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Heart Failure-Like Reaction Is Likely Involved in the Feeding Behaviour of Blood-Sucking Leeches

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Advances in Bioscience and Biotechnology 2024年第1期15卷 52-69页

作者： Li Yang jiao Shu Xiao Wang Wei yu Debin Wang Zichao Liu Bin Wang College of Pharmacy Dali University Dali China ERC of Novel Livestock & Poultry Vaccine & Crucial Industrial Tech of yunnan DOE Kunming University Kunming China Department of Pharmacy 920th Hospital of Joint Logistics Support Force PLA Kunming China

Medicinal leeches have been utilized in therapy for thousands of years. However, the adaptation physiology between leeches and hosts is not fully understand. To disclose the molecular mechanisms of adaptation between leech and host, the body transcriptomes of hunger and fed blood-sucking Poecilobdella javanica, Haemadipsa cavatuses, and Hirudo nipponia leeches were obtained by RNA sequencing, after comparison, a stratified unigenes group was obtained, which closely correlated to body distension. In the group, Rfamide receptor decreased significantly (P < 0.05) while serotonin receptor increased significantly (P < 0.05). Moreover, four KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways, including cardiac muscle contraction, complement and coagulation cascades, renin-angiotensin system, and hypertrophic cardiomyopathy were significantly enriched. The unigenes annotation, neuroregulators correlation analysis and induced function of the KEGG pathways, were consistently supported the same result as: vasoconstriction and systole reaction enhance in hunger leeches and vice versa vasodilation and diastole increase in fed leeches, meanwhile, Interspecific comparison and correlative analyses of physiological function showed that the strongest reaction of induced heart failure from four KEGG occur in strongest reaction of systole in hungry P. javanica and in strongest reaction of diastole in fed H. nipponia. Overall, heart failure is likely a physiological function involved in feeding behaviour.

关键词： Blood-Sucking Leeches Transcriptomic Analysis Heart Failure Feeding Behaviour

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铁路矮塔斜拉桥W形腹板箱梁力学性能分析

铁道标准设计 2024年第5期68卷 68-74页

作者：余鹏焦亚萌中铁工程设计咨询集团有限公司北京100055

W形腹板箱梁具有典型桁式体系受力特征,更符合单索面斜拉桥的受力要求,目前已在公路桥中推广应用。为指导铁路桥相关设计,通过采用有限元软件建立计算模型,对某铁路矮塔斜拉桥W形腹板箱梁设计开展系统分析,研究不同设计参数对箱梁各板... 详细信息

W形腹板箱梁具有典型桁式体系受力特征,更符合单索面斜拉桥的受力要求,目前已在公路桥中推广应用。为指导铁路桥相关设计,通过采用有限元软件建立计算模型,对某铁路矮塔斜拉桥W形腹板箱梁设计开展系统分析,研究不同设计参数对箱梁各板件内力的影响、荷载作用下箱梁截面横向受力性能、以及箱梁截面剪力滞效应。研究结果表明,同梁高、不同斜腹板倾角的铁路W形截面顶板、内腹板均受拉,底板与外腹板均受压;随着边斜腹板倾角减小和内腹板倾角增大,顶板、外腹板轴力变大,内腹板轴力减小,底板轴力则基本不变;根据计算分析得到不同位置处的W形截面在铁路荷载作用下,预应力筋合理的布置方式;剪力滞效应方面,荷载作用下,支点及拉索附近的剪力滞效应较为明显,剪力滞系数约为1.1。通过研究,对铁路荷载作用下该种新型截面形式有了系统全面的认识,合理选择截面参数的同时应考虑剪力滞效应以提高结构经济性。

关键词：铁路桥矮塔斜拉桥 W形腹板箱梁力学性能参数分析剪力滞效应

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黄河内蒙段开河期细菌群落结构特征研究

中国环境科学 2024年第3期44卷 1487-1496页

作者：史玉娇李文宝郭鑫内蒙古农业大学水资源利用与保护自治区重点实验室内蒙古呼和浩特010018 黄河流域内蒙段水资源与水环境综合治理协同创新中心内蒙古呼和浩特010018

