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Association of Cytokines with Clinical Indicators in Patients with Drug-Induced Liver Injury

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Biomedical and Environmental Sciences 2024年第5期37卷 494-502页

作者： CAO Wei Hua JIANG Ting Ting SHEN Ge DENG Wen WANG Shi Yu ZHANG Zi Yu LI Xin Xin LU Yao ZHANG Lu LIU Ru Yu CHANG Min WU Shu Ling GAO Yuan jiao HAO Hong Xiao CHEN Xiao Xue HU Lei Ping XU meng jiao YI Wei XIE Yao LI Ming Hui Department of Hepatology Division 2 Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Hepatology Division 2 Peking University Ditan Teaching HospitalBeijing 100015China Department of Gynecology and Obstetrics Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective To explore characteristics of clinical parameters and cytokines in patients with drug-induced liver injury(DILI)caused by different drugs and their correlation with clinical *** The study was conducted on patients who were up to Review of Uncertainties in Confidence Assessment for Medical Tests(RUCAM)scoring criteria and clinically diagnosed with *** on Chinese herbal medicine,cardiovascular drugs,non-steroidal anti-inflammatory drugs(NSAIDs),antiinfective drugs,and other drugs,patients were divided into five *** were measured by Luminex *** characteristics of clinical biochemical indicators and cytokines in DILI patients and their correlation were *** 73 patients were *** among five groups was statistically different(P=0.032).Alanine aminotransferase(ALT)(P=0.033)and aspartate aminotransferase(AST)(P=0.007)in NSAIDs group were higher than those in chinese herbal medicine ***-6(IL-6)and tumor necrosis factor alpha(TNF-α)in patients with Chinese herbal medicine(IL-6:P<0.001;TNF-α:P<0.001)and cardiovascular medicine(IL-6:P=0.020;TNF-α:P=0.001)were lower than those in NSAIDs *** was a positive correlation between ALT(r=0.697,P=0.025),AST(r=0.721,P=0.019),and IL-6 in NSAIDs *** Older age may be more prone to *** with NSAIDs have more severe liver damage in early stages of DILI,TNF-αand IL-6 may partake the inflammatory process of DILI.

关键词： Drug-induced liver injury Cytokines Non-steroidal anti-inflammatory drugs Inflammation

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陕南水稻根际细菌多样性变化趋势

江苏农业学报 2018年第3期34卷 552-558页

作者：王梦姣陕西理工大学陕西省资源生物重点实验室陕西汉中723000 陕西理工大学陕西省食药用菌工程技术研究中心陕西汉中723000 陕西理工大学生物科学与工程学院陕西汉中723000

为研究根际微生物与水稻的互作关系,本研究利用培养法,对陕西南部水稻-油菜轮作制种植方式下的3个采样点(汉滨、城固、宁强)的2个水稻品种(K优082、先丰优901)在3个生长时期(五叶期、分蘖期、孕穗期)的根际细菌进行了分离,并对其多样性... 详细信息

为研究根际微生物与水稻的互作关系,本研究利用培养法,对陕西南部水稻-油菜轮作制种植方式下的3个采样点(汉滨、城固、宁强)的2个水稻品种(K优082、先丰优901)在3个生长时期(五叶期、分蘖期、孕穗期)的根际细菌进行了分离,并对其多样性变化趋势进行分析。结果表明,汉滨和城固地区K优082的根际细菌菌落数大于先丰优901,宁强地区则相反;本研究共分离得到的细菌属于4个门(拟杆菌门、放线菌门、变形菌门和厚壁菌门),其中,厚壁菌门为优势菌种;在所有样本中共分离到26个属的细菌,枯草芽孢杆菌属细菌占总菌数的64.52%以上。

关键词：根际微生物多样性水稻-油菜轮作

PCK Study of Middle School Chemistry Teachers in Yan'an Based on the Core Quality of Chemistry Subject

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Journal of Contemporary Educational Research 2020年第11期4卷 15-19页

作者： Hua Yang meng-jiao Tuo Rui-zhu Xu Shu-jun Hou School of Chemistry and Chemical Engineering Yan'an UniversityYan'an 716000Shaanxi ProvinceChina

The new round of curriculum reform requires the promotion on the development of students'core literacy,and how the core literacy of chemistry can take root in the chemistry classroom is inseparable from the guidance and nurture of teachers in the teaching ***"Professional Standards for Secondary School Teachers"clearly stipulates that pedagogical content knowledge(PCK)is regarded as the professional knowledge of *** is the core content of teachers'professional knowledge and an important guarantee for teachers to carry out teaching ***5 PCK level is not only a direct measure of their teaching achievements,but also an important criterion for guiding novice teachers to become experienced *** research subjects selected for this study are the middle school chemistry teachers in Yan'an *** using the Delphi method to investigate the understanding of Yan'an middle school chemistry teachers on the core literacy of chemistry and to explore the PCK mastery of middle school chemistry teachers at different stages,it serves to deepen the Yan'an middle school chemistry teachers5 own knowledge and learning of PCK while help to promote the improvement of the teaching level and professional development of chemistry teachers in Yan'an middle *** the end of the paper,the relevant suggestions made based on the investigation of the chemistry PCK study of middle school chemistry teachers in Yan'an City on the core literacy of the chemistry subject will improve the overall building level of the middle school chemistiy teachers of Yan'an City.

