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Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2022

Chinese Chemical Letters 2024年第3期35卷 114-126页

作者： Xumeng Deng Kaihao Chen Kai Pang Xiaoting liu Minsong Gao Jie Ren Guanwen Yang Guangpeng Wu Chengjian Zhang Xufeng Ni Peng Zhang Jian Ji jianzhao liu Zhengwei Mao Ziliang Wu Zhen Xu Haoke Zhang Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

In 2022,The MOE Key Laboratory of Macromolecular Synthesis and Functionalization in Zhejiang University had achieved several important ***,a series of well-defined dinuclear organoboron catalysts were developed to precisely control the enchainment of ether and carbonate segments during the copolymerization of CO_(2)and ***,polyester had been synthesized through cationic copolymerization of cyclic ***,ring-opening polymerization of carbon dioxide based valerolactone had been achieved,revealing the prospect of 3-ethylidene-6-vinyltetrahydro-2H-pyran-2-one(EVL)in utilizing CO_(2)and synthesizing functional ***,machine learning methods have been applied to biomaterial research,enabling high-throughput screening of functional biomaterial surfaces for implantable devices,and searching for potent antimicrobial peptides in whole combinatorial peptide ***,methods of characterization of biomacromolecule RNA transcription and manipulation of nucleoside modification were ***,artificial enzymes-armed Bifidobacterium Longum probiotics were established to tune down gut ***,three-dimensional(3D)printing technologies were used to engineer tough supramolecular ***,hydroplastic foaming graphene frameworks for acoustic and conductive polymer composites were provided for ***,aggregate photophysics about the nature of through-space interactions(TSIs)and manipulating their strength in small molecules with non-conjugated structure had been ***,the forming mechanism of a newfound nested texture in poly(L-lactic acid)(PLLA)spherulitic films had been ***,the isotropically dyeing mechanism of KDP single crystals grown from hydrogels have been *** related works are reviewed in this paper.

关键词： Polymer Catalyst Biomaterial research mRNA Hydrogel Graphene Crystal

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非药物性干预措施对0~14岁儿童法定传染病发病的影响

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医学动物防制 2024年第6期40卷 531-537页

作者：刘建昭刘天秦周阮德欣向泉姚梦雷荆州市疾病预防控制中心湖北荆州434000 长江大学公共卫生研究中心

目的以荆州市数据为例,探讨非药物性干预措施(non-pharmaceutical interventions,NPIs)对0~14岁儿童法定传染病(notifiable infectious diseases,NIDs)发病的影响。方法2015年第1周—2020年第5周作为历史数据拟合贝叶斯结构时间序列(Bayesian structural time series,BSTS)模型并预测2020年6—53周NIDs发病例数。相对下降(relative risk,RR)评价指标被用于评价NPIs对NIDs的影响。分病种、年龄组、性别、人群、传播途径和时期进行亚组分析。结果荆州市2020年6—53周0~14岁儿童共报告NIDs 16种5219例,较2015—2019年同期下降64.57%。基于模型2020年6—53周NIDs发病例数总体下降54.51%,其中甲乙类传染病下降59.09%,丙类传染病下降54.28%。从传播途径看,呼吸道传染病的发病例数下降幅度最大(RR=87.58%,95%CI:56.64%~118.16%)。不同性别NIDs的发病例数下降幅度相当。从年龄看,6~<12岁年龄组的下降幅度最大(RR=83.39%,95%CI:35.5%~128.83%)。从人群分类看,学生NIDs的发病例数下降幅度最大(RR=79.62%,95%CI:18.02%~141.32%)。从病种看,流行性感冒(RR=90.37%,95%CI:58.78%~119.93%)、手足口病(RR=74.16%,95%CI:59.66%~88.60%)分别是呼吸道传染病、肠道传染病发病例数下降幅度最大疾病。结论NPIs能显著降低0~14岁儿童NIDs发病例数,在年龄、人群分类等亚组存在差异。应以此为依据,针对性采取严格NPIs以保护该人群。

关键词：非药物干预措施传染性疾病公共卫生措施荆州市

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a^(6)A-seq:N^(6)-allyladenosine-based cellular messenger RNA metabolic labelling and sequencing

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Fundamental Research 2023年第5期3卷 657-664页

作者： Xiao Shu Chenyang Huang Tengwei Li Jie Cao jianzhao liu MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityZheda Road 38Hangzhou 310027China Life Sciences Institute Zhejiang University866 Yuhangtang RdHangzhou 310058China