为探索黄河内蒙段开河初期水-土介质中细菌群落组成情况及生态网络结构,于2021年4月中旬进行取样,共获得黄河水样6个和土样4个.利用16S rRNA基因高通量测序方法对水、土样品进行测定,并从菌门及菌属水平对二者的细菌群落组成进行了分析... 详细信息

为探索黄河内蒙段开河初期水-土介质中细菌群落组成情况及生态网络结构,于2021年4月中旬进行取样,共获得黄河水样6个和土样4个.利用16S rRNA基因高通量测序方法对水、土样品进行测定,并从菌门及菌属水平对二者的细菌群落组成进行了分析.结果显示:河漫滩土样细菌群落结构的分布较水样更为分散,且土样中细菌群落丰富度、均匀度及多样性均高于水体,二者多样性存在显著的组间差异;在菌门水平上,变形菌门、放线菌门和酸杆菌门等是构成水-土样品的优势细菌门类,其中变形菌门在河水中相对丰度均值约为36.57%,在土样中则下降到25.39%,而酸杆菌门主要存在土样中,相对丰度约为14.17%;在菌属水平上, hgcI_clade(6.19%~12.75%)、CL500-29_marine_group(2.97%~5.05%)和Acinetobacter(0.74%~12.24%)是水体中的优势菌属,而norank_f__norank_o__norank_c__KD4-96(1.95%~4.91%)、 norank_f__norank_o__Vicinamibacterales(2.35%~4.67%)和norank_f__Gemmatimonadaceae (2.20%~4.73%)是土样中的优势菌属;不同菌属对水-土细菌群落结构的响应并不一致,其中分别归属于酸杆菌门和芽单胞菌门的norank_f__norank_o__Vicinamibacterales及norank_f__Gemmatimonadaceae等是联系水-土细菌群落的主要菌属,而归属于放线菌门的hgcI_clade和CL500-29_marine_group等是造成水、土优势菌门存在差异的主要菌属;虽然土样较水样拥有更大的生态网络结构,且Delftia、Candidatus_Methylopumilus、Arthrobacter和Rb41等是维持黄河内蒙段水、土介质生态网络结构的关键菌属,但相较于土样网络结构,水体网络结构中不同模块关键菌门及菌属间的生态功能较为一致.

关键词：细菌群落水土介质网络结构开河期黄河内蒙段

Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： yu-Cong Wang Xin-Yang Jin Zheng Lei Xiao-jiao Liu yu Liu Bang-Guo Zhang Jian Gong Lie-Tao Wang Lv-yuan Shi Ding-yuan Wan Xin Fu Lu-Ping Wang Ai-Jia Ma Yi-Song Cheng Jing Yang Min He Xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang Qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is unknown.This study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.AIM To assess the incidence of GI symptoms associated with heatstroke and its impact on outcomes.METHODS Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 centres.Patient history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or death.GI symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were recorded.The characteristics of patients with heatstroke concomitant with GI symptoms were described.Multivariable regression analyses were performed to determine significant predictors of GI symptoms.RESULTS A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one symptom.Patients with GI symptoms had a significantly higher ICU stay compared with those without.The mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI symptom.Multivariable logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI symptoms.CONCLUSION The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea

数据要素赋能内外贸一体化:内在机理与实践进路

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价格月刊 2024年第5期 13-20页

作者：张姣玉中央民族大学经济学院北京100081

内外贸一体化是数字时代下流通领域实践探索的前沿方向。数据要素作为动力引擎,为内外贸一体化提供全新的赋能路径。数据要素赋能内外贸一体化的内在机理分别是通过优化要素流动,促进内外贸市场资源共享;通过加快联动管理,深化内外贸流... 详细信息

