检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

GPU核函数细化研究

计算机工程 2010年第18期36卷 10-12页

作者：焦良葆陈瑞南京工程学院通信工程学院南京211167

GPU上的并行算法效率依赖于核函数在流多处理器上的平均运行效率,基于此,分析GPU核的执行方式,以及网格、线程块和线程之间的关系,采用细化核函数的方法将光线跟踪算法进行细化。实验结果证明,核的大小设置和分布方向影响了线程块内部... 详细信息

GPU上的并行算法效率依赖于核函数在流多处理器上的平均运行效率,基于此,分析GPU核的执行方式,以及网格、线程块和线程之间的关系,采用细化核函数的方法将光线跟踪算法进行细化。实验结果证明,核的大小设置和分布方向影响了线程块内部的一致性,核函数的细化能增加线程块中同时运行的线程捆的数量。

关键词：图形处理器计算统一设备体系结构光线跟踪

在线全文

学校读者我要写书评

暂无评论

飞机整体壁板战伤修理研究

航空学报 2000年第1期21卷 64-66页

作者：焦良张建华空军第一航空学院航空修理工程系河南信阳464000

为飞机整体壁板战伤应急胶接修理提出了波纹板补强方案,该方案改善了补片与其周围壁板间的刚度匹配,使被修复壁板承载能力得以提高,且无须改变原有的胶接修理工艺及胶粘剂。

关键词：飞机修理整体壁板战斗损伤胶接

在线全文

学校读者我要写书评

暂无评论

从系统论的角度看中医现代化

时珍国医国药 2005年第3期16卷 231-232页

作者：焦东亮南京中医药大学

从中西医理论的区别入手,通过分析两者在哲学基础和方法论上的差异,提出中医整体观和辨证论治的观点符合现代的认识论—系统论。并提出要解决中医的缺陷和推进中医的发展,必须以整体兼容还原的方法,来研究出中医理论特别是五脏实质的微... 详细信息

从中西医理论的区别入手,通过分析两者在哲学基础和方法论上的差异,提出中医整体观和辨证论治的观点符合现代的认识论—系统论。并提出要解决中医的缺陷和推进中医的发展,必须以整体兼容还原的方法,来研究出中医理论特别是五脏实质的微观本质,以探索中医的现代化之路。

关键词：系统论中医现代化整体兼容还原

Correction of a CADASIL point mutation using adenine base editors in hiPsCsandbloodvessel organoids

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 197-207页

作者： Jingwen Wang Lei Zhang Guanglan Wu Jinni Wu Xinyao Zhou Xiaolin Chen Yongxia Niu Yiren jiao Qianyi Liu Puping liang Guang Shi Xueqing Wu Junjiu Huang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Key Laboratory of Reproductive Medicine of Guangdong Province The First Affiliated Hospital and School of Life SciencesSun Yat-sen UniversityGuangzhouGuangdong 510275China Center of Reproductive Medicine Children's Hospital of Shanxi and Women Health Center of ShanxiTaiyuanShanxi 030013China

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic small vessel disease caused by mutations in the NOTCH3 gene. However, the pathogenesis of CADASIL remains unclear, and patients have limited treatment options. Here, we use human induced pluripotent stem cells (hiPSCs) generated from the peripheral blood mononuclear cells of a patient with CADASIL carrying a heterozygous NOTCH3 mutation (c.1261C>T, p.R421C) to develop a disease model. The correction efficiency of different adenine base editors (ABEs) is tested using the HEK293T-NOTCH3 reporter cell line. ABEmax is selected based on its higher efficiency and minimization of predicted off-target effects. Vascular smooth muscle cells (VSMCs) differentiated from CADASIL hiPSCs show NOTCH3 deposition and abnormal actin cytoskeleton structure, and the abnormalities are recovered in corrected hiPSC-derived VSMCs. Furthermore, CADASIL blood vessel organoids generated for in vivo modeling show altered expression of genes related to disease phenotypes, including the downregulation of cell adhesion, extracellular matrix organization, and vessel development. The dual adeno-associated virus (AAV) split-ABEmax system is applied to the genome editing of vascular organoids with an average editing efficiency of 8.82%. Collectively, we present potential genetic therapeutic strategies for patients with CADASIL using blood vessel organoids and the dual AAV split-ABEmax system.