关键词： Chemistiy subject core literacy Middle school chemistry teacher Pedagogical content knowledge

Zn含量对Mg-Gd-Zn合金显微组织与力学性能的影响

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稀有金属材料与工程 2015年第10期44卷 2429-2434页

作者：孟姣薛烽孙晶晶白晶东南大学江苏南京211189

研究了3种成分的Mg-11Gd-(1,1.5,2)Zn合金的显微组织和力学性能。结果表明,合金的铸态显微组织均由α-Mg基体、(Mg,Zn)3Gd共晶相和14H型LPSO相组成。铸态组织中(Mg,Zn)3Gd相的体积分数随Zn含量的增加而增大,且其热稳定性不断提高。同时... 详细信息

研究了3种成分的Mg-11Gd-(1,1.5,2)Zn合金的显微组织和力学性能。结果表明,合金的铸态显微组织均由α-Mg基体、(Mg,Zn)3Gd共晶相和14H型LPSO相组成。铸态组织中(Mg,Zn)3Gd相的体积分数随Zn含量的增加而增大,且其热稳定性不断提高。同时,合金中LPSO相的体积分数也随Zn含量的增加而逐渐增大。合金在常温时的抗拉强度随着Zn含量的增加而降低,其中Zn含量较少的Mg-11Gd-1Zn合金在T6处理后呈现最高的强度和良好的塑性。当Zn含量较多时,合金T6处理的效果却远低于T5处理。随Zn含量的增加,合金在200℃高温下的抗蠕变性能也略有下降,但3种合金的抗蠕变性能都优于WE54合金。

关键词： Zn Mg-Gd-Zn合金 LPSO

Hopf bifurcation and phase synchronization in memristor-coupled Hindmarsh–Rose and FitzHugh–Nagumo neurons with two time delays

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Chinese Physics B 2023年第3期32卷 594-607页

作者：郭展宏李志军王梦蛟马铭磷 School of Automation and Electronic Information Xiangtan UniversityXiangtan 41110China

A memristor-coupled heterogenous neural network consisting of two-dimensional(2D)FitzHugh–Nagumo(FHN)and Hindmarsh–Rose(HR)neurons with two time delays is *** the time delays as the control parameters,the existence of Hopf bifurcation near the stable equilibrium point in four cases is derived theoretically,and the validity of the Hopf bifurcation condition is verified by numerical *** results show that the two time delays can make the stable equilibrium point unstable,thus leading to periodic oscillations induced by Hopf ***,the time delays in FHN and HR neurons have different effects on the firing activity of neural *** firing patterns,such as quiescent state,chaotic spiking,and periodic spiking can be induced by the time delay in FHN neuron,while the neural network only exhibits quiescent state and periodic spiking with the change of the time delay in HR ***,phase synchronization between the heterogeneous neurons is explored,and the results show that the time delay in HR neurons has a greater effect on blocking the synchronization than the time delay in FHN ***,the theoretical analysis is verified by circuit simulations.

关键词： memristor time delay heterogeneous neurons hopf bifurcation phase synchronization

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粒子群优化极限学习机的短路电流预测技术

电机与控制学报 2022年第1期26卷 68-76页

作者：王梦娇魏新劳哈尔滨理工大学工程电介质及其应用教育部重点实验室黑龙江哈尔滨150080

针对传统极限学习机预测模型精度低和稳定性能差的问题,提出了一种利用粒子群算法优化极限学习机的短路电流峰值预测模型。建立超高压输电线路仿真模型,分析短路故障波形特点,获取全相角短路故障电流历史数据,利用平均相对误差、均方根... 详细信息

针对传统极限学习机预测模型精度低和稳定性能差的问题,提出了一种利用粒子群算法优化极限学习机的短路电流峰值预测模型。建立超高压输电线路仿真模型,分析短路故障波形特点,获取全相角短路故障电流历史数据,利用平均相对误差、均方根误差、灰色绝对关联度三种精度检验法作为粒子群算法的适应度函数,构建粒子群算法与极限学习机算法相结合的电流预测模型。实验结果表明,以灰色绝对关联度作为适应度函数的粒子群优化极限学习机算法,对短路电流峰值预测精度较高、速度较快,当故障点位置未知时,采用粒子群优化极限学习机算法依然可以准确预测短路电流峰值,提升了算法应用的实际意义,为超、特高压线路快速限制、消除短路故障奠定理论基础。

关键词：粒子群算法极限学习机短路电流峰值预测灰色绝对关联度适应度函数

一氧化碳中毒与中毒后迟发性脑病的大脑磁共振成像比较

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中华劳动卫生职业病杂志 2014年第7期32卷 533-536页

