaining lipid metabolism and energy homeostasis;however,recent research has shown that lipid droplets are highly adaptive organelles with diverse functions in the nervous *** addition to their role in regulating cell metabolism,lipid droplets play a protective role in various cellular stress ***,lipid droplets exhibit specific functions in neurons and glial *** of lipid droplet formation leads to cellular dysfunction,metabolic abnormalities,and nervous system *** review aims to provide an overview of the role of lipid droplets in the nervous system,covering topics such as biogenesis,cellular specificity,and ***,it will explore the association between lipid droplets and neurodegenerative *** the involvement of lipid droplets in cell metabolic homeostasis related to the nervous system is crucial to determine the underlying causes and in exploring potential therapeutic approaches for these diseases.

关键词： Alzheimer's disease lipid droplet biogenesis lipid droplets lipid metabolism nervous system neurodegenerative disorders oxidative stress Parkinson's disease

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Superballistic wavepacket spreading in double kicked rotor

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Science China(Physics,Mechanics & Astronomy) 2016年第8期59卷 9-15页

作者： Ping Fang jiao wang Department of Physics and Institute of Theoretical Physics and Astrophysics Xiamen University

We investigate possible ways in which a quantum wavepacket spreads. We show that in a general class of double kicked rotor system, a wavepacket may undergo superballistic spreading; i.e., its variance increases as the cubic of time. The conditions for the observed superballistic spreading and two related characteristic time scales are studied. Our results suggest that the symmetry of the studied model and whether it is a Kolmogorov-Arnold-Moser system are crucial to its wavepacket spreading behavior. Our study also sheds new light on the exponential wavepacket spreading phenomenon previously observed in the double kicked rotor system.

关键词： quantum chaos quantum transport matter waves semiclassical methods

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A pseudoclassical theory for the wavepacket dynamics of the kicked rotor model

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 34-43页

作者： Zhixing Zou jiao wang Department of Physics and Key Laboratory of Low Dimensional Condensed Matter Physics(Department of Education of Fujian Province) Xiamen UniversityXiamen 361005China Lanzhou Center for Theoretical Physics Lanzhou UniversityLanzhou 730000China

In this study, we propose a generalized pseudoclassical theory for the kicked rotor model in an attempt to discern the footprints of the classical dynamics in the deep quantum regime. Compared with the previous pseudoclassical theory that applies only in the neighborhoods of the lowest two quantum resonances, the proposed theory is applicable in the neighborhoods of all quantum resonances in principle by considering the quantum effect of the free rotation at a quantum resonance. In particular, it is confirmed by simulations that the quantum wavepacket dynamics can be successfully forecasted based on the generalized pseudoclassical dynamics, offering an intriguing example where it is feasible to bridge the dynamics in the deep quantum regime to the classical dynamics. The application of the generalized pseudoclassical theory to the PT-symmetric kicked rotor is also discussed.

关键词： quantum-classical correspondence kicked rotor model pseudoclassical theory wavepacket dynamics

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Tailoring edge and interface states in topological metastructures exhibiting the acoustic valley Hall effect

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Science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 82-92页

作者： jiao wang Yang Huang WeiQiu Chen Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Department of Engineering MechanicsZhejiang UniversityHangzhou 310027China State Key Lab of CAD&CG Zhejiang UniversityHangzhou 310058China Soft Matter Research Center Zhejiang UniversityHangzhou 310027China

In this study, we investigate the acoustic topological insulator or topological metastructure, where an acoustic wave can exist only in an edge or interface state instead of propagating in bulk. Breaking the structural symmetry enables the opening of the Dirac cone in the band structure and the generation of a new band gap, wherein a topological edge or interface state ***, we systematically analyze two types of topological states that stem from the acoustic valley Hall effect mechanism;one type is confined to the boundary, whereas the other type can be observed at the interface between two topologically different structures. Results denote that the selection of different boundaries along with appropriately designed interfaces provides the acoustic waves in the band gap range with abilities of one-way propagation, dual-channel propagation, immunity from backscattering at sharp corners, and/or transition between propagation at interfaces and boundaries. Furthermore, we show that the acoustic wave propagation paths can be tailored in diverse and arbitrary ways by combing the two aforementioned types of topological states.