关键词： CADASIL Induced pluripotent stem cells Adenine base editors AAV Blood vessel Organoid

基于第二代小波的序列图像超分辨率复原算法研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

宇航学报 2010年第2期31卷 521-525页

作者：焦斌亮宋俊玲燕山大学信息科学与工程学院秦皇岛066004

介绍了第二代小波(SGWs)的基本原理和特点,在此基础上提出了低分辨率采样图像高分辨率(HR)重建算法。它不但具有结构简单,逆变换容易,可扩展性好的优点,并且克服了第一代小波(FGWs)的不均匀采样和定义在有限区间上的难题,指出了小波变... 详细信息

介绍了第二代小波(SGWs)的基本原理和特点,在此基础上提出了低分辨率采样图像高分辨率(HR)重建算法。它不但具有结构简单,逆变换容易,可扩展性好的优点,并且克服了第一代小波(FGWs)的不均匀采样和定义在有限区间上的难题,指出了小波变换时数据不规则性的处理方法,并利用硬/软阈值对小波系数降噪,使得重构后的图像具有最佳的PSNR和最低的重构误差。实验和仿真结果表明,与传统方法相比,该算法在提高了图像的分辨率同时PSNR最多能提高3dB左右。

关键词：图像超分辨率第二代小波插值细分高分辨率重建

地佐辛和氟比洛芬酯用于颌面外科手术全身麻醉气管插管术后咽痛的比较

在线全文

学校读者我要写书评

暂无评论

北京大学学报（医学版） 2014年第1期46卷 104-106页

作者：焦亮刘瑞昌北京大学口腔医学院.口腔医院麻醉科北京100081

目的:比较地佐辛和氟比洛芬酯用于颌面外科手术全身麻醉气管插管术后咽痛的效果。方法:颌面外科手术患者90例,随机分为对照组(C组)、氟比洛芬酯组(F组)和地佐辛组(D组),每组30例患者。手术结束前30min,3组分别静脉注射生理盐水、氟比洛... 详细信息

目的:比较地佐辛和氟比洛芬酯用于颌面外科手术全身麻醉气管插管术后咽痛的效果。方法:颌面外科手术患者90例,随机分为对照组(C组)、氟比洛芬酯组(F组)和地佐辛组(D组),每组30例患者。手术结束前30min,3组分别静脉注射生理盐水、氟比洛芬酯(1 mg/kg)或地佐辛(0.1 mg/kg)。记录患者拔管后0.5 h、1 h、2 h、6 h咽痛的疼痛视觉模拟评分(visual analogue scale,VAS)、伯格曼舒适度评分(Bruggrmann comfort scale,BCS)以及每组的咽痛例数。结果:F组与C组术后咽痛的发生率差异无统计学意义,D组咽痛的发生率显著降低(P<0.05)。术后0.5 h、1 h时,F组咽痛的VAS低于C组(P<0.01),BCS高于C组(P<0.05);术后2 h、6 h时,F组的VAS、BCS评分与C组相比差异无统计学意义。D组术后咽痛的VAS低于F组,BCS高于F组。结论:地佐辛用于防治颌面外科手术全身麻醉气管插管的术后咽痛具有较好的作用。

关键词：地佐辛氟比洛芬插管法,气管内口腔外科手术咽炎

在线全文

学校读者我要写书评

暂无评论

MATLAB用于水下图像预处理技术

核电子学与探测技术 2011年第1期31卷 95-98页

作者：蒋洁焦斌亮燕山大学河北秦皇岛066004

水下激光成像技术在水下侦察、目标识别等海洋开发中具有重要的实用价值,但其所成图像易受到散斑噪声的污染造成分辨率下降,水体对光的"吸收"和"散射"效应给水下激光成像带来大量的背景噪声,是水下成像高噪声和低对比度的主要成因。为... 详细信息

水下激光成像技术在水下侦察、目标识别等海洋开发中具有重要的实用价值,但其所成图像易受到散斑噪声的污染造成分辨率下降,水体对光的"吸收"和"散射"效应给水下激光成像带来大量的背景噪声,是水下成像高噪声和低对比度的主要成因。为了进一步改善成像效果,就需要利用数字图像处理技术对水下成像进行后续加工,水下图像处理结果的好坏直接影响到特征提取和目标识别的成败。通过分析MATLAB对数字图像的直方图均衡化处理、对比度增强处理、平滑滤波处理中的应用,说明了MATLAB在图像处理中的强大功能。

