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Using the modified Delphi method to research the influencing factors of longterm health-related quality of life in patients with unruptured intracranial aneurysms after endovascular treatment

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Chinese Neurosurgical Journal 2020年第2期6卷 70-75页

作者： Xiao-Dong Zhai Chun-Xiu Wang Yong-Jie Ma Jia-Xing Yu Si-Shi Xiang han-Yi jiao Peng Shao Xin Guan Jun Wang Hong-Qi Zhang Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityNo.45 Changchun StreetXicheng DistrictBeijing 100053China China International Neuroscience Institute(China-INI) BeijingChina Department of Evidence-Based Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina

Background:The purpose of this study was to use the modified Delphi method to identify the influencing factors of health-related quality of life(HRQoL)in patients with unruptured intracranial aneurysms(UIAs)after endovascular ***:A modified Delphi method to obtain expert consensus on the content of potential influencing factors of HRQoL in patients with UIAs treated by endovascular intervention was *** research team consists of three neuroradiologists and one epidemiologist from Xuanwu Hospital of Capital Medical *** randomly selected 21 well-known experts in cerebrovascular disease diagnosis and treatment as participating *** importance of the indicator is based on the 5-Likert *** standard deviation(SD),coefficient of variation(CV),mean(x),and minimum and maximum scores of each indicator were *** consistency was described by Kendall coefficient of concordance with a p valuehan 3.5;CV for marital status and gender was higher than *** Kendall coefficient of concordance in the first round was 0.19(p<0.001),and the second round was 0.15(p<0.001).Conclusion:In this study,the factors affecting the recovery of HRQoL after endovascular treatment in patients with UIAs were analyzed by the modified Delphi method,which provided a valuable evidence for the clinical management and daily life guidance for UIAs patients.

关键词： Modified Delphi method Unruptured intracranial aneurysms Health-related quality of life

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创新创业对经济高质量发展的影响及其空间溢出效应:数字化转型的中介作用

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经济体制改革 2023年第6期 33-42页

作者：贾康韩娇华夏新供给经济学研究院北京100044 东北大学工商管理学院辽宁沈阳110819 辽宁科技学院创新创业学院

创新创业是新发展阶段构建新发展格局和实现高质量发展的重要议题。将内涵和外延原有异同的创新与创业的两个概念定义为一个集合概念,进而结合数字化转型中介作用,探讨创新创业促进区域经济高质量发展的效应及其影响机制。考察分析表明... 详细信息

创新创业是新发展阶段构建新发展格局和实现高质量发展的重要议题。将内涵和外延原有异同的创新与创业的两个概念定义为一个集合概念,进而结合数字化转型中介作用,探讨创新创业促进区域经济高质量发展的效应及其影响机制。考察分析表明:创新创业显著促进经济高质量发展;数字化转型在创新创业与经济高质量发展之间存在间接中介效应。采用IRIEC指数、Moran’I指数法和空间杜宾模型衡量创新创业空间效应,发现创新创业不仅会对本地区的经济高质量发展产生显著的正向影响,还对相邻区域的经济高质量发展产生正向的溢出效应。异质性分析发现,东部地区享受到的创新创业释放红利比中西部和东北地区更大。鉴于此,应着力提升区域创新创业能力,发挥数字化转型在创新创业进程中的作用,推进建立创新创业多元协同运行机制,以促进经济高质量发展。

关键词：创新创业数字化转型经济高质量发展空间溢出

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Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice

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Chinese Journal of Integrative Medicine 2024年第7期30卷 608-615页