The integration of RNA metabolic labelling by nucleoside analogues with high-throughput RNA sequencing has been harnessed to study RNA *** immunoprecipitation purification or chemical pulldown technique is generally required to enrich the analogue-labelled *** we developed an a^(6)A-seq method,which takes advantage of N^(6)-allyladenosine(a^(6)A)metabolic labelling on cellular mRNAs and profiles them in an immunoprecipitation-free and mutation-based manner.a^(6)A plays a role as a chemical sequencing tag in that the iodination of a^(6)A in mRNAs results in 1,N^(6)-cyclized adenosine(cyc-A),which induces base misincorporation during RNA reverse transcription,thus making a^(6)A-labelled mRNAs detectable by sequencing.A nucleic acid melting assay was utilized to investigate why cyc-A prefers to be paired with guanine.a^(6)A-seq was utilized to study cellular gene expression changes under a methionine-free stress *** with regular RNA-seq,a^(6)A-seq could more sensitively detect the change of mRNA production over a time *** experiment of a^(6)Acontaining mRNA immunoprecipitation followed by qPCR successfully validated the high-throughput a^(6)A-seq ***,our results show a^(6)A-seq is an effective tool to study RNA dynamics.

关键词： RNA sequencing Adenosine analogue Metabolic labelling Base mutation Nascent RNA RNA dynamics RNA tag

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Diagnostic Quantification of the Cloud Water Resource in China during 2000–2019

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Journal of Meteorological Research 2022年第2期36卷 292-310页

作者： Miao CAI Yuquan ZHOU jianzhao liu Yahui TANG Chao TAN Junjie ZHAO Jianjun OU CMA Key Laboratory for Cloud Physics Weather Modification CenterChina Meteorological Administration(CMA)Beijing 100081 Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102 University of Chinese Academy of Sciences Beijing 100049 Meteorological Disaster Prevention Technology Center of Shanxi Taiyuan 030032 Shanghai By Weather Technology Co. Shanghai 201306

By using the diagnostic quantification method for cloud water resource(CWR),the three-dimensional(3D)cloud fields of 1°×1°resolution during 2000-2019 in China are firstly obtained based on the NCEP reanalysis data and related satellite ***,combined with the Global Precipitation Climatology Project(GPCP)products,a 1°×1°gridded CWR dataset of China in recent 20 years is *** this basis,the monthly and annual CWR and related variables in China and its six weather modification operation sub-regions are obtained,and the CWR characteristics in different regions are analyzed *** results show that in the past 20 years,the annual total amount of atmospheric hydrometeors(GM_(h))and water vapor(GM_(v))in the Chinese mainland are about 838.1 and 3835.9 mm,*** deducting the annual mean precipitation of China(P_(s),661.7 mm),the annual CWR is about 176.4 *** the six sub-regions,the southeast region has the largest amount of cloud condensation(C_(vh))and precipitation,leading to the largest GM_(h) and CWR *** contrast,the annual P_(s),GM_(h),and CWR are all the least in the northwest ***,the monthly and interannual variation trends of P_(s),C_(vh),and GM_(h) in different regions are identical,and the evolution characteristics of CWR are also consistent with the hydrometeor inflow(Q_(hi)).For the north,northwest,and northeast regions,in spring and autumn the precipitation efficiency of hydrometeors(PEh)is not high(20%-60%),the renewal time of hydrometeors(RT_(h))is relatively long(5-25 h),and GM_(h) is relatively ***,there is great potential for the development of CWR through artificial precipitation enhancement(APE).For the central region,spring,autumn,and winter are suitable seasons for CWR *** the southeast and southwest regions,P_(s) and PE_(h) in summer are so high that the development of CWR should be *** different spatial scales,there are significant differences in the characterist

关键词： cloud water resource(CWR) diagnostic quantification weather modification regions monthly and annual variation development characteristics

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The chemical structures,biosynthesis,and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium:a review

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Chinese Journal of Natural Medicines 2024年第8期22卷 676-698页