关键词： acoustic crystals valley Hall effect edge states interface states Dirac cone

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Solute transport characteristics of a deep soil profile in the Loess Plateau,China

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Journal of Arid Land 2018年第4期10卷 628-637页

作者： wang jiao SHAO Ming'an Key Laboratory of Ecosystems Network Observation and Modeling Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100China

Understanding solute transport behaviors of deep soil profile in the Loess Plateau is helpful for ecological construction and agricultural production improvement. In this study, solute transport processes of a deep soil profile were measured by a conservative tracer experiment using 25 undisturbed soil cores （20 cm long and 7 cm diameter for each） continuously sampled from the surface downward to the depth of 500 cm in the Loess Plateau of China. The solute transport breakthrough curves （BTCs） were analyzed in terms of the convection-dispersion equation （CDE） and the mobile-immobile model （MIM）. Average pore-water velocity and dispersion coefficient （or effective dispersion coefficient） were calculated using the CDE and MIM. Basic soil properties and water infiltration parameters were also determined to explore their influence on the solute transport parameters. Both pore-water velocity and dispersion coefficient （or effective dispersion coefficient） generally decreased with increasing depth, and the dispersivity fluctuated along the soil profile. There was a good linear correlation between log-transformed pore-water velocity and dispersion coefficient, with a slope of about 1.0 and an average dispersivity of 0.25 for the entire soil profile. Generally speaking, the soil was more homogeneous along the soil profile. Our results also show that hydrodynamic dispersion is the dominant mechanism of solute transport of loess soils in the study area.

关键词： solute transport loess soil pore-water velocity dispersion coefficient hydraulic conductivity Loess Plateau

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The Material Deformation and Internal Structure Development of Granular Materials under Different Cyclic Loadings

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Computer Modeling in Engineering & Sciences 2022年第2期130卷 653-670页

作者： jiao wang Xihua Chu Jinbao wang School of Mechanics and Engineering Southwest Jiaotong UniversityChengdu610031China Department of Engineering Mechanics Wuhan UniversityWuhan430072China School of Marine Engineering Equipment Zhejiang Ocean UniversityZhoushan326022 China

Common structures in engineering such as slopes,roadbeds,ballasts,etc.,are closely related to granular *** are usually subjected to long-term cyclic *** study mainly focused on the mechanical behaviors of randomly arranged granular materials before they reach a stable state under different cyclic *** variation of the maximum axial strain and the influence of CSR(cyclic stress ratio)were *** energy consumed in each cycle under constant confining stress loading condition is significantly greater than that of the fixed wall loading *** internal deformation evolution of granular materials is studied in *** deformation mode of granular material under cyclic loading at different positions inside the material is different according to the strain *** addition,the strain,force chain structure and contact force magnitude are combined to explore their effects on local deformation of granular materials under cyclic *** the perspective of the deformation form,the material sample can be divided into several regions,and the ability to adjust particle positions determines the deformation mode of different *** changes of local strain with the cyclic loading also reflect the contribution of particle displacements to the evolution *** research will provide insights into the understanding of granular materials behaviors under cyclic loading.

关键词： Granular material DEM cyclic loading mesostructured force chain

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黄芩苷与苦参碱分子间相互作用的量子化学计算与验证

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原子与分子物理学报 2025年第4期42卷 8-14页

作者：董志舒启江田爽王皎侯安国王文苹云南中医药大学中药学院云南省南药可持续利用重点实验室昆明650500

为探究苦参碱能极大增强黄芩苷在水中的溶解度的原因,采用量子计算对二者反应过程及共存状态进行分析,并使用单晶衍射和红外图谱验证计算结果.本研究表明,黄芩苷和苦参碱并非简单的以非共价作用相结合,二者存在质子转移现象,反应生成黄... 详细信息

为探究苦参碱能极大增强黄芩苷在水中的溶解度的原因,采用量子计算对二者反应过程及共存状态进行分析,并使用单晶衍射和红外图谱验证计算结果.本研究表明,黄芩苷和苦参碱并非简单的以非共价作用相结合,二者存在质子转移现象,反应生成黄芩苷阴离子和苦参碱阳离子,以静电作用为主导形成共无定型物,导致水溶性极大增加.