作者： WEI Ya-ru HOU Yun-long YIN Yu-jie LI Zhen LIU Yi han Ning-xin WANG Zi-xuan LIU Lu WANG Xiao-qi HAO Yuan-jie MA Kun GU jiao-jiao JIA Zhen-hua Graduate School Hebei University of Chinese MedicineShijiazhuang050090China Shijiazhuang Yiling Pharmaceutical New Drug Evaluation Center Shijiazhuang050035China Hebei Institute of Integrated Traditional and Western Medicine Shijiazhuang050035China National Key Laboratory for Innovation and Transformation of Luobing Theory Shijiazhuang050035China Department of Cardiology Hebei Yiling HospitalShijiazhuang050091China Graduate School Hebei Medical UniversityShijiazhuang050017China

Objective To investigate the potential role of Tongxinluo(TXL)in attenuating myocardial fibrosis after myocardial ischemia-reperfusion injury(MIRI)in *** A MIRI mouse model was established by left anterior descending coronary artery ligation for 45 *** to a random number table,66 mice were randomly divided into 6 groups(n=11 per group):the sham group,the model group,the LY-294002 group,the TXL group,the TXL+LY-294002 group and the benazepril(BNPL)*** day after modeling,TXL and BNPL were administered by *** injection of LY-294002 was performed twice a week for 4 consecutive *** was used to measure cardiac function in *** staining was used to evaluate the degree of myocardial fibrosis in *** and quantitative analysis of endothelial mesenchymal transition(EndMT)after MIRI was performed by immunohistochemistry,immunofluorescence staining and flow cytometry,*** protein expressions of platelet endothelial cell adhesion molecule-1(CD31),α-smoth muscle actin(α-SMA),phosphatidylinositol-3-kinase(PI3K)and phospho protein kinase B(p-AKT)were assessed using Western *** TXL improved cardiac function in MIRI mice,reduced the degree of myocardial fibrosis,increased the expression of CD31 and inhibited the expression ofα-SMA,thus inhibited the occurrence of EndMT(P0.05).In addition,the use of the PI3K/AKT pathway-specific inhibitor LY-294002 to block this pathway and combination with TXL intervention,eliminated the protective effect of TXL,further supporting the protective effect of *** TXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice.

关键词： myocardial fibrosis endothelial mesenchymal transition myocardial ischemia-reperfusion injury phosphatidylinositol-3-kinase/protein kinase B(PI3K/AKT)pathway

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Aerobic respiration Lactococcus lactis ameliorate Salmonella induced infection and intestinal dysfunctions by oxygen-scavenging and maintaining immune balance and regulating intestinal microbiota

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Food Science and Human Wellness 2024年

作者： Yulong Zhang han Yang Zhiliang Cheng Hui Ha Fei Liu Yuehua jiao Key Laboratory of Dairy Science， Ministry of Education， Food College， Northeast Agricultural University Center of Drug Safety Evaluation， Heilongjiang University of Chinese Medicine

Salmonella grows better under aerobic conditions as a facultative anaerobic foodborne pathogenic bacteria. The oxygen-scavenging activity of Lactococcus lactis in the intestinal tract is a promising strategy for preventing Salmonella infection. In this study， the aerobic respiration requirement and preventive mechanism of Lactococcus lactis subsp. lactis (L. lactis) KLDS 4.0325 in murine models infected by Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) SL1344 were investigated. Results indicate that L. lactis KLDS 4.0325 is capable of aerobic respiratory metabolism in the host intestine when exogenous heme exists， and decrease intestinal oxygen concentration， which in turn trigger autophagy of intestinal cells to reduce S. Typhimurium load， improve gut microbiota composition， alleviate intestinal barrier injury and inflammation response. These results suggest that aerobic respiration L. lactis KLDS 4.0325 can prevent S. Typhimurium infection in a new way in which by restoring intestinal cell hypoxia， maintaining immune balance and regulating intestinal flora.

