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Carbonate dynamics in a tropical coastal system in the South China Sea featuring upwelling, river plumes and submarine groundwater discharge

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Science China Earth Sciences 2022年第12期65卷 2267-2284页

作者： Wei YANG Xianghui GUO Zhimian CAO jianzhong su Liguo GUO Lifang WANG Yi XU Tao HUANG Yan LI Yanping XU Zhe WANG Guizhi WANG Minhan DAI State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China

This study examined carbonate dynamics in the northwestern South China Sea(NWSCS),an area jointly influenced by upwelling,river plumes and submarine groundwater *** were obtained from two cruises conducted in summer 2009 and *** 2009,a high salinity-low temperature water mass occurred nearshore off northeastern Hainan Island,indicative of upwelling,commonly referred to as HNEU.A river plume fueled primarily by local rivers and characterized by low salinity and high temperature was observed in the NWSCS off the mainland roughly along the 30 m *** 2012,coastal upwelling off northeastern Hainan Island was not detectable at the surface,but was observed at a different location off eastern Hainan Island(HEU).River plume waters in 2012 were patchily distributed,with a low salinity zone further westerly than that in 2009 and another on the mid-shelf of the NWSCS sourced from the Pearl River which reached out~250 km from the mouth of the Pearl River *** 2009,elevated dissolved inorganic carbon(DIC)and total alkalinity(TA)occurred in the coastal plume,where submarine groundwater discharge contributed DIC and TA additions of 38.9±20.5 and 42.5±22.3μmol kg^(−1),respectively,with a DIC/TA ratio of~0.92,which made a minor contribution to the variation of seawater partial pressure of CO_(2)(pCO_(2)),pH and the aragonite saturation state index(Ω_(arag)).Additionally,high surface phytoplankton production consumed DIC of 10.0±10.4μmol kg^(−1) but did not significantly affect TA,which dominated pCO_(2) drawdown in the coastal plume water and increased the pH andΩ_(arag) at *** groundwater discharge was also observed in the region influenced by upwelling,but to a lesser degree than that impacted by coastal *** pH andΩ_(arag) and higher pCO_(2) values than in offshore waters were observed downstream of the upwelling system,attributable largely to organic matter remineralization with a DIC addition of 23.8±8.4μmol kg^(−1).In 2012,submari

关键词： Carbonate system Northwestern South China Sea Coastal upwelling submarine groundwater discharge Ocean acidification

Identification of biological feature based on high-throughput DNA Methylome

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Identification of biological feature based on high-throughpu...

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： jianzhong su Haidan Yan 张岩 College of Bioinformatics Science and Technology Harbin Medical University

DNA methylation is an important epigenetic modification for genomic regulation in higher organisms that plays a crucial role in the progression of development or *** integration and mining of DNA methylome by methylation-specific PCR and genome-wide profiling technology could greatly assist the discovery of novel candidate *** permits systemslevel analysis of genomic methylation patterns associated with gene expression and chromatin structure. A comprehensive tool,CpGMPs,is developed for identification and analysis of unmethylated and methylated regions from bisulfite sequencing data,and to identify conserved and differentially methylated regions of various methylation patterns for paired or multiple samples. CpGMPs accurately identifies and analyzes methylated and unmethylated CpG patterns in genomic regions from bisulfite sequencing data using hotspot *** identifies conserved and differentially methylated regions among multiple samples(cells or tissues) using linear *** methylation patterns of genomic regions are qualitatively and dynamically identified using the methylation status of neighboring CpGs,without knowledge of predefined regions or the average methylation of CpGs in the genomic *** identified the methylation patterns in genomic regions from five human bisulfite sequencing data during cellular *** cell-specific methylation pattern *** potentially functional regions form candidate regions for analysis of the function of DNA methylation during cellular differentiation. CpGPs is the first user-friendly tool for identifying methylation patterns of genomic regions from bisulfite sequencing data,permitting further investigation of the biological functions of genome-scale methylation patterns.