内外贸一体化是数字时代下流通领域实践探索的前沿方向。数据要素作为动力引擎,为内外贸一体化提供全新的赋能路径。数据要素赋能内外贸一体化的内在机理分别是通过优化要素流动,促进内外贸市场资源共享;通过加快联动管理,深化内外贸流通体制改革;通过提高流通算力,推进内外贸流通渠道衔接;通过升级生产技术,加强内外贸企业供给创新。赋能进程也存在一些现实困境,如国际贸易保护主义抬头与国内需求疲软、内外贸税收政策与结算模式仍存在差异、内外贸标准规则认证与监管体系有差别、内外贸业务模式与市场开拓渠道不同等。相应地,数据要素赋能内外贸一体化的实践进路体现为新业态新模式激活国内需求市场、提升对外开放水平和供应链韧性、制定统一的内外贸财政金融政策、推进内外贸行政联动管理数字化和促进内外贸企业内部建设智能化。

关键词：数据要素内外贸一体化市场资源共享流通体制改革企业供给创新

Dimethyl Sulfoxide/Visible-Light Comediated Chemoselective C-S Bond Formation Between Tryptophans and Thiophenols Enables Site-Selective Functionalization of Peptides

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CCS Chemistry 2024年第6期6卷 1547-1556页

作者： Guangjun Bao Peng Wang Jingyue Li Xinyi Song Tingli yu jiao Zhang Yiping Li Zeyuan He Ruiyao E Xiaokang Miao Junqiu Xie Jingman Ni Rui Wang Wangsheng Sun Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000 State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

Late-stage peptide modification showcases a huge potential for the construction of peptide libraries,and the investigation of structure-activity relationships.Herein we report a dimethyl sulfoxide/visible light comediated chemoselective modification of tryptophan residue by forging the C-S structure using thiophenols irradiated with blue light-emitting diodes at room temperature.This method shows excellent chemoselectivity toward the C-2 position of the tryptophan residue and good compatibility with diverse thiophenol derivatives bearing various functional groups.Both protected oligopeptides and unmasked bioactive peptides smoothly underwent site-selective modification,furnishing the corresponding products.Above all,this study provides a new competent toolkit for late-stage peptide modification,labelling,and peptide-drug conjugation and provides a clue for protein bioconjugation.

关键词： peptide modification late-stage diversification photocatalysis tryptophan thiophenol

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废旧GFRP回收及其增强沥青性能

北京工业大学学报 2024年第4期50卷 443-452页

作者：余森开林娇王大为中铁十六局集团路桥工程有限公司北京101500 哈尔滨工业大学交通科学与工程学院哈尔滨150090

玻璃纤维增强复合材料(glass fiber reinforced polymer,GFRP)因其优异的力学性能和耐腐蚀性而广泛应用于航空、船舶和风力发电等领域。GFRP的广泛使用导致大量废弃物的产生,对环境造成了巨大的危害,因此废旧GFRP的回收处理问题备受关... 详细信息

玻璃纤维增强复合材料(glass fiber reinforced polymer,GFRP)因其优异的力学性能和耐腐蚀性而广泛应用于航空、船舶和风力发电等领域。GFRP的广泛使用导致大量废弃物的产生,对环境造成了巨大的危害,因此废旧GFRP的回收处理问题备受关注。将废旧环氧基GFRP和聚氨酯基GFRP破碎粉末(直径<0.075 mm)作为沥青增强材料,研究了其对沥青基本性能的影响,并对比了硅烷偶联剂对增强作用的影响。结果表明,2种GFRP粉末对沥青的增强作用并不明显,而使用硅烷偶联剂对GFRP粉末进行表面处理后,能够显著改善GFRP粉末与沥青间相互作用,并提高沥青的流变性能和表面自由能,降低玻璃化转变温度,其中硅烷偶联剂对环氧基GFRP的改善效果优于聚氨酯基GFRP。该文为废弃GFRP提供了一种相对有效且环保的物理回收方法,并为纤维增强复合材料(fiber reinforced polymer,FRP)的回收利用提供了新思路。

关键词：玻璃纤维增强复合材料(GFRP) 固体废弃物回收利用沥青增强作用,表面处理

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大尺寸三维超声振动系统的智能优化设计

物理学报 2024年第8期73卷 181-194页

作者：林基艳孙姣夏林书玉榆林学院榆林市大数据与智能决策重点实验室榆林719000 陕西师范大学陕西省超声学重点实验室西安710119

对大尺寸三维超声换能器系统的耦合振动进行有效控制,优化系统的性能,一直都是功率超声领域亟待解决的难题.研究发现,一些声子晶体槽、孔结构可以对大尺寸换能器系统的横向振动进行抑制,提高系统振幅分布均匀度,且可以通过改变声子晶体... 详细信息