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Resilience and response:Unveiling the impacts of extreme droughts on forests through integrated dendrochronological and remote sensing analyses

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Forest Ecosystems 2024年第4期11卷 491-501页

作者： han Shi Xi Peng Yong-jiao Zhou Ai-Ying Wang Xue-Kai Sun Na Li Quan-Sheng Bao Gude Buri Guang-You Hao CAS Key Laboratory of Forest Ecology and Silviculture Institute of Applied EcologyChinese Academy of SciencesShenyang110016China Daqinggou Ecological Research Station Institute of Applied EcologyChinese Academy of SciencesShenyang110016China University of Chinese Academy of Sciences Beijing100049China School of Life Science and Engineering Shenyang UniversityShenyang110044China Wudantala Forestry Forestry and Grassland Administration of Horqin Northeast CountyTongliao028100China

Extreme droughts are anticipated to have detrimental impacts on forest ecosystems,especially in water-limited regions,due to the influence of climate ***,considerable uncertainty remains regarding the patterns in species-specific responses to extreme ***,we conducted a study integrating dendrochronology and remote sensing methods to investigate the mosaic-distributed maple-oak(native)natural forests and poplar plantations(introduced)in the Horqin Sandy Land,Northeast *** assessed the impacts of extreme droughts on tree performances by measuring interannual variations in radial growth and vegetation *** results showed that precipitation and self-calibrated palmer drought severity index(scPDSI)are the major factors influencing tree-ring width index(RWI)and normalized difference vegetation index(NDVI).The severe droughts between 2000 and 2004 resulted in reduced RWI in the three studied tree species as well as led to NDVI reductions in both the maple-oak natural forests and the poplar *** RWI reached the nadir during the2000-2004 severe droughts and remained at low levels two years after the severe drought,creating a legacy *** contrast to the lack of significant correlation between RWI and scPDSI,NDVI exhibited a significant positive correlation with scPDSI indicating the greater sensitivity of canopy performance to droughts than radial ***,interspecific differences in RWI and NDVI responses were observed,with the fast-growing poplar species experiencing a more significant RWI decrease and more negative NDVI anomaly during severe droughts than native species,highlighting the species-specific trade-offs between drought resilience and growth *** study emphasizes the importance of combining tree-level radial growth with landscape-scale canopy remote sensing to understand forest resilience and *** study improves our understanding of forest responses to extreme drought and highlights species di

关键词： Introduced tree species Native tree species NDVI Severe drought Tree-ring width

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金沙江干热河谷不同植被坡面土壤水分时空分布特征

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干旱区地理 2019年第1期42卷 121-129页

作者：韩姣姣段旭赵洋毅西南林业大学生态与水土保持学院云南昆明650224 国家林业局云南玉溪森林生态系统定位观测研究站云南昆明650224

于2016年7～12月和2017年4月的旱、雨季期间,以金沙江干热河谷苴那小流域内的银合欢(Leucaena Benth)林地、车桑子(Dodonaea viscosa)灌丛地和扭黄茅(Heteropogon contortus)草地为研究对象,通过网格法和土钻法采集并测定了(0～100 cm)... 详细信息

于2016年7～12月和2017年4月的旱、雨季期间,以金沙江干热河谷苴那小流域内的银合欢(Leucaena Benth)林地、车桑子(Dodonaea viscosa)灌丛地和扭黄茅(Heteropogon contortus)草地为研究对象,通过网格法和土钻法采集并测定了(0～100 cm)土层的土壤含水量,应用经典统计法和地统计学方法分析该区域不同林草植被下坡面土壤水分的动态变化特征。结果表明:(1)研究区土壤含水量总体较低,雨季显著大于旱季,旱、雨季均表现为灌丛地>草地>林地,呈中度至强度变异(0. 07～0. 28之间)。(2)不同林草植被下旱、雨季土壤水分具有相似的空间自相关性,自相关系数均由正向负转变,但由正向负转变的滞后距离有所不同,且雨季大于旱季,呈中等或强等空间自相关性。(3)不同林草植被下的土壤水分空间结构不同,林地、灌丛地和草地旱雨季最佳拟合模型均为球状模型;相同林草植被下各土层旱、雨季土壤水分的空间分布特征相似,但旱季的分布格局差异更显著,不同林草植被下深层土壤水分分布比表层土壤水分的分布更为复杂,土壤水分呈明显的斑块或条带状分布,含水量高值区和低值区位置不固定。总之不同林草植被类型会改变局部地段土壤水分空间分布,降雨会加强这种差异的趋势,但土壤水分仍具一定空间连续性。