关键词： DNA methylation Bisulfite sequencing Methylation patterns Differentially methylated regions

A simulation study of HPA model in the pain therapy

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A simulation study of HPA model in the pain therapy

第十八届全国非线性振动暨第十五届全国非线性动力学和运动稳定性学术会议（NVND2021）

作者： Ying Du Xinyu Wang Weimin Bao jianzhong su School of Science East China University of Science and Technology Department of Mathematics University of Texas at Arlington

It is crucial of how pain transitions from acute to chronic for patients. Except the clinical approach, there is an increasingly need for a quantitative and predictive method to evaluate how pain trajectories are classified and how we can more effectively intervene. In this study, we use a computational hypothalamic-pituitary-adrenal(HPA) model to simulate pain trajectories. The result shows that different cortisol level can express various situation of acute, manic-style pain and intermittent pain pattern. Also, we can construct a good pain trajectory not only for an individual patient, but also for a group of patients. These results show the feasibility and the potential of developing such a mathematical model for patient evaluations.

关键词： low back pain pain trajectories HPA model simulation

Identification and characterization of partially hypermethylation in under-methylated regions

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Identification and characterization of partially hypermethyl...

2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： Xinyu Wang Lijun Dai Qingran Qong jianzhong su Wenzhou Medical Universiy

DNA methylation plays key regulatory role in regulation of gene transcription by multiple features such as length,genome location,and CpG density,So the regulatory programs of DNA methylation is very complex and has not yet been fully *** deep analysis of hypermethylated CpG sites in the under-methylated regions by a new computing framework hyperUMR we designed,we observed a bimodal methylation status,named partially and fully *** Hyper could not be quantified by traditional mean methylation level of CpG within a predefined *** with fully Hyper,partially Hyper exhibits a more complex transcriptional regulation pattern,and it associates with up-regulation of gene expression maybe mediated by inhibiting the methylation-sensitive ***-cancer analysis verified the universality of partially *** study provides a computational tool for the precise identification of DNA methylation patterns,suggesting the complexity of regulational role of DNA methylation.

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Predicting cancer-related genes with DNA methylation based on protein-protein interaction network

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Predicting cancer-related genes with DNA methylation based o...

第五届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会高通量时代的生物信息学与系统生物学

作者： Hui Liu jianzhong su Hongbo Liu Yan Zhang College of Bioinformaties Science and Technology Harbin Medical University

Background:DNA methylation plays a crucial role in the occurrence of complex *** that interact directly or indirectly may have the same or similar functions in the biological processes in which they are involved and together contribute to the related disease *** complicated relations between genes can be clearly represented using network theory.A protein-protein interaction(PPI) network offers a platform from which to systematically identify disease-related genes from the relations between genes with similar functions. Methods:A weighted human PPI network(WHPN) is constructed using DNA methylation correlations based on human protein-protein interactions.A cancer-associated subnetwork(CASN) is obtained from WHPN by selecting genes associated with seed genes which were known to be methylated in the four *** neighborhood-weighting decision rule,the potential cancer-related genes are prioritized,and than are carried to functional *** provides a comprehensive approach for prioritizing the cancer-related genes with abnormal methylation from genome and epigenome data. Results:WHPN that we built represents the relationships of DNA methylation levels in gene pairs for four cancer *** we found that CASN had a more densely connected network community than WHPN,indicating that the genes in CASN were much closer to seed *** prioritized 154 potential cancer-related genes with aberrant methylation in CASN. A function enrichment analysis for GO and KEGG indicated that the optimized genes were mainly involved in the biological processes of regulating cell apoptosis and programmed cell *** analysis of expression profiling data revealed that many of the optimized genes were expressed differentially in the four *** examining the PubMed co-citations,we found 43 optimized genes were related with cancers and aberrant methylation,and 10 genes were validated to be methylated aberrantly in *** 154 optimized genes,27 were a

关键词： cancer DNA methylation network theory epigenetics

Reconstructions for Continuous-Wave Diffuse Optical Tomography by a Globally Convergent Method

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Journal of Applied Mathematics and Physics 2014年第5期2卷 204-213页

作者： jianzhong su Yueming Liu Zi-Jing Lin Steven Teng Aubrey Rhoden Natee Pantong Hanli Liu Department of Mathematics University of Texas at Arlington Arlington Texas USA Department of Bioengineering University of Texas at Arlington Arlington Texas USA

In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.