关键词：苦参碱黄芩苷质子转移离子共无定型物

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Direct Imaging of Titania Nanotubes Located in Mouse Neural Stem Cell Nuclei

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Nano Research 2009年第7期2卷 543-552页

作者： Yanli wang Jia wang Xiaoyong Deng jiao wang Haifang wang Minghong Wu Zheng jiao Yuanfang Liu Institute of Nanochemistry and Nanobiology Shanghai UniversityShanghai 200444China Institute of Systems Biology Shanghai UniversityShanghai 200444China Beijing National Laboratory for Molecular Sciences Department of Chemical BiologyCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Titania nanotubes(TiO2-NTs)are a potential drug vehicle for use in *** this end,a preliminary study of the interaction of a model cell with TiO2-NTs has been carried ***2-NTs were first conjugated with a fl uorescent label,fl uorescein isothiocyanate(FITC).FITC-conjugated titania nanotubes(FITC-TiO2-NTs)internalized in mouse neural stem cells(NSCs,line C17.2)can be directly imaged by confocal *** confocal imaging showed that FITC-TiO2-NTs readily entered into the *** co-incubation with cells for 24 h,FITC-TiO2-NTs localized around the cell nucleus without crossing the *** interestingly,the nanotubes passed through the karyotheca entering the cell nucleus after co-incubation for 48 *** force microscopy(AFM)and transmission electron microscopy(TEM)were also employed in tracking the nanotubes in the *** results will be of benefit in future studies of TiO2-NTs for use as a drug vehicle,particularly for DNA-targeting drugs.

关键词： Titania nanotubes mouse neural stem cells nucleus confocal imaging atomic force microscopy

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Conformal minimal two-spheres in Q_n

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Science China Mathematics 2011年第4期54卷 817-830页

作者： jiao XiaoXiang wang Jun School of Mathematics Graduate UniversityChinese Academy of SciencesBeijing 100049China

In this paper we study,using moving frames,conformal minimal two-spheres S2 immersed into a complex hyperquadric Qn equipped with the induced Fubini-Study metric from a complex projective n+1-space CPn+*** associated functions τX and τY are introduced to classify the problem into several *** is proved that τX or τY must be identically zero if f:S2 → Qn is a conformal minimal *** the Gaussian curvature K and the Khler angle θ are constant if the conformal immersion is totally *** is also shown that the conformal minimal immersion is totally geodesic holomorphic or antiholomorphic if K = *** the case K = 4,conformal minimal immersion f:S2 → Q2 with Gaussian curvature K2 must be totally geodesic with(K,θ) ∈ {(2,0),(2,π/2),(2,π)}.

关键词： complex hyperquadric Gaussian curvature Khler angle minimal immersion totally geodesic

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Feedback Mechanism-driven Mutation Reptile Search Algorithm for Optimizing Interpolation Developable Surfaces

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Journal of Bionic Engineering 2024年第1期21卷 527-571页

作者： Gang Hu jiao wang Xiaoni Zhu Muhammad Abbas Department of Applied Mathematics Xi'an University of TechnologyXi'an 710054China School of Mechanical and Precision Instrument Engineering Xi'an University of TechnologyXi'an 710048China Department of Mathematics University of SargodhaSargodha 40100Pakistan

Curvature lines are special and important curves on *** is of great significance to construct developable surface interpolated on curvature lines in engineering *** this paper,the shape optimization of generalized cubic ball developable surface interpolated on the curvature line is studied by using the improved reptile search ***,based on the curvature line of generalized cubic ball curve with shape adjustable,this paper gives the construction method of SGC-Ball developable surface interpolated on the ***,the feedback mechanism,adaptive parameters and mutation strategy are introduced into the reptile search algorithm,and the Feedback mechanism-driven improved reptile search algorithm effectively improves the solving *** IEEE congress on evolutionary computation 2014,2017,2019 and four engineering design problems,the feedback mechanism-driven improved reptile search algorithm is compared with other representative methods,and the result indicates that the solution performance of the feedback mechanism-driven improved reptile search algorithm is *** last,taking the minimum energy as the evaluation index,the shape optimization model of SGC-Ball interpolation developable surface is *** developable surface with the minimum energy is achieved with the help of the feedback mechanism-driven improved reptile search algorithm,and the comparison experiment verifies the superiority of the feedback mechanism-driven improved reptile search algorithm for the shape optimization problem.

关键词： Reptile search algorithm Feedback mechanism Adaptive parameter Mutation strategy SGC-Ball interpolation developable surface Shape optimization

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