关键词：干热河谷土壤水分时空分布植被地统计学

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Exploring the Lagged Correlation Between Baidu Index and Influenza-Like Illness-China,2014-2019

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China CDC weekly 2024年第26期6卷 629-634页

作者： Xuan han jiao Yang Yan Luo Dazhu Huo Xuya Yu Xuancheng Hu Ling Xin Liuyang Yang Hualei Xin Ting Zhang Zhongjie Li Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijingChina School of Health Policy and Management Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Department of management science and information system Faculty of Management and EconomicsKunming University of Science and TechnologyKunming CityYunnan ProvinceChina

Introduction:This study investigated the lagged correlation between Baidu Index for influenza-related keywords and influenza-like illness percentage(ILI%)across regions in *** aim is to establish a scientific foundation for utilizing Baidu Index as an early warning tool for influenza-like illness ***:In this study,data on ILI%and Baidu Index were collected from 30 provincial-level administrative divisions(PLADs)spanning April 2014 to March *** Baidu Index was categorized into Overall Index,Ordinary Index,Prevention Index,Symptom Index,and Treatment Index based on search query *** lagged correlation between the Baidu Index and ILI%was examined through the cross-correlation function(CCF)***:Correlating the Baidu Overall Index of 30 PLADs with ILI%revealed CCF values ranging from 0.46 to 0.86,with a median lag of 0.5 *** analysis indicated that the Prevention Index and Symptom Index exhibited quicker responses to ILI%,with median lags of−9 and−0.5 days,respectively,compared to 0 and 3 days for the Ordinary and Treatment *** median lag days between the Baidu Index and the ILI%were earlier in the northern PLADs compared to the southern ***:The Prevention and Symptom Indexes show promising predictive capabilities for influenzalike illness epidemics.

关键词： utilizing illness Baidu

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铝合金等离子-MIG复合焊接电弧行为

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焊接学报 2022年第2期43卷 45-49,I0005页

作者：韩蛟韩永全洪海涛王学龙内蒙古工业大学教育部先进轻金属材料开发与加工防护工程研究中心呼和浩特010051

试验发现铝合金等离子-MIG复合焊中,等离子弧焊接电流为130 A,MIG焊接电流为180 A(基值电流95 A)时,基值时期的MIG电弧在等离子弧附近燃弧阻抗小,复合焊中MIG电弧电压在脉冲基值时期低于单独MIG焊,电荷流效应使MIG电弧在基值时期偏向等... 详细信息

试验发现铝合金等离子-MIG复合焊中,等离子弧焊接电流为130 A,MIG焊接电流为180 A(基值电流95 A)时,基值时期的MIG电弧在等离子弧附近燃弧阻抗小,复合焊中MIG电弧电压在脉冲基值时期低于单独MIG焊,电荷流效应使MIG电弧在基值时期偏向等离子弧,偏向等离子弧方向的MIG电弧主要电离介质为氩气.当MIG焊接电流增加到240 A(基值电流122 A)后,以上现象消失.由于焊接电弧存在热惯性,当MIG电弧在基值时期偏向等离子弧时,在脉冲电流上升阶段,以及电流刚达到峰值时,MIG电弧仍会偏向等离子弧,此阶段复合焊中MIG电弧电压高于单独MIG焊.当复合焊中存在MIG电弧偏向等离子弧燃弧的现象时,MIG电弧稳定性有所下降,随着MIG焊接电流的增加,电弧稳定性增加.