关键词： Inverse Problems Diffuse Optical Tomography Medical and Biological Imaging Globally Convergence Method

Design,methodology,and baseline of whole city‑million scale children and adolescents myopia survey(CAMS)in Wenzhou,China

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Eye and Vision 2021年第1期8卷 303-316页

作者： Liangde Xu Youyuan Zhuang Guosi Zhang Yunlong Ma Jian Yuan Changseng Tu MiaoMiao Li Wencan Wang Yaru Zhang Xiaoyan Lu Jing Li Xinting Liu Zhengbo Xue Meng Zhou Jie sun Jinhua Bao Ming Li Fan Lu Hong Wang jianzhong su Jia Qu School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityWenzhou 325027China State Key Laboratory of Ophthalmology Optometry and Visual ScienceWenzhou 325027China Institute of Biomedical Big Data Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Ocular Disease Wenzhou 325027China College of Bioinformatics Science and Technology Harbin Medical UniversityHarbin 150081People’s Republic of China

Background:Myopia is the most common visual impairment in children and adolescents *** study described an economical and effective population-based screening pipeline and performed the project of a million scale children and adolescents myopia survey(CAMS),which will shed light on the further study of myopia from the level of epidemiology and precision ***:We developed a novel population-based screening pattern,an intelligent screening process and internetbased information transmission and analysis system to carry out the survey consisting of school children in Wenzhou,*** examination items include unaided distance visual acuity,presenting distance visual acuity,and noncycloplegic *** and high myopia were defined as spherical equivalent(SE)≤−1.00 diopters(D)and SE≤−6.00 D,***,the reports of the vision checking were automatically sent to parents and the related *** CAMS project will be done two to four times annually with the support of the *** online eyesight status information management system(OESIMS)was developed to construct comprehensive and efficient electronic vision health records(EVHRs)for myopia information inquiry,risk pre-warning,and further ***:The CAMS completed the first-round of screening within 30 days for 99.41%of Wenzhou students from districts and counties,in June 2019.A total of 1,060,925 participants were eligible for CAMS and 1,054,251(99.37%participation rate)were selected through data quality control,which comprised 1305 schools,and 580,609,251,050 and 170,967 elementary,middle,and high school *** mean age of participants was 12.21±3.32 years(6-20 years),the female-to-male ratio was *** prevalence of myopia in elementary,middle,and high school students was 38.16%,77.52%,and 84.00%,respectively,and the high myopia incidence was 0.95%,6.90%,and 12.98%.Conclusions:The CAMS standardized myopia screening model involves automating large-scal

关键词： Baseline Vision screening Myopia prevention and control Population-based

压缩体上圆片系统和曲面上的曲线的交(英文)

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黑龙江大学自然科学学报 2008年第1期25卷 116-121,126页

作者：苏建忠雷逢春哈尔滨工业大学数学系哈尔滨150001 大连理工大学数学系大连116024

主要研究压缩体上的完全圆片系统和带边可定向的三维流形的强不可约的Heegaard分解。+W表示压缩体W的正边界。找到了压缩体W的完全圆片系统,并且证明了真嵌入到W中且边界在+W上的任何本质圆片都可以由压缩体的这个圆片系统中的圆片的连... 详细信息

主要研究压缩体上的完全圆片系统和带边可定向的三维流形的强不可约的Heegaard分解。+W表示压缩体W的正边界。找到了压缩体W的完全圆片系统,并且证明了真嵌入到W中且边界在+W上的任何本质圆片都可以由压缩体的这个圆片系统中的圆片的连通和表示出来。进一步研究了曲面+W上与柄体的每一个圆片至少交n次的简单闭曲线,给出了一个判定简单闭曲线是n闭的一个有限的组合条件,并且给出一个带边的可定向的三维流形的Heegaard分解是强不可约的判定条件。

关键词：连通和完全圆片系统 Heegaard分解

Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 896-908页

作者： Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou jianzhong su Chen Wu Dongxin Lin Department of Etiology and Carcinogenesis National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Beijing Advanced Innovation Center for Genomics Biomedical Pioneering Innovation CenterPeking UniversityBeijing 100871China Cancer Institute Affiliated Cancer Hospital of Xinjiang Medical UniversityUrumqi 830000China School of Biomedical Engineering School of Ophthalmology and Optometry and Eye HospitalWenzhou Medical UniversityWenzhou 325011China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China CAMS Key Laboratory of Genetics and Genomic Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaGuangzhou 510060China

This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages hassurvival *** genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns.

关键词： esophageal squamous diagnosis