关键词：水下激光成像 MATLAB 直方图均衡化平滑滤波

E2F1-mediated Up-regulation of NCAPG Promotes Hepatocellular Carcinoma Development by Inhibiting Pyroptosis

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第1期12卷 25-35页

作者： Cuicui Xiao jiao Gong Yusheng Jie Weicheng liang Yan Tai Wei Qin Tongyu Lu Yutian Chong Ziqing Hei Bo Hu Qi Zhang Biotherapy Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Anesthesiology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Key Laboratory of Liver Disease of Guangdong Province Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Infectious Diseases Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Cell-Gene Therapy Translational Medicine Research Center Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina

Background and Aims:As a subunit of the condensin complex,NCAPG has an important role in maintaining chromosome condensation,but its biological function and regulatory mechanism in hepatocellular carcinoma(HCC)remains ***:The prognostic ability of NCAPG in HCC patients was examined by univariate and multivariate Cox regression *** curves were plotted to compare the predictive ability of NCAPG and *** luciferase reporter system,and ChIP were used to investigate transcriptional potential of E2F1 to *** was observed by scanning electron *** expression of NCAPG,E2F1,and major proteins constituting NLRP3 inflammasome was determined by western blotting and *** in vivo tumor formation assay was conducted to verify the in vitro ***:Up-regulated NCAPG was identified in HCC tissues compared with adjacent tissue and high NCAPG was positively correlated with poor *** NCAPG mRNA level was a prognostic factor in HCC patients and also a diagnostic factor with higher predictive ability compared with AFP[AUROC 0.766(95%CI:0.650–0.881)vs.0.649(95%CI 0.506–0.793)].HBx transfection resulted in concomitant up-regulation of E2F1 and NCAPG.E2F1 significantly increased the activity of luciferase reporter fused with NCAPG reporter,and the interaction of E2F1 and NCAPG gene was confirmed by *** of E2F1 resulted in significant down-regulation of *** of NCAPG promote pyroptosis mediated by NLRP3 inflammasome activation in multiple HCC cell lines and also suppressed tumorigenesis in ***:We identified a novel role of NCAPG in the regulation of NLRP3 inflammasome-mediated pyroptosis,which was regulated by its upstream transactivator,*** role of E2F1-NCAPG-NLRP3 regulation of pyroptosis network may be a potential target in HCC treatment.

关键词： NCAPG Hepatocellular carcinoma Pyroptosis NLRP3 inflammasome Serum marker circulating RNA.

Development of a polarized ~3He neutron spin filter based on spin exchange optical pumping at China Mianyang Research Reactor

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 119-122页

作者： Song Yan Mo-Fan Zhang Wen-Chuan Guo Wen-Zhao Wang Jian Gong Tian-jiao liang Ben-Qiong Liu Mei Peng Shu-Ming Peng GuanAi Sun Xiao-Qing Tu Hai-Yang Yan Jian-Hua Zhang Hao Zheng Key Laboratory of Neutron Physics Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyang 621900China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Department of Physics Beijing Jiaotong UniversityBeijing 100044China ABeijing Computational Science Research Center Beijing 100142China Dongguan Neutron Science Center Dongguan 523803China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Spin-polarized^3He gas is widely used in many research *** is used to search for new spin-dependent interactions beyond the standard model[1,2].It works as a target for electron scattering when studying the spin structure of neurons in high-energy and nuclear physics[3].Also,it works as a neutron spin filter(NSF)for polarizing/analyzing neutron polarizations in scattering experiments[4-7].One of the advantages of neutron scattering is that the neutron has a magnetic moment;thus,it can detect a magnetic structure with high *** the neutrons are polarized,this advantage can be greatly improved because polarized neutron scattering techniques can easily differentiate between magnetic and nuclear *** comparison,it is not very easy for other techniques such as X-ray scattering to separate magnetic interactions from electrical ones in magnetic samples because the latter is usually much stronger than the ***,by encoding energy change and scattering angle information into precessions of the neutron polarization,the energy and angle resolutions for scattering can be significantly increased using the so-called spin echo techniques.

关键词： polarized latter exchange