作者： QI jianzhao WU Jing KANG Shijie GAO Jingming Hirokazu Kawagishi liu Hongwei liu Chengwei Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life ScienceNortheast Forestry UniversityHarbin 150040China Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China Faculty of Agriculture Shizuoka UniversityShizuoka 422-8529Japan State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Fungal phytochemicals derived from higher fungi,particularly those from the culinary-medicinal genus Hericium,have gained significant attention in drug discovery and *** review aims to provide a comprehensive analysis of the chemical structures,biosynthetic pathways,biological activities,and pharmacological properties of monomeric compounds isolated from Hericium *** the past 34 years,253 metabolites have been identified from various Hericium species,including cyathane diterpenes,alkaloids,benzofurans,chromenes,phenols,pyrones,steroids,and other miscellaneous *** investigations into the biosynthesis of erinacines,a type of cyathane diterpene,have led to the discovery of novel cyathane *** research has highlighted the biological activities and pharmacological properties of Hericium-derived compounds,with particular emphasis on their neuroprotective and neurotrophic effects,immunomodulatory capabilities,anti-cancer activity,antioxidant properties,and antimicrobial *** A,in particular,has been extensively ***,transcriptomic,and proteomic analyses of Hericium species have facilitated the discovery of new compounds and provided insights into enzymatic reactions through genome *** diverse chemical structures and biological activities of Hericium compounds underpin their potential applications in medicine and as dietary *** review not only advances our understanding of Hericium compounds but also encourages further research into Hericium species within the realms of medicine,health,functional foods,and agricultural *** broad spectrum of compound types and their diverse biological activities present promising opportunities for the development of new pharmaceuticals and edible products.

关键词： Hericium Secondary metabolites Biological activity Biosynthesis

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Key progresses of MOE key laboratory of macromolecular synthesis and functionalization in 2020

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Chinese Chemical Letters 2022年第4期33卷 1650-1658页

作者： Jie Ren Xiao Shu Ya Wang Di Wang Guangpeng Wu Xinghong Zhang Qiao Jin jianzhao liu Ziliang Wu Zhen Xu Chang-Zhi Li Hanying Li MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

In 2020, the MOE Key Laboratory of Macromolecular Synthesis and Functionalization in Zhejiang University had made progresses in several aspects. First, a series of metal-free organoboron catalysts had been designed and synthesized facilely, exhibiting outstanding reactivity, thermalstability and productivity in different kinds of polymerization and cycloaddition reactions. Second, a variety of chalcogen(O, S, Se)-rich polymers had been synthesized via organocatalysis and fabricated to be the ionic conductive and photoluminescent materials. Third, diverse microenvironment-sensitive nanoparticles had been designed,and novel strategies had been realized, to enhance the therapeutic efficacy in cancer as well as biofilmassociated infections. Fourth, m6 A modification on cellular transcriptome-wide messenger RNA had been successfully mapped at single base resolution using a metabolic labeling method. Fifth, a hydrogel-based robot had been developed, showing swift locomotion as a response to dynamic light stimulations. Sixth,the conformation-size scaling law and the conformation evolution map of 2 D macromolecules in solution had been elucidated experimentally, in the single-layer graphene oxide model. Seventh, semitransparent polymer solar cells, promising as building-integrated photovoltaics, have been developed with the fine balance among power conversion efficiency, visible light transparency and infrared photon radiation rejection. Finally, long-range ordered bulk-heterojunctions of organic semiconductors had been achieved,and their superior optoelectronic properties and potential application in photoelectric conversion had been revealed. The related work progresses are reviewed in this paper.

关键词： Polymer Catalyst Drug nanocarrier RNA methylation Gel 2D Macromolecule Organic optoelectronics

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Exploration of biocompatible AIEgens from human trichochrome

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Science China Materials 2022年第11期65卷 3175-3181页

作者： Qiguang Zang Jie Zhang Chenyang Huang Haoke Zhang jianzhao liu Jing Zhi Sun Ben Zhong Tang MOE Key Laboratory of Macromolecules Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Institute of Health Materials of Zhejiang University&Shaoxing City Shaoxing 312000China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China

Natural chromophores wildly exist in living bodies and have been utilized for thousands of years[1].Many of them,such as quinine[2],luciferin[3-5],coelenteramide[6,7],and coumarin[8],can fluoresce and have been widely... 详细信息

关键词：聚集诱导发光结构测试生物安全性生物相容性溶解状态光物理特性结构改造设计合成

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基于城市更新的“工业上楼”设计技术研究

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建筑节能（中英文） 2024年第5期52卷 74-78页

作者：王宏彦刘建钊王雁飞刁鸿鹏彭添张青华中建二局第二建筑工程有限公司广东深圳518066

随着土地使用效率低下与资源紧缺之间的矛盾不断加深,产业结构轻型化和智能化要求不断提高,在产城融合的时代背景下,“工业上楼”作为一种新型的城市更新项目,集聚高端制造企业,其设计、建造、运营相比一般工业厂房在各方面的要求均更... 详细信息