对大尺寸三维超声换能器系统的耦合振动进行有效控制,优化系统的性能,一直都是功率超声领域亟待解决的难题.研究发现,一些声子晶体槽、孔结构可以对大尺寸换能器系统的横向振动进行抑制,提高系统振幅分布均匀度,且可以通过改变声子晶体结构的配置参数人为地实现对大尺寸三维超声振动系统性能的调控.但过多的设计参数必然会增加系统设计的复杂度,且目前大尺寸三维超声换能器系统的优化设计依赖于经验试错法,设计效率和成功率较低,性能也无法保证.研究引入同质位错、点缺陷结构对大尺寸三维超声振动系统进行优化设计,并利用数据分析技术评价了同质位错、点缺陷结构的配置对系统辐射面的纵向位移振幅、振幅分布均匀度、辐射声功率、工作带宽等的影响规律,建立了同质位错结构、近周期缺陷结构的结构参数——大尺寸超声换能器系统性能的预测模型,实现了对大尺寸功率超声换能器系统的智能设计,提高了设计效率和成功率,降低了设计成本.

关键词：耦合振动大尺寸三维超声振动系统同质位错点缺陷智能化设计

Effectiveness and safety of combined nimotuzumab and S-1 chemotherapy with concurrent radiotherapy for locally advanced esophageal cancer in malnourished and elderly patients:A prospective phase Ⅱ study

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Chinese Journal of Cancer Research 2024年第3期36卷 270-281页

作者： Guojie Feng jiao Li Nuo yu Ziyu Zheng Xiongtao Yang Lei Deng Tao Zhang Wenqing Wang Wenyang Liu Jianyang Wang Qinfu Feng Jima Lyu Zefen Xiao Zongmei Zhou Nan Bi Jianjun Qin Xin Wang Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective: Definitive chemoradiotherapy(dCRT) is the standard treatment for unresectable locally advanced esophageal cancer. However, this treatment is associated with substantial toxicity, and most malnourished or elderly patients are unable to complete this therapy. Therefore, there is a need for a more suitable radiotherapy combination regimen for this population. This study was aimed to evaluate the efficacy and safety of a combination regimen comprising chemotherapy with nimotuzumab and S-1 and concurrent radiotherapy for patients with fragile locally advanced esophageal cancer with a high Nutritional Risk Screening 2002(NRS-2002) score.Methods: Eligible patients with unresectable esophageal carcinoma who had an NRS-2002 score of 2 or higher were enrolled. They were treated with S-1 and nimotuzumab with concurrent radiotherapy, followed by surgery or definitive radiotherapy. The primary endpoint was the locoregional control(LRC) rate.Results: A total of 55 patients who met the study criteria were enrolled. After completion of treatment, surgery was performed in 15 patients and radiotherapy was continued in 40 patients. The median follow-up period was 33.3[95% confidence interval(95% CI), 31.4-35.1)] months. The LRC rate was 77.2%(95% CI, 66.6%-89.4%) at 1 year in the entire population. The overall survival(OS) rate and event-free survival(EFS) rate were 57.5% and 51.5% at 3 years, respectively. Surgery was associated with better LRC [hazard ratio(HR)=0.16; 95% CI,0.04-0.70; P=0.015], OS(HR=0.19; 95% CI, 0.04-0.80; P=0.024), and EFS(HR=0.25; 95% CI, 0.08-0.75;P=0.013). Most adverse events were of grade 1 or 2, and no severe adverse events occurred.Conclusions: For malnourished or elderly patients with locally advanced esophageal cancer, radiotherapy combined with nimotuzumab and S-1 is effective and has a good safety profile.

关键词： Esophageal carcinoma squamous cell carcinoma nutritional risk score nimotuzumab S-1 definitive chemoradiotherapy