关键词：复合焊接等离子-MIG复合焊接电弧行为特征粒子

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基于光谱诊断的VPPA-MIG复合电弧耦合机理分析

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焊接学报 2023年第11期44卷 104-109,I0008,I0009页

作者：韩蛟韩永全洪海涛孙振邦内蒙古工业大学教育部“先进轻金属材料开发与加工防护”工程研究中心呼和浩特010051

铝合金变极性等离子弧(variable polarity plasma arc,VPPA)-MIG复合焊中,VPPA焊接电流为130 A,MIG焊接电流200 A时,MIG电弧等离子体在电流基值期间偏向正极性(钨极接负)阶段的VPPA等离子体并与之相连,并未与反极性阶段(钨极接正)的VPP... 详细信息

铝合金变极性等离子弧(variable polarity plasma arc,VPPA)-MIG复合焊中,VPPA焊接电流为130 A,MIG焊接电流200 A时,MIG电弧等离子体在电流基值期间偏向正极性(钨极接负)阶段的VPPA等离子体并与之相连,并未与反极性阶段(钨极接正)的VPPA等离子体产生连接,且基值阶段的MIG电弧电压在VPPA正极性时更低.为了阐明上述行为机理,对复合电弧进行了光谱诊断.基于Boltzmann图解法和Stark展宽法计算了VPPA-MIG复合电弧位于试板上方2.5 mm处,VPPA区,耦合区及MIG区中心位置的平均温度和电子密度,证明了上述位置等离子体的平均状态处于局部热力学平衡状态.基于发射系数与等离子体温度的关系,利用Ar794.8 nm窄带滤波结合高速摄像的方法,发现VPPA在反极性期间的高温区面积大于其在正极性期间的高温区面积.而且VPPA中的Al 396.1 nm谱线在反极性期间,辐射强度更高,范围更广.由此证明了复合焊中基值阶段的MIG电弧电压的降低,主要来自于阴极压降而非弧柱压降.

关键词： VPPA-MIG复合焊接光谱诊断局部热力学平衡状态电弧耦合机理

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Synthesis of ordered mesoporous crystalline boron phosphate scaffold with double diamond surface structure

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Science China Chemistry 2024年

作者： Chao Wang Wen-Duo Lu jiao Wang Shun-Ai Che An-Hui Lu Lu han School of Chemical Science and Engineering Tongji University State Key Laboratory of Fine Chemicals Liaoning Key Laboratory for Catalytic Conversion of Carbon ResourcesSchool of Chemical Engineering Dalian University of Technology School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

Ordered mesoporous materials have received great attention due to their well-defined pore structures and potential applications in catalysis, adsorption, separation, drug delivery, etc. Although various compositions of mesoporous solids have been successfully prepared, the preparation of crystalline non-metallic oxyacid salts with ordered mesoporosity remains a major challenge. Herein, we report the synthesis of a mesoporous solid acid crystalline boron phosphate（BPO4） catalyst with a bicontinuous shifted double diamond（SDD） hyperbolic surface structure. The BPO4scaffold was obtained by synergistic selfassembly in a mixed solvent of water and tetrahydrofuran using the diblock copolymer poly（ethylene oxide）-block-polystyrene as template and phosphoric acid and orthoboric acid as inorganic sources. The structure consists of two sets of diamond networks adjacent to each other with a mesostructural scale tetragonal symmetry（space group I41/amd） with unit cell parameters of a =80 nm and c = 113 nm, which affords the scaffold a specific surface area of 44 m2/g. As a solid acid catalytic material, the SDD BPO4scaffold exhibited excellent catalytic activity at room temperature with a conversion of furfural to 2-（dimethoxymethyl）furan over 70% and can be reused after recovery without serious loss of activity. In the propane oxidative dehydrogenation reaction, SDD BPO4demonstrated high olefin productivity and selectivity while maintaining high reaction rate. This study provides ideas for the preparation of ordered mesoporous crystalline catalytic materials and demonstrates their potential for practical applications.

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