随着土地使用效率低下与资源紧缺之间的矛盾不断加深,产业结构轻型化和智能化要求不断提高,在产城融合的时代背景下,“工业上楼”作为一种新型的城市更新项目,集聚高端制造企业,其设计、建造、运营相比一般工业厂房在各方面的要求均更高。不同类型的厂房、不同的工艺、不同的生产线集中在同一个楼栋中,各方对设计的要求均不相同。因此,构建“工业上楼”业态下的设计研究是亟需的。该业态需要实现“生产”“生活”“生态”融合,进而需要对整体园区设计规划、空间布局、微观和整体交通疏导、厂房减振隔振技术、消防设计等内容进行更多细化调整。在城市更新的大背景下,以上的研究方向很值得探讨和分析,将有助于“工业上楼”在城市更新工作方面做出贡献。

关键词：城市更新工业上楼设计规划消防设计减隔振设计

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Quantifying the Cloud Water Resource:Methods Based on Observational Diagnosis and Cloud Model Simulation

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Journal of Meteorological Research 2020年第6期34卷 1256-1270页

作者： Miao CAI Yuquan ZHOU jianzhao liu Chao TAN Yahui TANG Qianrong MA Qi LI Jietai MAO Zhijin HU CMA Key Laboratory for Cloud Physics Chinese Academy of Meteorological SciencesChina Meteorological Administration(CMA)Beijing 100081 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesCMABeijing 100081 Jilin Weather Modification Office Changchun 130062 Nanjing University of Information Science&Technology Nanjing 210044 School of Physics Peking UniversityBeijing 100871

Based on the concepts of cloud water resource(CWR)and related variables proposed in the first part of this study,this paper provides details of two methods to quantify the *** is diagnostic quantification(CWR-DQ)based on satellite observations,precipitation products,and atmospheric reanalysis data;and the other is numerical quantification(CWR-NQ)based on a cloud resolving model developed at the Chinese Academy of Meteorological Sciences(CAMS).The two methods are applied to quantify the CWR in April and August 2017 over North China,and the results are evaluated against all available *** results are as follows.(1)For the CWR-DQ approach,reference cloud profiles are firstly derived based on the Cloud Sat/CALIPSO joint satellite observations for 2007–*** NCEP/NCAR reanalysis data in 2000–2017 are then employed to produce three-dimensional cloud *** budget/balance equations of atmospheric water substance are lastly used,together with precipitation observations,to retrieve CWR and related *** is found that the distribution and vertical structure of clouds obtained by the diagnostic method are consistent with observations.(2)For the CWR-NQ approach,it assumes that the cloud resolving model is able to describe the cloud microphysical processes completely and precisely,from which four-dimensional distributions of atmospheric water vapor,hydrometeors,and wind fields can be *** data are then employed to quantify the CWR and related terms/*** one-month continuous integration,the mass of atmospheric water substance becomes conserved,and the tempospatial distributions of water vapor,hydrometeors/cloud water,and precipitation are consistent with observations.(3)Diagnostic values of the difference in the transition between hydrometeors and water vapor(Cvh-Chv)and the surface evaporation(Es)are well consistent with their numerical values.(4)Correlation and bias analyses show that the diagnostic CWR contributors are well co

关键词： cloud water resource(CWR) atmospheric hydrometeors precipitation efficiency quantification method observation diagnosis cloud model simulation

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N6-Allyladenosine:a New Small Molecule for RNA Labeling Identified by Mutation Assay

N6-Allyladenosine:a New Small Molecule for RNA Labeling Iden...

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第十届全国化学生物学学术会议

作者： Xiao Shu jianzhao liu Department of Polymer Science and Engineering Zhejiang University

RNA labeling is crucial for study of RNA structure and metabolism. Here we report N-allyladenosine(aA) as a new small molecule for RNA labeling through both metabolic and enzyme-assisted manners. aA behaves like A and can be metabolically incorporated into newly synthesized RNAs inside mammalian cells. We also show that human RNA N-methyladenosine(m6) methyltransferases METTL3/METTL14[1] can work with synthetic cofactor, namely allyl-SAM that is S-adenosyl methionine[2] with methyl replaced by allyl, to site-specifically install an allyl group to N-position of A within specific sequence to generate aA-labeled RNAs. The iodination of N-allyl group of aA under mild buffer conditions spontaneously induces formation of N, N-cyclized adenosine and creates mutations at its opposite site during complementary DNA synthesis of reverse transcription. The existing mA in RNA is inert to methyltransferase-assisted allyl labeling, which offers a chance to differentiate mA from A at individual RNA sites. Our work demonstrates a new method for RNA labeling, which could find applications in developing sequencing methods for nascent RNAs and RNA modifications.

关键词： N~6-allyladenosine m~6A methyltransferases allyl-SAM cofactor chemical labelling of adenosine

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