作者：郭军孟郊韩彤 300060 天津市环湖医院核磁共振室天津市疾病预防控制中心

目的探讨单纯一氧化碳（CO）中毒和CO中毒后迟发性脑病磁共振（MRI）特点,以及二者脑损伤程度的差异.方法回顾性分析经临床确诊的27例单纯急性CO中毒的患者和35例CO中毒后迟发性脑病的患者的临床和MRI资料,选取10例健康志愿者作为对照... 详细信息

目的探讨单纯一氧化碳（CO）中毒和CO中毒后迟发性脑病磁共振（MRI）特点,以及二者脑损伤程度的差异.方法回顾性分析经临床确诊的27例单纯急性CO中毒的患者和35例CO中毒后迟发性脑病的患者的临床和MRI资料,选取10例健康志愿者作为对照组.所有受试者均行常规MRI及DWI扫描,采用圆形感兴趣区（ROI）分别对称性测量苍白球、侧脑室周围白质、半卵圆中心平均表观弥散系数（ADC）值,并对ADC值进行比较.结果 27例CO中毒患者中,13例CO中毒患者的MRI表现为双侧苍白球对称性异常信号,其中8例为单纯苍白球区受累,5例并发有其他部位受累.8例CO中毒患者的皮质及皮质下白质区受累,4例表现为双侧脑室周围及双侧半卵圆中心弥漫性异常信号.2例CO中毒患者表现为多部位同时受累.35例CO中毒后迟发性脑病患者的MRI表现为脑实质内多个部位对称性脱髓鞘改变,脑组织弥漫性肿胀,33例累及到脑室周围白质及半卵圆中心,23例累及到脑深部的神经核团,3例可见脑皮层受累.CO中毒组和CO中毒后迟发性脑病组脑室周围白质及双侧半卵圆中心的ADC值明显低于正常对照组,且CO中毒后迟发性脑病患者的ADC值明显低于CO中毒患者,差异有统计学意义（P＜0.05）.CO中毒组苍白球区ADC值明显低于正常对照组,差异有统计学意义（P＜0.05）;CO中毒后迟发性脑病患者苍白球区ADC值明显高于和CO中毒组和正常对照组,差异有统计学意义（P＜0.05）.结论常规MRI和ADC值能够从病变累及的范围和从更微观的角度评价CO中毒和CO中毒后迟发性脑病患者的脑组织损伤程度,对治疗方案的选择和预后的评估提供有价值的信息.

关键词：一氧化碳中毒大脑皮质磁共振成像

Effects of periodically varying codes on separation of multisource blended data

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Applied Geophysics 2021年第3期18卷 331-344,432页

作者： jiao meng-Yao Hu Tian-Yue Liu Yang Yu Zhen-Zhen Liang Shang-Lin Liu Li-Chao Ji-Wei School of Earth and Space Sciences Peking UniversityBeijing 100871China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Karamay834000China

Current exploration needs are satisfied by multisource technology,which offers low cost,high efficiency,and high *** delay time,which determines the separation effects of the multisource blended data,is one of the most crucial parameters in the acquisition and separation of multisource *** study uses the deblending method of multisource data based on a periodically varying cosine code and analyses the effects of the two parameters,namely,the period amplitude and period length,used in this method on the separation of the multisource blended ***,the obtained coherence data is used to prove the correlation between the separation of multisource data and the two *** of synthetic and field data are adopted to demonstrate that from a qualitative perspective,increasing the amplitude of the periodic code improves the separation effect within a reasonable delay time *** the period length varies in a suitable range,the secondary noise becomes relatively incoherent,resulting in the separation result with a higher signal-to-noise ratio(SNR).From a quantitative perspective,the significant values(Sig.)of the period amplitude and length on the SNRs are less than 0.05,verifying the correlation between the separation of multisource data and the two parameters.

关键词： multisource technology periodically varying cosine code period amplitude period length correlation

网文为媒：中国核心术语“道”的涵化传播研究

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山西大学学报(哲学社会科学版) 2024年第6期47卷 125-131页

作者：焦朦袁军北京外国语大学国际新闻与传播学院北京外国语大学学术委员会

中国核心术语“道”经历了从精英话语到平民话语的跨文化传播转向。其中，网络文学发挥了重要作用，它借助东方奇幻小说传播“道”的知识观念，衍生趣缘型的“道友”部落，更以支持海外原创的方式实现“道”的再传播。区别于单向、晦涩... 详细信息

中国核心术语“道”经历了从精英话语到平民话语的跨文化传播转向。其中，网络文学发挥了重要作用，它借助东方奇幻小说传播“道”的知识观念，衍生趣缘型的“道友”部落，更以支持海外原创的方式实现“道”的再传播。区别于单向、晦涩、意识形态式的术语传播，网络文学以持续渐进、双向互动的涵化传播方式，将“道”的文化意涵生动触达海外。海外读者也在文化接触、文化适应和文化采借过程中，实现对“道”的深层接受、内化和转化。这种以网文为媒的涵化传播方式为创新中国核心术语跨文化传播路径提供了启示。

关键词：中国核心术语中国网络文学道家思想文化涵化跨文化传播

来源：博看期刊